{"id":16967,"date":"2021-12-28T07:07:14","date_gmt":"2021-12-28T07:07:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16967"},"modified":"2021-12-29T12:08:04","modified_gmt":"2021-12-29T12:08:04","slug":"lonsurf","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lonsurf\/","title":{"rendered":"Lonsurf &#8211; Trifluridine \/ Tipiracil uses, dose and side effects"},"content":{"rendered":"\n<p>15 mg \/ 6.14 mg and 20 mg \/ 8.19 mg&nbsp;film-coated tablets<br>trifluridine \/ tipiracil<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lonsurf is and what it is used for<\/h2>\n\n\n\n<p>Lonsurf is a type of\u00a0chemotherapy\u00a0used to treat cancer.\u00a0It belongs to a group of medicines called cytostatic\u00a0antimetabolites.<\/p>\n\n\n\n<p>Lonsurf contains two different active substances: trifluridine and tipiracil.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Trifluridine stops the growth of cancer cells.<\/li><li>Tipiracil prevents the breakdown of trifluridine in the body and helps trifluridine to work for a long time.<\/li><\/ul>\n\n\n\n<p>Lonsurf is used to treat adults with cancer of the colon or rectum, so-called colorectal cancer, and stomach cancer (including cancer of the connection between the esophagus and stomach).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>It is used when the cancer has spread to other parts of the body (&nbsp;metastasize&nbsp;).<\/li><li>It is used when other treatment has not had an effect or when other treatment is not suitable for you.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Lonsurf<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Lonsurf<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to trifluridine or tipiracil or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>Do not take Lonsurf if the above applies to you.&nbsp;If you are not sure, talk to your doctor before taking Lonsurf.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Lonsurf<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have kidney problems<\/li><li>if you have liver problems<\/li><\/ul>\n\n\n\n<p>If you are not sure, talk to your doctor or pharmacist before taking Lonsurf.<\/p>\n\n\n\n<p>Treatment may cause the following&nbsp;side effects&nbsp;(see section 4):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>reduced number of a certain type of&nbsp;white blood cell&nbsp;(&nbsp;neutropenia&nbsp;) that is important to protect the body against&nbsp;bacterial&nbsp;or fungal infections.&nbsp;As a result of&nbsp;neutropenia&nbsp;, fever (febrile&nbsp;neutropenia&nbsp;) and&nbsp;infection&nbsp;in the blood (&nbsp;septic&nbsp;shock&nbsp;)&nbsp;may occur&nbsp;.<\/li><li>decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>decreased number of&nbsp;platelets&nbsp;(&nbsp;thrombocytopenia&nbsp;) which are important for stopping bleeding and which cause the blood to clot in case of damage to the blood vessels<\/li><li>problems in the gastrointestinal tract.<\/li><\/ul>\n\n\n\n<p><strong>Samples and examinations<\/strong><\/p>\n\n\n\n<p>Your doctor will take blood samples before each Lonsurf treatment cycle.\u00a0You start a new treatment cycle every four weeks.\u00a0The tests are necessary because Lonsurf can sometimes affect the\u00a0blood cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine is not intended for the treatment of children and adolescents under 18 years of age, as it may not work or be safe for these patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Lonsurf<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This also applies to over-the-counter medicines and herbal medicines.