25 mg \/ 50 mg \/ 100 mg \/ 200 mg prolonged-release tablet is
metoprolol tartrate<\/p>\n\n\n\n
The active substance in\u00a0Metoprolol\u00a0Orion,\u00a0metoprolol, belongs to a group of medicines called selective\u00a0beta-blockers, which have a special effect on the heart.\u00a0The drug affects how the body responds to certain nerve signals, especially in the heart.\u00a0Thereby, the drug lowers\u00a0blood pressure\u00a0and increases the pumping power of the heart.<\/p>\n\n\n\n
Metoprolol Orion is used to<\/p>\n\n\n\n
Children and adolescents aged 6-18 years:<\/p>\n\n\n\n
For the treatment of high blood pressure ( hypertension )<\/p>\n\n\n\n
Do not take Metoprolol Orion<\/strong><\/p>\n\n\n\n Patients with chronic heart failure should not take metoprolol:<\/p>\n\n\n\n Talk to your doctor, pharmacist, or nurse before taking\u00a0Metoprolol\u00a0Orion if any of the following apply to you, or if you develop any of the following conditions during treatment.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n Inhaled anesthetic<\/em>\u00a0enhances the heart rate lowering effect of\u00a0metoprolol.<\/p>\n\n\n\n Metoprolol\u00a0may potentiate the effects of\u00a0antihypertensive drugs<\/em>\u00a0(eg reserpine, alpha methyldopa,\u00a0clonidine, guanfacine, and cardiac glycosides).\u00a0This can, for example, lead to a greatly reduced\u00a0heart rate.<\/p>\n\n\n\n The following substances may increase the concentration of metoprolol in the blood and thereby enhance the effect of Metoprolol Orion:<\/p>\n\n\n\n The effect of adrenaline on the treatment of hypersensitivity reactions may be impaired.<\/p>\n\n\n\n Metoprolol\u00a0and alcohol may increase each other’s hypnotic effects.\u00a0Therefore, you should not drink alcohol while taking\u00a0metoprolol.<\/p>\n\n\n\n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n Pregnancy<\/em><\/p>\n\n\n\n Breast-feeding<\/em><\/p>\n\n\n\n Metoprolol accumulates in breast milk.<\/p>\n\n\n\n Although no\u00a0side effects\u00a0are expected when\u00a0metoprolol\u00a0is used in standard treatment doses, breastfed infants should be monitored for the effects of the drug.<\/p>\n\n\n\n During treatment with\u00a0Metoprolol\u00a0Orion, dizziness and fatigue may occur.\u00a0Your ability to react may change to such an extent that your ability to drive, use machines, or work without protective equipment is impaired.\u00a0This is especially true in combination with alcohol or when the metoprolol dose is increased.<\/p>\n\n\n\n You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n Always take this medicine exactly as your doctor has told you.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0If your doctor has not prescribed another\u00a0dose\u00a0for you, the usual dose is:<\/p>\n\n\n\n Prolonged-release prolonged-release tablets\u00a0are available for these\u00a0doses.<\/p>\n\n\n\n Dose adjustment is not required.<\/p>\n\n\n\n Patients with hepatic impairment<\/em><\/p>\n\n\n\n It may be necessary to reduce the dose to patients with severe hepatic impairment, e.g. shunt -operated patients (portocaval shunt ).<\/p>\n\n\n\n Use for children and adolescents<\/em><\/p>\n\n\n\n High blood pressure: For children 6 years or older, the dose is one based on the child’s body weight. The doctor will calculate the correct dose for the child.<\/p>\n\n\n\n The usual starting dose is 0.5 mg\/kg once daily but does not exceed 50 mg.\u00a0Dose\u00a0one will be adjusted to the nearest tablet strength.\u00a0Your doctor may increase the\u00a0dose\u00a0one to 2.0 mg\/kg depending on the blood pressure response.\u00a0Doses\u00a0over 200 mg once daily have not been studied in children and adolescents.\u00a0Metoprolol\u00a0Orion is not recommended for children under 6 years of age.<\/p>\n\n\n\n Elderly patients over 80 years<\/em><\/p>\n\n\n\n There are no adequate data from the use of metoprolol in patients over 80 years of age. Therefore, special care is required when increasing the dose to these patients.