{"id":17846,"date":"2022-01-27T09:34:07","date_gmt":"2022-01-27T09:34:07","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17846"},"modified":"2022-02-03T07:46:51","modified_gmt":"2022-02-03T07:46:51","slug":"metoprolol-sandoz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/metoprolol-sandoz\/","title":{"rendered":"Metoprolol Sandoz &#8211; Metoprolol succinate uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg, 50 mg, 100 mg and 200 mg&nbsp;prolonged-release tablets&nbsp;are<br>metoprolol succinate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Metoprolol Sandoz is and what it is used for<\/h2>\n\n\n\n<p>Metoprolol succinate, which is the active ingredient in\u00a0Metoprolol\u00a0Sandoz, blocks certain\u00a0beta receptors\u00a0in your body, especially the\u00a0beta receptors\u00a0in your heart (\u00a0selective\u00a0beta-blockers\u00a0).<\/p>\n\n\n\n<p>Metoprolol&nbsp;Sandoz is used for the following conditions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>high&nbsp;blood pressure<\/strong><\/li><li><strong>angina (&nbsp;angina pectoris&nbsp;)<\/strong><\/li><li><strong>disturbances of heart rhythm<\/strong>&nbsp;with rapid&nbsp;pulse<\/li><li>preventive treatment after the acute phase of a&nbsp;<strong>heart attack<\/strong><\/li><li><strong>unpleasant sensations that the heart is beating irregularly and \/ or too hard<\/strong><\/li><li><strong>migraine<\/strong>&nbsp;prevention<strong><\/strong><\/li><li>treatment of&nbsp;<strong>heart failure&nbsp;.<\/strong><\/li><\/ul>\n\n\n\n<p>Children and adolescents aged 6-18 years<\/p>\n\n\n\n<p>For the treatment of high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;).<\/p>\n\n\n\n<p>Metoprolol contained\u00a0in\u00a0Metoprolol\u00a0Sandoz may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Metoprolol Sandoz<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Metoprolol Sandoz<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to metoprolol succinate or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to any other&nbsp;beta&nbsp;-blocker<\/li><li>if you have severe&nbsp;asthma&nbsp;or severe wheezing attacks<\/li><li>if you suffer from&nbsp;shock&nbsp;due to severe heart disease<\/li><li>if you have a conduction disorder in the heart (grade II or III atrioventricular block, high-grade sinoatrial block) or heart rhythm disorder (sick sinus syndrome) except in patients with permanent pacemaker<\/li><li>if you have severe blood&nbsp;<strong>circulation<\/strong>&nbsp;disorders (severe&nbsp;peripheral&nbsp;arterial&nbsp;disease)<\/li><li>if you have untreated&nbsp;heart failure&nbsp;that is out of control (this usually causes shortness of breath and swelling of the ankles)<\/li><li>if your heart beats slowly (&nbsp;heart rate&nbsp;below 50 beats \/ minute at rest before treatment)<\/li><li>if you have very low&nbsp;blood pressure&nbsp;(systolic&nbsp;blood pressure&nbsp;below 90 mmHg)<\/li><li>if you have been told that your blood has a higher acidity than normal (a condition called metabolic&nbsp;acidosis&nbsp;)<\/li><li>if you are taking any of the following medicines:<ul><li>monoamine oxidase inhibitors&nbsp;(&nbsp;MAOIs&nbsp;) (for depression)<\/li><li>verapamil and&nbsp;diltiazem&nbsp;(to lower&nbsp;blood pressure&nbsp;)<\/li><li>antiarrhythmic drugs such as&nbsp;disopyramide&nbsp;to treat abnormal heart rhythms.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Patients with&nbsp;chronic&nbsp;heart failure&nbsp;should not take&nbsp;metoprolol&nbsp;if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>they suffer from unstable uncompensated&nbsp;heart failure&nbsp;(which can manifest itself in the form of fluid accumulation in the lungs, poor blood circulation or low&nbsp;blood pressure&nbsp;)<\/li><li>they receive&nbsp;continuous&nbsp;or temporary treatment with drugs that increase the heart&#8217;s pumping ability<\/li><li>they have a slow heart rate (less than 68 beats \/ minute at rest, before treatment)<\/li><li>their systolic (upper)&nbsp;blood pressure&nbsp;is constantly below 100 mmHg.