{"id":17248,"date":"2022-01-06T08:00:52","date_gmt":"2022-01-06T08:00:52","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17248"},"modified":"2022-01-06T10:32:17","modified_gmt":"2022-01-06T10:32:17","slug":"lyxumia","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lyxumia\/","title":{"rendered":"Lyxumia &#8211; Lixisenatide uses, dose and side effects"},"content":{"rendered":"\n<p>LYXUMIA 10 micrograms solution for injection LYXUMIA 20 micrograms solution for injection<br>lixisenatide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lyxumia is and what it is used for<\/h2>\n\n\n\n<p>Lyxumia contains the active substance lixisenatide.<br>Lyxumia is medicine for\u00a0injection\u00a0that is used to help the body control your blood sugar level in cases where it is too high.\u00a0It is used in adults with type 2\u00a0diabetes.<\/p>\n\n\n\n<p>Lyxumia is used with other diabetes medicines when these are not enough to control your blood sugar levels.&nbsp;These may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>oral diabetes medicines (such as&nbsp;metformin&nbsp;, pioglitazone, sulphonylurea medicines) and \/ or<\/li><li>a basal insulin, a type of&nbsp;insulin&nbsp;that works throughout the day<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Lyxumia<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Lyxumia<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to lixisenatide or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Lyxumia about:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have type 1&nbsp;diabetes&nbsp;or&nbsp;diabetic&nbsp;ketoacidosis&nbsp;(a complication of&nbsp;diabetes&nbsp;that occurs when the body can not break down&nbsp;glucose&nbsp;because there is not enough&nbsp;insulin&nbsp;) because this medicine will not be right for you<\/li><li>you have or have had&nbsp;inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;)<\/li><li>you have severe problems with the stomach or intestines, such as a disease of the abdominal muscle called gastroparesis which leads to delay in gastric emptying<\/li><li>you have severe kidney disease or if you are receiving dialysis treatment, as the use of this medicine is not recommended<\/li><li>you also use a sulphonylurea or a basal insulin, as it can cause low blood sugar (&nbsp;hypoglycaemia&nbsp;).&nbsp;Your doctor may want to check your blood sugar level and then decide whether to&nbsp;reduce the&nbsp;dose of&nbsp;a basal insulin or sulphonylurea.&nbsp;Lyxumia should not be used with a combination of both basal insulin and sulphonylurea.<\/li><li>you are taking other medicines, as there are other medicines such as&nbsp;antibiotics&nbsp;or gastric juice-resistant tablets or capsules that should not be left in the stomach for too long (see section Other medicines and Lyxumia)<\/li><li>you experience fluid loss \/ dehydration, such as vomiting, nausea and diarrhea.&nbsp;It is important to avoid&nbsp;dehydration&nbsp;by drinking a lot, especially when starting treatment with Lyxumia.<\/li><li>you suffer from heart problems that can cause shortness of breath or swollen ankles, as there is limited experience from this population.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Experience from the treatment of children and adolescents under the age of 18 is lacking and therefore Lyxumia is not recommended for this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Lyxumia<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines.<br>The effect of certain medicines that you swallow may be affected by Lyxumia.\u00a0Some medicines such as\u00a0antibiotics\u00a0or gastric juice-resistant tablets or capsules that should not be left in the stomach for too long may need to be taken at least one hour before or four hours after\u00a0injection\u00a0with Lyxumia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Lyxumia should not be used during pregnancy.\u00a0It is not known if Lyxumia can harm your fetus.<br>Lyxumia should not be used if you are breastfeeding.\u00a0It is not known if Lyxumia passes into breast milk.<br>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you use Lyxumia with a sulphonylurea or basal insulin you may have low blood sugar (hypoglycemia).\u00a0This can impair your ability to concentrate and you may feel dizzy or sleepy.\u00a0If this happens, do not drive or use any tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of Lyxumia<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.