{"id":17621,"date":"2022-01-19T11:58:08","date_gmt":"2022-01-19T11:58:08","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17621"},"modified":"2022-01-20T10:54:56","modified_gmt":"2022-01-20T10:54:56","slug":"mesalazine-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/mesalazine-orion\/","title":{"rendered":"Mesalazine Orion &#8211; Mesalazine uses, dose and side effects"},"content":{"rendered":"\n<p>500 mg&nbsp;enteric-tablet&nbsp;is<br>mesalazine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Mesalazine Orion is and what it is used for<\/h2>\n\n\n\n<p>Mesalazine Orion&nbsp;enteric-tablet&nbsp;contains 500 mg of the active substance mesalazine (also known as 5-aminosalicylic acid), which belongs to a group of medicines used to treat inflammatory bowel disease.<\/p>\n\n\n\n<p>Mesalazine Orion is used to treat&nbsp;ulcerative colitis, an&nbsp;inflammatory&nbsp;bowel disease.<\/p>\n\n\n\n<p>Mesalazine contained in Mesalazine Orion may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Mesalazine Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Mesalazine Orion:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to mesalazine or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to&nbsp;acetylsalicylic acid&nbsp;or other salicylates<\/li><li>if you have a disease that makes you bleed easily<\/li><li>if you have severe renal and \/ or hepatic impairment<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Mesalazine Orion.<\/p>\n\n\n\n<p>Tell your doctor before starting treatment with Mesalazin Orion:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are or want to become pregnant<\/li><li>if you are breast-feeding<\/li><li>if you have liver or kidney problems<\/li><li>if you have any lung disease, such as&nbsp;asthma<\/li><li>if you have previously had an&nbsp;allergic reaction&nbsp;to sulfasalazine<\/li><li>if you have stomach or intestinal ulcers<\/li><li>if you have a history of heart inflammation (which may be caused by a heart infection)<\/li><li>if you have ever developed severe skin rash or dandruff, blistering and \/ or sores in your mouth after using mesalazine.<\/li><\/ul>\n\n\n\n<p>If you get allergic symptoms (such as rash,&nbsp;itching&nbsp;), cramps, abdominal pain, severe headache, and fever during treatment, do not take more tablets and contact a doctor immediately.<\/p>\n\n\n\n<p>Before and regularly while taking Mesalazin Orion, your doctor may want to take urine and blood samples to check if your liver, kidneys, blood, and lungs are working properly.<\/p>\n\n\n\n<p>Kidney stones&nbsp;can form when using mesalazine.&nbsp;Symptoms may include pain in the sides of the abdomen and blood in the urine.&nbsp;Be sure to drink enough fluids during treatment with mesalazine.<\/p>\n\n\n\n<p>Serious skin reactions, such as&nbsp;Stevens-Johnson syndrome&nbsp;and&nbsp;toxic epidermal necrolysis, have been reported with mesalazine treatment.&nbsp;Stop using mesalazine and seek medical attention immediately if you experience any of the symptoms of these severe skin reactions as described in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Safety information for the use of this medicine in children and adolescents is limited.&nbsp;Not given to children under 5 years.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Mesalazin Orion<\/h2>\n\n\n\n<p>You can usually continue treatment with other medicines while using Mesalazin Orion.&nbsp;However, tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>Mesalazine Orion may affect or be affected by other medicines if taken at the same time.<\/p>\n\n\n\n<p>This applies in particular to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines used to lower blood sugar (antidiabetic drugs)<\/li><li>medicines used to lower&nbsp;blood pressure&nbsp;(antihypertensive medicines \/ diuretics)<\/li><li>drugs used to treat or prevent gout attacks<\/li><li>medicines that help the bowel movements (&nbsp;laxatives&nbsp;that contain&nbsp;lactulose&nbsp;)<\/li><li>medicines that prevent blood clots (&nbsp;anticoagulants&nbsp;)<\/li><li>drugs that reduce the activity of the immune system (eg azathioprine or 6-mercaptopurine or thioguanine)<\/li><li>medicines used to treat pain and&nbsp;inflammation&nbsp;(anti-inflammatory drugs).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>There is limited experience with the use of mesalazine during pregnancy and lactation.