aliskiren<\/li><\/ul><\/li><\/ul>\n\n\n\nYour doctor may need to check your kidney function,\u00a0blood pressure,\u00a0and the number of\u00a0electrolytes\u00a0(eg\u00a0potassium\u00a0) in\u00a0your\u00a0blood at regular intervals.<\/p>\n\n\n\n
See also the information under the heading “Do not take Losartan Krka”.<\/p>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Losartan has been studied in children. Ask your doctor for more information.<\/p>\n\n\n\n
Other medicines and Losartan Krka<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n
It is especially important to tell your doctor if you are taking any of the following medicines while taking Losartan Krka:<\/p>\n\n\n\n
other antihypertensive drugs as they can lower your\u00a0blood pressure\u00a0further.\u00a0Blood pressure\u00a0can also be lowered with any of the following drugs\/drug groups: tricyclic antidepressants, antipsychotics, baclofen, amifostine<\/p>\n\n\n\n
potassium-sparing drugs, or drugs that increase potassium levels (potassium supplements, potassium-containing salt substitutes, or potassium-sparing drugs such as certain\u00a0diuretics\u00a0(amiloride, triamterene,\u00a0spironolactone\u00a0) or\u00a0heparin\u00a0)<\/p>\n\n\n\n
non-steroidal anti-inflammatory drugs such as indomethacin, including\u00a0COX-2\u00a0inhibitors (medicines for\u00a0inflammation\u00a0and pain) as they may reduce the antihypertensive effect of\u00a0losartan\u00a0\u00a0If you have renal impairment, concomitant use of these drugs may lead to impaired renal function. Medicines containing lithium should not be used in combination with\u00a0losartan\u00a0without close monitoring by your doctor.\u00a0Special precautions (eg blood tests) may be appropriate.<\/p>\n\n\n\n
Your doctor may need to change your\u00a0dose\u00a0and\/or take other precautions:<\/p>\n\n\n\n
If you are taking an ACE inhibitor or aliskiren (see also the information under the headings “Do not take Losartan Krka” and “Warnings and precautions”).<\/p>\n\n\n\n
Losartan Krka with food, drink and alcohol<\/h2>\n\n\n\n
Losartan Krka can be taken with or without food.<\/p>\n\n\n\n
Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n
Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n
Pregnancy<\/strong><\/p>\n\n\n\nIf you think you may be pregnant (or become pregnant) during treatment, consult your doctor.\u00a0Usually, your doctor suggests that you stop taking\u00a0Losartan\u00a0Krka before pregnancy or as soon as you know you are pregnant and instead recommend another medicine for you.\u00a0Losartan\u00a0Krka should not be used in early pregnancy and should not be used during the last 6 months of pregnancy as it may cause birth defects.<\/p>\n\n\n\n
Breastfeeding<\/strong><\/p>\n\n\n\nTell your doctor if you are breastfeeding planning to start breastfeeding\u00a0Breastfeeding of a newborn baby, especially premature babies, is not recommended when using\u00a0Losartan\u00a0Krka.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
No studies have been performed.\u00a0Losartan\u00a0Krka is not expected to affect your ability to drive or use machines.\u00a0However, keep in mind that, as with many other medicines used to treat high\u00a0blood pressure losartan\u00a0may cause dizziness and drowsiness in some patients.\u00a0If you experience dizziness or drowsiness, consult your doctor before performing any of these activities.<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Losartan Krka contains excipients<\/h2>\n\n\n\n
This medicine contains\u00a0lactose\u00a0\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n
How to use Losartan Krka<\/h2>\n\n\n\n