<\/p>\n\n\n\n How to take the medicine<\/em><\/p>\n\n\n\n The prolonged-release tablets should be taken once daily, preferably with breakfast. The prolonged-release tablets should be swallowed whole or divided but must not be chewed or crushed. They should be taken with water (at least \u00bd glass).<\/p>\n\n\n\n The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n Duration of treatment<\/em><\/p>\n\n\n\n The doctor decides how long the treatment should last.<\/p>\n\n\n\n Depending on the amount of medication you have taken, the following symptoms may occur: severe drop in blood pressure, low\u00a0heart rate, heart rhythm disturbance,\u00a0heart failure, circulatory collapse, cardiac arrest, narrowing\/spasms in the airways, unconsciousness (including\u00a0coma\u00a0), nausea, vomiting and cyan discoloration).<\/p>\n\n\n\n Concomitant intake of alcohol, antihypertensive drugs,\u00a0quinidine\u00a0(antiarrhythmic drugs), or\u00a0barbiturates\u00a0(sedatives) may worsen the symptoms.<\/p>\n\n\n\n The first signs of overdose occur 20 minutes to 2 hours after taking the medicine.<\/p>\n\n\n\n Do not take a double dose to make up for a forgotten tablet. Continue to take the tablets according to your doctor’s instructions.<\/p>\n\n\n\n Discuss with your doctor if you want to stop treatment temporarily or if you want to end treatment with Metoprolol Orion prematurely.<\/p>\n\n\n\n Beta-blocker therapy\u00a0must not be stopped abruptly.\u00a0If treatment is to be discontinued, this should always be done slowly for at least 2 weeks and, if possible, by\u00a0gradually reducing\u00a0dose one by half until the lowest\u00a0dose\u00a0of one 25 mg\u00a0prolonged-release tablet\u00a0(equivalent to 12.5 mg metoprolol tartrate) is reached.\u00a0The lowest\u00a0dose\u00a0should be used for at least 4 days before stopping treatment completely.\u00a0If any symptoms occur, the\u00a0dose\u00a0should be reduced more slowly.<\/p>\n\n\n\n Sudden discontinuation of beta-blocker\u00a0therapy may lead to a worsening of\u00a0heart failure\u00a0and may increase the risk of myocardial infarction and sudden cardiac death.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n Contact a doctor immediately if you get one or more of the following symptoms:<\/strong><\/p>\n\n\n\n \u2022 chest pain<\/strong><\/p>\n\n\n\n \u2022 shortness of breath<\/strong><\/p>\n\n\n\n Yellowing of the skin and\/or eyes (this may be a sign of hepatitis)<\/strong><\/p>\n\n\n\n If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.<\/p>\n\n\n\n Other side effects are<\/p>\n\n\n\n Very common (may affect more than 1 in 10 people):<\/em><\/p>\n\n\n\n Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the carton and blister after \u201cEXP\u201d. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Do not store above 25 \u00b0 C.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Content declaration<\/p>\n\n\n\n – The active substance is metoprolol succinate.<\/p>\n\n\n\n Each prolonged-release tablet contains 23.75 mg, 47.5 mg, 95 mg or 190 mg metoprolol succinate equivalent to 25 mg, 50 mg, 100 mg or 200 mg metoprolol tartrate.<\/p>\n\n\n\n – The other ingredients are:<\/p>\n\n\n\n Tablet core:<\/em>\u00a0sucrose, corn starch, macrogol, ethyl acrylate-methyl methacrylate copolymer, talc, povidone, microcrystalline cellulose, magnesium stearate, anhydrous\u00a0colloidal\u00a0silica, D-\u00a0glucose.<\/p>\n\n\n\n Tablet coating:<\/em> hypromellose, talc, macrogol, titanium dioxide (E 171).<\/p>\n\n\n\n Metoprolol\u00a0Orion\u00a0prolonged-release tablets\u00a0are white, oblong, and biconvex with a scoreline on both sides.<\/p>\n\n\n\n Metoprolol\u00a0Orion\u00a0prolonged-release tablets\u00a0are supplied in aluminum\/aluminum blisters of 10, 14, 20, 28, 30, 50, 60, 98, or 100\u00a0prolonged-release tablets\u00a0and in HDPE cans that have PP snap caps and contain 30, 60, 100, 250 or 500\u00a0prolonged-release tablets\u00a0are.<\/p>\n\n\n\n Not all pack sizes may be marketed.