\u00a0This is because Lonsurf may affect the effectiveness of certain other medicines.\u00a0Some other medicines may also affect the effect of Lonsurf.<\/p>\n\n\n\n<p>In particular, tell your doctor or pharmacist if you are taking medicines to treat\u00a0HIV, such as zidovudine.\u00a0This is because zidovudine may have a worse effect when used concomitantly with Lonsurf.\u00a0Talk to your doctor to find out if you need to switch to another\u00a0HIV\u00a0medicine.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Lonsurf if the above applies to you (or if you are unsure).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.\u00a0Lonsurf can harm the fetus.<\/p>\n\n\n\n<p>If you become pregnant, you and your doctor must determine if the benefits of Lonsurf outweigh the risk of harm to your baby.<\/p>\n\n\n\n<p>You should not breastfeed during treatment with Lonsurf as it is unknown if Lonsurf passes into breast milk.<\/p>\n\n\n\n<p><strong>Preventive method<\/strong><\/p>\n\n\n\n<p>You must not become pregnant during treatment with this medicine, as it may cause birth defects.<\/p>\n\n\n\n<p>You and your partner should use effective contraception during treatment with this medicine.&nbsp;You should also continue to do so for 6 months after stopping treatment.&nbsp;If you or your partner become pregnant during this period, consult a doctor or pharmacist immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>It is unknown whether Lonsurf affects the ability to drive or use machines.&nbsp;Do not drive or use tools or machines if you experience symptoms that may affect your ability to concentrate and react.<\/p>\n\n\n\n<p><strong>Lonsurf contains&nbsp;lactose<\/strong><\/p>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Lonsurf<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will determine the appropriate&nbsp;dose&nbsp;for you based on your weight and height and any kidney problems.<\/li><li>Lonsurf is available in two strengths.&nbsp;Your doctor may prescribe both strengths to help you achieve your prescribed&nbsp;dose&nbsp;.<\/li><li>Your doctor will tell you how many tablets to take at a time.<\/li><li>You should take a&nbsp;dose&nbsp;twice a day.<\/li><\/ul>\n\n\n\n<p><strong>When using Lonsurf<\/strong><\/p>\n\n\n\n<p>You should take Lonsurf for 10 days during the first 2 weeks and then take a break of 2 weeks.\u00a0These 4 weeks are called a treatment cycle.\u00a0The specific dosing schedule is as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Week 1<\/strong><\/li><li>take&nbsp;dose&nbsp;2 times daily for 5 days<\/li><li>then make a break of 2 days &#8211; no medicine<\/li><li><strong>Week 2<\/strong><\/li><li>take&nbsp;dose&nbsp;2 times daily for 5 days<\/li><li>then make a break of 2 days &#8211; no medicine<\/li><li><strong>Week 3<\/strong><\/li><li>no medicine<\/li><li><strong>Week 4<\/strong><\/li><li>no medicine<\/li><\/ul>\n\n\n\n<p>Then you start a new treatment cycle of 4 weeks according to the schedule above<\/p>\n\n\n\n<p><strong>How to take the medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take the medicine by mouth.<\/li><li>Swallow the tablets whole with a glass of water.<\/li><li>Take the tablets within 1 hour after breakfast and supper.<\/li><li>Wash hands after handling the medicine<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Lonsurf than you should &nbsp;<\/h2>\n\n\n\n<p>If you take more Lonsurf than you should, contact a doctor immediately or go to a hospital.&nbsp;Take the medicine pack with you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Lonsurf<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you miss a&nbsp;dose&nbsp;, contact your doctor or pharmacist.