{"id":16878,"date":"2021-12-24T09:30:29","date_gmt":"2021-12-24T09:30:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16878"},"modified":"2021-12-27T07:28:42","modified_gmt":"2021-12-27T07:28:42","slug":"livopan","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/livopan\/","title":{"rendered":"Livopan &#8211; Nitric oxide \/ Oxygen uses, dose and side effects"},"content":{"rendered":"\n<p>50% \/ 50%&nbsp;medical gas, compressed<br>Nitric oxide \/ Oxygen<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Livopan is and what it is used for<\/h2>\n\n\n\n<p>Livopan contains a complete&nbsp;mixture&nbsp;of nitrous oxide (medical &#8216;nitrous oxide&#8217;, N&nbsp;<sub>2<\/sub>&nbsp;O) and oxygen (medical oxygen, O&nbsp;<sub>2<\/sub>&nbsp;), 50% of each, and should be used by inhaling the gas mixture.<\/p>\n\n\n\n<p><strong>The effects of Livopan<\/strong><\/p>\n\n\n\n<p>Nitrous oxide constitutes 50% of the gas mixture.\u00a0Nitrous oxide has an analgesic effect, reduces the pain experience, and raises the pain threshold.\u00a0Nitrous oxide also provides a relaxing and slightly calming effect.\u00a0These effects are caused by nitrous oxide affecting neurotransmitters in your nervous system.<\/p>\n\n\n\n<p>The 50% concentration of oxygen, just over twice as much as in ordinary air, guarantees a safe oxygen content in the inhaled gas.<\/p>\n\n\n\n<p><strong>What Livopan is used for<\/strong><\/p>\n\n\n\n<p>Livopan should be used when rapid onset and rapid onset of analgesic effects are desired and when the\u00a0intensity\u00a0of the pain being treated is mild to moderate and short-lived.\u00a0Livopan provides an analgesic effect already after a few breaths and the analgesic effects subside within minutes after the end of use.\u00a0Livopan can be used by adults and children from 1 month of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Livopan<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Livopan:<\/h2>\n\n\n\n<p>Before using Livopan, tell your doctor if you have any of the following symptoms\/symptoms;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Gas-filled cavities or gas bubbles<\/strong>&nbsp;: If, due to illness or for any other reason, you may have air in the alveoli or gas bubbles in the blood or in another organ.&nbsp;For example.&nbsp;if you have dived with diving tubes and may have gas bubbles in the blood, if you have been treated with an&nbsp;injection&nbsp;of gas in the eye e.g.&nbsp;due to retinal detachment or the like.&nbsp;Such gas bubbles can grow and thereby cause damage.<\/li><li><strong>Heart disease<\/strong>&nbsp;: If you have&nbsp;heart failure&nbsp;or severe heart function, then the weak damping effect of nitrous oxide on the heart muscle can further dampen heart function.<\/li><li><strong>Damage to the&nbsp;central nervous system<\/strong>&nbsp;: If you have increased pressure in the brain as an effect of e.g.&nbsp;a brain tumor or cerebral haemorrhage, as nitrous oxide may cause further increased pressure in the brain with the risk of injury.<\/li><li><strong>Deficiency disease<\/strong>&nbsp;: If you have been&nbsp;<em>diagnosed&nbsp;<\/em><em>but&nbsp;<\/em>&nbsp;<em>untreated&nbsp;<\/em>vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;deficiency or <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triobe\/\">folic acid<\/a> deficiency, then the use of nitrous oxide may aggravate the symptoms caused by deficiency of&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;and folic acid.<\/li><li><strong>Intestinal upset:<\/strong>&nbsp;If you have severe stomach upset;&nbsp;symptoms that could be intestinal upset, as Livopan may further increase the tension of the intestines.<\/li><li><strong>In case of injury to the jaw and face<\/strong>&nbsp;, then the use of a face mask can involve difficulties or risks.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Also, tell your doctor if you have the following problems:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Decreased awareness or persistent symptoms of confusion<\/strong>&nbsp;: Tell your doctor if you feel unwell or if you do not feel fully awake due to illness or accident.