Always take this medicine exactly as your doctor has told you.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0Your doctor will decide on the appropriate\u00a0dose\u00a0of\u00a0Losartan\u00a0Krka, depending on your medical condition and whether you are taking other medicines.\u00a0you must continue to take\u00a0Losartan\u00a0Krka according to your doctor’s\u00a0prescription\u00a0to maintain even control of your\u00a0blood pressure\u00a0<\/p>\n\n\n\n
Losartan\u00a0Krka is available in strengths of 12.5 mg, 50 mg, and 100 mg.<\/p>\n\n\n\n
Adult patients with high blood pressure<\/strong><\/p>\n\n\n\nTreatment is usually started with 50 mg\u00a0losartan\u00a0(one\u00a050 mg\u00a0Losartan\u00a0Krka\u00a0tablet\u00a0) once daily.\u00a0The maximum blood pressure-lowering effect is achieved within 3-6 weeks after starting treatment.\u00a0In some patients, the\u00a0dose\u00a0may\u00a0then be increased to 100 mg\u00a0losartan\u00a0(two tablets\u00a0Losartan\u00a0Krka 50 mg, or one tablet\u00a0Losartan\u00a0Krka 100 mg) once daily.<\/p>\n\n\n\n
If you have the impression that the effect of losartan is too strong or too weak, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Adult patients with high blood pressure and type 2 diabetes<\/strong><\/p>\n\n\n\nTreatment is usually started with 50 mg losartan (one 50 mg Losartan Krka tablet ) once daily. Dose one can then be increased to 100 mg losartan (two tablets Losartan Krka 50 mg, or one tablet Losartan Krka 100 mg) once daily depending on your blood pressure response.<\/p>\n\n\n\n
Losartan\u00a0tablets can be given with other antihypertensive drugs (eg\u00a0diuretics calcium channel blockers, alpha- or beta-blockers, and centrally acting drugs) as well as with\u00a0insulin\u00a0and other commonly used drugs that lower blood glucose levels (eg sulphonylureas, glitazones, and glucosidase inhibitors).<\/p>\n\n\n\n
Adult patients with heart failure<\/strong><\/p>\n\n\n\nTreatment is usually started with 12.5 mg\u00a0losartan\u00a0(one tablet\u00a0Losartan\u00a0Krka 12.5 mg) once daily.\u00a0Depending on your condition, the\u00a0dose\u00a0should\u00a0be increased step by step, weekly (ie 12.5 mg daily during the first week, 25 mg daily during the second week, 50 mg daily during the third week, 100 mg daily during the fourth week 150 mg daily for the fifth week), up to the usual maintenance dose determined by your doctor.\u00a0A maximum\u00a0dose\u00a0of 150 mg\u00a0losartan\u00a0(eg three tablets\u00a0Losartan\u00a0Krka 50 mg or one tablet of both\u00a0Losartan\u00a0Krka 100 mg and\u00a0Losartan\u00a0Krka 50 mg) once daily can be used.<\/p>\n\n\n\n
In the treatment of\u00a0heart failure, losartan is\u00a0often combined\u00a0with a\u00a0diuretic\u00a0(a medicine that increases the excretion of urine from your kidneys) and\/digitalis\u00a0(a medicine that helps the heart to function better and more efficiently) and\/or \u03b2-blocker.<\/p>\n\n\n\n
Dosage in special patient groups<\/strong><\/p>\n\n\n\nYour doctor may\u00a0prescribe\u00a0a lower\u00a0dose especially for initial treatment in some patients, such as in patients treated with high-dose diuretics, in patients with hepatic impairment, or patients over 75 years of age.\u00a0The use of\u00a0losartan\u00a0is not recommended in patients with severe hepatic impairment (see section: Do not take\u00a0Losartan\u00a0Krka).<\/p>\n\n\n\n
Administration<\/strong><\/p>\n\n\n\nThe tablets should be swallowed together with a glass of water.\u00a0Try to take your daily\u00a0dose\u00a0at the same time each day.\u00a0you must continue to take\u00a0Losartan\u00a0Krka according to your doctor’s\u00a0prescription\u00a0<\/p>\n\n\n\n
Use for children and adolescents<\/h2>\n\n\n\n