<\/li><li>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0may occur when using this medicine:<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Immediately tell the doctor<\/strong>\u00a0if you notice any of the following serious\u00a0adverse reactions\u00a0are (many of the\u00a0side effects\u00a0were seen in laboratory tests, such as the\u00a0side effect\u00a0is affecting\u00a0blood cells):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decrease in&nbsp;white blood cells&nbsp;(&nbsp;<em>very common<\/em>&nbsp;), febrile&nbsp;neutropenia&nbsp;(&nbsp;<em>common<\/em>&nbsp;) and&nbsp;septic&nbsp;shock&nbsp;(&nbsp;<em>uncommon<\/em>&nbsp;).&nbsp;Symptoms include chills, fever, sweating or other signs of&nbsp;bacterial&nbsp;or fungal infection (see section 2).<\/li><li>anemia&nbsp;(&nbsp;<em>very common<\/em>&nbsp;).&nbsp;Symptoms include a feeling of shortness of breath, fatigue or paleness (see section 2).<\/li><li>vomiting (&nbsp;<em>very common<\/em>&nbsp;) and diarrhea (&nbsp;<em>very common<\/em>&nbsp;), which in severe or prolonged cases can lead to dehydration.<\/li><li>severe stomach and intestinal problems: abdominal pain (&nbsp;<em>common<\/em>&nbsp;), abdominal fluid (&nbsp;<em>uncommon<\/em>&nbsp;), colitis (&nbsp;<em>uncommon<\/em>&nbsp;),&nbsp;acute&nbsp;pancreatitis (&nbsp;<em>uncommon<\/em>&nbsp;), intestinal obstruction (&nbsp;<em>uncommon<\/em>&nbsp;) and incomplete intestinal obstruction (&nbsp;<em>uncommon<\/em>&nbsp;).&nbsp;Symptoms include severe abdominal or abdominal pain which may be associated with vomiting, blocked or partially blocked bowel, fever or abdominal swelling.<\/li><li>reduction in&nbsp;platelet count&nbsp;(&nbsp;<em>very common<\/em>&nbsp;).&nbsp;Symptoms include unusual bruising or bleeding (see section 2).<\/li><li>pulmonary embolism&nbsp;(&nbsp;<em>uncommon<\/em>&nbsp;): blood clot in the lungs.&nbsp;Symptoms include shortness of breath and pain in the chest or legs.<\/li><li>interstitial lung disease has been reported in patients receiving this drug.&nbsp;Symptoms include difficulty breathing, shortness of breath with cough or fever.<\/li><\/ul>\n\n\n\n<p>Some of these serious&nbsp;side effects&nbsp;can lead to death.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you notice any of the following\u00a0side effects.\u00a0Many of the\u00a0side effects\u00a0are seen in laboratory tests, e.g.\u00a0the\u00a0side effects\u00a0that affect the\u00a0blood cells.\u00a0Your doctor will check your test results to see if you have any of these\u00a0side effects.<\/p>\n\n\n\n<p><strong>Very common: may affect more than 1 user in 10:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased appetite<\/li><li>severe fatigue (fatigue)<\/li><li>nausea<\/li><li>decreased number of&nbsp;white blood cells&nbsp;called&nbsp;leukocytes&nbsp;, which can increase the risk of&nbsp;infection<\/li><\/ul>\n\n\n\n<p><strong>Common: may affect up to 1 in 10 users:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever<\/li><li>hair loss<\/li><li>weight loss<\/li><li>taste changes<\/li><li>constipation<\/li><li>general malaise<\/li><li>low level of albumin in the blood<\/li><li>increased levels of&nbsp;bilirubin&nbsp;in the blood, which can cause yellowing of the skin or eyes<\/li><li>decreased number of&nbsp;white blood cells&nbsp;called&nbsp;lymphocytes&nbsp;, which may increase the risk of&nbsp;infection<\/li><li>swelling of the hands, legs or feet<\/li><li>redness&nbsp;, swelling, pain in palms and soles of the feet (hand-foot syndrome)<\/li><li>feeling of numbness or