{"id":17809,"date":"2022-01-26T11:08:02","date_gmt":"2022-01-26T11:08:02","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17809"},"modified":"2022-01-26T12:27:30","modified_gmt":"2022-01-26T12:27:30","slug":"methomylan","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/methomylan\/","title":{"rendered":"Methomylan &#8211; Metoprolol succinate uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg prolonged-release tablets, 100 mg prolonged-release tablets, 200 mg&nbsp;prolonged-release tablets&nbsp;are<br>metoprolol succinate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Metomylan is and what it is used for<\/h2>\n\n\n\n<p>The active substance in Metomylan,&nbsp;metoprolol, belongs to a group of medicines called selective&nbsp;beta-blocker blockers, which have a special effect on the heart.&nbsp;The drug affects the body&#8217;s response to certain nerve signals, especially in the heart.&nbsp;The result is that&nbsp;blood pressure&nbsp;is lowered at the same time as the heart&#8217;s pumping power increases.<\/p>\n\n\n\n<p>Methomylan is used to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treat high&nbsp;blood pressure&nbsp;.<\/li><li>treat insufficient blood supply to the coronary arteries of the heart (coronary heart disease, angina).<\/li><li>treat arrhythmias where the heart beats too fast (&nbsp;tachycardia&nbsp;), especially if they start in the atrium of the heart (&nbsp;supraventricular&nbsp;tachycardia&nbsp;).<\/li><li>help prevent a new heart attack after a previous heart attack (maintenance treatment).<\/li><li>treat functional cardiovascular disease (such as when it feels like the heart is overworking, eg it beats very fast).<\/li><li>help prevent migraine attacks.<\/li><li><strong>treat mild to moderate, stable,&nbsp;chronic&nbsp;heart failure<\/strong>&nbsp;(with impaired left ventricular pump function)&nbsp;<strong>in addition to standard treatment.<\/strong><\/li><\/ul>\n\n\n\n<p>Methomylan can also be used to treat high&nbsp;blood pressure&nbsp;in children aged six years and adolescents.<\/p>\n\n\n\n<p>Metoprolol&nbsp;contained in Metomylan may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Metomylan<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Metomylan<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic to&nbsp;metoprolol<\/strong>&nbsp;, other&nbsp;beta-blocker blockers&nbsp;or any of the other ingredients of this medicine (see section 6).<\/li><li>if you have&nbsp;<strong>certain types<\/strong>&nbsp;of arrhythmias ( grade II or III&nbsp;AV block&nbsp;or high grade SA block).<\/li><li>if you have a&nbsp;<strong>slow&nbsp;heart rate<\/strong>&nbsp;(below 50 beats \/ minute).<\/li><li>if you have&nbsp;<strong>sinus node dysfunction<\/strong>&nbsp;in the heart (diseased sinus node) unless you have a permanent pacemaker.<\/li><li>if you have suffered from&nbsp;<strong>circulatory collapse<\/strong>&nbsp;, mainly due to insufficient heart function.<\/li><li>if you have&nbsp;<strong>severe circulatory<\/strong>&nbsp;disorders in your arms and \/ or legs.<\/li><li>if you have&nbsp;<strong>morbidly low&nbsp;blood pressure<\/strong>&nbsp;, ie when the systolic pressure (hypertension) is lower than 90 mmHg.<\/li><li>if you have an&nbsp;<strong>untreated, hormone-producing&nbsp;tumor<\/strong>&nbsp;in the adrenal medulla (&nbsp;pheochromocytoma&nbsp;).<\/li><li>if you have&nbsp;<strong>high acid<\/strong>&nbsp;levels in your blood caused by metabolic disorder.<\/li><li>if you have&nbsp;<strong>severe&nbsp;asthma<\/strong>&nbsp;or&nbsp;chronic&nbsp;lung disease that makes your airways narrow.<\/li><li>if you are also being treated with&nbsp;<strong>MAOIs<\/strong>&nbsp;(medicines used to treat depression, however, MAO-B inhibitors do not apply).