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking&nbsp;Metoprolol&nbsp;Sandoz<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have&nbsp;asthma&nbsp;,&nbsp;bronchitis&nbsp;or similar lung problems<\/li><li>if you have problems with your heart (such as a slow heartbeat) or with your blood circulation (&nbsp;Metoprolol&nbsp;Sandoz may make your condition worse)<\/li><li>if you are prescribed the drug fingolimod (used to treat relapsing-remitting&nbsp;multiple sclerosis&nbsp;);&nbsp;concomitant use of these two drugs may potentiate the heart-lowering effect during the first days of treatment with fingolimod<\/li><li>if you have&nbsp;diabetes<\/li><li>if you have thyroid problems<\/li><li>if you have severe liver disease<\/li><li>if you have ever had a severe&nbsp;allergic reaction&nbsp;to anything<\/li><li>if you have a rare form of angina called Prinzmetal&#8217;s angina<\/li><li>if you are going to have an operation that requires anesthesia.&nbsp;Tell your anesthetist that you are taking&nbsp;Metoprolol&nbsp;Sandoz.<\/li><li>if you have a hormone-producing&nbsp;tumor&nbsp;in the adrenal medulla (&nbsp;pheochromocytoma&nbsp;): in this case, prior and concomitant use of an alpha-receptor blocker is required<\/li><li>if you have&nbsp;psoriasis&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is limited experience in treating children under 6 years of age.\u00a0The use of\u00a0Metoprolol\u00a0Sandoz is not recommended for children under 6 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Metoprolol Sandoz<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Metoprolol&nbsp;Sandoz interacts with many other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for high&nbsp;blood pressure&nbsp;(including prazosin,&nbsp;clonidine&nbsp;,&nbsp;hydralazine&nbsp;, guanetidine, betanidine, reserpine, alpha-methyldopa,&nbsp;clonidine&nbsp;and medicines called calcium channel blockers, such as verapamil,&nbsp;diltiazem&nbsp;or nifedipine).<\/li><li>Other&nbsp;beta-blockers&nbsp;(also in the form of&nbsp;eye drops&nbsp;).<\/li><li>Drugs that affect the peripheral blood circulation (fingers and toes), e.g.&nbsp;ergot alkaloids that can be used to treat&nbsp;migraines&nbsp;.<\/li><li>Antidepressants.<\/li><li>Medicines for other mental illnesses.<\/li><li>Antiretroviral drugs, used to treat&nbsp;AIDS&nbsp;and certain other diseases.<\/li><li>Antihistamines&nbsp;(including over-the-counter medicines for hay fever and other&nbsp;allergies&nbsp;, colds and other conditions).<\/li><li>Drugs that prevent&nbsp;malaria&nbsp;.<\/li><li>Medicines for fungal infections.<\/li><li>Drugs that affect liver enzymes, e.g.&nbsp;rifampicin used to&nbsp;treat tuberculosis&nbsp;.<\/li><li>Medicines for heart problems, including angina, e.g.&nbsp;amiodarone&nbsp;,&nbsp;digoxin&nbsp;, nitrates and antiarrhythmic drugs.<\/li><li>fingolimod (a drug used to treat relapsing&nbsp;multiple sclerosis&nbsp;in adults, children and adolescents);&nbsp;concomitant use with&nbsp;beta-blockers&nbsp;may potentiate the heart rate-lowering effect during the first days of treatment with fingolimod<\/li><li>aldesleukin (a synthetic protein drug used to treat kidney cancer that has spread to other organs);&nbsp;concomitant use with&nbsp;beta-blockers&nbsp;may potentiate the antihypertensive effect<\/li><li>Insulin&nbsp;or other diabetes medicines.<\/li><li>Drugs called&nbsp;NSAIDs&nbsp;that are used to treat pain and&nbsp;inflammation&nbsp;.<\/li><li>A local anesthetic called&nbsp;lidocaine&nbsp;.<\/li><li>A drug called dipyridamole that prevents blood clots.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Metoprolol Sandoz with food, drink and alcohol<\/h2>\n\n\n\n<p>Metoprolol\u00a0Sandoz and\u00a0<strong>alcohol<\/strong>\u00a0may\u00a0<strong>increase each other\u00a0&#8216;s sedative\u00a0(sedative) effects<\/strong>.