Tell your doctor if you are breast-feeding. The use of Loxentia during breast-feeding is not recommended. Consult your doctor or pharmacist.<\/li><\/ul>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
Loxentia may make you feel sleepy or dizzy. Do not drive or use any tools or machines until you know how Loxentia affects you.<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Loxentia contains sucrose<\/h2>\n\n\n\n
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n
How to use Loxentia<\/h2>\n\n\n\n
Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n
Loxentia is taken by mouth. Swallow the capsule whole with a glass of water.<\/p>\n\n\n\n
The usual\u00a0dose\u00a0is a 40 mg Loxentia capsule twice daily (in the morning and late afternoon\/evening).\u00a0However, your doctor may choose to start your treatment with a 20 mg capsule twice daily for two weeks and then increase the\u00a0dose\u00a0one to 40 mg twice daily.<\/p>\n\n\n\n
It is easier to remember to take Loxentia if you take it at the same time each day.<\/p>\n\n\n\n
Do not stop taking Loxentia, or change the\u00a0dose, without first discussing this with your doctor.\u00a0For you to feel better, it is important to treat your illness in the right way.\u00a0If left untreated, it can persist and become more severe and difficult to treat.<\/p>\n\n\n\n
If you use more Loxentia than you should <\/h2>\n\n\n\n
Symptoms of overdose include drowsiness,\u00a0coma, serotonergic syndrome (a rare reaction that can cause severe feelings of happiness, drowsiness, clumsiness, restlessness, intoxication, fever, sweating, or stiff muscles), seizures, vomiting, and rapid heartbeat.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
Very common side effects (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n- nausea, dry mouth , constipation<\/li>
- fatigue<\/li><\/ul>\n\n\n\n
Common side effects (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n- loss of appetite<\/li>
- difficulty falling asleep, feeling upset, decreased sexual desire, anxiety, poor sleep<\/li>
- headache, dizziness, feeling sluggish, feeling drowsy, tremors and numbness, which include numbness or tingling in the skin<\/li>
- dimsyn<\/li>
- dizziness<\/li>
- high blood pressure , redness<\/li>
- diarrhea, stomach pain, nausea and vomiting, heartburn or indigestion<\/li>
- increased sweating<\/li>
- weakness, chills<\/li><\/ul>\n\n\n\n
Uncommon side effects (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n- pharyngitis causing hoarse voice<\/li>
- allergic reactions<\/li>
- impaired thyroid function, which can cause fatigue or weight gain<\/li>
- dehydration<\/li>
- gnashing of teeth, feeling disoriented, lack of motivation, difficulty getting or not having an orgasm, strange dreams<\/li>
- feeling nervous, difficulty concentrating, changes in taste, poor sleep<\/li>
- large pupil er (the dark field in the middle of the eye), visual disturbances, the eyes feel dry<\/li>
- tinnitus (sensation of sound in the ear without external sound source), pain in the ears<\/li>
- palpitations, rapid and \/ or irregular heartbeat<\/li>
- fainting<\/li>
- yawning<\/li>
- bloody vomiting or black tarry stools, gastrointestinal inflammation, inflammation of the mouth, belching, difficulty swallowing, flatulence, bad breath<\/li>
- inflammation of the liver that can cause abdominal pain and yellowing of the skin and whites of the eyes<\/li>
- (itchy) rash, night sweats, hives, cold sweats, increased tendency to bruise<\/li>
- muscle pain, muscle tension, muscle twitching, cramping in the jaw muscles<\/li>
- difficulty urinating, painful urination, need to empty the bladder during the night, frequent bladder emptying, abnormal odor on the urine<\/li>
- abnormal vaginal bleeding, menopausal symptoms<\/li>
- chest pain, feeling cold, thirsty, feeling hot<\/li>
- weight loss, weight gain<\/li>
- Loxentia can cause effects that you do not notice, such as an increase in liver enzymes or the level of potassium , creatine phosphokinase, sugar or cholesterol in the blood.<\/li><\/ul>\n\n\n\n
Rare side effects (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n- severe allergic reactions that cause difficulty breathing or dizziness, with swollen tongue or swollen lips<\/li>
- low sodium level in the blood (mostly affects the elderly); the symptoms may be feeling dizzy, weak, confused, sleepy or very tired, nausea or vomiting, more serious symptoms are fainting, seizures or falls, insufficient secretion of antidiuretic hormone (SIADH)<\/li>
