{"id":17568,"date":"2022-01-17T10:35:49","date_gmt":"2022-01-17T10:35:49","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17568"},"modified":"2022-01-17T12:16:33","modified_gmt":"2022-01-17T12:16:33","slug":"mentixa","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/mentixa\/","title":{"rendered":"Mentixa &#8211; Memantine hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg and 20 mg&nbsp;film-coated tablet<br>memantine hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Mentixa is and what it is used for<\/h2>\n\n\n\n<p>The active substance memantine in Mentixa belongs to a group of medicines known as anti-dementia medicines.&nbsp;Memory loss in&nbsp;Alzheimer&#8217;s disease&nbsp;is due to a disturbance of message signals in the brain.&nbsp;The brain contains so-called N-methyl-D-aspartate (NMDA)&nbsp;receptors&nbsp;that are involved in the transmission of nerve signals that are important for learning and memory.&nbsp;Mentixa belongs to a group of medicines called NMDA receptor antagonists.&nbsp;Mentixa acts on these NMDA&nbsp;receptors&nbsp;by improving the transmission of nerve signals and memory.<\/p>\n\n\n\n<p>Mentixa is used to treat patients with moderate to severe\u00a0Alzheimer&#8217;s disease.<\/p>\n\n\n\n<p>Memantine hydrochloride contained in Mentixa may also be approved for the treatment of other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Mentixa<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Mentixa<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to memantine hydrochloride or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Mentixa:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a history of epileptic seizures<\/li><li>if you have recently had a myocardial infarction (heart attack) or if you suffer from untreated&nbsp;heart failure&nbsp;or uncontrolled&nbsp;hypertension&nbsp;(high&nbsp;blood pressure&nbsp;)<\/li><\/ul>\n\n\n\n<p>In these situations, treatment should be closely monitored and the clinical benefit of Mentixa should be regularly assessed by your doctor.<\/p>\n\n\n\n<p>If you suffer from impaired kidney function (kidney problems), your doctor should closely monitor your kidney function and, if necessary, adjust the memantine doses accordingly.<\/p>\n\n\n\n<p>The use of drugs containing amantadine (for the treatment of&nbsp;Parkinson&#8217;s disease&nbsp;), ketamine (a substance commonly used as an anesthetic), dextromethorphan (generally used to treat cough), and other NMDA&nbsp;antagonists&nbsp;with Mentixa should be avoided.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Mentixa is not recommended for children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Mentixa<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Mentixa may in particular affect the effects of the following medicines and these&nbsp;doses&nbsp;may need to be changed by your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>amantadine, ketamine, dextromethorphan<\/li><li>dantrolen, baklofen<\/li><li>cimetidine, ranitidine,&nbsp;procainamide&nbsp;,&nbsp;quinidine&nbsp;, quinine, nicotine<\/li><li>hydrochlorothiazide&nbsp;(or any combination with&nbsp;hydrochlorothiazide&nbsp;)<\/li><li>anticholinergics (substances commonly used to treat movement disorders or intestinal cramps)<\/li><li>antiepileptics&nbsp;(substances used to prevent and relieve seizures)<\/li><li>barbiturates&nbsp;(substances commonly used for insomnia)<\/li><li>dopaminergic&nbsp;agonists&nbsp;(substances such as&nbsp;L-dopa&nbsp;, bromocriptine)<\/li><li>neuroleptics&nbsp;(substances used in the treatment of mental illness)<\/li><li>oral&nbsp;anticoagulants<\/li><\/ul>\n\n\n\n<p>If you are hospitalized, tell your doctor that you are taking Mentixa.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mentixa with food, drink and alcohol<\/h2>\n\n\n\n<p>You should tell your doctor if you have recently changed or intend to change your diet significantly (eg from a regular diet to a vegetarian diet only) or if you suffer from a condition of\u00a0renal\u00a0tubular\u00a0acidosis\u00a0(RTA, an excess of acid formation). substances in the blood due to kidney dysfunction (impaired kidney function)) or severe\u00a0urinary\u00a0tract infection (the structure that directs the urine), as your doctor may need to adjust the\u00a0dose\u00a0of your medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.