&nbsp;The newborn can develop allergic reactions after breastfeeding, e.g.&nbsp;diarrhea.&nbsp;If the newborn develops diarrhea, breastfeeding should be discontinued.<\/p>\n\n\n\n<p>Women who are pregnant or breastfeeding should not use Mesalazine Orion except on the advice of a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Mesalazine Orion has no or negligible effect on the operation of vehicles and machinery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mesalazine Orion contains sodium<\/h2>\n\n\n\n<p>This medicine contains 2.13 mmol (or 49 mg)&nbsp;sodium&nbsp;(the main ingredient in table salt\/table salt) per&nbsp;enteric tablet.&nbsp;This corresponds to 2.5% of the maximum recommended daily&nbsp;sodium&nbsp;intake for adults.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist if you need 8&nbsp;tablets of entering&nbsp;daily for a long period, especially if you have been prescribed a low-salt (sodium-poor) diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Mesalazine Orion<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Your doctor will tell you how long you should be treated with this medicine.&nbsp;Do not stop treatment earlier, even if you feel better, as the symptoms may return if you stop treatment too soon.<\/p>\n\n\n\n<p>Always follow the doctor&#8217;s treatment instructions strictly, both in the acute inflammatory phase and in the maintenance treatment that has been agreed upon.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adults is:<\/p>\n\n\n\n<p>To treat&nbsp;<strong>an&nbsp;acute&nbsp;relapse&nbsp;of&nbsp;colitis<\/strong>, your doctor will usually prescribe between 1.5 grams (3&nbsp;enteric tablets&nbsp;) and 4 grams (8&nbsp;enteric tablets&nbsp;) of mesalazine per day, which can be given once a day or in divided&nbsp;doses.<\/p>\n\n\n\n<p>To&nbsp;<strong>prevent multiple&nbsp;relapses<\/strong>, your doctor may prescribe a&nbsp;dose&nbsp;between 1.5 grams (3&nbsp;enteric tablets&nbsp;) and 3 grams (6&nbsp;enteric tablets&nbsp;) of mesalazine per day, which can be given once a day or in divided&nbsp;doses.<\/p>\n\n\n\n<p>Mesalazine Orion&nbsp;enteric-tablet&nbsp;should be taken orally.<\/p>\n\n\n\n<p>The enteric tablets&nbsp;should be swallowed whole with liquid and taken before meals.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Mesalazine Orion is not recommended for use in children and adolescents below 18 years due to a lack of data on safety and efficacy.&nbsp;Not given to children under 5 years.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>All medicines can cause allergic reactions, but severe allergic reactions are very rare.&nbsp;If you get any of the following symptoms after taking this medicine, stop taking the tablets and contact your doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic skin rash<\/li><li>fever<\/li><li>breathing difficulties.<\/li><\/ul>\n\n\n\n<p>If you get a fever or irritation in your throat or mouth, stop taking the tablets and contact a doctor immediately.&nbsp;These symptoms can, in very rare cases, be due to a decreased number of&nbsp;white blood cells&nbsp;in your blood (a condition called&nbsp;agranulocytosis&nbsp;).<\/p>\n\n\n\n<p>Stop using mesalazine and seek medical attention immediately if you get any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reddish, not raised, spots on the torso that resemble targets or are round, often with blisters in the middle, scaly skin, sores in the mouth, pharynx, nose, genitals and eyes.&nbsp;These severe skin rashes can be preceded by fever and&nbsp;flu-like symptoms&nbsp;.<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have also been reported in patients taking mesalazine:<\/p>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abdominal pain, diarrhea,&nbsp;flatulence&nbsp;, nausea and vomiting<\/li><li>headache, dizziness<\/li><li>chest pain, shortness of breath or swollen arms and legs due to heart effects<\/li><li>increased sensitivity of the skin to sunlight and ultraviolet light (&nbsp;photosensitivity&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>impaired renal function, sometimes with swollen arms and legs or radiating pain in the side of the lower back (flank pain)<\/li><li>severe abdominal pain due to&nbsp;acute&nbsp;pancreatitis<\/li><li>worsening of colitis symptoms<\/li><li>fever, sore throat or malaise due to decreased&nbsp;blood cell&nbsp;count<\/li><li>shortness of