What Lopinavir \/ Ritonavir Accord is and what it is used for<\/h2>\n\n\n\n
Your doctor has prescribed Lopinavir \/ Ritonavir Accord to help keep your human immunodeficiency virus ( HIV ) infection under control. Lopinavir \/ Ritonavir Accord does this by slowing down the spread of infection in your body.<\/li>
Lopinavir \/ Ritonavir Accord not a cure for HIV – infection or AIDS .<\/li>
Lopinavir \/ Ritonavir Accord is used by children 2 years of age and older, adolescents and adults infected with HIV , the virus that causes AIDS .<\/li>
Lopinavir \/ Ritonavir Accord contains the active substances lopinavir and ritonavir. Lopinavir \/ Ritonavir Accord is an antiretroviral medicine. It belongs to a group of medicines called protease inhibitors .<\/li>
Lopinavir \/ Ritonavir Accord is prescribed for use in combination with other antiviral medicines. Your doctor will discuss with you and decide which drugs are best for you.<\/li><\/ul>\n\n\n\n
Lopinavir and ritonavir contained in Lopinavir \/ Ritonavir Accord may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n
What you need to know before you or your child take Lopinavir \/ Ritonavir Accord<\/h2>\n\n\n\n
Do not take Lopinavir \/ Ritonavir Accord<\/h2>\n\n\n\n
if you are allergic to lopinavir, ritonavir or any of the other ingredients of this medicine (listed in section 6).<\/li>
if you have severe liver problems.<\/li><\/ul>\n\n\n\n
Do not take Lopinavir \/ Ritonavir Accord with any of the following medicines:<\/strong><\/p>\n\n\n\n
astemizole or terfenadine (often used to treat allergic symptoms – these medicines may be over-the-counter);<\/li>
oral midazolam, triazolam (used to relieve anxiety and \/ or sleep problems);<\/li>
pimozide (used to treat schizophrenia);<\/li>
quetiapine (used to treat schizophrenia, bipolar disorder and major depression);<\/li>
lurasidone (used to treat depression);<\/li>
ranolazine (used to treat chronic chest pain [angina]);<\/li>
cisapride (used to relieve certain stomach problems);<\/li>
ergotamine , dihydroergotamine, ergonovine, methylergonovine (used to treat headaches);<\/li>
amiodarone , dronedarone (used to treat abnormal heartbeats);<\/li>
lovastatin, simvastatin (used to lower blood cholesterol);<\/li>
lomitapide (used to lower blood cholesterol);<\/li>
alfuzosin (used in men to treat symptoms of prostate enlargement ( benign prostatic hyperplasia [BPH]);<\/li>
fusidic acid (used to treat skin infections caused by Staphylococcus bacteria such as impetigo and infected dermatitis ). Fusidic acid used to treat long-term bone and joint infections can be taken under medical supervision (see section Other medicines and Lopinavir \/ Ritonavir Accord);<\/li>
colchicine (used to treat gout ) if you have kidney and \/ or liver problems (see section Other medicines and Lopinavir \/ Ritonavir Accord<\/strong> );<\/li>
elbasvir \/ grazoprevir (used to treat hepatitis C virus [HCV]);<\/li>
ombitasvir \/ paritaprevir \/ ritonavir with or without dasabuvir (used to treat hepatitis C virus [HCV]);<\/li>
neratinib (used to treat breast cancer);<\/li>
avanafil and vardenafil (used to treat erectile dysfunction );<\/li>
sildenafil (used to treat pulmonary arterial hypertension (high blood pressure in the pulmonary artery)).For the treatment of erectile dysfunction , sildenafil can be taken in consultation with a doctor (see section Other medicines and Lopinavir \/ Ritonavir Accord<\/strong> );<\/li>
products containing St. John’s wort ( Hypericum perforatum<\/em> ).<\/li><\/ul>\n\n\n\n
Read the list of medicines below under the section \u201cOther medicines and Lopinavir \/ Ritonavir Accord\u201d<\/strong> for information on other medicines that require special attention.<\/p>\n\n\n\n
If you are currently taking any of these medicines, ask your doctor to make the necessary changes either in the treatment of your other ailments or in your antiretroviral treatment.<\/p>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Talk to your doctor or pharmacist before taking Lopinavir \/ Ritonavir Accord.<\/p>\n\n\n\n
Important information<\/strong><\/p>\n\n\n\n
People taking Lopinavir \/ Ritonavir Accord may still develop infections or other diseases associated with HIV or AIDS . It is therefore important that you remain under the supervision of your doctor while taking Lopinavir \/ Ritonavir Accord.<\/li>
You can still transmit HIV infection while taking this medicine<\/strong> , even though the risk of effective antiviral therapy is reduced . Discuss with your doctor the necessary steps to avoid infecting others.<\/li><\/ul>\n\n\n\n