\u00a0The use of memantine in pregnant women is not recommended.\u00a0Women taking Mentixa should not breastfeed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Your doctor will tell you if your illness allows you to drive and use machines safely.&nbsp;Mentixa may also alter your ability to react, making it unsuitable to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mentixa contains lactose and sodium<\/h2>\n\n\n\n<p>Mentixa contains&nbsp;lactose&nbsp;.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Mentixa<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0of Mentixa for adults and elderly patients is 20 mg once a day.\u00a0To reduce the risk of\u00a0side effects, this\u00a0dose\u00a0is achieved gradually through the following daily treatment schedule:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Week 1<\/td><td>Half a 10 mg tablet<\/td><\/tr><tr><td>Week 2<\/td><td>One 10 mg tablet<\/td><\/tr><tr><td>Week 3<\/td><td>One and a half 10 mg tablet<\/td><\/tr><tr><td>Week 4<\/td><td>Two 10 mg tablets or one 20 mg tablet<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>The usual starting dose is half a 10 mg film-coated tablet once a day (1 x 5 mg) for the first week.&nbsp;This is increased to a 10 mg film-coated tablet once a day (1 x 10 mg) during the second week and to one and a half 10 mg film-coated tablets once a day (1 x 15 mg) during the third week.&nbsp;From the fourth week onwards, the usual&nbsp;dose&nbsp;is one 10 mg film-coated tablet or one 20 mg film-coated tablet once a day (1 x 20 mg).<\/p>\n\n\n\n<p><strong>Dosage&nbsp;in patients with renal impairment<\/strong><\/p>\n\n\n\n<p>If you have impaired kidney function, your doctor will prescribe a&nbsp;dose&nbsp;that suits your condition.&nbsp;In this case, your doctor should examine your kidney function at certain intervals.<\/p>\n\n\n\n<p><strong>Administration<\/strong><\/p>\n\n\n\n<p>Mentixa should be taken orally once a day.\u00a0For you to benefit from your medicine, you must take it regularly every day at the same time of day.\u00a0The tablets should be swallowed with a little water.\u00a0The 10 mg tablet can be divided into two equal\u00a0doses.\u00a0The tablets can be taken with or without food.<\/p>\n\n\n\n<p><strong>Treatment time<\/strong><\/p>\n\n\n\n<p>Keep taking Mentixa for as long as your doctor tells you to.&nbsp;Your doctor should regularly evaluate your treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Mentixa than you should&nbsp;<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>In general, it should not hurt you if you take too much Mentixa.\u00a0You may experience increased symptoms as described in section 4. Possible\u00a0side effects\u00a0.<\/li><li>If you are taking a large dose of Mentixa, contact your doctor or doctor for medical advice, as you may need care.<\/li><li><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Mentixa<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you notice that you have forgotten to take your&nbsp;dose&nbsp;of Mentixa, wait and take your next&nbsp;dose&nbsp;at the usual time.<\/li><li>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>In general, the&nbsp;side effects&nbsp;observed are mild to moderate.<\/p>\n\n\n\n<p><em>Common (&nbsp;<\/em><em>may affect up to 1 in 10 people&nbsp;<\/em><em>):<\/em><\/p>\n\n\n\n<p>Headache, drowsiness, constipation, elevated liver function tests, dizziness, balance disorders, shortness of breath, high\u00a0blood pressure,\u00a0and drug hypersensitivity<\/p>\n\n\n\n<p><em>Uncommon (&nbsp;<\/em><em>may affect up to 1 in 100 people&nbsp;<\/em><em>):<\/em><\/p>\n\n\n\n<p>Fatigue, fungal infections, confusion, hallucinations, vomiting, gait disorders,\u00a0heart failure,\u00a0and blood clots in veins (thrombosis\/thromboembolism)<\/p>\n\n\n\n<p><em>Very rare (&nbsp;<\/em><em>may affect up to 1 in 10,000 people&nbsp;<\/em><em>):<\/em><\/p>\n\n\n\n<p>Cramps<\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n<p>Pancreatitis, hepatitis,\u00a0and\u00a0psychotic reactions<\/p>\n\n\n\n<p>Alzheimer&#8217;s disease\u00a0has been associated with depression, suicidal ideation, and\u00a0suicide.