tingling and tingling in the hands or feet<\/li><li>pain or discomfort in the mouth<\/li><li>swelling of the mucous membranes inside the nose, mouth, throat, eyes, vagina, lungs or intestines<\/li><li>increased content of liver enzymes<\/li><li>protein&nbsp;is in the urine<\/li><li>rash, itchy or dry skin<\/li><li>feeling of shortness of breath, infections of the respiratory tract, lungs or breasts<\/li><\/ul>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 people:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low or high&nbsp;blood pressure<\/li><li>blood clot e.g.&nbsp;in the brain or bones<\/li><li>blood test results that indicate problems with blood clotting so that you bleed more easily<\/li><li>more noticeable heartbeat, chest pain<\/li><li>abnormal increase or decrease in heart rate<\/li><li>changes in the heart curve (&nbsp;electrocardiogram&nbsp;&#8211;&nbsp;ECG&nbsp;)<\/li><li>increased&nbsp;white blood cell count<\/li><li>increased number of&nbsp;white blood cells&nbsp;called&nbsp;monocytes&nbsp;you<\/li><li>increased level of&nbsp;lactate dehydrogenase&nbsp;in the blood<\/li><li>low levels of&nbsp;phosphate&nbsp;,&nbsp;sodium&nbsp;,&nbsp;potassium&nbsp;or&nbsp;calcium&nbsp;in the blood<\/li><li>decreased number of&nbsp;white blood cells&nbsp;called&nbsp;granulocytes&nbsp;or&nbsp;monocytes&nbsp;, which may increase the risk of&nbsp;infection<\/li><li>high blood sugar (&nbsp;hyperglycaemia&nbsp;), increased levels of salt,&nbsp;urea&nbsp;,&nbsp;creatinine&nbsp;and&nbsp;potassium&nbsp;in the blood<\/li><li>blood test results indicating&nbsp;inflammation&nbsp;(increase in C-reactive&nbsp;protein&nbsp;)<\/li><li>ear pain<\/li><li>rotating sensation (&nbsp;vertigo&nbsp;)<\/li><li>dizziness, headache<\/li><li>runny nose or nosebleeds, sinus problems<\/li><li>sore throat, hoarse voice, voice problems<\/li><li>red and itchy eyes,&nbsp;eye infection&nbsp;, watery eyes<\/li><li>dry eyes<\/li><li>visual disturbances such as blurred vision, double vision, visual impairment, cataracts<\/li><li>dehydration<\/li><li>bloating, gas problems, indigestion<\/li><li>pain or&nbsp;inflammation&nbsp;in the upper or lower part of the gastrointestinal tract<\/li><li>inflammation&nbsp;, swelling or bleeding in the intestine<\/li><li>inflammation&nbsp;and&nbsp;infection&nbsp;of the intestine<\/li><li>inflammation&nbsp;or increased amount of acid in the stomach or esophagus, regurgitation<\/li><li>pain in the tongue,&nbsp;polyps&nbsp;in the mouth, cold sores, nausea<\/li><li>bad breath,&nbsp;caries&nbsp;, problems with teeth or gums, bleeding gums, gingivitis<\/li><li>reddening of the skin<\/li><li>swelling or pain in joints or big toes<\/li><li>pain or discomfort in arms or legs<\/li><li>pain, including cancer pain<\/li><li>skeletal pain, muscle aches, muscle weakness or &#8211;&nbsp;spasms&nbsp;, pain in tendons, nerves or ligaments<\/li><li>feeling cold<\/li><li>shingles&nbsp;(pain and rash with blisters over nerve pathways due to nerve inflammation caused by&nbsp;herpes&nbsp;zoster&nbsp;virus&nbsp;)<\/li><li>liver disease<\/li><li>inflammation&nbsp;or&nbsp;infection&nbsp;of the bile ducts, increase of the diameter of the bile ducts<\/li><li>kidney failure<\/li><li>virus infection<\/li><li>cough,&nbsp;sinus infection&nbsp;, throat infection&nbsp;<\/li><li>inflammation&nbsp;or&nbsp;infection&nbsp;of the bladder<\/li><li>changes in urine test results, blood in the urine<\/li><li>urination difficulties (&nbsp;urinary retention&nbsp;), loss of bladder control (&nbsp;incontinence&nbsp;)<\/li><li>athlete&#8217;s foot&nbsp;, yeast infections<\/li><li>accumulation of fluid in