<\/li><li>in case of&nbsp;<strong>suspected myocardial infarction<\/strong>&nbsp;and&nbsp;heart rate&nbsp;one is below 45 beats per minute, the overpressure is less than 100 mmHg and some heart rhythm disorders occur.<\/li><li>You should not be given certain medicines to treat&nbsp;cardiac arrhythmia&nbsp;, e.g.&nbsp;calcium channel blockers such as verapamil and&nbsp;diltiazem&nbsp;or class 1&nbsp;antiarrhythmics&nbsp;(eg diopyramide)&nbsp;intravenous&nbsp;(exception: intensive care medicine).<\/li><\/ul>\n\n\n\n<p>If you have&nbsp;chronic&nbsp;heart failure, you must not take&nbsp;metoprolol&nbsp;if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have unstable, uncompensated&nbsp;heart failure&nbsp;(which can manifest itself in the form of fluid accumulation in the lungs, poor blood circulation or low&nbsp;blood pressure&nbsp;), unless the condition has stabilized with the help of medication.<\/li><li>you are continuously or temporarily on drug treatment that increases the heart&#8217;s pumping power, e.g.&nbsp;dobutamine&nbsp;.<\/li><li>your systolic&nbsp;blood pressure&nbsp;(hypertension) is always below 100 mmHg or has lowered&nbsp;heart rate&nbsp;(less than 68 beats \/ min).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Metomylan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have&nbsp;<strong>asthma<\/strong>&nbsp;:&nbsp;metoprolol&nbsp;may worsen the symptoms of&nbsp;asthma&nbsp;.&nbsp;The effect of some asthma medications may be impaired.&nbsp;Methomylane should not be used if you have severe&nbsp;asthma&nbsp;.<\/li><li>if you have severe liver problems.<\/li><li>if you have&nbsp;<strong>diabetes<\/strong>&nbsp;:&nbsp;metoprolol&nbsp;may mask low blood sugar symptoms.&nbsp;Regular checks of blood sugar levels are required.<\/li><li>if you have a mild form of certain&nbsp;<strong>cardiac arrhythmias<\/strong>&nbsp;(1st degree&nbsp;AV block&nbsp;).<\/li><li>if you have a type of angina called&nbsp;<strong>Prinzmetal&#8217;s angina.<\/strong><\/li><li>if you have&nbsp;<strong>mild to moderate circulatory disorders<\/strong>&nbsp;in your arms and \/ or legs.<\/li><li>if you have a hormone-producing&nbsp;tumor&nbsp;in the adrenal medulla (&nbsp;<strong>pheochromocytoma<\/strong>&nbsp;): you must be treated with an alpha-receptor blocker before starting Metomylan.<\/li><li>if you have&nbsp;<strong>an overactive&nbsp;thyroid gland&nbsp;.<\/strong><\/li><li>if you are going to have surgery.&nbsp;Before the operation, tell your anesthetist that you are using Metomylan.<\/li><li>if you have&nbsp;<strong>psoriasis&nbsp;.<\/strong><\/li><li>if you are prone to&nbsp;<strong>allergic reactions<\/strong>&nbsp;, as&nbsp;metoprolol&nbsp;may increase both the sensitivity to allergens (&nbsp;allergens&nbsp;) and the severity of an&nbsp;allergic reaction&nbsp;.&nbsp;Methomylan may also reduce the effect of medicines used to treat severe allergic reactions, such as&nbsp;adrenaline<\/li><\/ul>\n\n\n\n<p>The use of&nbsp;metoprolol&nbsp;may lead to positive results in doping tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Metomylan<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p><strong><u>Careful medical attention<\/u>&nbsp;is required if any of the following medicines are taken with Metomylan:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs for the&nbsp;treatment of cardiac arrhythmias&nbsp;, e.g.&nbsp;calcium channel blockers such as verapamil and&nbsp;diltiazem&nbsp;or class I&nbsp;antiarrhythmics&nbsp;(eg&nbsp;disopyramide&nbsp;).&nbsp;You must not be given this type of medicine&nbsp;intravenously&nbsp;(except in intensive care).