&nbsp;This is important because Livopan contains a sedative component.&nbsp;There is a risk that the sedative effect may have a negative effect on your protective reflexes.<\/li><li><strong>Ear problems<\/strong>&nbsp;: As e.g.&nbsp;ear infection, as Livopan may increase the pressure in the middle ear<\/li><li><strong>Chronic&nbsp;obstructive pulmonary disease&nbsp;(COPD)<\/strong>&nbsp;, as the use of oxygen can cause impaired breathing.<\/li><li><strong>Has or has had drug or drug abuse,<\/strong>&nbsp;as there is then a higher risk of developing dependence on nitrous oxide during repeated use.&nbsp;Your doctor will decide if Livopan treatment is appropriate in your case.<\/li><li><strong>Deficiency disease<\/strong>&nbsp;If&nbsp;you&nbsp;<em>suspect<\/em>&nbsp;that you have&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;deficiency or folic acid deficiency, then the use of nitrous oxide can aggravate the symptoms caused by deficiency of&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;and folic acid.<\/li><\/ul>\n\n\n\n<p>Your doctor will assess whether it is appropriate to use Livopan.<\/p>\n\n\n\n<p>Repeated or prolonged use of nitrous oxide can increase the risk of&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;deficiency, which can lead to damage to the&nbsp;bone marrow&nbsp;or the nervous system.&nbsp;Your doctor may perform blood tests before and after treatment, to assess the consequences of any&nbsp;vitamin&nbsp;B&nbsp;<sub>12<\/sub>&nbsp;deficiency.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Livopan<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Methotrexate for the treatment of e.g.&nbsp;rheumatoid arthritis&nbsp;.&nbsp;Using Livopan with methotrexate may affect your blood count.<\/li><li>If you are taking other medicines that affect the brain or brain functions e.g.&nbsp;benzodiazepines (sedatives) or morphine-like medicines, tell your doctor.&nbsp;Livopan may potentiate the effects of these medicines.&nbsp;Livopan in combination with other drugs that affect the&nbsp;central nervous system&nbsp;increases the risk of&nbsp;side effects&nbsp;.<\/li><li>Bleomycin (for cancer) or&nbsp;amiodarone&nbsp;(used to treat irregular heartbeat) before taking Livopan, as a toxic effect on the lungs may occur due to the high concentration of oxygen.<\/li><li>Nitrofurantoin&nbsp;or similar&nbsp;antibiotics&nbsp;(for&nbsp;infection&nbsp;)<\/li><\/ul>\n\n\n\n<p>Livopan exacerbates the&nbsp;side effects&nbsp;of these drugs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or nurse for advice before taking this medicine.<\/p>\n\n\n\n<p>Livopan can be used during pregnancy if your doctor thinks it is medically necessary.\u00a0It can also be used during childbirth.\u00a0If Livopan is used near the time of delivery, your baby should be monitored for breathing difficulties (\u00a0respiratory depression\u00a0) and other\u00a0side effects.<\/p>\n\n\n\n<p>Livopan can be used during the breastfeeding period, but should not be used at the time of breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Please note that you must have time for recovery after receiving Livopan.\u00a0The nitrous oxide part of Livopan disappears quickly from the body after a short inhalation.\u00a0The effect on cognitive ability can be affected for several hours.\u00a0For safety reasons, you should therefore avoid driving, using machines, or performing complicated tasks until you are fully recovered (for at least 30 minutes).<\/p>\n\n\n\n<p>Make sure that healthcare professionals give you advice when it is safe for you to drive a car.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Livopan<\/h2>\n\n\n\n<p>Livopan is always given in the presence of staff who are familiar with this form of medicine.\u00a0During the entire time that Livopan is used, you and the supply must be monitored so that it safely takes place.\u00a0Even after the supply is completed, you will be monitored by competent staff until you have recovered.<\/p>\n\n\n\n<p>Always use this medicine exactly as your doctor or nurse has told you.&nbsp;If you are not sure, talk to your doctor or nurse.