breath, cough, wheezing, abnormalities in the chest X-ray due to an allergic and \/ or inflammatory lung condition<\/li><li>diarrhea and severe abdominal pain due to&nbsp;allergic reaction&nbsp;to the drug in the intestine<\/li><li>skin rash or&nbsp;inflammation<\/li><li>muscle and joint pain<\/li><li>jaundice or abdominal pain due to liver disease or impaired bile flow<\/li><li>hair loss and development of baldness<\/li><li>erythema multiforme (serious&nbsp;side effect&nbsp;affecting the skin and mucous membranes)<\/li><li>numbness and tingling in fingers and toes (&nbsp;peripheral&nbsp;neuropathy&nbsp;)<\/li><li>transient decrease in sperm production<\/li><li>disorders of blood values.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong>&nbsp;(occurs in an unknown number of users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney stones&nbsp;and kidney pain (see also section 2).<\/li><\/ul>\n\n\n\n<p>Increased skin sensitivity to sunlight and ultraviolet light (&nbsp;photosensitivity&nbsp;) More severe reactions have been reported in patients with pre-existing skin conditions such as atopic dermatitis\/dermatitis and&nbsp;atopic eczema.<\/p>\n\n\n\n<p>If these symptoms persist or become more severe, consult your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Mesalazin Orion<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is mesalazine.<\/li><li>Each&nbsp;enteric-&nbsp;containing tablet contains 500 mg of mesalazine.<\/li><li>The other ingredients are anhydrous sodium carbonate,&nbsp;glycine&nbsp;, povidone, microcrystalline cellulose, sodium croscarmellose,&nbsp;colloidal&nbsp;anhydrous silica, calcium stearate, methacrylic acid-ethyl acrylate copolymer (1: 1)&nbsp;dispersion&nbsp;30 percent, methacrylic acid-methylmacacrylate copolymer (1: 1): methacrylate copolymer , dibutyl sebacate, talc, titanium dioxide (E171), macrogol, yellow iron oxide (E172) and red iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Mesalazine Orion&nbsp;enteric tablets&nbsp;are oblong with an orange coating.<\/p>\n\n\n\n<p>The medicine is marketed in OPA \/ Alu \/ PVC \/ Alu-blister packed in cartons containing 100&nbsp;enteric tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Faes Farma, SA<\/p>\n\n\n\n<p>M\u00e1ximo Aguirre, 14<\/p>\n\n\n\n<p>48940 Leioa (Bizkaia)<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p>For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd, medinfo@orionpharma.com<\/p>\n\n\n\n<p>This medicinal product is authorized under the European Economic Area under the names:<\/p>\n\n\n\n<p><strong>Finland:<\/strong>&nbsp;Mesalazine Orion 500 mg enterotabletite<\/p>\n\n\n\n<p><strong>Denmark:<\/strong>&nbsp;Mesalazine Orion 500 mg&nbsp;Enterotablett<\/p>\n\n\n\n<p><strong>Sweden:<\/strong>&nbsp;Mesalazine Orion 500 mg&nbsp;enteric-tablet&nbsp;is<\/p>\n\n\n\n<p><strong>Norway:<\/strong>&nbsp;Mesalazine Orion 500 mg&nbsp;Enterotablett<\/p>\n\n\n\n<p><strong>Malta:<\/strong>&nbsp;Mecolzine 500 mg gastro-resistant tablets<\/p>\n\n\n\n<p><strong>Cyprus:<\/strong>&nbsp;Mecolzine 500 mg gastro-resistant tablets<\/p>\n\n\n\n<p><strong>Bulgaria:<\/strong>&nbsp;Mecolzine 500 mg gastro-resistant tablets<\/p>\n\n\n\n<p><strong>Spain:<\/strong>&nbsp;Azzavix 500 mg compresses gastrointestinal disorder<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mesalazine Orion enteric-tablet contains 500 mg of the active substance mesalazine (also known as 5-aminosalicylic acid), which belongs to a group of medicines used to treat inflammatory bowel disease.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[17089,17095,9949,17090,17094,17093,17088,9952,9950,17091,9951,17092],"class_list":["post-17621","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-mesalazine","tag-benefits-of-mesalazine-orion","tag-mesalazine","tag-mesalazine-orion","tag-mesalazine-orion-side-effects","tag-mesalazine-orion-tablet","tag-mesalazine-side-effects","tag-mesalazine-tablet","tag-what-is-mesalazine","tag-what-is-mesalazine-orion","tag-what-mesalazine-is-used-for","tag-what-mesalazine-orion-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17621","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17621"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17621\/revisions"}],"predecessor-version":[{"id":17675,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17621\/revisions\/17675"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}