Tell your doctor if you or your child have\/have had<\/strong><\/p>\n\n\n\n
Hemophilia<\/strong> type A or B as Lopinavir \/ Ritonavir Accord may increase the risk of bleeding.<\/li>
Diabetes<\/strong> because high blood sugar has been reported in patients receiving lopinavir \/ ritonavir.<\/li>
Previous liver problems<\/strong> when patients with previous liver diseases, including chronic hepatitis B or C, have an increased risk of severe and potentially life-threatening liver side effects.<\/li><\/ul>\n\n\n\n
Tell your doctor if you or your child are experiencing<\/strong><\/p>\n\n\n\n
Nausea, vomiting, abdominal pain, breathing problems and pronounced weakness in the muscles of the legs and arms as these symptoms may indicate elevated lactic acid levels.<\/li>
Thirst, frequent urination, blurred vision or weight loss as this may indicate an elevated blood sugar level.<\/li>
Nausea, vomiting, abdominal pain because a sharp increase in triglycerides (fats in the blood) has been judged to be a risk factor for pancreatitis ( inflammation of the pancreas) and these symptoms may indicate this condition.<\/li>
In some patients with advanced HIV – infection and the background of opportunistic infection s, signs and symptoms of previous infection you occur soon after a treatment for HIV begins. It is believed that these symptoms are due to an improvement in the body’s immune response , which allows the body to fight infections that may have existed without noticeable symptoms. In addition to the opportunistic infections are also autoimmune disorders (a condition that occurs when the immune system attacks healthy body tissue) may occur after you start taking medicines to treat your HIV – infection. Autoimmune diseases can occur several months after starting treatment. If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness that starts in the hands and feet and goes up in the body, palpitations, tremors or hyperactivity, inform your doctor immediately for the necessary treatment.<\/li>
Joint stiffness, aches and pains<\/strong> (especially hip, knee and shoulder) and difficulty moving as some of the patients taking these drugs may develop a bone disease called osteonecrosis (bone tissue dies due to lost blood supply to the bone). The duration of the combination antiretroviral therapy, the use of corticosteroids , alcohol consumption, severe weakening of the immune system (decrease in the activity of the immune system), higher body mass index, among others, can be some of the many risk factors for developing this disease.<\/li>
Muscle pain<\/strong> , tenderness or weakness, especially in combination with these drugs. On rare occasions, these muscle problems have been serious.<\/li>
Symptoms of dizziness, fainting or feeling of abnormal heartbeat. Lopinavir \/ Ritonavir Accord may cause changes in your heart rhythm and the electrical activity of your heart. These changes can be seen on the ECG ( electrocardiogram ).<\/li><\/ul>\n\n\n\n
Other medicines and Lopinavir \/ Ritonavir Accord<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you or your child are taking, have recently taken, or might take any other medicines.<\/strong><\/p>\n\n\n\n
cancer drugs (eg abemaciclib, afatinib, apalutamide, ceritinib, encorafenib, ibrutinib, venetoclax, most tyrosine kinase inhibitors such as dasatinib and nilotinib, including vincristine and vinblastine);<\/li>
medicines for gout (eg colchicine). You must not take Lopinavir \/ Ritonavir Accord with colchicine if you have kidney and \/ or liver problems (see also Do not take Lopinavir \/ Ritonavir Accord<\/strong> above);<\/li>
drugs against tuberculosis (bedakilin, delamanide);<\/li>
antiviral drugs used to treat chronic hepatitis C virus ( HCV ) infection in adults (eg glekaprevir \/ pibrentasvir, simeprevir and sofosbuvir \/ velpatasvir \/ voxilaprevir);<\/li>
drugs for impaired erection (eg sildenafil and tadalafil);<\/li>
fusidic acid used to treat long-term infections in bone and joints (eg osteomyelitis);<\/li>
drugs for the treatment of platelet deficiency (eg fostamatinib);<\/li>
drugs used to lower blood cholesterol (eg atorvastatin, lovastatin, rosuvastatin or simvastatin );<\/li>
drugs used to treat asthma and other lung problems such as chronic obstructive pulmonary disease (COPD) (eg salmeterol );<\/li>
drugs used to treat high blood pressure in the pulmonary artery ( pulmonary arterial hypertension ) (eg bosentan , riociguat, sildenafil, tadalafil);<\/li>
drugs that affect the immune system (eg cyclosporine, sirolimus (rapamycin), tacrolimus);<\/li>