{"id":17802,"date":"2022-01-26T10:46:20","date_gmt":"2022-01-26T10:46:20","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17802"},"modified":"2022-01-26T12:27:54","modified_gmt":"2022-01-26T12:27:54","slug":"metojectpen","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/metojectpen\/","title":{"rendered":"Metojectpen – Methotrexate uses, dose and side effects"},"content":{"rendered":"\n
What Metojectpen is and what it is used for<\/h2>\n\n\n\n
Metojectpen is intended for the treatment of<\/p>\n\n\n\n
active rheumatoid arthritis in adult patients<\/li>
polyarthritic forms of severe, active juvenile idiopathic arthritis , when treatment with non-steroidal anti-inflammatory drugs ( NSAIDs ) has given insufficient response<\/li>
moderate to severe psoriasis in adult patients and severe psoriatic arthritis in adults<\/li>
mild to moderate Crohn’s disease in adult patients when there is a lack of appropriate treatment with other drugs.<\/li><\/ul>\n\n\n\n
Rheumatoid arthritis <\/strong>(RA) is a chronic collagen disease, which is characterized by inflammation of the synovial membranes (synovial membranes). These membranes produce a fluid that acts as a lubricant for many joints. Inflammation causes the skin to thicken and the joint to swell.<\/p>\n\n\n\n
Juvenile arthritis<\/strong> occurs in children and adolescents under 16 years of age. Polyarthritic forms are those that affect five or more joints during the first 6 months of the disease.<\/p>\n\n\n\n
Psoriasis<\/strong> is a common, chronic skin condition characterized by red spots covered with thick, dry, silvery scaly scales.<\/p>\n\n\n\n
Psoriatic<\/strong> arthritis is a type of arthritis ( inflammatory joint disease) with psoriatic ulcers in the skin and nails, especially at the joints of the fingers and toes.<\/p>\n\n\n\n
Metojectpen relieves and slows the course of the disease.<\/p>\n\n\n\n
Crohn’s disease is a type of inflammatory bowel disease that can affect all parts of the gastrointestinal tract and lead to symptoms such as abdominal pain, diarrhea, vomiting, or weight loss.<\/p>\n\n\n\n
Methotrexate contained in Metojectpen may also be approved for the treatment of other conditions not mentioned in this product information. Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n
What you need to know before using Metojectpen<\/h2>\n\n\n\n
Do not use Metojectpen<\/h2>\n\n\n\n
if you are allergic to methotrexate or any of the other ingredients of this medicine (listed in section 6).<\/li>
if you have liver disease or severe kidney disease or blood disease<\/li>
if you regularly drink large amounts of alcohol<\/li>
if you have a serious infection , such as tuberculosis , HIV or other immune deficiency syndromes<\/li>
if you have sores in your mouth, stomach ulcers or sores in your intestines<\/li>
if you are pregnant or breast-feeding (see section “Pregnancy, breast-feeding and fertility”)<\/li>
if you are being vaccinated with live vaccines at the same time.<\/li><\/ul>\n\n\n\n
Special precautions for use with Metojectpen<\/strong><\/p>\n\n\n\n
Methotrexate temporarily affects sperm and egg production, an effect that in most cases decreases after the end of treatment. Methotrexate can cause miscarriage and severe congenital malformations. You must avoid becoming pregnant while using methotrexate and for at least 6 months after stopping treatment. See also section “Pregnancy, breast-feeding and fertility”<\/p>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Talk to your doctor or pharmacist before using Metojectpen if:<\/p>\n\n\n\n
you are older or if you generally feel sick and weak<\/li>
you have problems with liver function<\/li>
you are dehydrated (dehydration).<\/li><\/ul>\n\n\n\n
Recommended follow-up examinations and safety measures<\/strong><\/p>\n\n\n\n
Even when Metojectpen is given in low doses, serious side effects can occur. For them to be detected in time, your doctor must perform checks and laboratory tests.<\/p>\n\n\n\n
Before treatment<\/strong><\/p>\n\n\n\n