\u00a0This medicine contains metacresol, which may cause allergic reactions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Lyxumia<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor, pharmacist or nurse has told you.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p><strong>How much to inject<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The starting dose is 10 micrograms once daily for the first 14 days &#8211; injected with the&nbsp;<strong>green<\/strong>&nbsp;pen.<\/li><li>The&nbsp;next dose will be 20 micrograms once daily &#8211; injected with the&nbsp;<strong>purple<\/strong>&nbsp;pen.<\/li><\/ul>\n\n\n\n<p><strong>When to inject<\/strong><br>Inject Lyxumia within one hour before any meal during the day.&nbsp;Decide on which meal suits you best, then inject Lyxumia preferably before the same meal every day.<\/p>\n\n\n\n<p><strong>Where to inject<\/strong><br>Inject Lyxumia under the skin (\u00a0subcutaneously\u00a0) into the abdomen, upper leg (thigh), or upper arm.<\/p>\n\n\n\n<p><strong>Learning how to use pre-filled pens<\/strong><br>Before using Lyxumia for the first time, your doctor or nurse will show you how to inject Lyxumia.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Always read the instructions in the package.<\/strong><\/li><li><strong>Always use the pen as described in the instructions for use.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Other important information regarding the use of pre-filled pens<\/strong><br>There is more information on how to use the pens in the instruction manual.&nbsp;The most important points are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Always use a new needle for each&nbsp;injection&nbsp;.&nbsp;You must dispose of the needle after each use in a suitable needle can, according to local guidelines.&nbsp;Talk to your doctor, nurse or pharmacist about how to dispose of needles.<\/li><li>Use only needles that are intended for use with the Luxury Pen (see instructions for use).<\/li><li><strong>You must activate the Luxury pen before using it for the first time.&nbsp;<\/strong>This is to ensure that it works correctly and that the&nbsp;dose&nbsp;for the first&nbsp;injection&nbsp;is correct.<\/li><li>Do not use the Luxury Pen if you think it is damaged, take a new one instead.&nbsp;Do not try to fix the pen.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Lyxumia than you should<\/h2>\n\n\n\n<p>If you use more Lyxumia than you should, talk to a doctor or nurse immediately.&nbsp;Too much Lyxumia can make you feel sick or vomit.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Lyxumia<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose of\u00a0Lyxumia, you can inject Lyxumia within one hour before the next meal.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Lyxumia<\/h2>\n\n\n\n<p>Do not stop using Lyxumia without talking to your doctor.&nbsp;If you stop using Lyxumia, your blood sugar levels may increase.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Some severe allergic reactions (such as anaphylactic reactions) have been reported very rarely in patients receiving Lyxumia.\u00a0You should contact a doctor immediately if you experience symptoms such as swelling of the face, tongue, or throat which causes difficulty breathing.<\/p>\n\n\n\n<p>Stop using Lyxumia and contact your doctor immediately if you notice any of the following serious side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe and persistent pain in the abdominal area that can also be felt in the back, as well as nausea and vomiting, as it can be a sign of inflamed pancreas (&nbsp;pancreatitis&nbsp;)<\/li><\/ul>\n\n\n\n<p>The most frequent&nbsp;adverse reactions&nbsp;reported with Lyxumia may affect more than 1 in 10 patients (frequency very common) were nausea and vomiting.&nbsp;These&nbsp;side effects&nbsp;were mostly mild and usually subsided over time in most patients.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;include:<\/p>\n\n\n\n<p>Very common side effects: may affect more than 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><li>Headache<\/li><li>Low blood sugar (&nbsp;hypoglycaemia&nbsp;) especially when Lyxumia is used with&nbsp;insulin&nbsp;or a sulphonylurea<\/li><\/ul>\n\n\n\n<p>The warning signs of low blood sugar may include cold sweats, pallor, headache, drowsiness, weakness, dizziness, confusion or irritation, hunger, palpitations, and tremors.