Use for children and adolescents (6-18 years)<\/em><\/p>\n\n\n\nThe recommended starting dose for patients with a body weight of 20-50 kg is 0.7 mg losartan\/body weight once daily (maximum 25 mg\u00a0losartan\u00a0).\u00a0If the desired blood pressure effect is not achieved, the doctor may increase the\u00a0dose\u00a0one.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n
If you experience any of the following, stop taking losartan tablets and talk to your doctor immediately or seek medical attention:<\/p>\n\n\n\n
A severe\u00a0allergic reaction\u00a0(rash,\u00a0itching swelling of the face, lips, mouth, or throat, which can cause difficulty swallowing and breathing).<\/p>\n\n\n\n
This is a serious but rare\u00a0side effect affecting more than 1 in 10,000 people and less than 1 in 1,000 users.\u00a0You may need\u00a0emergency\u00a0medical care or hospitalization.<\/p>\n\n\n\n
The following side effects have been reported with losartan:<\/p>\n\n\n\n
Common (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n- dizziness<\/li>
- low blood pressure (especially after severe fluid loss from the body, eg in patients with severe heart failure or during treatment with high-dose diuretics)<\/li>
- dose- related orthostatic effects such as a drop in blood pressure when getting up quickly from a lying or sitting position<\/li>
- impotence<\/li>
- fatigue<\/li>
- low blood sugar ( hypoglycaemia )<\/li>
- excess potassium in the blood ( hyperkalaemia ).<\/li>
- change in renal function including renal failure<\/li>
- decreased number of red blood cells ( anemia )<\/li>
- increase in blood urea, serum creatinine and serum potassium in patients with heart failure<\/li><\/ul>\n\n\n\n
Uncommon (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n- somnolence<\/li>
- headache<\/li>
- sleep disorders<\/li>
- feeling that the heart is beating fast (palpitations)<\/li>
- severe chest pain ( angina pectoris )<\/li>
- shortness of breath ( dyspnoea )<\/li>
- abdominal pain<\/li>
- constipation<\/li>
- diarrhea<\/li>
- nausea<\/li>
- vomiting<\/li>
- hives ( urticaria )<\/li>
- itching ( pruritus )<\/li>
- rash<\/li>
- swelling ( edema )<\/li>
- cough<\/li><\/ul>\n\n\n\n
Rare (may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n- hypersensitivity<\/li>
- angioedema<\/li>
- inflammation of the blood vessels ( vasculitis including Henoch-Sch\u00f6nlein purpura)<\/li>
- numbness or tingling<\/li>
- fainting<\/li>
- fast and irregular heartbeat ( atrial fibrillation )<\/li>
- stroke<\/li>
- inflammation of the liver ( hepatitis )<\/li>
- elevated alanine aminotransferase ( ALT ) levels in the blood, usually reversible after discontinuation of treatment.<\/li><\/ul>\n\n\n\n
Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n- decreased platelet count<\/li>
- migraine<\/li>
- abnormal liver function<\/li>
- muscle and joint pain<\/li>
- flu-like symptoms<\/li>
- back pain and urinary tract infection<\/li>
- increased sensitivity to the sun ( photosensitivity )<\/li>
- unexplained muscle pain with dark (tea-colored) urine ( rhabdomyolysis )<\/li>
- impotence<\/li>
- pancreatitis ( pancreatitis )<\/li>
- low levels of sodium in the blood ( hyponatremia )<\/li>
- Depression<\/li>
- general malaise<\/li>
- ringing, buzzing, throbbing or clicking in the ears ( tinnitus )<\/li>
- altered sense of taste ( dysgeusia )<\/li><\/ul>\n\n\n\n
The side effects in children are similar to the side effects in adults.<\/p>\n\n\n\n
How to store Losartan Krka<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
No special storage instructions.<\/p>\n\n\n\n
Polyethylene (HDPE) tablet jar with safety-sealed polypropylene closure<\/strong><\/p>\n\n\n\nLosartan\u00a0Krka 12.5 mg: The product should be used within 250 days of fthe irst opening.<\/p>\n\n\n\n