<\/p>\n\n\n\n Orion Corporation<\/p>\n\n\n\n Orionintie 1<\/p>\n\n\n\n FI-02200 Espoo<\/p>\n\n\n\n Finland<\/p>\n\n\n\n For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n Orion Pharma AB, Danderyd, medinfo@orionpharma.com<\/p>\n","protected":false},"excerpt":{"rendered":" The active substance in Metoprolol Orion, metoprolol , belongs to a group of medicines called selective beta-blockers , which have a special effect on the heart. The drug affects how the body responds to certain nerve signals, especially in the heart. Thereby, the drug lowers blood pressure and increases the pumping power of the heart.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[17426,16350,17422,17425,16341,16344,17290,17423,16342,17424,16343],"class_list":["post-17844","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-metoprolol-orion","tag-benefits-of-metoprolol-tartrate","tag-metoprolol-orion","tag-metoprolol-orion-side-effects","tag-metoprolol-tartrate","tag-metoprolol-tartrate-side-effects","tag-metoprolol-tartrate-tablet","tag-what-is-metoprolol-orion","tag-what-is-metoprolol-tartrate","tag-what-metoprolol-orion-is-used-for","tag-what-metoprolol-tartrate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17844"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17844\/revisions"}],"predecessor-version":[{"id":17902,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17844\/revisions\/17902"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Warnings and cautions<\/h2>\n\n\n\n
Other medicines and Metoprolol Orion<\/h2>\n\n\n\n
Careful medical supervision<\/em> is required when taking the following medicines with Metoprolol Orion:<\/strong><\/p>\n\n\n\n
Other interactions:<\/strong><\/p>\n\n\n\n
If you also use an anti-inflammatory drug<\/em> (eg indomethacin or another inhibitor of prostaglandin synthetase), the antihypertensive effect of metoprolol may be reduced.<\/p>\n\n\n\n
Rifampicin<\/em> (an antibiotic used to treat, for example, tuberculosis ) and barbituric acid derivatives (used as sedatives or sedatives, for example) reduce the antihypertensive effect of metoprolol.<\/p>\n\n\n\n
Beta-blockers\u00a0may\u00a0inhibit\u00a0the release\u00a0of\u00a0insulin\u00a0<\/em>in patients with type 2\u00a0diabetes. You should therefore check your blood sugar regularly.\u00a0If necessary, your doctor will change your diabetes treatment (\u00a0dose\u00a0of\u00a0insulin\u00a0or oral antidiabetic drugs).<\/p>\n\n\n\n
Your blood pressure can be significantly increased if you take Metoprolol Orion at the same time as norepinephrine<\/em> or adrenaline<\/em> (neurotransmitters that occur naturally in the body and which raise blood pressure through its stimulating effect on the heart and vessels ) or other drugs with a similar effect.<\/em><\/em><\/p>\n\n\n\n
Metoprolol\u00a0may reduce the secretion of other medicines (eg\u00a0lidocaine, a local anesthetic).<\/p>\n\n\n\n
If concomitant treatment with clonidine<\/em> (a medicine used to treat high blood pressure ) has to be stopped, treatment with Metoprolol Orion should be stopped several days before clonidine treatment.<\/p>\n\n\n\nMetoprolol Orion with food, drink and alcohol<\/h2>\n\n\n\n
Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n
Metoprolol should only be used during pregnancy if there are special reasons and after careful risk-benefit assessment by the treating physician. There is evidence that metoprolol reduces blood flow to the placenta and can therefore cause growth disorders in the fetus. Treatment with metoprolol should be discontinued 48-72 hours before the estimated date of delivery. If this is not possible, the newborn baby should be closely monitored 48-72 hours after birth.<\/p>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
Metoprolol Orion contains glucose and sucrose<\/h2>\n\n\n\n
How to use Metoprolol Orion<\/h2>\n\n\n\n
Therapeutic indication<\/strong><\/th> The usual\u00a0dose, once daily<\/strong><\/th> If necessary, the daily dose can be increased as follows:<\/strong><\/th><\/tr> High blood pressure<\/td> 1 prolonged-release tablet of 50 mg\u00bd 100 mg prolonged-release tablets