<\/li><li>If you are taking other&nbsp;beta&nbsp;-blocker blockers (eg&nbsp;eye drops&nbsp;containing&nbsp;timolol&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Other interactions:<\/strong><\/p>\n\n\n\n<p>Inhaled anesthetics&nbsp;enhance the heart rate lowering effect of metoprolol.<\/p>\n\n\n\n<p>Metoprolol&nbsp;may potentiate the effect of&nbsp;antihypertensive drugs&nbsp;e.g.&nbsp;nifedipine, prazosin, reserpine, alpha methyldopa,&nbsp;clonidine, guanfacine, and cardiac glycosides.&nbsp;This can, for example, lead to a sharply reduced&nbsp;pulse.<\/p>\n\n\n\n<p>If you are being treated with&nbsp;clonidine&nbsp;(a medicine used to treat high&nbsp;blood pressure&nbsp;) at the same time and treatment needs to be stopped, treatment with Metomylan should be stopped several days before clonidine treatment.<\/p>\n\n\n\n<p>The following substances may increase the concentration of&nbsp;metoprolol&nbsp;in the blood and thus enhance the effect of Metomylan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>alcohol<\/li><li>drugs used to treat high levels of stomach acid&nbsp;, e.g.&nbsp;cimetidine<\/li><li>blood pressure lowering drugs&nbsp;e.g.&nbsp;hydralazine<\/li><li>certain&nbsp;drugs used in depression&nbsp;, e.g.&nbsp;paroxetine&nbsp;,&nbsp;fluoxetine&nbsp;and&nbsp;sertraline<\/li><li>drugs used to treat insomnia,&nbsp;e.g.&nbsp;diphenhydramine<\/li><li>certain&nbsp;drugs used to treat joint problems&nbsp;, e.g.&nbsp;hydroxychloroquine and celecoxib<\/li><li>certain&nbsp;drugs used to treat fungal infections,&nbsp;e.g.&nbsp;terbinafine<\/li><li>neuroleptics&nbsp;used in psychotic illness, e.g.&nbsp;chlorpromazine, triflupromazine and chlorprotixen<\/li><li>certain&nbsp;drugs used to treat cardiac arrhythmias&nbsp;, e.g.&nbsp;amiodarone&nbsp;,&nbsp;quinidine&nbsp;and possibly&nbsp;propafenone<\/li><\/ul>\n\n\n\n<p>If you also use&nbsp;anti-inflammatory drugs,&nbsp;e.g.&nbsp;indomethacin or other prostaglandin synthesis inhibitors, the antihypertensive effect of metoprolol may be reduced.<\/p>\n\n\n\n<p>Rifampicin&nbsp;(an&nbsp;antibiotic&nbsp;used to treat&nbsp;tuberculosis&nbsp;) and barbituric acid derivatives (used as sedatives or hypnotics) reduce the antihypertensive effect of metoprolol.<\/p>\n\n\n\n<p>Beta-receptor blockers&nbsp;may&nbsp;inhibit&nbsp;the release&nbsp;of&nbsp;insulin&nbsp;in patients with type II&nbsp;diabetes&nbsp;or affect medicines taken to lower blood sugar.&nbsp;You should check your blood sugar regularly.&nbsp;If necessary, your doctor will adjust the&nbsp;dosage&nbsp;of one of your blood sugar-lowering medicines (&nbsp;insulin&nbsp;and oral antidiabetic medicines).<\/p>\n\n\n\n<p>Your&nbsp;blood pressure&nbsp;may increase significantly if you take Metomylan at the same time as&nbsp;norepinephrine&nbsp;or&nbsp;adrenaline&nbsp;(neurotransmitters that occur naturally in the body and which increase&nbsp;blood pressure&nbsp;due to its stimulating effect on the heart and&nbsp;vessels&nbsp;) or other drugs with a similar effect (eg cough medicines, nasal drops or&nbsp;eye drops&nbsp;).<\/p>\n\n\n\n<p>The effect of&nbsp;adrenaline&nbsp;in the treatment of&nbsp;hypersensitivity reactions&nbsp;may be impaired.<\/p>\n\n\n\n<p>Metoprolol&nbsp;may reduce the body&#8217;s ability to secrete other medicines (eg&nbsp;lidocaine&nbsp;which is a topical anesthetic).<\/p>\n\n\n\n<p>If you are also being treated with medicines containing guanidine (a substance that blocks sympathetic&nbsp;ganglion&nbsp;), which are used to prevent the release of&nbsp;adrenaline&nbsp;and&nbsp;norepinephrine&nbsp;into your body, you may need to be closely monitored by your doctor while taking Metomylan.