{"id":17357,"date":"2022-01-11T06:10:19","date_gmt":"2022-01-11T06:10:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17357"},"modified":"2022-01-11T09:36:32","modified_gmt":"2022-01-11T09:36:32","slug":"marcain-adrenalin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/marcain-adrenalin\/","title":{"rendered":"Marcain Adrenalin | Bupivacaine hydrochloride and adrenaline | uses, dose and side effects"},"content":{"rendered":"\n<p>2.5 mg \/ ml + 5 micrograms \/ ml and 5 mg \/ ml + 5 micrograms \/ ml&nbsp;injection&nbsp;solution<br>bupivacaine hydrochloride and&nbsp;adrenaline<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Marcain Adrenaline is and what it is used for<\/h2>\n\n\n\n<p>Marcain\u00a0Adrenaline\u00a0contains two different active substances.\u00a0One is bupivacaine hydrochloride, which is a local anesthetic that temporarily blocks the nerve signals in the area where it is injected.\u00a0The other is\u00a0adrenaline\u00a0which prolongs the effect of bupivacaine.\u00a0Adrenaline also\u00a0reduces the risk of\u00a0side effects.<\/p>\n\n\n\n<p>Marcain&nbsp;Adrenaline&nbsp;is used to temporarily reduce or remove the sensation in a part of the body.<\/p>\n\n\n\n<p>Marcain&nbsp;Adrenaline&nbsp;2.5 mg \/ ml + 5 micrograms \/ ml is given as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>local anesthetic before surgery for adults and children over 12 years of age<\/li><li>acute&nbsp;painkillers for adults and children over 1 year of age<\/li><\/ul>\n\n\n\n<p>Marcain&nbsp;Adrenaline&nbsp;5 mg \/ ml + 5 micrograms \/ ml is given as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>local anesthetic before surgery for adults and children over 12 years of age<\/li><li>acute&nbsp;pain relief for adults and children over 12 years of age<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Marcain Adrenaline<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Marcain Adrenaline<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;adrenaline&nbsp;, bupivacaine hydrochloride or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to other local anesthetics belonging to the same group (eg mepivacaine,&nbsp;lidocaine&nbsp;)<\/li><li>if you have very low&nbsp;blood pressure<\/li><li>intravenously&nbsp;(Biers blockade)<\/li><li>to anesthetize an area with end arteries (such as the penis).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before giving Marcain&nbsp;Adrenaline&nbsp;.<\/p>\n\n\n\n<p>You may need to be monitored more closely or given a smaller\u00a0dose\u00a0if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>has a type of arrhythmia in the heart called&nbsp;AV block&nbsp;II or III<\/li><li>have ischemic heart disease such as heart attack or angina<\/li><li>have severe&nbsp;diabetes<\/li><li>has impaired heart function and blood circulation<\/li><li>have a serious liver disease<\/li><li>has severe renal impairment<\/li><li>have too much&nbsp;hormone&nbsp;production in the thyroid gland (&nbsp;hyperthyroidism&nbsp;)<\/li><li>have problems with blood circulation in the brain<\/li><li>is pregnant (especially in later stages of pregnancy)<\/li><li>have very high&nbsp;blood pressure&nbsp;or high&nbsp;blood pressure&nbsp;that is left untreated<\/li><li>is older<\/li><li>has a reduced general permit<\/li><li>if you are being treated with antiarrhythmic drugs.<\/li><\/ul>\n\n\n\n<p>The doctor will be observant of any&nbsp;side effects&nbsp;that may occur in connection with the administration of the drug in the eye.<\/p>\n\n\n\n<p>The doctor will also be careful when giving the medicine in peripheral parts of the body such as fingers (or parts of the body that otherwise have a low blood supply) and when giving large amounts.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Marcain&nbsp;Adrenaline&nbsp;should not be given to newborns and children under 1 year of age as available data is limited.&nbsp;For pain relief in children aged 1-12 years, the lower strength of Marcain&nbsp;Adrenaline&nbsp;should be used.