the lungs<\/li><li>changes in the menstrual cycle<\/li><li>anxiety<\/li><li>fainting (&nbsp;syncope&nbsp;)<\/li><li>burning sensation, unpleasant increase or loss of sensation and other non-serious neurological disorders<\/li><li>protruding itchy rash, reddening of the skin, blisters, skin flaking,&nbsp;hives&nbsp;,&nbsp;acne<\/li><li>excessive sweating, photosensitivity, nail diseases<\/li><li>difficulty sleeping or falling asleep<\/li><li>low level of total protein in the blood<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lonsurf<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the outer carton or blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>Lonsurf 15 mg \/ 6.14 mg film-coated tablets<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are trifluridine and tipiracil.&nbsp;One film-coated tablet contains 15 mg trifluridine and 6.14 mg tipiracil.<\/li><li>Other ingredients are:<ul><li>Tablet core:&nbsp;lactose monohydrate&nbsp;, pregelatinised&nbsp;starch&nbsp;(maize) and stearic acid (see section 2 \u201cLonsurf contains lactose\u201d).<\/li><li>Film coating: hypromellose, macrogol (8000), titanium dioxide (E171) and magnesium stearate.<\/li><li>Ink: shellac, red iron oxide (E172), yellow iron oxide (E172), titanium dioxide (E171), indigo carmine aluminum lacquer (E132), carnauba wax and talc.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Lonsurf 20 mg \/ 8.19 mg film-coated tablets<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are trifluridine and tipiracil.&nbsp;One film-coated tablet contains 20 mg trifluridine and 8.19 mg tipiracil.<\/li><li>Other ingredients are:<ul><li>Tablet core:&nbsp;lactose monohydrate&nbsp;, pregelatinised&nbsp;starch&nbsp;(maize) and stearic acid (see section 2 \u201cLonsurf contains lactose\u201d).<\/li><li>Film coating: hypromellose, macrogol (8000), titanium dioxide (E171), red iron oxide (E172) and magnesium stearate.<\/li><li>Ink: shellac, red iron oxide (E172), yellow iron oxide (E172), titanium dioxide (E171), indigo carmine aluminum lacquer (E132), carnauba wax and talc.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Lonsurf 15 mg \/ 6.14 mg is a white, biconvex, round, film-coated tablet, marked with \u201c15\u201d on one side and \u201c102\u201d and \u201c15 mg\u201d on the other with gray ink.<\/li><li>Lonsurf 20 mg \/ 8.19 mg is a pale red, biconvex, round, film-coated tablet, marked with \u201c20\u201d on one side and \u201c102\u201d and \u201c20 mg\u201d on the other with gray ink.<\/li><\/ul>\n\n\n\n<p>Each pack contains 20 film-coated tablets (2 blisters of 10 tablets) or 40 film-coated tablets (4 blisters of 10 tablets) or 60 film-coated tablets (6 blisters of 10 tablets).\u00a0Each blister foil contains a desiccant.\u00a0<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Servier Laborierires Servier<\/p>\n\n\n\n<p>50 rue Carnot<\/p>\n\n\n\n<p>92284 Suresnes Cedex<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>The Laboratories Servier Industrie<\/p>\n\n\n\n<p>905, route de Saran<\/p>\n\n\n\n<p>45520 Gidy<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th scope=\"col\"><strong>Belgium \/ Belgique \/ Belgien<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/th><th scope=\"col\"><strong>Lithuania<\/strong>UAB \u201cSERVIER PHARMA\u201dTel: +370 (5) 2 63 86 28<\/th><\/tr><tr><td><strong>Bulgaria<\/strong>Medical LODG serviceTel: +359 2 921 57 00<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/td><\/tr><tr><td><strong>\u010c&nbsp;<\/strong><strong>ESC&nbsp;<\/strong><strong>\u00e1&nbsp;<\/strong><strong>republika<\/strong>Servier sroTel: +420 222 118 