Excessive intake of coffee, caffeinated beverages and black tea should be avoided during treatment with Metotab.<\/li><\/ul>\n\n\n\nPregnancy, breastfeeding and fertility<\/h2>\n\n\n\n
Pregnancy<\/p>\n\n\n\n
Do not use Metotab during pregnancy or if you are trying to get pregnant.\u00a0Methotrexate can cause congenital malformations, birth defects, and miscarriages.\u00a0It is associated with malformations of the skull, face, heart and blood vessels, brain and arms, and legs.\u00a0It is therefore very important that methotrexate is not given to pregnant patients or patients planning to become pregnant.\u00a0Infertile women, pregnancy must be ruled out by appropriate measures, e.g.\u00a0a pregnancy test before starting treatment.\u00a0You must avoid becoming pregnant while taking methotrexate and for at least 6 months after stopping treatment, using reliable contraception during this time (see also section \u201cWarnings and precautions\u201d).<\/p>\n\n\n\n
If you become pregnant during treatment or suspect you may be pregnant, talk to your doctor as soon as possible. You should be offered medical advice on the risk of harmful effects on the child due to the treatment.<\/p>\n\n\n\n
If you wish to become pregnant, consult your doctor, who may refer you to specialist advice before the planned start of treatment.<\/p>\n\n\n\n
Breast-feeding<\/p>\n\n\n\n
Breast-feeding should be discontinued before and during treatment with Metotab.<\/p>\n\n\n\n
Fertility in men<\/p>\n\n\n\n
Available data do not indicate an increased risk of malformations or miscarriages if the father takes less methotrexate than 30 mg\/week.\u00a0However, risk can not be completely ruled out.\u00a0Methotrexate may be genotoxic.\u00a0This means that the drug can cause gene mutation.\u00a0Methotrexate can affect sperm production and can cause congenital malformations.\u00a0Therefore, you should avoid getting a woman pregnant and donating sperm while taking methotrexate and for at least 6 months after stopping treatment.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Side effects that affect the central nervous system such as fatigue and dizziness may occur during treatment with Metotab. Therefore, the ability to drive or use machines may be impaired in some cases. If you feel tired or dizzy, do not drive or use machines.<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Metotab contains lactose monohydrate<\/h2>\n\n\n\n
Metotab contains\u00a0lactose monohydrates.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n
How to take Metotab<\/h2>\n\n\n\n
Recommended dose:<\/strong><\/p>\n\n\n\nDose for rheumatoid arthritis and psoriasis<\/p>\n\n\n\n
Take Metotab\u00a0only once a week<\/strong>.\u00a0You and your doctor will decide on a suitable day of the week for taking the tablet.<\/p>\n\n\n\nThe tablets should be swallowed whole with a glass of water, in a straight-up or standing position. The notch is not intended for splitting the tablet.<\/p>\n\n\n\n
Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n
Your doctor will decide on a\u00a0dose\u00a0that is tailor-made for you.\u00a0It usually takes 4 – 8 weeks before the treatment has any effect in\u00a0rheumatoid arthritis\u00a0and 2 – 6 weeks in\u00a0psoriasis\u00a0Vulgaris.\u00a0The treatment time is determined by your doctor.<\/p>\n\n\n\n
If you have the impression that the effect of Metotab is too strong or too weak, talk to your doctor or pharmacist.<\/p>\n\n\n\n
If you take more Metotab than you should<\/h2>\n\n\n\n
Follow your doctor’s dose recommendations.\u00a0Do not change the\u00a0dose\u00a0yourself.<\/p>\n\n\n\n
The doctor will decide which treatment is appropriate depending on the severity of the poisoning.<\/p>\n\n\n\n
If you forget to take Metotab<\/h2>\n\n\n\n
Do not take a double dose to make up for a forgotten tablet. Consult your doctor. Take the dose prescribed by your doctor as soon as possible and every week thereafter.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
The frequency of side effects as well as the severity of\u00a0side effects\u00a0depends on the dose level and the frequency with which Metotab is given.\u00a0As serious\u00a0side effects\u00a0can occur even with low\u00a0doses, you must be checked regularly by your doctor.\u00a0Your doctor will perform\u00a0tests to check for abnormalities\u00a0in your blood (such as low\u00a0white blood cell count, low\u00a0platelet count,\u00a0lymphoma\u00a0) and changes in your kidneys and liver.<\/p>\n\n\n\n
