{"id":16955,"date":"2021-12-28T06:57:07","date_gmt":"2021-12-28T06:57:07","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16955"},"modified":"2021-12-29T12:08:47","modified_gmt":"2021-12-29T12:08:47","slug":"lokelma","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lokelma\/","title":{"rendered":"Lokelma &#8211; Sodium zirconium cyclosilicate uses, dose and side effects"},"content":{"rendered":"\n<p>5 g, 10 g&nbsp;powder for&nbsp;oral&nbsp;suspension<br>sodium&nbsp;zirconium cyclosilicate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lokelma is and what it is used for<\/h2>\n\n\n\n<p>Lokelma contains the active substance&nbsp;sodium&nbsp;\u2011zirconium \u2011 cyclosilicate.<\/p>\n\n\n\n<p>Lokelma is used to treat&nbsp;hyperkalemia&nbsp;in adults.&nbsp;Hyperkalaemia&nbsp;means that there is a high content of&nbsp;potassium&nbsp;in the blood.<\/p>\n\n\n\n<p>Lokelma lowers high levels of&nbsp;potassium&nbsp;in the body and helps keep it at a normal level.&nbsp;When Lokelma passes through the stomach and intestines,&nbsp;potassium&nbsp;binds&nbsp;to the medicine and leaves the body via the stool, and this lowers the amount of&nbsp;potassium&nbsp;in the body.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Lokelma<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Lokelma<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to the active substance.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Monitoring<\/strong><\/p>\n\n\n\n<p>Your doctor or nurse will check the level of&nbsp;potassium&nbsp;in your blood when you start taking this medicine:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This is done to ensure that you receive the correct&nbsp;dose&nbsp;.&nbsp;Dose&nbsp;one can be increased or decreased depending on the potassium content in the blood.<\/li><li>The treatment can be stopped if the level of&nbsp;potassium&nbsp;in the blood becomes too low.<\/li><\/ul>\n\n\n\n<p>While taking Lokelma, tell your doctor or nurse<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you should undergo an X-ray examination, as Lokelma can influence the interpretation of the results.<\/li><li>you get sudden or severe pain in the abdomen as this may be a sign of a problem observed with other drugs acting on the gastrointestinal tract.<\/li><\/ul>\n\n\n\n<p>Consult a doctor or pharmacist if you need Lokelma 5 grams or more daily for an extended period, especially if you have been prescribed a low-salt (sodium-poor) diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not give this medicine to children and adolescents under 18 years of age.&nbsp;The reason is that the effects of Lokelma in children and adolescents are not known.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Lokelma<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>In particular,&nbsp;tell us&nbsp;about medicines that may alter your blood potassium levels, as your&nbsp;dose of&nbsp;Lokelma may need to be changed.&nbsp;This applies to the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diuretics&nbsp;(drugs that increase urine production)<\/li><li>angiotensin converting&nbsp;enzyme&nbsp;(ACE)&nbsp;inhibitors&nbsp;such as&nbsp;enalapril&nbsp;, and angiotensin receptor blockers whose names end in sartan (medicines for high&nbsp;blood pressure&nbsp;and heart problems)<\/li><li>renin inhibitors such as aliskiren (for high&nbsp;blood pressure&nbsp;).<\/li><\/ul>\n\n\n\n<p>Also, tell your doctor or nurse if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ketoconazole&nbsp;, itraconazole and posaconazole (used to treat fungal infections)<\/li><li>atazanavir, nelfinavir, indinavir, ritonavir, saquinavir, raltegravir, ledipasvir and rilpivirine (used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;)<\/li><li>tyrosine kinase inhibitors such as erlotinib, dasatinib and nilotinib (used to treat cancer).<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor, pharmacist or nurse before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Do not use this medicine during pregnancy as there is no information on its use during pregnancy.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>No effects are expected on breastfed newborns\/infants as the uptake of Lokelma into the blood of the breastfeeding woman is negligible.