111<\/td><td><strong>Magyarorsz&nbsp;<\/strong><strong>\u00e1&nbsp;<\/strong><strong>g<\/strong>Servier Hungaria Kft.Tel: +36 1 238 7799<\/td><\/tr><tr><td><strong>Denmark<\/strong>Servier Danmark A \/ STel: +45 36 44 22 60<\/td><td><strong>Malta<\/strong>VJ Salomone Pharma LtdTel: + 356 21 22 01 74<\/td><\/tr><tr><td><strong>Germany<\/strong>Servier Deutschland GmbHTel: +49 (0) 89 57095 01<\/td><td><strong>The Netherlands<\/strong>Servier Nederland Farma BVTel: +31 (0) 71 5246700<\/td><\/tr><tr><td><strong>Eesti<\/strong>Servier Laboratories O\u00dcTel: + 372 664 5040<\/td><td><strong>Norway<\/strong>Servier Danmark A \/ STel: +45 36 44 22 60<\/td><\/tr><tr><td><strong>E&nbsp;<\/strong><strong>\u03bb\u03bb\u03ac\u03b4\u03b1<\/strong>\u0395\u03a0\u0395 \u0395\u039b\u039b\u0391\u03a3 \u03a6\u0391\u03a1\u039c\u0391\u039a\u0395\u03a5\u03a4\u0399\u039a\u0397 \u0395\u03a0\u0395:\u0397\u03bb: +30 210 939 1000<\/td><td><strong>Austria<\/strong>Servier Austria GmbHTel: +43 (1) 524 39 99<\/td><\/tr><tr><td><strong>Spain<\/strong>Servierios Servier SLTel: +34 91 748 96 30<\/td><td><strong>Poland<\/strong>Servier Polska Sp.&nbsp;z ooTel: +48 (0) 22 594 90 00<\/td><\/tr><tr><td><strong>France<\/strong>Servier Laborierires ServierTel: +33 (0) 1 55 72 60 00<\/td><td><strong>Portugal<\/strong>Servier Portugal, LdaTel .: +351 21 312 20 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Servier Pharma, dooTel .: +385 (0) 1 3016 222<\/td><td><strong>Romania<\/strong>Servier Pharma SRLTel: +4 021 528 52 80<\/td><\/tr><tr><td><strong>Ireland<\/strong>Servier Laboratories (Ireland) Ltd.Tel: +353 (0) 1 663 8110<\/td><td><strong>Slovenia<\/strong>Servier Pharma dooTel .: +386 (0) 1 563 48 11<\/td><\/tr><tr><td><strong>Iceland<\/strong>Servier Laboratoriesc \/ o Icepharma hfPhone: +354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Servier Slovensko spol.&nbsp;s roTel: +421 (0) 2 5920 41 11<\/td><\/tr><tr><td><strong>Italy<\/strong>Servier Italia SpATel: +39 06 669081<\/td><td><strong>Finland \/ Finland<\/strong>Servier Finland OyP. \/ Tel: +358 (0) 9 279 80 80<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>CA Papaellinas Ltd.:\u0397\u03bb: +357 22741741<\/td><td><strong>Sweden<\/strong>Servier Sverige ABTel: +46 (0) 8 522 508 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Servier LatviaTel: +371 67502039<\/td><td><strong>United Kingdom<\/strong>Servier Laboratories LtdTel: +44 (0) 1753 666409<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Lonsurf is a type of chemotherapy used to treat cancer. It belongs to a group of medicines called cytostatic antimetabolites .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[16277,16280,16269,16272,16273,16276,16278,16270,16274,16279,16271,16275],"class_list":["post-16967","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-lonsurf","tag-lonsurf-tablet","tag-tipiracil","tag-tipiracil-tablet","tag-trifluridine","tag-trifluridine-tablet","tag-what-is-lonsurf","tag-what-is-tipiracil","tag-what-is-trifluridine","tag-what-lonsurf-is-used-for","tag-what-tipiracil-is-used-for","tag-what-trifluridine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16967","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16967"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16967\/revisions"}],"predecessor-version":[{"id":17011,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16967\/revisions\/17011"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16967"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16967"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16967"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}