<\/p>\n\n\n\n<p>Your doctor or nurse should inform you about how to use Livopan and how Livopan works and what effects occur during use.<\/p>\n\n\n\n<p>You usually breathe Livopan through a breathing mask connected to a special valve that allows you to have full control of the gas flow through your breathing.\u00a0The valve is only open when inhaled.\u00a0Livopan can also be applied via a so-called nose mask.<\/p>\n\n\n\n<p>Regardless of which mask you use, you should breathe normally with normal breaths in the mask.<\/p>\n\n\n\n<p><strong>Use for children<\/strong><\/p>\n\n\n\n<p>For children who are unable to understand and follow the instructions given, Livopan should be administered under the supervision of competent medical personnel who can help them keep the mask in place and actively monitor the administration.&nbsp;At such times, Livopan can be supplied with a constant gas flow.<\/p>\n\n\n\n<p>After stopping using Livopan, you should rest and recover until you feel mentally recovered.<\/p>\n\n\n\n<p><strong>Safety instructions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Smoking and open flames are strictly forbidden in rooms where treatment with Livopan is in progress.<\/li><li>Livopan is intended for medical use only.<\/li><\/ul>\n\n\n\n<p>See also instructions on storage and handling of gas cylinders.&nbsp;(5. How to store Livopan)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Livopan than you should&nbsp;<\/h2>\n\n\n\n<p>It is very unlikely that you can get too much gas as you control the supply and the gas mixture is solid, (contains 50% nitrous oxide and 50% oxygen).<\/p>\n\n\n\n<p>If you breathe faster than usual and thereby get more nitrous oxide in you than during normal breathing, you may feel noticeably tired and you may feel that you to some extent lose contact with the environment.&nbsp;You must then immediately inform the staff and interrupt the supply.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><em>Common<\/em>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<p>Dizziness, dizziness,&nbsp;euphoria&nbsp;as well as nausea and vomiting<\/p>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<p>Pronounced fatigue.&nbsp;Cover for the ears, if you have used Livopan for a long time.&nbsp;This is because Livopan increases the pressure in the middle ear.<\/p>\n\n\n\n<p>Flatulence since Livopan slowly increases the volume of gas in the intestines.<\/p>\n\n\n\n<p><em>Has been reported<\/em>\u00a0(occurs in the unknown number of users):<\/p>\n\n\n\n<p>Impact on nerve function, numbness, and weakness, usually in the legs.<\/p>\n\n\n\n<p>Effects on&nbsp;bone marrow&nbsp;that may cause&nbsp;anemia&nbsp;(decreased&nbsp;red blood cell count&nbsp;) and leukopenia (decreased&nbsp;white blood cell count&nbsp;).&nbsp;<\/p>\n\n\n\n<p>You may also experience headaches and confusion after completing the\u00a0administration.<\/p>\n\n\n\n<p>Psychiatric effects such as\u00a0psychosis, confusion, and anxiety have been reported on extremely rare occasions.<\/p>\n\n\n\n<p>Respiratory depression&nbsp;(shallow and slow breathing)<\/p>\n\n\n\n<p>Dependent<\/p>\n\n\n\n<p>Cramps<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Livopan<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the gas bottle.<\/p>\n\n\n\n<p>Do not store below -5 \u00b0 C.<\/p>\n\n\n\n<p>If Livopan is suspected of being stored too cold, the bottles must be stored lying at a temperature above + 10 \u00b0 C for at least 48 hours before they can be used.<\/p>\n\n\n\n<p>Store the bottle in a locked space reserved for medical gases.<\/p>\n\n\n\n<p>Store away from flammable substances.<\/p>\n\n\n\n<p>Provide good ventilation.<\/p>\n\n\n\n<p>Vapors may cause drowsiness and dizziness<\/p>\n\n\n\n<p>Smoking forbidden.&nbsp;Do not expose to strong heat.<\/p>\n\n\n\n<p>Carried to safety in case of fire.&nbsp;Keep the bottle clean and dry and free of oil and grease.<\/p>\n\n\n\n<p>Make sure that the bottle is not exposed to shocks and falls.<\/p>\n\n\n\n<p>Store and transport with closed valve.