\u00a0Blood alcohol levels can reach higher levels and decrease more slowly.\u00a0<strong>Avoid alcohol<\/strong>\u00a0while taking\u00a0Metoprolol\u00a0Sandoz.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Metoprolol&nbsp;Sandoz should only be used during pregnancy if necessary and if the treating physician has carefully weighed the expected benefit against any possible risks.&nbsp;There is evidence that&nbsp;metoprolol&nbsp;reduces blood flow in the placenta and can cause disruption of fetal growth.<\/p>\n\n\n\n<p>Treatment with&nbsp;Metoprolol&nbsp;Sandoz should be stopped 48-72 hours before the expected delivery.&nbsp;If this is not possible, the newborn baby should be closely monitored by a doctor for 48\u201172 hours after birth.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Metoprolol&nbsp;Sandoz is excreted in human milk.<\/p>\n\n\n\n<p>Metoprolol succinate should not be taken during breastfeeding unless necessary.\u00a0Although no\u00a0side effects\u00a0are expected after using\u00a0Metoprolol\u00a0Sandoz at the recommended\u00a0dose, breast-fed infants should be closely monitored (eg, physician monitoring of cardiac function) for symptoms that may occur with the drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p><strong>Dizziness<\/strong>\u00a0or\u00a0<strong>tiredness<\/strong>\u00a0may occur during treatment with\u00a0Metoprolol\u00a0Sandoz.\u00a0This can affect the ability to react to such an extent that the ability to drive, the ability to use machines, and the ability to work in potentially dangerous situations can be weakened.\u00a0This is especially the case after concomitant use of alcohol and after switching from or to the drug.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Metoprolol Sandoz contains glucose, lactose and sucrose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Metoprolol Sandoz<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your doctor will tell you how many tablets to take and when to take them.&nbsp;The dose&nbsp;you are prescribed depends on your illness and its severity.<\/p>\n\n\n\n<p><strong>Unless your doctor prescribes otherwise, the usual&nbsp;dose&nbsp;is as follows:<\/strong><\/p>\n\n\n\n<p><strong>High&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Patients with&nbsp;<strong>mild or moderate&nbsp;hypertension<\/strong>&nbsp;should take&nbsp;<strong>47.5 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<\/li><li>If necessary, your doctor&nbsp;<strong>may increase the&nbsp;dose&nbsp;to 95-190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.&nbsp;Other antihypertensive agents may also be used as supplements.<\/li><\/ul>\n\n\n\n<p><strong>Angina&nbsp;pectoris&nbsp;_<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;is&nbsp;<strong>95-190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<\/li><li>If necessary, other drugs for the treatment of coronary heart disease can also be used as a supplement.<\/li><\/ul>\n\n\n\n<p><strong>Disorders of the heart rhythm with a rapid\u00a0pulse\u00a0(\u00a0cardiac arrhythmias\u00a0)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;is&nbsp;<strong>95-190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Treatment after a heart attack<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;is&nbsp;<strong>190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Unpleasant feelings of irregular and\/or strong heartbeat (palpitations)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;is&nbsp;<strong>95 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<\/li><li>If necessary, your doctor&nbsp;<strong>may increase the&nbsp;dose&nbsp;to 190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Prevention of&nbsp;migraines<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;is&nbsp;<strong>95-190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Muscle weakness in the heart (&nbsp;heart failure&nbsp;)<\/strong><\/p>\n\n\n\n<p>In the treatment of\u00a0heart failure, the disease must first be stabilized with standard treatment for\u00a0heart failure, and the\u00a0dose of\u00a0Metoprolol\u00a0Sandoz\u00a0must be adjusted individually.