Losartan\u00a0Krka 100 mg: The product should be used within 100 days of fthe irst opening.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the package and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n- The active substance is losartan potassium. One film-coated tablet contains 12.5 mg, 50 mg or 100 mg of losartan potassium, equivalent to 11.4 mg, 45.8 mg or 91.6 mg of losartan .<\/li>
- The other ingredients in Losartan Krka 12.5 mg are maize starch , pregelatinised starch , microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate, cell lactose (a mixture of cellulose and lactose monohydrate ) in the tablet core and hypromellose, talc, propylene glycol17 (propylene glycol1) E104) in the film coating.<\/li>
- The other ingredients of Losartan Krka 50 mg and Losartan Krka 100 mg are maize starch , pregelatinised starch , microcrystalline cellulose, colloidal anhydrous silica, magnesium stearate, cell lactose (a mixture of cellulose and lactose monohydrate ) in the tablet core and hypromellose (E1), propylene glycol, talc, talc the film coating.<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Losartan Krka 12.5 mg: oval, convex, yellow film-coated tablets<\/p>\n\n\n\n
Losartan\u00a0Krka 50 mg: round, convex, white film-coated tablets with bbevelededges and a notch on one side.\u00a0The notch is not intended for splitting the tablet.<\/p>\n\n\n\n
Losartan Krka 100 mg: oval, convex, white film-coated tablets.<\/p>\n\n\n\n
Blister (PVC \/ PVDC blister with transparent foil with aluminum foil as cover, cardboard)<\/strong><\/p>\n\n\n\nLosartan Krka 12.5 mg: 7, 10,14, 15, 20, 21, 28, 30, 50, 56, 60, 84, 90, 98, 100, 112 film-coated tablets.<\/p>\n\n\n\n
Losartan Krka 50 mg: 10, 14, 15,20, 28, 30, 50, 56, 60, 84, 90, 98, 100, 112 film-coated tablets.<\/p>\n\n\n\n
Losartan Krka 100 mg: 7, 10, 14, 15, 20, 28, 30, 50, 56, 60, 84, 90, 98,100, 112 film-coated tablets.<\/p>\n\n\n\n
Polyethylene (HDPE, white) tablet jar with polypropylene closure. Polyethylene drying capsule filled with silica gel<\/strong><\/p>\n\n\n\nLosartan Krka 50 mg: 250 film-coated tablets, in a carton.<\/p>\n\n\n\n
Polyethylene (HDPE, white) tablet jar with safety-sealed polypropylene closure<\/strong><\/p>\n\n\n\nLosartan Krka 12.5 mg: 250 film-coated tablets, in a carton.<\/p>\n\n\n\n
Losartan Krka 100 mg: 100 film-coated tablets, in a carton.<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Manufacturer<\/strong><\/p>\n\n\n\nKRKA dd Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n
TAD Pharma GmbH, Heinz-Lohmann-Stra\u00dfe 5, 27472 Cuxhaven, Germany<\/p>\n","protected":false},"excerpt":{"rendered":"
Losartan belongs to a group of medicines called angiotensin II receptor antagonists. Angiotensin II is a body-specific substance that binds to receptors in blood vessels and causes them to constrict. This causes the blood pressure to rise. Losartan prevents the binding of angiotensin II to these receptors , which causes the blood vessels to dilate and the blood pressure to drop. Losartan prevents further renal impairment in patients with high blood pressure and type 2 diabetes .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[16581,16587,16443,16582,16586,16585,16580,16579,16444,16583,16445,16584],"class_list":["post-17159","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-losartan","tag-benefits-of-losartan-krka","tag-losartan","tag-losartan-krka","tag-losartan-krka-side-effects","tag-losartan-krka-tablet","tag-losartan-side-effect","tag-losartantablet","tag-what-is-losartan","tag-what-is-losartan-krka","tag-what-losartan-is-used-for","tag-what-losartan-krka-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17159"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17159\/revisions"}],"predecessor-version":[{"id":17221,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17159\/revisions\/17221"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}