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are:<br>nitrous oxide 50% = medical nitrous oxide (chemical name: N&nbsp;<sub>2<\/sub>&nbsp;O) and<br>oxygen 50% = medical oxygen (chemical name: O&nbsp;<sub>2<\/sub>&nbsp;)<\/li><li>No other ingredients are included in Livopan<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Livopan is a colorless, odorless, tasteless gas provided in a gas bottle that has a valve to control the outflow of gas.&nbsp;<\/p>\n\n\n\n<p>Pharmaceutical form: medical gas, compressed.<\/p>\n\n\n\n<p>The shoulder of the gas bottle is marked with white and blue colors (oxygen \/ nitrous oxide).\u00a0The body of the gas bottle is white (medical gas).<br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20060113000032#\" rel=\"noopener\">Show larger<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Pack sizes in liters<\/td><td>2<\/td><td>5<\/td><td>10<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Linde Sverige AB<\/p>\n\n\n\n<p>R\u00e4ttarv\u00e4gen 3<\/p>\n\n\n\n<p>169 68 Solna<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Manufacturer<\/h3>\n\n\n\n<p>AGA Gas AB<\/p>\n\n\n\n<p>Rotev\u00e4gen 2<\/p>\n\n\n\n<p>SE-192 78 Sollentuna (Rotebro site)<\/p>\n\n\n\n<p>Linde France<\/p>\n\n\n\n<p>16 avenue de la Saudrune<\/p>\n\n\n\n<p>Industrial zone of the Bois Vert31 120 Portet sur Garonne<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Linde Gaz Polska Sp.&nbsp;z oo<\/p>\n\n\n\n<p>ul.&nbsp;Wirowa 4<\/p>\n\n\n\n<p>33-100 Tarn\u00f3w<\/p>\n\n\n\n<p>Poland<\/p>\n\n\n\n<p>LINDE GAZ POLSKA Sp.&nbsp;z oo<\/p>\n\n\n\n<p>Oddzia\u0142 w Warszawie<\/p>\n\n\n\n<p>ul.&nbsp;Kasprowicza 132<\/p>\n\n\n\n<p>01-949 Warsaw<\/p>\n\n\n\n<p>Poland<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Information provided by:<\/h3>\n\n\n\n<p>Linde Healthcare (division within AGA AB)<\/p>\n\n\n\n<p>Tel: 08- 731 10 00<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/th><\/tr><\/thead><tbody><tr><td>Belgium<\/td><td>RELIVOPAN<\/td><\/tr><tr><td>Cyprus<\/td><td>ENTONOX<\/td><\/tr><tr><td>Denmark<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Estonia<\/td><td>ENTONOX<\/td><\/tr><tr><td>Finland<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Greece<\/td><td>ENTONOX<\/td><\/tr><tr><td>Iceland<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Italy<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Latvia<\/td><td>ENTONOX<\/td><\/tr><tr><td>Lithuania<\/td><td>ENTONOX<\/td><\/tr><tr><td>Luxembourg<\/td><td>RELIVOPAN<\/td><\/tr><tr><td>Netherlands<\/td><td>RELIVOPAN<\/td><\/tr><tr><td>Norway<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Poland<\/td><td>ENTONOX<\/td><\/tr><tr><td>Portugal<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Romania<\/td><td>ENTONOX<\/td><\/tr><tr><td>Slovakia<\/td><td>ENTONOX<\/td><\/tr><tr><td>Spain<\/td><td>ENTONOX<\/td><\/tr><tr><td>Czech Republic<\/td><td>ENTONOX<\/td><\/tr><tr><td>Germany<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Sweden<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Hungary<\/td><td>LIVOPAN<\/td><\/tr><tr><td>Austria<\/td><td>LIVOPAN<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Livopan contains a complete mixture of nitrous oxide (medical &#8216;nitrous oxide&#8217;, N 2 O) and oxygen (medical oxygen, O 2 ), 50% of each, and should be used by inhaling the gas mixture.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[16244,16250,16240,16245,16243,6656,16246,16249,16251,16241,16247,16242,16248],"class_list":["post-16878","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-livopan","tag-benefits-of-nitric-oxide","tag-livopan","tag-livopan-medical-gas","tag-livopan-side-effects","tag-medical-gas","tag-nitric-oxide","tag-nitric-oxide-side-effects","tag-oxygen","tag-what-is-livopan","tag-what-is-nitric-oxide","tag-what-livopan-is-used-ffor","tag-what-nitric-oxide-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16878"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16878\/revisions"}],"predecessor-version":[{"id":16943,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16878\/revisions\/16943"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16878"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16878"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}