- suicidal behavior, suicidal ideation, mania (overactivity, thoughtlessness and decreased need for sleep), feelings of aggression and anger<\/li>
- “Serotonergic syndrome” (a rare reaction that may cause feelings of happiness, drowsiness, clumsiness, restlessness, feeling intoxicated, fever, sweating or stiff muscles), seizures, sudden involuntary twitching or twitching of the muscles, a feeling of restlessness and difficulty sitting or stand still, difficulty controlling movements e.g. lack of coordination or involuntary movements in the muscles, restless legs (numbness and tingling sensation in the legs)<\/li>
- increased pressure in the eye ( glaucoma )<\/li>
- fainting and dizziness when getting up, cold fingers and \/ or toes<\/li>
- feel thick in the throat, nosebleeds<\/li>
- cough, wheezing and shortness of breath that may be accompanied by high body temperature<\/li>
- bright red blood in the stool, inflammation of the colon (causes diarrhea)<\/li>
- liver problems, yellowing of the skin and whites of the eyes (jaundice)<\/li>
- Stevens-Johnson syndrome (severe disease with blisters on the skin, mouth, eyes and genitals), severe allergic reactions that cause swelling of the face and throat ( angioedema ), sensitivity to sunlight<\/li>
- muscle twitching<\/li>
- difficulty or inability to urinate, need to empty bladder more often than usual, decreased urine flow<\/li>
- abnormal menstruation, including heavy, painful, irregular or prolonged menstruation, unusually short or absent menstruation, abnormal production of breast milk<\/li>
- severe vaginal bleeding shortly after delivery ( postpartum haemorrhage )<\/li>
- fall accidents (mostly in the elderly), abnormal gait<\/li><\/ul>\n\n\n\n
Very rare side effects (may affect up to 1 in 10,000 people)<\/strong><\/p>\n\n\n\n- inflammation of the blood vessels of the skin ( cutaneous vasculitis )<\/li><\/ul>\n\n\n\n
How to store Loxentia<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Do not store above 25 \u00b0 C.<\/p>\n\n\n\n
Store in the original package. Moisture sensitive.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the package and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n
The active substance is duloxetine. Each capsule contains 20 mg or 40 mg of duloxetine (as duloxetine hydrochloride).<\/p>\n\n\n\n
Other ingredients are:<\/p>\n\n\n\n
Capsule contents:<\/strong>\u00a0Sugar spheres (sucrose, maize starch), hypromellose 6 cp, sucrose, hypromellose phthalate, talc, and triethyl citrate.<\/p>\n\n\n\nCapsule shell:<\/strong>\u00a0Gelatin, titanium dioxide (E171), indigotin (E132), yellow iron oxide (E172) – only in 40 mg capsules, red iron oxide (E172) – only in 40 mg capsules, ink (shellac, black iron oxide (E172)).<\/p>\n\n\n\nSee section 2 “Loxentia contains sucrose”<\/p>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
20 mg enteric capsule:<\/strong>\u00a0White to off-white pellets in a size 4 hard gelatin capsule (mean length 14.4 mm).\u00a0The body and lid of the capsule are light blues.\u00a0The capsule body is marked with “20” in black.<\/p>\n\n\n\n40 mg enteric capsule:<\/strong> White to off-white pellets in a size 2 hard gelatin capsule (mean length 17.9 mm). The body of the capsule is light orange and the lid is light blue. The capsule body is marked with “40” in black.<\/p>\n\n\n\nLoxentia is available in packs containing 7, 10, 14, 28, 30, 56, 60, 90, and 100 hard enteric capsules in blisters.<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/em><\/p>\n\n\n\nKRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n
Manufacturer<\/em><\/p>\n\n\n\nKRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n","protected":false},"excerpt":{"rendered":"
Loxentia contains the active substance duloxetine. Loxentia increases the amount of serotonin and norepinephrine in the nervous system.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[16542,16548,5053,5056,5055,16543,16546,16547,10054,5054,16544,16545],"class_list":["post-17177","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-duloxetine","tag-benefits-of-loxentia","tag-duloxetine","tag-duloxetine-capsule","tag-duloxetine-side-effects","tag-loxentia","tag-loxentia-capsule","tag-loxentia-side-effects","tag-what-duloxetine-is-used-for","tag-what-is-duloxetine","tag-what-is-loxentia","tag-what-loxentia-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17177"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17177\/revisions"}],"predecessor-version":[{"id":17216,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17177\/revisions\/17216"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}