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In patients with&nbsp;NYHA&nbsp;<strong>grade III-IV&nbsp;<\/strong><strong>heart failure<\/strong>&nbsp;, the recommended initial dose during the&nbsp;<strong>first week is 11.88 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<strong><\/strong><strong><\/strong><strong><\/strong>Dose&nbsp;one may be increased during the&nbsp;<strong>second week of treatment<\/strong>&nbsp;to&nbsp;<strong>23.75 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.In patients with&nbsp;NYHA&nbsp;<strong>grade II&nbsp;<\/strong><strong>heart failure<\/strong>&nbsp;, the recommended initial dose for the&nbsp;<strong>first two weeks is 23.75 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;.<strong><\/strong><strong><\/strong><strong><\/strong><\/li><li>Thereafter, the&nbsp;dose&nbsp;should be doubled.&nbsp;<strong>Dose&nbsp;one can be doubled every two weeks up to 190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;or to the highest&nbsp;dose&nbsp;you tolerate.<\/li><li><strong>The recommended&nbsp;dose&nbsp;for long-term maintenance treatment<\/strong>&nbsp;is&nbsp;<strong>190 mg<\/strong>&nbsp;metoprolol succinate&nbsp;<strong>once daily<\/strong>&nbsp;or the highest&nbsp;dose&nbsp;you can tolerate.<\/li><\/ul>\n\n\n\n<p><strong>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>High blood pressure: For children aged 6 years and older, the&nbsp;dose&nbsp;depends on the child&#8217;s weight.&nbsp;The doctor will calculate the correct&nbsp;dose&nbsp;for your child.<\/p>\n\n\n\n<p>The usual starting dose is 0.48 mg\/kg metoprolol succinate once daily but not more than 47.5 mg.\u00a0Dose\u00a0one is adjusted to the nearest tablet strength.\u00a0Your doctor may increase the\u00a0dose\u00a0one to 1.9 mg\/kg depending on how\u00a0your blood pressure\u00a0reacts to the treatment.\u00a0Doses\u00a0above 190 mg once daily have not been studied in children and adolescents.<\/p>\n\n\n\n<p>Metoprolol&nbsp;Sandoz tablets are not recommended for children under 6 years of age.<\/p>\n\n\n\n<p>Your doctor will decide how long you should take&nbsp;Metoprolol&nbsp;Sandoz.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist if you have the impression that the effect of&nbsp;Metoprolol&nbsp;Sandoz is too strong or too weak.<\/p>\n\n\n\n<p><strong>Older<\/strong><\/p>\n\n\n\n<p>No studies have been performed on patients over 80 years of age.\u00a0Therefore, special care is required when increasing the\u00a0dosage\u00a0for patients\u00a0over 80 years of age.<\/p>\n\n\n\n<p>Metoprolol&nbsp;Sandoz is for oral use.<\/p>\n\n\n\n<p>Take the tablets once a day, preferably with breakfast.\u00a0The tablets can be divided into two equal\u00a0doses.\u00a0You can swallow the tablets either whole or divided, but avoid chewing or crushing them.\u00a0Take the tablets with water (at least \u00bd glass).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Metoprolol Sandoz than you should<\/h2>\n\n\n\n<p>Bring the medicine pack with you so that the doctor can see which medicine you have taken and can start appropriate treatment.<\/p>\n\n\n\n<p><strong><br>Symptoms of overdose<\/strong><\/p>\n\n\n\n<p>In case of overdose with\u00a0Metoprolol\u00a0Sandoz, the symptoms may include dangerously low\u00a0blood pressure, severe heart complications, difficulty breathing, unconsciousness (including\u00a0coma\u00a0), convulsions, nausea, vomiting, cyanosis (blue or purple skin), and death.<\/p>\n\n\n\n<p>The first signs of overdose occur 20 minutes to 2 hours after taking&nbsp;Metoprolol&nbsp;Sandoz, and with severe overdose, the effects may persist for several days.<\/p>\n\n\n\n<p><strong>Treatment in case of overdose<\/strong><\/p>\n\n\n\n<p>The patient must be admitted to the hospital and cared for in an intensive care unit.