Before starting treatment, you will be given blood samples so that your doctor can check that you have enough blood cells and test your liver function, the level of serum albumin (a protein in the blood), and kidney function. Your doctor will also check if you have tuberculosis (a contagious disease with small lumps in the affected tissue) and have you have a lung X-ray.<\/p>\n\n\n\n
During treatment<\/strong><\/p>\n\n\n\n
You will undergo the following tests at least once a month for the first six months and thereafter at least every three months:<\/p>\n\n\n\n
examination of the mouth and throat to see if there have been any changes in the mucous membrane<\/li>
blood tests<\/li>
control of liver function<\/li>
control of renal function<\/li>
control of the respiratory system and, if necessary, lung function test.<\/li><\/ul>\n\n\n\n
Acute hemorrhage from the lungs of patients with the underlying rheumatic disease has been reported with methotrexate. If you experience symptoms such as blood in the saliva or bloody cough, contact your doctor immediately.<\/p>\n\n\n\n
Methotrexate may affect your immune system and your vaccination results. It can also affect the results of immunological tests. Inactive, chronic infections (such as herpes zoster [shingles], tuberculosis, hepatitis B or C) can flare-up. You must not be vaccinated with live vaccines while being treated with Metojectpen.<\/strong><\/p>\n\n\n\n
Radiation-induced dermatitis and increased sun sensitivity with the risk of skin burns may recur during treatment with methotrexate (“recall” reaction). Psoriasis lesions may be exacerbated by UV radiation and concomitant administration of methotrexate.<\/p>\n\n\n\n
Enlarged lymph nodes ( lymphoma ) can occur and if this happens, treatment must be stopped.<\/p>\n\n\n\n
Diarrhea can be a possible side effect of Metojectpen and requires discontinuation of treatment. If you have diarrhea, you should talk to your doctor.<\/p>\n\n\n\n
Certain brain diseases (encephalopathy\/leukoencephalopathy) have been reported in cancer patients receiving methotrexate treatment. Such side effects can not be ruled out when methotrexate is used to treat other diseases.<\/p>\n\n\n\n
If you, your partner, or your healthcare provider discover new or worsening neurological symptoms, such as general muscle weakness, visual disturbances, changes in thinking ability, memory, and orientation that lead to confusion and personality changes, you should contact your doctor immediately as these may be symptoms of a very rare, severe brain infection called progressive multifocal leukoencephalopathy (PML).<\/p>\n\n\n\n
Other medicines and Metojectpen<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. Please note that this also applies to medicines that you will take in the future.<\/p>\n\n\n\n
The effect of the treatment can be affected if Metojectpen is given at the same time as certain other medicines:<\/p>\n\n\n\n
antibiotics<\/strong> such as: tetracyclines , chloramphenicol and non-absorbable broad-spectrum antibiotics, penicillins , glycopeptides, sulfonamides , ciprofloxacin and cephalothin (medicines that prevent \/ fight certain infections )<\/li>
non-steroidal anti-inflammatory<\/strong> drugs or salicylates<\/strong> (medicines for pain and \/ or inflammation ) such as acetylsalicylic acid , diclofenac and ibuprofen or pyrazole)<\/li>
probenecid<\/strong> (anti- gout medicine )<\/li>
weak organic acids such as loop diuretics<\/strong> (“diuretic tablets”).<\/li>
drugs that may have adverse effects on bone marrow<\/strong> , such as trimethoprim-sulfamethoxazole (an antibiotic <\/strong>) and pyrimethamine<\/li>
other drugs used to treat rheumatoid arthritis <\/strong>such as leflunomide, sulfasalazine and azathioprine<\/li>
mercaptopurine (a cytotoxic drug<\/strong> )<\/li>
retinoids (medicines for psoriasis<\/strong> and other skin diseases)<\/li>
theophylline (medicine for bronchial asthma<\/strong> and other lung diseases)<\/li>
certain medicines for stomach problems<\/strong> such as omeprazole and pantoprazole<\/li>
hypoglycaemic agents (medicines used to lower blood sugar<\/strong> ).<\/li><\/ul>\n\n\n\n