The most relevant side effects are effects on blood formation and the gastrointestinal tract.<\/p>\n\n\n\n
Tell your doctor immediately if<\/strong>\u00a0you get any of the following symptoms, as these may indicate a serious, possibly life-threatening\u00a0side effect, which requires urgent, special treatment:<\/p>\n\n\n\n- persistent dry, unproductive cough, shortness of breath and fever; <\/strong>its symptoms may be signs of pneumonia [common].<\/li>
- blood in saliva or cough; <\/strong>these symptoms may be signs of bleeding from the lungs [no known frequency].<\/li>
- symptoms of liver damage, such as yellowing of the skin and whites of the eyes; <\/strong>methotrexate can cause cirrhosis of the liver, scar tissue formation in the liver (liver fibrosis), fatty liver [all uncommon], hepatitis ( acute hepatitis ) [rare] and liver failure [very rare].<\/li>
- allergic reactions such as rash including red, itchy skin, swollen hands, feet, ankles, face, lips, mouth or throat (which may make it difficult to swallow or breathe) and you will feel dizzy; <\/strong>these symptoms may be signs of a severe allergic reaction [rare].<\/li>
- symptoms of kidney damage such as swollen hands, ankles or feet, altered urination frequency, decreased urine output ( oliguria ) or lack of urine ( anuria ); <\/strong>these symptoms may be signs of kidney failure [rare].<\/li>
- symptoms of infection are, e.g. fever, chills, diffuse pain, sore throat; <\/strong>Methotrexate may make you more susceptible to infection . Severe infections such as a certain type of pneumonia ( Pneumocystis jirovecii pneumonia<\/em> ) or sepsis can occur [rare].<\/li>
- symptoms such as weakness \/ paralysis in one side of the body ( stroke ) or pain, swelling, redness and abnormal heat in one of the legs (deep vein thrombosis ). <\/strong>These symptoms can occur in connection with a detached blood clot blocking a blood vessel (thromboembolic event) [rare].<\/li>
- fever and severe deterioration of the general condition or sudden fever together with sore throat or mouth, or urination problems; <\/strong>methotrexate can cause a sharp decrease in the number of white blood cells ( agranulocytosis ) and severe bone marrow inhibition [very rare].<\/li>
- unexpected bleeding, e.g. bleeding gums, blood in the urine, bloody vomiting or bruising; <\/strong>these symptoms may be signs of a sharp decrease in the number of platelets caused by severe bone marrow suppression [very rare].<\/li>
- symptoms such as very severe headache often in combination with fever, stiff neck, nausea, vomiting, confusion and sensitivity to light<\/strong> may indicate an inflammation of the meninges ( acute aseptic meningitis ) [very rare].<\/li>
- Certain brain diseases (encephalopathy \/ leukoencephalopathy) have been reported in cancer patients receiving methotrexate. Such side effects can not be ruled out when methotrexate is used to treat other diseases. Signs of this type of brain disease can be altered mental state, movement disorders ( ataxia ), visual disturbances or memory disorders<\/strong> [no known frequency].<\/li>
- severe skin rash or blisters on the skin (this can also affect the mouth, eyes and genitals); <\/strong>these symptoms can be signs of a condition called Stevens-Johnson syndrome or burn-like condition (toxic epidermal necrolysis \/ Lyell’s syndrome) [very rare].<\/li><\/ul>\n\n\n\n
Listed below are all other side effects that may occur:<\/p>\n\n\n\n
Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n- inflammation of the oral mucosa, stomach upset, nausea, loss of appetite, abdominal pain<\/li>
- abnormal liver function values \u200b\u200b( AST , ALT , bilirubin , alkaline phosphatase).<\/li><\/ul>\n\n\n\n
Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n- sores in the mouth, diarrhea<\/li>
- rash, redness of the skin, itching<\/li>
- headache, fatigue, drowsiness<\/li>
- impaired blood cell formation with decreased number of white blood cells , decreased number of red blood cells , decreased number of platelets .<\/li><\/ul>\n\n\n\n
Uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n- inflammation of the pharynx<\/li>
- inflammation of the intestines, vomiting, pancreatitis, black or tar-like stools, ulcers and bleeding in the gastrointestinal tract<\/li>
- increased photosensitivity, hair loss, increased number of rheumatic nodules, skin ulcers, shingles ( herpes zoster), inflammation of the blood vessels, herpes-like skin rash, hives<\/li>
- trigger of diabetes mellitus<\/li>