\u00a0Even seemingly unaffected patients who have taken a small overdose should be closely monitored for at least 4 hours for signs of poisoning.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Metoprolol Sandoz<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose, but continue the treatment prescribed by your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Metoprolol Sandoz<\/h2>\n\n\n\n<p>Ask your doctor before stopping or stopping treatment with&nbsp;Metoprolol&nbsp;Sandoz prematurely.<\/p>\n\n\n\n<p>Treatment with\u00a0Metoprolol\u00a0Sandoz\u00a0<strong>should not be stopped abruptly<\/strong>\u00a0but the\u00a0dose\u00a0should be reduced gradually.\u00a0Abrupt discontinuation of beta-blocker\u00a0therapy may lead to worsening\u00a0heart failure\u00a0and may increase the risk of myocardial infarction and sudden cardiac death.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fatigue.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness, headache<\/li><li>slow heart rate (&nbsp;bradycardia&nbsp;)<\/li><li>palpitation<\/li><li>sharp drop in blood pressure, especially when getting up after lying down, very rarely accompanied by unconsciousness<\/li><li>cold hands and feet<\/li><li>shortness of breath on exertion in sensitive patients (eg patients with&nbsp;asthma&nbsp;)<\/li><li>nausea, abdominal pain, diarrhea, constipation.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weight gain<\/li><li>depression, drowsiness, sleep disorders, nightmares, impaired concentration<\/li><li>ant crawling, tingling sensation or numbness in the skin (&nbsp;paresthesia&nbsp;)<\/li><li>temporarily aggravated symptoms of&nbsp;heart failure&nbsp;(with swelling of the ankles and feet), 1st degree disturbance of the conduction of the electrical impulse from the atrium to the ventricle (&nbsp;AV block&nbsp;of grade I), pain in the heart area (chest pain), poor pumping ability of the heart (&nbsp;cardiogenic&nbsp;shock&nbsp;) in patients with myocardial infarction (&nbsp;acute&nbsp;myocardial infarction&nbsp;)<\/li><li>bronchospasm (&nbsp;bronchospasm&nbsp;)<\/li><li>skin rash (psoriasis&nbsp;-like hives&nbsp;and dystrophic skin changes), increased sweating<\/li><li>muscle cramps<\/li><li>vomiting.<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>exacerbated&nbsp;diabetes&nbsp;without the characteristic symptoms (&nbsp;latent&nbsp;diabetes mellitus&nbsp;)<\/li><li>nervousness, anxiety<\/li><li>impaired vision, dryness or irritation of the eyes (should be noted when wearing contact lenses),&nbsp;inflammation&nbsp;of the&nbsp;conjunctiva of the eye<\/li><li>disorders of the heart rhythm, conduction disturbance<\/li><li>nasal congestion<\/li><li>dry mouth<\/li><li>deviating liver function values<\/li><li>hair loss<\/li><li>impotence&nbsp;and changes in sexual desire, Peyronie&#8217;s disease (hardening of the erectile&nbsp;tissue&nbsp;in the penis, induratio penis plastica).<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;), decreased&nbsp;white blood cell count&nbsp;(leukocytopenia)<\/li><li>impaired memory, confusion, hallucinations, personality changes (eg mood swings)<\/li><li>tinnitus, hearing disorders<\/li><li>tissue death (&nbsp;necrosis&nbsp;) in patients with severe impaired&nbsp;peripheral&nbsp;blood circulation when starting treatment<\/li><li>taste changes<\/li><li>hepatitis<\/li><li>photosensitivity with skin rash after exposure to light, aggravated&nbsp;psoriasis&nbsp;, onset of&nbsp;psoriasis<\/li><li>joint pain, muscle weakness.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal levels of certain types of fat, e.g.&nbsp;cholesterol&nbsp;and&nbsp;triglycerides&nbsp;in the blood<\/li><li>aggravated symptoms in patients suffering from &#8221;&nbsp;intermittent claudication&nbsp;&#8221; or vasospasm which results in poor blood circulation and whiteness of the toes and fingers (Raynaud&#8217;s syndrome).