\u00a0Your doctor will tell you what to do if you get low blood sugar.\u00a0Hypoglycemia<br>is more likely to\u00a0occur if you take sulphonylurea or basal insulin.\u00a0Your doctor may reduce the\u00a0dose of\u00a0one of these medicines before you start using Lyxumia.<\/p>\n\n\n\n<p>Common side effects: may affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Influenza<\/li><li>Cold (&nbsp;upper respiratory tract&nbsp;infection&nbsp;)<\/li><li>Dizziness<\/li><li>Indigestion (&nbsp;dyspepsia&nbsp;)<\/li><li>Back pain<\/li><li>Cystitis&nbsp;(&nbsp;cystitis&nbsp;)<\/li><li>Viral infections<\/li><li>Low blood sugar (when Lyxumia is used with&nbsp;metformin&nbsp;)<\/li><li>Drowsiness (sleepiness)<\/li><li>Injection site reactions (such as&nbsp;pruritus&nbsp;)<\/li><\/ul>\n\n\n\n<p>Rare side effects: may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hives (&nbsp;urticaria&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lyxumia<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br>Do not use this medicine after the expiry date which is stated on the pen label and the carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Before first use<\/strong><br>Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).&nbsp;Do not freeze.&nbsp;Store protected from freezer compartments.<\/p>\n\n\n\n<p><strong>Using the pen The<\/strong><br>a pen can be used for 14 days when stored at room temperature at a maximum of 30 \u00b0 C.\u00a0Do not freeze.<br>Do not store with a needle attached.\u00a0When you are not using the pen, keep the protective cap on the pen to protect it from light.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is lixisenatide.<\/li><li>Lyxumia 10 micrograms&nbsp;solution for injection&nbsp;: Each&nbsp;dose&nbsp;contains 10 micrograms lixisenatide (50 micrograms per ml).<\/li><li>Lyxumia 20 micrograms&nbsp;solution for injection&nbsp;: Each&nbsp;dose&nbsp;contains 20 micrograms lixisenatide (100 micrograms per ml).<\/li><li>The other ingredients are&nbsp;glycerol&nbsp;85%, sodium acetate trihydrate, methionine, metacresol,&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment), sodium hydroxide solution (for&nbsp;pH&nbsp;adjustment) and water for&nbsp;injection&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Lyxumia is a clear and colorless solution (&nbsp;solution for injection&nbsp;) filled in a&nbsp;glass ampoule&nbsp;into a pre-filled pen.<\/p>\n\n\n\n<p>Each green pencil Lyxumia 10 micrograms&nbsp;solution for injection&nbsp;contains 3 ml of solution and delivers 14 doses of 10 micrograms.&nbsp;Pack size is 1 pre-filled pen.<\/p>\n\n\n\n<p>Each purple pencil Lyxumia 20 micrograms\u00a0solution for injection\u00a0contains a 3 ml solution and delivers 14 doses of 20 micrograms.\u00a0Pack sizes are 1, 2, or 6 pre-filled pens.\u00a0Not all pack sizes may be marketed in your country.<\/p>\n\n\n\n<p>A\u00a0starter pack\u00a0is also available for use during the first 28 days of treatment.\u00a0Starter pack\u00a0one contains a green pen of Lyxumia 10 micrograms\u00a0solution for injection\u00a0and a purple pen of Lyxumia 20 micrograms\u00a0solution for injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>sanofi-aventis groupe<br>54, rue La Bo\u00e9tie<br>F &#8211; 75008 Paris<br>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br>Sanofi-Aventis Deutschland GmbH<br>Industriepark H\u00f6chst &#8211; 65926 Frankfurt am Main<br>Germany<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<p>Sanofi AB<\/p>\n\n\n\n<p>Tel: +46 (0) 8 634 50 0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lyxumia is medicine for injection that is used to help the body control your blood sugar level in cases where it is too high. It is used in adults with type 2 diabetes .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[16597,16602,16593,16596,16598,16601,16594,16599,16595,16600],"class_list":["post-17248","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-lixisenatide","tag-benefits-of-lyxumia","tag-lixisenatide","tag-lixisenatide-side-effects","tag-lyxumia","tag-lyxumia-side-effects","tag-what-is-lixisenatide","tag-what-is-lyxumia","tag-what-lixisenatide-is-used-for","tag-what-lyxumia-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17248"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17248\/revisions"}],"predecessor-version":[{"id":17280,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17248\/revisions\/17280"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}