{"id":17359,"date":"2022-01-11T06:11:37","date_gmt":"2022-01-11T06:11:37","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17359"},"modified":"2022-01-11T09:36:18","modified_gmt":"2022-01-11T09:36:18","slug":"marcain-spinal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/marcain-spinal\/","title":{"rendered":"Marcain spinal &#8211; Bupivacaine hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg \/ ml&nbsp;injection&nbsp;solution<br>bupivacaine hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Marcain spinal is and what it is used for<\/h2>\n\n\n\n<p>Marcain&nbsp;spinal&nbsp;contains the active substance bupivacaine hydrochloride, which is a local anesthetic and is injected into the lower back.&nbsp;It temporarily blocks the nerve signals in the area where it is injected.<\/p>\n\n\n\n<p>Marcain&nbsp;spinal&nbsp;is used to temporarily reduce or remove the sensation in a part of the body.<\/p>\n\n\n\n<p>Marcain&nbsp;spinal&nbsp;is used in adults and children of all ages before surgery to numb the lower body.&nbsp;It is used, for example, in bone or hip surgeries that last 3-4 hours.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Marcain spinal<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Marcain spinal<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to bupivacaine hydrochloride or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to other local anesthetics belonging to the same group (eg mepivacaine,&nbsp;lidocaine&nbsp;)<\/li><li>if you have diseases of the brain, spinal cord or spine<\/li><li>if you have blood poisoning<\/li><li>if you have a malignant&nbsp;infection&nbsp;at or near the injection site<\/li><li>if you have an injury to the spine<\/li><li>if you are in a state of shock<\/li><li>if your blood does not clot properly or if you are taking medicines to prevent blood clots<\/li><li>if you have problems with the spinal cord due to&nbsp;anemia&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before giving Marcain\u00a0a spinal.<\/p>\n\n\n\n<p>You may need to be monitored more closely or given a smaller\u00a0dose\u00a0if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>has a type of arrhythmia in the heart called AV \u2011 block II or III<\/li><li>treated with antiarrhythmic drugs<\/li><li>have a serious liver disease<\/li><li>has severe renal impairment<\/li><li>is older<\/li><li>has generally impaired general condition<\/li><li>is pregnant (especially in later stages of pregnancy)<\/li><\/ul>\n\n\n\n<p>Neurological diseases are probably not aggravated by anesthesia, but caution should be exercised.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Marcain spinal<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Marcain&nbsp;spinal&nbsp;can affect or be affected by other drugs, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other local anesthetics<\/li><li>drugs for arrhythmias in the heart.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy:<\/em><\/p>\n\n\n\n<p>There are no known risks when using this medicine for the fetus during pregnancy.&nbsp;In later stages of pregnancy, however, the&nbsp;dose&nbsp;should be&nbsp;reduced.<\/p>\n\n\n\n<p><em>Breast-feeding:<\/em><\/p>\n\n\n\n<p>Marcain&nbsp;spinal&nbsp;passes into breast milk, but it is unlikely to have any effects on the breast-fed baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Depending on the&nbsp;dose&nbsp;you receive, Marcain&nbsp;spinal can&nbsp;have a transient effect on your mobility and coordination.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marcain spinal contains sodium chloride<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per milliliter, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Marcain spinal<\/h2>\n\n\n\n<p>You will receive the medicine from a doctor or nurse in the form of an\u00a0injection\u00a0in the lower back.\u00a0Dose\u00a0one of Marcain&#8217;s\u00a0spinal\u00a0is determined by the doctor and depends on the type of anesthesia you need, the area to be anesthetized, and how long the anesthesia should work.\u00a0Your\u00a0doctor will adjust\u00a0dose\u00a0one to your age, weight, and general health, using the lowest possible\u00a0dose\u00a0that provides adequate anesthesia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much Marcain spinal&nbsp;<\/h2>\n\n\n\n<p>You will be given this medicine in a hospital and it is unlikely that you will be given too much.&nbsp;If you are worried that you have been given too high a&nbsp;dose&nbsp;or if you have any questions about the&nbsp;dose&nbsp;you have been given, talk to your doctor or nurse who will give you the medicine.<\/p>\n\n\n\n<p>Dose\u00a0one given in the spine with Marcain\u00a0spinal\u00a0is low which means that overdose is unlikely.