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Marcain Adrenaline<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Be especially careful if you are taking the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other local anesthetics<\/li><li>drugs for arrhythmias in the heart)<\/li><li>medicines for high&nbsp;blood pressure&nbsp;, angina,&nbsp;heart failure&nbsp;, arrhythmias and&nbsp;glaucoma&nbsp;, for the prevention of&nbsp;migraines&nbsp;and after myocardial infarction (non-selective&nbsp;beta-blockers&nbsp;, eg propranolol)<\/li><li>antidepressants&nbsp;and painkillers (&nbsp;tricyclic antidepressants&nbsp;)<\/li><li>medicines used to expel the placenta and reduce bleeding after childbirth (ergot-type medicines)<\/li><li>inhaled anesthetics (eg halothane)<\/li><li>medicines used to&nbsp;treat psychosis&nbsp;, such as sleeping pills and nausea (phenothiazines and butyrophenones).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy:<\/em><\/p>\n\n\n\n<p>When Marcain&nbsp;Adrenaline&nbsp;is used for cervical anesthesia during childbirth, there is an increased risk of an increase or decrease in the baby&#8217;s heart rhythm.&nbsp;The baby&#8217;s heart rhythm will be checked.&nbsp;In addition,&nbsp;adrenaline&nbsp;can&nbsp;reduce uterine contractions and blood flow.<\/p>\n\n\n\n<p><em>Breast-feeding:<\/em><\/p>\n\n\n\n<p>Bupivacaine passes into breast milk, but it is unlikely to have any effects on the breast-fed baby.&nbsp;It is not known whether&nbsp;adrenaline&nbsp;passes into breast milk, but it is unlikely that breastfed babies can be affected.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Depending on the&nbsp;dose&nbsp;you receive, Marcain&nbsp;Adrenaline can&nbsp;have a transient effect on your mobility and coordination.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marcain Adrenaline contains sodium chloride and sodium metabisulfite<\/h2>\n\n\n\n<p>This medicine contains 67 mg of\u00a0sodium\u00a0(the main ingredient in table salt\/table salt) per\u00a0vial.\u00a0This corresponds to 2.9% of the maximum recommended daily\u00a0sodium\u00a0intake\u00a0for adults.<\/p>\n\n\n\n<p>Marcain&nbsp;Adrenaline&nbsp;contains sodium metabisulfite (E 223) which in rare cases can cause severe&nbsp;hypersensitivity reactions&nbsp;and convulsions in the trachea.&nbsp;Tell your healthcare provider if you are allergic to sodium metabisulfite.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Marcain Adrenaline<\/h2>\n\n\n\n<p>You will receive Marcain\u00a0Adrenaline\u00a0from a doctor or nurse, in the form of an\u00a0injection.\u00a0The dose of\u00a0one of the medicines is determined by the doctor and depends on the type of anesthesia you need, the area to be anesthetized, and the duration of the anesthesia.\u00a0The doctor adjusts\u00a0dose\u00a0one to your age, weight, and general health and uses the lowest possible\u00a0dose\u00a0one that provides adequate anesthesia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Marcain Adrenaline than you should &nbsp;<\/h2>\n\n\n\n<p>You will be given this medicine in a hospital and it is unlikely that you will be given too much.&nbsp;If you are worried that you have been given too high a&nbsp;dose&nbsp;or if you have any questions about the&nbsp;dose&nbsp;you have been given, talk to your doctor or nurse who will give you the medicine.<\/p>\n\n\n\n<p>In case of overdose, poisoning reactions may occur, usually within 15-60 minutes after\u00a0injection.\u00a0If Marcain\u00a0Adrenaline\u00a0is accidentally injected into a blood vessel, poisoning reactions can occur quickly (within seconds or minutes).\u00a0The reactions mainly affect the\u00a0central nervous system\u00a0and the cardiovascular system, see section 4.