- dizziness, impaired thinking ( cognitive dysfunction ), confusion, depression<\/li>
- decreased level of serum albumin<\/li>
- decreased number of all blood cells and platelets<\/li>
- inflammation and ulcers in the bladder or vagina, impaired renal function, disturbed urination<\/li>
- joint pain, muscle pain, decreased bone mass.<\/li><\/ul>\n\n\n\n
Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n- poor absorption of nutrients, gingivitis<\/li>
- increased skin pigmentation, acne , blue spots due to bleeding from blood vessels ( ecchymosis , petechiae ), allergic inflammation of blood vessels<\/li>
- decreased amount of antibody in the blood<\/li>
- infection (incl. reactivation of inactive chronic infection ), red eyes (conjunctivitis)<\/li>
- Mood swings<\/li>
- visual disturbances<\/li>
- pericarditis, accumulation of fluid in the pericardium, prevented blood filling of the heart due to fluid in the pericardium<\/li>
- low blood pressure<\/li>
- formation of scar tissue in the lungs ( pulmonary fibrosis ), shortness of breath and bronchial asthma , accumulation of fluid in the alveoli<\/li>
- fracture as a result of stress or overload of the skeleton (stress fracture)<\/li>
- electrolyte disturbances<\/li>
- fever, impaired wound healing.<\/li><\/ul>\n\n\n\n
Very rare (may affect up to 1 in 10,000 people)<\/strong><\/p>\n\n\n\n- sudden sharp enlargement of the intestine (toxic megacolon)<\/li>
- increased pigmentation of the nails, cuticle inflammation ( acute paronychia ), deep infection of the hair follicles ( furunculosis ), visible dilation of small blood vessels<\/li>
- pain, decreased muscle strength or a feeling of numbness or tingling \/ lower sensitivity to stimulation than normal, taste changes (metallic taste), cramps, paralysis, meninigism<\/li>
- impaired vision, non- inflammatory eye disease ( retinopathy )<\/li>
- loss of sexual drive, impotence , enlargement of the mammary glands in men, defective spermatogenesis (oligospermia), impaired ovulation, impaired spermatogenesis, sterility, menstrual disorders, vaginal discharge<\/li>
- enlargement of the lymph nodes ( lymphoma )<\/li>
- lymphoproliferative disorders (abnormal growth of white blood cells ).<\/li><\/ul>\n\n\n\n
Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n- increased white blood cell count<\/li>
- nosebleeds<\/li>
- protein is in the urine<\/li>
- impotence<\/li>
- bone damage in the jaw (as a result of abnormal growth of white blood cells )<\/li>
- reddening of the skin and scaly skin<\/li>
- swelling.<\/li><\/ul>\n\n\n\n
How to store Metotab<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not store above 25 \u00b0 C. Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment<\/p>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n- The active substance is methotrexate: 2.5 mg; 7.5 mg and 10 mg methotrexate respectively (as methotrexate disodium).<\/li>
- The other ingredients are lactose monohydrate , pregelatinized starch , magnesium stearate.<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Yellow, slightly speckled, round, biconvex tablets. The 10 mg tablet has a score that is for identification purposes only.<\/p>\n\n\n\n
PVC \/ PVDC \/ aluminum blister, containing 10, 30, 50 or 100 tablets.<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
medac society for clinical specialties mbH<\/p>\n\n\n\n
Theater.\u00a06<\/p>\n\n\n\n
22880 Wedel<\/p>\n\n\n\n
Germany<\/p>\n\n\n\n
tel: +49 4103 8006 0<\/p>\n\n\n\n
fax: +49 4103 8006 100<\/p>\n\n\n\n
This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"2.5 mg, 7.5 mg, 10 mg tablet
\nmethotrexate<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[12794,17410,4858,4860,17249,17405,17409,17408,4859,17406,12793,17407],"class_list":["post-17850","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-methotrexate","tag-benefits-of-metotab","tag-methotrexate","tag-methotrexate-side-effects","tag-methotrexate-tablet","tag-metotab","tag-metotab-side-effects","tag-metotab-tablet","tag-what-is-methotrexate","tag-what-is-metotab","tag-what-methotrexate-is-used-for","tag-what-metotab-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17850","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17850"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17850\/revisions"}],"predecessor-version":[{"id":17944,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17850\/revisions\/17944"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17850"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}