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Methomylane with alcohol<\/h2>\n\n\n\n<p>Metoprolol&nbsp;may make you tired \/ lethargic and this effect may be exacerbated by consuming alcohol.&nbsp;Alcohol can also increase the concentration of Metomylan in the blood.&nbsp;Therefore, you should not drink alcohol while using Metomylan.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>Metoprolol&nbsp;should only be used during pregnancy if there are special reasons and after careful risk-benefit assessment by the treating physician.&nbsp;There is evidence that&nbsp;metoprolol&nbsp;reduces the blood supply to the placenta&nbsp;and&nbsp;can thereby cause growth disorders in the fetus.<\/p>\n\n\n\n<p>If Metomylan has been used during pregnancy, treatment should be stopped 48-72 hours before the expected date of delivery.&nbsp;If this is not possible, the newborn should be closely monitored for the first 48-72 hours after delivery.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Metoprolol&nbsp;accumulates (stores) in breast milk.<\/p>\n\n\n\n<p>No&nbsp;side effects&nbsp;are expected when&nbsp;metoprolol&nbsp;is used in regular treatment doses, but breastfed infants should still be observed regarding the effects of the drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Dizziness and fatigue may occur during treatment with Metomylan.&nbsp;Your ability to react can be affected to such an extent that your ability to drive, operate machinery and work without safety equipment is impaired.&nbsp;This is especially true in combination with alcohol, at the beginning of treatment, or if the&nbsp;dose&nbsp;of metoprolol&nbsp;is increased.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Methomylan contains glucose and sucrose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.&nbsp;Patients with rare hereditary problems of&nbsp;fructose intolerance, glucose-galactose malabsorption, or glucose-isomaltase deficiency should not take this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Metomylan<\/h2>\n\n\n\n<p>Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Administration<\/strong><\/p>\n\n\n\n<p>The prolonged-release tablets&nbsp;should&nbsp;<strong>be taken once daily,<\/strong>&nbsp;with or without food, preferably in the morning.&nbsp;The prolonged-release tablets&nbsp;should be swallowed whole or divided, but must not be chewed or crushed.&nbsp;They should be taken with at least half a glass of water.<\/p>\n\n\n\n<p>Please note that&nbsp;doses&nbsp;lower than 25 mg are not available for this product!<\/p>\n\n\n\n<p>Unless otherwise specified by your doctor, the recommended dose is:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Therapeutic&nbsp;indication<\/strong><\/td><td><strong>The recommended&nbsp;dose, once daily<\/strong><\/td><td><strong>If necessary, the&nbsp;dose&nbsp;can be increased as follows:<\/strong><\/td><\/tr><tr><td>High&nbsp;blood pressure<\/td><td>1&nbsp;prolonged-release tablet of&nbsp;50 mg\u00bd&nbsp;100 mg&nbsp;prolonged-release tablet there are more strengths to use initially for treating the condition<\/td><td>Maximum dose:4&nbsp;prolonged-release tablets&nbsp;are 50 mg each2&nbsp;prolonged-release tablets&nbsp;are 100 mg1&nbsp;prolonged-release tablet of&nbsp;200 mg<br>Your doctor may also prescribe additional treatment with other antihypertensive drugs<\/td><\/tr><tr><td>Insufficient blood supply to the coronary arteries (coronary heart disease, angina)<\/td><td>1-4&nbsp;prolonged-release tablets&nbsp;are 50 mg\u00bd-2&nbsp;prolonged-release tablets&nbsp;are 100 mg\u00bd-1&nbsp;prolonged-release tablet&nbsp;of 200 mg<\/td><td>Maximum dose:4&nbsp;prolonged-release tablets&nbsp;are 50 mg each2&nbsp;prolonged-release