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you experience the following symptoms, stop treatment and&nbsp;contact&nbsp;a doctor&nbsp;<strong>immediately<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs of intoxication reactions in the&nbsp;central nervous system&nbsp;, such as cramps, tingling or numbness around the mouth, numbness in the tongue, increased sensitivity to sound, visual disturbances, loss of consciousness, tremors, intoxication,&nbsp;tinnitus&nbsp;, difficulty speaking clearly (&nbsp;<em>less common&nbsp;side effects&nbsp;may occur in up to 1 out of 100 users)<\/em><\/li><li>cardiac arrest (&nbsp;<em>rare&nbsp;side effect&nbsp;,&nbsp;<\/em><em>may affect up to 1 in 1,000 people<\/em>&nbsp;)<\/li><li>respiratory depression&nbsp;(&nbsp;<em>rare&nbsp;side effect&nbsp;,&nbsp;<\/em>&nbsp;<em>may affect up to 1 in 1,000 people&nbsp;<\/em><em>)<\/em><\/li><li>severe&nbsp;allergic reaction&nbsp;that may be life-threatening, with symptoms such as difficulty breathing, swelling of the lips, throat and tongue and low&nbsp;blood pressure&nbsp;(anaphylactic&nbsp;shock&nbsp;) (&nbsp;<em>rare&nbsp;side effect&nbsp;, may affect up to 1 in 1,000 people<\/em>&nbsp;)<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur:<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>nausea<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>tingling sensation (tingling) in the skin<\/li><li>dizziness<\/li><li>slow heart rate (&nbsp;bradycardia&nbsp;)<\/li><li>high&nbsp;blood pressure<\/li><li>vomiting<\/li><li>urinary&nbsp;retention&nbsp;(&nbsp;urinary retention&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>double vision<\/li><li>allergic reactions<\/li><li>nerve damage<\/li><li>inflammation&nbsp;of the cobweb (the middle meninges)<\/li><li>paralysis<\/li><li>irregular heartbeat<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Marcain Adrenaline<\/h2>\n\n\n\n<p>Marcain&nbsp;Adrenaline&nbsp;is stored in a hospital by a doctor or nurse, out of sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Do not freeze.&nbsp;Keep the vial in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are bupivacaine hydrochloride and&nbsp;adrenaline&nbsp;.&nbsp;One ml contains 2.5 mg bupivacaine hydrochloride and 5 micrograms&nbsp;adrenaline&nbsp;or 5 mg bupivacaine hydrochloride and 5 micrograms&nbsp;adrenaline&nbsp;.<\/li><li>The other ingredients are sodium chloride, sodium metabisulfite, sodium hydroxide and \/ or&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment) and water for injections.&nbsp;See section 2 &#8220;Marcain&nbsp;Adrenaline&nbsp;contains sodium chloride and sodium metabisulfite&#8221; for further information.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Marcain&nbsp;Adrenaline&nbsp;is a clear, colorless&nbsp;solution for injection&nbsp;provided in glass vials.&nbsp;One&nbsp;vial&nbsp;contains 20 ml.<\/p>\n\n\n\n<p>One pack contains 5 vials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive, Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p>Tel.&nbsp;0046 856642572<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Marcain Adrenaline contains two different active substances. One is bupivacaine hydrochloride, which is a local anesthetic that temporarily blocks the nerve signals in the area where it is injected. The other is adrenaline which prolongs the effect of bupivacaine. Adrenaline also reduces the risk of side effects .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[4044,4046,8254,8258,16795,16798,11524,8257,4045,8255,16796,16797],"class_list":["post-17357","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-adrenaline","tag-adrenaline-side-effects","tag-bupivacaine-hydrochloride","tag-bupivacaine-hydrochloride-side-effects","tag-marcain-adrenalin","tag-marcain-adrenalin-side-effects","tag-what-adrenaline-is-used-for","tag-what-bupivacaine-hydrochloride-is-used-for","tag-what-is-adrenaline","tag-what-is-bupivacaine-hydrochloride","tag-what-is-marcain-adrenalin","tag-whattttttttttttttttttttt-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17357"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17357\/revisions"}],"predecessor-version":[{"id":17396,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17357\/revisions\/17396"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}