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Metoprolol Sandoz<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister, jar, and carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is metoprolol succinate.Metoprolol&nbsp;Sandoz 25 mg:One&nbsp;prolonged-release tablet&nbsp;contains 23.75 mg metoprolol succinate equivalent to 25 mg metoprolol tartrate.<br>Metoprolol&nbsp;Sandoz 50 mg:One&nbsp;prolonged-release tablet&nbsp;contains 47.5 mg metoprolol succinate equivalent to 50 mg metoprolol tartrate.<br>Metoprolol&nbsp;Sandoz 100 mg:One&nbsp;prolonged-release tablet&nbsp;contains 95 mg metoprolol succinate equivalent to 100 mg metoprolol tartrate.<br>Metoprolol&nbsp;Sandoz 200 mg:One&nbsp;prolonged-release tablet&nbsp;contains 190 mg metoprolol succinate equivalent to 200 mg metoprolol tartrate.<\/li><li>The other ingredients are microcrystalline cellulose (E460), crospovidone,&nbsp;glucose&nbsp;, hypromellose,&nbsp;lactose monohydrate&nbsp;, macrogol 4000, magnesium stearate, corn starch, polyacrylate, anhydrous&nbsp;colloidal&nbsp;silica, sucrose, talc, titanium dioxide (E171).<br><em>In addition to 100 mg&nbsp;prolonged-release tablets&nbsp;:<\/em>Yellow iron oxide (E172)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p><em>25 mg, 50 mg, and 200 mg prolonged-release tablets:<\/em><\/p>\n\n\n\n<p>White, oblong tablets with a scoreline on both sides of the tablet.\u00a0The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n<p><em>100 mg prolonged-release tablets:<\/em><\/p>\n\n\n\n<p>Light yellow and oblong tablets with a scoreline on both sides of the tablet.\u00a0The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n<p>The prolonged-release tablets\u00a0are packaged in blisters of PP\/aluminum or PVC \/ foil\/aluminum and placed in a carton or are packed in an HDPE jar and inserted in a carton.<\/p>\n\n\n\n<p>Blister:<\/p>\n\n\n\n<p><em>25 mg and 200 mg:<\/em><\/p>\n\n\n\n<p>Pack sizes: 10, 20, 28, 30, 50, 50&#215;1, 60, 100 and 112&nbsp;prolonged-release&nbsp;tablets<\/p>\n\n\n\n<p><em>50 mg and 100 mg:<\/em><\/p>\n\n\n\n<p>Pack sizes: 10, 20, 28, 30, 50, 50&#215;1, 60, 90, 100 and 112&nbsp;prolonged-release&nbsp;tablets<\/p>\n\n\n\n<p>HDPE jar<\/p>\n\n\n\n<p>Pack sizes: 30, 60, 100, 250 and 500&nbsp;prolonged-release&nbsp;tablets<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Sandoz A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Salutas Pharma GmbH, Otto-von-Guericke-Allee 1, D-39179 Barleben, Germany (blister packs)<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Lek Pharmaceuticals dd, Verov\u0161kova 57, 1526 Ljubljana, Slovenia (HDPE j<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metoprolol succinate, which is the active ingredient in Metoprolol Sandoz, blocks certain beta receptors in your body, especially the beta receptors in your heart ( selective beta blockers ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[17421,17302,17417,17420,17297,17301,17418,17298,17419,17299],"class_list":["post-17846","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-metoprolol-sandoz","tag-benefits-of-metoprolol-succinate","tag-metoprolol-sandoz","tag-metoprolol-sandoz-side-effects","tag-metoprolol-succinate","tag-metoprolol-succinate-side-effects","tag-what-is-metoprolol-sandoz","tag-what-is-metoprolol-succinate","tag-what-metoprolol-sandoz-is-used-for","tag-what-metoprolol-succinate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17846","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17846"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17846\/revisions"}],"predecessor-version":[{"id":17900,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17846\/revisions\/17900"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17846"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17846"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17846"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}