Other dosage strengths are available for initial treatment of this condition<\/td>Maximum dose4 prolonged-release tablets of 50 mg
2 prolonged-release tablets of 100 mg
1 prolonged-release tablet of 200 mg or concomitant treatment with another antihypertensive drug<\/td><\/tr>Insufficient blood supply to the coronary arteries (coronary heart disease, angina)<\/td> 1 to 4 prolonged-release tablets of 50 mg
\u00bd to 2 prolonged-release tablets of 100 mg
Other dosage strengths are available for initial treatment of this condition<\/td>Maximum dose4 prolonged-release tablets of 50 mg
2 prolonged-release tablets of 100 mg
1 prolonged-release tablet of 200 mg or concomitant treatment with another antihypertensive drug<\/td><\/tr>Fast heartbeat<\/td> 1 to 4 prolonged-release tablets of 50 mg
\u00bd to 2 prolonged-release tablets of 100 mg
Other dosage strengths are available for initial treatment of this condition<\/td>Maximum dose
4 prolonged-release tablets are 50 mg
2 prolonged-release tablets are 100 mg
1 prolonged-release tablet 200 mg<\/td><\/tr>Functionalcardiovascular disorders<\/td> 1 to 4 prolonged-release tablets of 50 mg
\u00bd to 2 prolonged-release tablets of 100 mg
Other dosage strengths are available for initial treatment of this condition<\/td>Maximum dose
4 prolonged-release tablets are 50 mg
2 prolonged-release tablets are 100 mg
1 prolonged-release tablet 200 mg<\/td><\/tr>Maintenance treatment after a heart attack<\/td> 1 to 4 prolonged-release tablets of 50 mg
\u00bd to 2 prolonged-release tablets of 100 mg
Other dosage strengths are available for initial treatment of this condition<\/td>Maximum dose
4 prolonged-release tablets are 50 mg
2 prolonged-release tablets are 100 mg
1 prolonged-release tablet 200 mg<\/td><\/tr>Migraine prevention treatment<\/td> 2 prolonged-release tablets are 50 mg
1 prolonged-release tablet 100 mg
\u00bd 200 mg prolonged-release tablet<\/td>Maximum dose
4 prolonged-release tablets are 50 mg
2 prolonged-release tablets are 100 mg
1 prolonged-release tablet 200 mg<\/td><\/tr>Treatment of\u00a0heart failure, NYHA II The treating physician should have experience in the treatment of stable\u00a0symptomatic\u00a0heart failure.<\/td> Starting dose during<\/em> the first two weeks
1\u00a0prolonged-release tablet\u00a0of 25 mg
\u00bd\u00a0prolonged-release tablet\u00a0of 50 mg *
The patient’s condition should be closely monitored after each dose increase.<\/td>From week 3:<\/em>2\u00a0prolonged-release tablets\u00a0are 25 mg
1\u00a0prolonged-release tablet\u00a050 mg
\u00bd\u00a0prolonged-release tablet\u00a0100 mg dose\u00a0one is then doubled every two weeks to a maximum\u00a0dose\u00a0of
8\u00a0prolonged-release tablets\u00a0of 25 mg
4\u00a0prolonged-release tablets\u00a0of 50 mg2\u00a0prolonged-release tablets\u00a0of 100 mg
1\u00a0prolonged-release tablet\u00a0of 200 mg (equivalent to 200 mg * metoprolol tartrate) or at the highest\u00a0dose\u00a0tolerated by the patient.200 mg * metoprolol tartrate is also the recommended\u00a0dose\u00a0for long-term treatment of\u00a0heart failure.<\/td><\/tr>Treatment of\u00a0heart failure, NYHA III<\/td> Starting dose<\/em>
During the first week
12.5 mg * metoprolol tartrate<\/strong> (equivalent to \u00bd 25 mg prolonged-release tablet *)<\/td>Dose one can be increased to1 prolonged-release tablet of 25 mg\u00bd 50 mg * prolonged-release tablet during the second week.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
Patients with renal impairment<\/em><\/p>\n\n\n\nIf you use more Metoprolol Orion than you should\u00a0<\/h2>\n\n\n\n
If you forget to use Metoprolol Orion<\/h2>\n\n\n\n
If you stop using Metoprolol Orion<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Uncommon (may affect up to 1 in 100 people):<\/em><\/li>
Rare (may affect up to 1 in 1,000 people):<\/em><\/li>
Very rare (may affect up to 1 in 10,000 people):<\/em><\/li>How to store Metoprolol Orion<\/h2>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n