\u00a0These events have been reported in patients treated with Mentixa.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Mentixa<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p><em>Tablet jar:<\/em><\/p>\n\n\n\n<p>After the first opening of the jar, the contents must be consumed within 3 months.&nbsp;Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is memantine hydrochloride<strong>Mentixa 10 mg film-coated tablets<\/strong>Each film-coated tablet contains 10 mg memantine hydrochloride equivalent to 8.31 mg memantine.<strong>Mentixa 20 mg film-coated tablets<\/strong>Each film-coated tablet contains 20 mg memantine hydrochloride equivalent to 16.62 mg memantine.<\/li><li>Other ingredients (excipients) are:<em>Tablet core<\/em>&nbsp;:&nbsp;Lactose monohydrate&nbsp;, microcrystalline cellulose (E460),&nbsp;colloidal&nbsp;anhydrous silica, talc (E553b) and magnesium stearate (E470b).<em>Film coating<\/em>&nbsp;: Methacrylic acid &#8211; ethyl acrylate copolymer (1: 1), sodium lauryl sulfate, polysorbate 80, talc (E553b), triacetin and simethicone emulsion (contains dimethicone,&nbsp;colloidal&nbsp;aqueous silica, macrogol stearyl ether,&nbsp;hydrogen peroxide&nbsp;, sorbic acid, water).&nbsp;See section 2 &#8220;Mentixa contains&nbsp;lactose&nbsp;and sodium&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p><strong>Mentixa 10 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>The tablets are white, oval, biconvex film-coated tablets with a scoreline on one side (tablet length: 12.2 &#8211; 12.9 mm, thickness: 3.5 &#8211; 4.5 mm).<\/p>\n\n\n\n<p>The tablets can be divided into equal\u00a0doses.<\/p>\n\n\n\n<p><strong>Mentixa 20 mg film-coated tablets<\/strong><\/p>\n\n\n\n<p>The tablets are white, oval, biconvex film-coated tablets (tablet length: 15.7 &#8211; 16.4 mm, thickness: 4.7 &#8211; 5.7 mm).<\/p>\n\n\n\n<p>Mentixa is available in packs of:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>14, 28, 30, 42, 50, 56, 60, 70, 84, 90, 98, 100 and 112 film-coated tablets in blisters.<\/li><li>100 film-coated tablets in a tablet jar with a safety seal.<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>KRKA dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n<p>TAD Pharma GmbH, Heinz-Lohmann-Stra\u00dfe.&nbsp;5, 27472 Cuxhaven, Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The active substance memantine in Mentixa belongs to a group of medicines known as anti-dementia medicines. Memory loss in Alzheimer&#8217;s disease is due to a disturbance of message signals in the brain. The brain contains so-called N-methyl-D-aspartate (NMDA) receptors that are involved in the transmission of nerve signals that are important for learning and memory. Mentixa belongs to a group of medicines called NMDA receptor antagonists. Mentixa acts on these NMDA receptors by improving the transmission of nerve signals and memory.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[16805,17019,4842,4844,4845,17014,17018,17017,4843,17015,16804,17016],"class_list":["post-17568","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-memantine-hydrochloride","tag-benefits-of-mentixa","tag-memantine-hydrochloride","tag-memantine-hydrochloride-side-effects","tag-memantine-hydrochloride-tablet","tag-mentixa","tag-mentixa-side-effects","tag-mentixa-tablet","tag-what-is-memantine-hydrochloride","tag-what-is-mentixa","tag-what-memantine-hydrochloride-is-used-for","tag-what-mentixa-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17568"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17568\/revisions"}],"predecessor-version":[{"id":17597,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17568\/revisions\/17597"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}