tablets&nbsp;are 100 mg1&nbsp;prolonged-release tablet of&nbsp;200 mg l<br>Your doctor may also prescribe additional treatment with other antihypertensive drugs<\/td><\/tr><tr><td>Fast heartbeat<\/td><td>1-4&nbsp;prolonged-release tablets&nbsp;are 50 mg\u00bd-2&nbsp;prolonged-release tablets&nbsp;are 100 mg\u00bd-1&nbsp;prolonged-release tablet&nbsp;of 200 mg<\/td><td>Maximum dose:4&nbsp;prolonged-release tablets&nbsp;are 50 mg each2&nbsp;prolonged-release tablets&nbsp;are 100 mg1&nbsp;prolonged-release tablet of&nbsp;200 mg<\/td><\/tr><tr><td>Functional cardiovascular disease<\/td><td>1-4&nbsp;prolonged-release tablets&nbsp;are 50 mg\u00bd-2&nbsp;prolonged-release tablets&nbsp;are 100 mg\u00bd-1&nbsp;prolonged-release tablet&nbsp;of 200 mg<\/td><td>Maximum dose:4&nbsp;prolonged-release tablets&nbsp;are 50 mg each2&nbsp;prolonged-release tablets&nbsp;are 100 mg1&nbsp;prolonged-release tablet of&nbsp;200 mg<\/td><\/tr><tr><td>Maintenance treatment after a heart attack<\/td><td>2-4&nbsp;prolonged-release tablets&nbsp;are 50 mg1-2&nbsp;prolonged-release tablets&nbsp;are 100 mg\u00bd-1&nbsp;prolonged-release tablet&nbsp;of 200 mg<\/td><td>Maximum dose:4&nbsp;prolonged-release tablets&nbsp;are 50 mg each2 prolonged-release tablets of 100 mg1&nbsp;prolonged-release tablet of&nbsp;200 mg<\/td><\/tr><tr><td>Prevention of&nbsp;migraines<\/td><td>2&nbsp;prolonged-release tablets&nbsp;are 50 mg1&nbsp;prolonged-release tablet of&nbsp;100 mg<\/td><td>Maximum dose:2&nbsp;prolonged-release tablets&nbsp;are 50 mg1&nbsp;prolonged-release tablet&nbsp;is 100 mg<\/td><\/tr><tr><td>Treatment of&nbsp;heart failure&nbsp;NYHA class II<br>The treating physician must have experience in treating stable&nbsp;heart failure<\/td><td>Starting dose during the first two weeks:\u00bd&nbsp;50 mg&nbsp;prolonged-release tablet<br>The patient&#8217;s condition should be closely monitored after each dose increase<\/td><td>From week three onwards:1&nbsp;prolonged-release tablet of&nbsp;50 mg\u00bd&nbsp;100 mg&nbsp;prolonged-release tablet<br>Dose&nbsp;one is doubled every two weeks up to the maximum&nbsp;dose&nbsp;if4&nbsp;prolonged-release tablets&nbsp;are 50 mg each2&nbsp;prolonged-release tablets&nbsp;are 100 mg1&nbsp;prolonged-release tablet&nbsp;is 200 mg or to the highest&nbsp;dose&nbsp;tolerated by the patient.&nbsp;200 mg Metomylan is also the recommended&nbsp;dose&nbsp;for&nbsp;long-term treatment&nbsp;of&nbsp;heart failure.<\/td><\/tr><tr><td>Treatment of&nbsp;heart failure&nbsp;NYHA class III<\/td><td>Starting dose during the first week:12.5 mg<\/td><td>Dose&nbsp;one can&nbsp;be increased&nbsp;during the second week to:\u00bd&nbsp;50 mg&nbsp;prolonged-release tablet dose&nbsp;one is doubled every two weeks to a maximum&nbsp;dose&nbsp;of:<br>4&nbsp;prolonged-release tablets&nbsp;are 50 mg each1&nbsp;prolonged-release tablet&nbsp;is 200 mg or the highest&nbsp;dose&nbsp;the patient tolerates.200 mg Metomylan is also the recommended&nbsp;dose&nbsp;for&nbsp;long-term treatment&nbsp;of&nbsp;heart failure.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Use in patients with renal impairment<\/strong><\/p>\n\n\n\n<p>Dose adjustment is not necessary.<\/p>\n\n\n\n<p><strong>Use in patients with hepatic impairment<\/strong><\/p>\n\n\n\n<p>For patients with severe hepatic impairment, e.g.&nbsp;shunt&nbsp;-operated patients, it may be necessary to reduce&nbsp;dose&nbsp;one.<\/p>\n\n\n\n<p><strong>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>In children over 6 years of age and adolescents,&nbsp;dose&nbsp;one is based on body weight.&nbsp;Normally, your doctor should talk about how much you can give to children and adolescents.&nbsp;The maximum recommended&nbsp;dose&nbsp;is 200 mg daily.