<\/p>\n\n\n\n<p>Lokelma can be used during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine has no or negligible effect on the ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Lokelma<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to take<\/strong><\/p>\n\n\n\n<p><em>Starting dose &#8211; to lower high potassium levels to normal:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is 10 g &#8211; three times daily.<\/li><li>It takes one to two days before the drug takes effect.<\/li><li>Do not take this starting dose for more than three days.<\/li><\/ul>\n\n\n\n<p><em>Maintenance dose &#8211; to keep your potassium level within the normal range once it has been lowered:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is 5 g &#8211; once a day.<\/li><li>Your doctor may decide to&nbsp;increase or decrease&nbsp;your&nbsp;dose&nbsp;.<\/li><li>Do not take a maintenance dose higher than 10 g once daily.<\/li><\/ul>\n\n\n\n<p><em>If you are receiving treatment with hemodialysis:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Take Lokelma only on days when you do not receive&nbsp;hemodialysis&nbsp;.<\/li><li>The recommended starting dose is 5 g once daily.<\/li><li>Your doctor may decide that you need more (up to 15 g once daily).<\/li><li>Do not take more than 15 g once daily.<\/li><\/ul>\n\n\n\n<p><strong>Take Lokelma as follows:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Try to take Lokelma at the same time each day.<\/li><li>You can take this medicine with or without food.<\/li><\/ul>\n\n\n\n<p><strong>How to take the medicine:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Open the sachet and pour the powder into a drinking glass with about 45 ml of water, not carbonated.<\/li><li>Stir well and drink the tasteless liquid immediately.<\/li><li>The powder does not dissolve and the liquid looks cloudy.&nbsp;The white powder sinks rapidly into the glass.&nbsp;If this happens, stir the liquid again and drink everything.<\/li><li>Rinse the glass with more water and drink everything so that you get all the medicine in you.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Lokelma than you should<\/h2>\n\n\n\n<p>Talk to your doctor immediately if you have taken too much of this medicine.&nbsp;Do not take more until you have talked to a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Lokelma<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you forget to take a&nbsp;dose&nbsp;of this medicine, skip the missed&nbsp;dose&nbsp;.<\/li><li>Then take the next&nbsp;dose&nbsp;as usual at the usual time.<\/li><li>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Lokelma<\/h2>\n\n\n\n<p>You should not reduce the&nbsp;dose of&nbsp;one of these medicines or stop taking it without talking to the doctor who prescribed it, you may then have high potassium levels in your blood again.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Tell your doctor or nurse immediately if any of the following occur:<\/p>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you start to feel tired or have muscle weakness or cramps &#8211; it may be a sign that the level of&nbsp;potassium&nbsp;in the blood has become too low.&nbsp;Talk to your doctor immediately if these symptoms become severe.<\/li><li>you begin to accumulate fluid in the&nbsp;tissues&nbsp;, which leads to swelling somewhere in the body (usually in the feet and ankles).<\/li><\/ul>\n\n\n\n<p>No known frequency (can not be calculated from the available data).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you begin to experience abdominal pain or discomfort, nausea, vomiting, diarrhea or constipation.<\/li><li>you begin to get&nbsp;itchy&nbsp;skin or see&nbsp;redness&nbsp;or peeling of the skin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lokelma<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton or sachet after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>This medicine does not require any special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is&nbsp;sodium&nbsp;\u2011zirconium \u2011 cyclosilicate.<\/p>\n\n\n\n<p><strong>Lokelma 5 g powder for&nbsp;oral&nbsp;suspension<\/strong><\/p>\n\n\n\n<p>1&nbsp;sachet&nbsp;contains 5 g&nbsp;sodium&nbsp;\u2011zirconium \u2011 cyclosilicate.<\/p>\n\n\n\n<p><strong>Lokelma 10 g powder for&nbsp;oral&nbsp;suspension<\/strong><\/p>\n\n\n\n<p>1&nbsp;sachet&nbsp;contains 10 g&nbsp;sodium&nbsp;\u2011zirconium \u2011 cyclosilicate.