\u00a0If signs of overdose still occur, the physician should immediately discontinue the administration of the drug and begin appropriate treatment.<\/p>\n\n\n\n<p>In case of an overdose of Marcain\u00a0spinal, acute poisoning\u00a0reactions\u00a0may occur.\u00a0The risk of poisoning reactions increases if the drug is accidentally injected into a blood vessel or if other local anesthetics are given at the same time.\u00a0The reactions mainly affect the\u00a0central nervous system\u00a0and the cardiovascular system.\u00a0For symptoms see section 4, Possible\u00a0side effects.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you experience the following symptoms, stop treatment and&nbsp;contact&nbsp;a doctor&nbsp;<strong>immediately<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs of intoxication reactions in the&nbsp;central nervous system&nbsp;, such as numbness, tingling, loss of movement (paralysis), muscle weakness or dysesthesia (emotional disturbances)&nbsp;<em>(less common&nbsp;side effects&nbsp;, may occur in up to 1 in 100 users).<\/em><\/li><li>cardiac arrest&nbsp;<em>(rare&nbsp;side effect<\/em><em>&nbsp;, may affect up to 1 in 1,000 people&nbsp;<\/em><em>)<\/em><\/li><li>respiratory depression&nbsp;<em>(rare&nbsp;side effect<\/em><em>&nbsp;, may affect up to 1 in 1,000 people&nbsp;<\/em><em>)<\/em><\/li><li>severe&nbsp;allergic reaction&nbsp;that may be life-threatening, with symptoms such as difficulty breathing, swelling of the lips, throat and tongue and low&nbsp;blood pressure&nbsp;(anaphylactic&nbsp;shock&nbsp;)&nbsp;<em>(rare&nbsp;side effect<\/em><em>&nbsp;,&nbsp;<\/em><em>may affect up to 1 in 1,000 people)<\/em><\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur:<\/p>\n\n\n\n<p><em>Very common: (may affect more than 1 user in 10)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>nausea<\/li><li>slow heart rate (&nbsp;bradycardia&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Common: (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>vomiting<\/li><li>urinary&nbsp;retention&nbsp;(&nbsp;urinary retention&nbsp;)<\/li><li>Involuntary urination (urinary incontinence)<\/li><\/ul>\n\n\n\n<p><em>Uncommon: (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>back pain<\/li><\/ul>\n\n\n\n<p><em>Rare: (may affect up to 1 in 1000 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nerve damage<\/li><li>inflammation&nbsp;of the cobweb (the middle meninges)<\/li><li>paralysis<\/li><li>allergic reactions<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Marcain spinal<\/h2>\n\n\n\n<p>Marcain&nbsp;spinal&nbsp;is stored in a hospital by a doctor or nurse, out of sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is bupivacaine hydrochloride.&nbsp;One ml contains 5 mg of bupivacaine hydrochloride.<\/li><li>The other ingredients are sodium chloride (see section 2 &#8220;Marcain&nbsp;spinal&nbsp;contains sodium chloride&#8221; for further information), sodium hydroxide and \/ or&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment) and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Marcain\u00a0spinal\u00a0is a\u00a0solution for injection\u00a0in a\u00a0glass ampoule.\u00a0One\u00a0glass ampoule\u00a0contains 4 ml of solution.<\/p>\n\n\n\n<p>Glass ampoule&nbsp;one is marked with two orange color markings around the neck of the ampoule.<\/p>\n\n\n\n<p>One pack contains 5&nbsp;glass&nbsp;ampoules.&nbsp;The glass ampoules&nbsp;are sterile packaged in blisters.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive, Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Cenexi<\/p>\n\n\n\n<p>52 Rue Marcel and Jacques Gaucher<\/p>\n\n\n\n<p>94120 Fontenay sous Bois<\/p>\n\n\n\n<p>France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Marcain spinal contains the active substance bupivacaine hydrochloride, which is a local anesthetic and is injected into the lower back. It temporarily blocks the nerve signals in the area where it is injected.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[13782,16794,8254,16782,8258,16789,16792,16793,8257,8255,16790,16791],"class_list":["post-17359","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-bupivacaine-hydrochloride","tag-benefits-of-marcain-spinal","tag-bupivacaine-hydrochloride","tag-bupivacaine-hydrochloride-injection","tag-bupivacaine-hydrochloride-side-effects","tag-marcain-spinal","tag-marcain-spinal-injection","tag-marcain-spinal-side-effects","tag-what-bupivacaine-hydrochloride-is-used-for","tag-what-is-bupivacaine-hydrochloride","tag-what-is-marcain-spinal","tag-what-marcain-spinal-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17359"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17359\/revisions"}],"predecessor-version":[{"id":17395,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17359\/revisions\/17395"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}