<\/p>\n\n\n\n<p>Experience with&nbsp;metoprolol&nbsp;in children under 6 years of age and adolescents is limited.<\/p>\n\n\n\n<p>The use of&nbsp;metoprolol&nbsp;is not recommended for children under 6 years of age.<\/p>\n\n\n\n<p><strong>Use in elderly patients over 80 years of age<\/strong><\/p>\n\n\n\n<p>There are no adequate data from the use of&nbsp;metoprolol&nbsp;in patients over 80 years of age.&nbsp;Therefore, special care is required when increasing the dose to these patients.<\/p>\n\n\n\n<p><strong>Duration of treatment<\/strong><\/p>\n\n\n\n<p>The duration of treatment is determined by your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Tell&nbsp;<strong>your doctor or emergency doctor<\/strong>&nbsp;if you get one or more of the following symptoms:<\/p>\n\n\n\n<p><em><u>Uncommon (may affect up to 1 in 100 people):<\/u><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Transient worsening of the symptoms of&nbsp;heart failure&nbsp;,<\/strong>&nbsp;some form of heart rhythm disturbances (first-degree&nbsp;AV block&nbsp;),&nbsp;<strong>pain around the heart, shortness of breath.<\/strong><\/li><\/ul>\n\n\n\n<p><em><u>Rare (may affect up to 1 in 1,000 people):<\/u><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Exacerbation of&nbsp;diabetes&nbsp;<\/strong>that has been without any typical symptoms (&nbsp;latent&nbsp;diabetes mellitus&nbsp;)<\/li><\/ul>\n\n\n\n<p><em><u>Very rare (may affect up to 1 in 10,000 people):<\/u><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Yellowing of the skin and \/ or eyes<\/strong>&nbsp;(this may be a sign of&nbsp;inflammation&nbsp;in the liver).<\/li><li>Tissue death (&nbsp;necrosis&nbsp;) in patients with severe circulatory disorders in the arms and \/ or legs before treatment.<\/li><\/ul>\n\n\n\n<p>Other side effects:<\/p>\n\n\n\n<p><em><u>Very common: (may affect more than 1 user in 10):<\/u><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sharp drop in blood pressure, even when rising from a supine position (very rare with fainting)<\/li><li>fatigue<\/li><\/ul>\n\n\n\n<p><em>Common: (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>slow&nbsp;heart rate&nbsp;(&nbsp;bradycardia&nbsp;), balance difficulties (very rare with fainting), feeling of irregular or strong heartbeat (&nbsp;palpitation&nbsp;)<\/li><li>dizziness, headache<\/li><li>shortness of breath on exertion<\/li><li>nausea, abdominal pain, diarrhea, constipation<\/li><li>cold hands and feet<\/li><\/ul>\n\n\n\n<p><em><u>Uncommon: (may affect up to 1 in 100 people):<\/u><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>tingling in the skin (&nbsp;paresthesia&nbsp;)<\/li><li>bronchospasm (&nbsp;bronchospasm&nbsp;)<\/li><li>vomiting<\/li><li>skin changes, psoriasis-like rash, increased sweating<\/li><li>muscle cramps<\/li><li>weight gain<\/li><li>fluid accumulation in the body&#8217;s&nbsp;tissues&nbsp;(&nbsp;edema&nbsp;)<\/li><li>depression, impaired concentration, drowsiness or insomnia, nightmares<\/li><li>circulatory collapse (it is more likely to occur after a heart attack)<\/li><\/ul>\n\n\n\n<p><em>Rare: (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>functional heart disease such as galloping rhythm (when the heart skips a beat), or rapid heartbeat, certain heart rhythm disorders (conduction disturbances in the heart)<\/li><li>visual disturbances, dry or irritated eyes, conjunctivitis (&nbsp;conjunctivitis&nbsp;)<\/li><li>snuva<\/li><li>dry mouth<\/li><li>hair loss<\/li><li>abnormal values \u200b\u200bon liver function tests<\/li><li>impotence&nbsp;and other sexual disorders (eg hardening of the soft&nbsp;tissue&nbsp;of the penis in the corpus cavernosum, ie