<\/p>\n\n\n\n<p>There are no other ingredients in this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>The powder for\u00a0oral\u00a0suspension\u00a0is a white, free-flowing powder, substantially free of dust and particles.\u00a0It is delivered in a\u00a0sachet.<\/p>\n\n\n\n<p><strong>Lokelma 5 g powder for&nbsp;oral&nbsp;suspension<\/strong><\/p>\n\n\n\n<p>1&nbsp;sachet&nbsp;contains 5 g of powder.<\/p>\n\n\n\n<p><strong>Lokelma 10 g powder for&nbsp;oral&nbsp;suspension<\/strong><\/p>\n\n\n\n<p>1&nbsp;sachet&nbsp;contains 10 g of powder.<\/p>\n\n\n\n<p>The sachets are delivered in a carton containing 3, 28, or 30 sachets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>AstraZeneca AB<\/p>\n\n\n\n<p>SE-151 85 S\u00f6dert\u00e4lje<\/p>\n\n\n\n<p>Sweden<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>AstraZeneca AB<\/p>\n\n\n\n<p>G\u00e4rtunav\u00e4gen<\/p>\n\n\n\n<p>SE-151 85 S\u00f6dert\u00e4lje<\/p>\n\n\n\n<p>Sweden<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td><td><strong>Lithuania<\/strong>UAB AstraZeneca LietuvaTel: +370 5 2660550<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Australia Bulgaria \u0415\u041e\u041e\u0414Tel: +359 24455000<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>AstraZeneca Czech Republic sroTel: +420 222 807 111<\/td><td><strong>Hungary<\/strong>AstraZeneca Kft.Tel .: +36 1 883 6500<\/td><\/tr><tr><td><strong>Denmark<\/strong>AstraZeneca A \/ STel: +45 43 66 64 62<\/td><td><strong>Malta<\/strong>Associated Drug Co.&nbsp;Ltd.Tel: +356 2277 8000<\/td><\/tr><tr><td><strong>Germany<\/strong>AstraZeneca GmbHTel: +49 41 03 7080<\/td><td><strong>The Netherlands<\/strong>AstraZeneca BVTel: +31 79 363 2222<\/td><\/tr><tr><td><strong>Eesti<\/strong>AstraZenecaTel: +372 6549 600<\/td><td><strong>Norway<\/strong>AstraZeneca ASTel: +47 21 00 64 00<\/td><\/tr><tr><td><strong>Greece<\/strong>AstraZeneca AE:\u0397\u03bb: +30 210 6871500<\/td><td><strong>Austria<\/strong>AstraZeneca \u00d6sterreich GmbHTel: +43 1 711 31 0<\/td><\/tr><tr><td><strong>Spain<\/strong>AstraZeneca Pharmac\u00e9utica Spain, SATel: +34 91 301 91 00<\/td><td><strong>Poland<\/strong>AstraZeneca Pharma Poland Sp.&nbsp;z ooTel .: +48 22 245 73 00<\/td><\/tr><tr><td><strong>France<\/strong>AstraZenecaTel: +33 1 41 29 40 00<\/td><td><strong>Portugal<\/strong>AstraZeneca Pharmaceutical Products, Lda.Tel: +351 21 434 61 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>AstraZeneca dooTel: +385 1 4628 000<\/td><td><strong>Romania<\/strong>AstraZeneca Pharma SRLTel: +40 21 317 60 41<\/td><\/tr><tr><td><strong>Ireland<\/strong>AstraZeneca Pharmaceuticals (Ireland) LtdTel: +353 1609 7100<\/td><td><strong>Slovenia<\/strong>AstraZeneca UK LimitedTel: +386 1 51 35 600<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>AstraZeneca AB, ozTel: +421 2 5737 7777<\/td><\/tr><tr><td><strong>Italy<\/strong>AstraZeneca SpATel: +39 02 9801 1<\/td><td><strong>Finland \/ Finland<\/strong>AstraZeneca OyPuh \/ Tel: +358 10 23 010<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Alexander the Great:\u0397\u03bb: +357 22490305<\/td><td><strong>Sweden<\/strong>AstraZeneca ABTel: +46 8 553 26 000<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA AstraZeneca LatvijaTel: +371 67377100<\/td><td><strong>United Kingdom<\/strong>AstraZeneca UK LtdTel: +44 1582 836 836<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Lokelma contains the active substance sodium \u2011zirconium \u2011 cyclosilicate.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[16323,16318,16319,16322,16314,16317,16320,16315,16321,16316],"class_list":["post-16955","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-lokelma","tag-benefits-of-sodium-zirconium-cyclosilicate","tag-lokelma","tag-lokelma-side-effects","tag-sodium-zirconium-cyclosilicate","tag-sodium-zirconium-cyclosilicate-side-effects","tag-what-is-lokelma","tag-what-is-sodium-zirconium-cyclosilicate","tag-what-lokelma-is-used-for","tag-what-sodium-zirconium-cyclosilicate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16955","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16955"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16955\/revisions"}],"predecessor-version":[{"id":17016,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16955\/revisions\/17016"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16955"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16955"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}