the swollen body)<\/li><li>nervousness, anxiety<\/li><\/ul>\n\n\n\n<p><em><u>Very rare: (may affect up to 1 in 10,000 people):<\/u><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;), decreased&nbsp;white blood cell count&nbsp;(&nbsp;leukopenia&nbsp;)<\/li><li>tinnitus&nbsp;,&nbsp;tinnitus<\/li><li>taste changes<\/li><li>photosensitivity, worsening&nbsp;psoriasis&nbsp;, onset of&nbsp;psoriasis&nbsp;, psoriasis-like skin changes<\/li><li>joint pain, muscle weakness<\/li><li>deterioration in patients with&nbsp;intermittent claudication&nbsp;(ie&nbsp;peripheral&nbsp;circulatory insufficiency \/&nbsp;peephole disease&nbsp;which manifests itself in a convulsive sensation in the legs during exertion) and cramps in the blood vessels of the fingers (&nbsp;Raynaud&#8217;s disease&nbsp;)<\/li><li>forgetfulness or impaired memory, confusion, hallucinations, personality changes (eg mood swings)<\/li><\/ul>\n\n\n\n<p><em><u>Has been reported (occurs in an unknown number of users):<\/u><\/em><\/p>\n\n\n\n<p>Masking of symptoms of low blood sugar (&nbsp;hypoglycemia&nbsp;), e.g.&nbsp;palpitation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Metomylan<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton, can or blister after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is metoprolol tartrate.<\/li><li>Each&nbsp;prolonged-release tablet&nbsp;contains 47.5 mg, 95 mg or 190 mg of metoprolol succinate equivalent to 50 mg, 100 mg or 200 mg of metoprolol tartrate.<\/li><li>Other ingredients are:Tablet core:&nbsp;Sucrose&nbsp;<strong>,<\/strong>&nbsp;corn starch, macrogol, polyacrylate, talc, povidone, microcrystalline cellulose, magnesium stearate, anhydrous&nbsp;colloidal&nbsp;silica, D-&nbsp;glucose&nbsp;.Tablet coating:&nbsp;Hypromellose, talc, macrogol, titanium dioxide (E 171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Methomylan 50 mg, 100 mg, 200 mg&nbsp;prolonged-release tablets&nbsp;are white, oblong, biconvex with a scored notch on both sides.<\/p>\n\n\n\n<p>Blister pack size (aluminum \/ aluminum):<\/p>\n\n\n\n<p>10, 14, 20, 28, 30, 50, 60, 90, 98 and 100<\/p>\n\n\n\n<p>Size HDPE cans (PP screw cap):<\/p>\n\n\n\n<p>30, 60, 100, 250 and 500<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>McDermott Laboratories to Gerard Laboratories, 35\/36 Baldoyle Industrial Estate, Grange Road, Dublin 13, Ireland<\/p>\n\n\n\n<p>Mylan Hungary Kft, H-2900 Kom\u00e1rom, Mylan utca 1, Hungary<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in Metomylan, metoprolol, belongs to a group of medicines called selective beta-blocker blockers, which have a special effect on the heart. The drug affects the body&#8217;s response to certain nerve signals, especially in the heart. The result is that blood pressure is lowered at the same time as the heart&#8217;s pumping power increases.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[17308,17302,17303,17307,17306,17297,17301,17300,17304,17298,17305,17299],"class_list":["post-17809","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-methomylan","tag-benefits-of-metoprolol-succinate","tag-methomylan","tag-methomylan-side-effects","tag-methomylan-tablet","tag-metoprolol-succinate","tag-metoprolol-succinate-side-effects","tag-metoprolol-succinate-tablet","tag-what-is-methomylan","tag-what-is-metoprolol-succinate","tag-what-methomylan-is-used-for","tag-what-metoprolol-succinate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17809"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17809\/revisions"}],"predecessor-version":[{"id":17835,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17809\/revisions\/17835"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}