2.5 mg tablets
tibolone<\/p>\n\n\n\n
Livial is a preparation used for hormonal\u00a0substitution therapy\u00a0(\u00a0Hormone\u00a0Replacement\u00a0Therapy,\u00a0HRT\u00a0).\u00a0Livial is used for women whose menstruation has stopped (\u00a0menopause\u00a0), at least 12 months after their last natural menstruation.<\/p>\n\n\n\n
Livial is used to:<\/p>\n\n\n\n
Relieve symptoms during and after menopause<\/strong><\/p>\n\n\n\n When menstruation ends (\u00a0menopause\u00a0), the woman’s\u00a0estrogen\u00a0decreases.\u00a0It can cause problems such as sweating and hot flashes.\u00a0Livial relieves these symptoms after\u00a0menopause.\u00a0Livial should only be used if the problems cause problems in daily life.<\/p>\n\n\n\n Prevent osteoporosis<\/strong><\/p>\n\n\n\n After menopause, some women suffer from osteoporosis. Discuss all possible options with your doctor.<\/p>\n\n\n\n If you have an increased risk of\u00a0fractures\u00a0(bone fractures) and other medicines that are not suitable for you, you can use Livial to prevent osteoporosis after\u00a0menopause.<\/p>\n\n\n\n Medical background and regular check-ups<\/strong><\/p>\n\n\n\n The use of HRT or Livial involves risks that must be taken into account when deciding to start treatment or continue ongoing treatment.<\/p>\n\n\n\n Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed). If you belong to that group, the risks of HRT or Livial may be different. Talk to your doctor.<\/p>\n\n\n\n Before starting treatment (or resuming treatment) with\u00a0HRT\u00a0or Livial, your doctor will ask about your own, and your family’s, medical background.\u00a0Your doctor may do a general medical and gynecological examination, which also includes the examination of your breasts.<\/p>\n\n\n\n Once you have started treatment, you should go for regular medical check-ups, at least once a year. During these check-ups, you should discuss with your doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n Perform regular examinations of the breasts according to the doctor’s recommendations.<\/p>\n\n\n\n Do not take Livial:<\/strong><\/p>\n\n\n\n if any of the following apply to you. If you are not sure, talk to your doctor before taking Livial.<\/p>\n\n\n\n Do not take Livial<\/p>\n\n\n\n If any of the above affects you the first time you use Livial, stop taking Livial and contact a doctor immediately.<\/p>\n\n\n\n Talk to your doctor if you have or have had any of the following problems before starting treatment. They may recur or worsen during treatment with Livial. Should this occur, have more frequent check-ups with a doctor.<\/p>\n\n\n\n You should contact your doctor immediately and discontinue treatment if any of the following occur:<\/strong><\/p>\n\n\n\n For more information, see below “Blood clots in a vein ( thrombosis )”.<\/p>\n\n\n\n Note:<\/strong> Livial is not a contraceptive. If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy. Consult your doctor.<\/p>\n\n\n\n HRT and cancer<\/strong><\/p>\n\n\n\n Severe thickening of the uterine lining ( endometrial hyperplasia ) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n There are reports and studies on an increased risk of uterine cancer in women using Livial. The risk increases with the length of the treatment period.<\/p>\n\n\n\n Irregular bleeding<\/strong><\/p>\n\n\n\n Irregular spotting or spotting may occur during the first 3-6 months of taking Livial. But about the bleeding:<\/p>\n\n\n\n you should see a doctor as soon as possible.<\/strong><\/p>\n\n\n\n Breast cancer<\/strong><\/p>\n\n\n\n Data show that treatment with tibolone increases the risk of breast cancer. The extra risk depends on how long you use tibolone. Studies of HRT show that when treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used HRT for more than 5 years. There are no data on whether there is a residual risk after discontinuation of tibolone, but a similar pattern cannot be ruled out.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n Women who take Livial have a lower risk than women who use combined\u00a0HRT\u00a0and a comparable risk with\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone.<\/p>\n\n\n\n Check your breasts regularly. Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n Ovarian cancer<\/strong><\/p>\n\n\n\n Ovarian cancer is rare – much more rare than breast cancer.\u00a0Use of\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone\u00a0or combined\u00a0estrogen\u00a0–\u00a0progestogens\u00a0has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n The risk of ovarian cancer varies with age.\u00a0The diagnosis of ovarian cancer will, for example, be made on about 2 women out of 2,000 aged 50 to 54 over 5 years.\u00a0For women who have taken\u00a0HRT\u00a0for 5 years, there will be 3 cases per 2,000 users (ie about 1 extra case).<\/p>\n\n\n\n When using Livial, the increased risk of ovarian cancer is similar to that of other types of\u00a0HRT.<\/p>\n\n\n\n How HRT affects the heart and blood circulation<\/strong><\/p>\n\n\n\n Blood clot in a friend ( thrombosis )<\/strong><\/p>\n\n\n\n The risk of blood clots in the veins<\/strong> is 1.3-3 times higher for women who take HRT than for those who do not, especially during the first year of treatment.<\/p>\n\n\n\n Blood clots can be serious. If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n It is more likely that you get a blood clot in a vein the older you get and if any of the following applies to you. Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n The symptoms of a blood clot are described in the section “You should contact a doctor immediately and stop the treatment”.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n For women in their 50s who do not take\u00a0HRT, an average of 4-7 out of 1,000 people are expected to have a blood clot in a vein over 5 years.<\/p>\n\n\n\n For women in their 50s who have taken\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for more than 5 years, 9-12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases).<\/p>\n\n\n\n With the use of Livial, the increased risk of blood clots is similar to that of other types of\u00a0HRT.<\/p>\n\n\n\n Heart disease (heart attack)<\/strong><\/p>\n\n\n\n There is no evidence that HRT prevents heart attacks.<\/p>\n\n\n\n For women over 60 who take\u00a0HRT\u00a0with\u00a0estrogen-progestogen, the risk of developing heart disease is slightly higher than those who do not take\u00a0HRT.\u00a0As the risk of heart disease is strongly age-dependent, the number of extra cases of heart disease due to the use of\u00a0HRT\u00a0with\u00a0estrogen-progestogen is\u00a0very low in healthy women near\u00a0menopause\u00a0but increases with increasing age.<\/p>\n\n\n\n There is no evidence that the risk of myocardial infarction with Livial differs from the risk of other\u00a0HRT.<\/p>\n\n\n\n Stroke<\/strong><\/p>\n\n\n\n There is data to suggest that\u00a0HRT\u00a0and Livial increase the risk of\u00a0stroke.\u00a0This increased risk has mainly been observed in older postmenopausal women over 60 years of age.\u00a0If you have had a\u00a0stroke\u00a0before,\u00a0discuss with your doctor if the benefits of treatment outweigh a possible increased risk.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n For women in their 50s who do not take Livial, an average of 3 out of 1,000 people are expected to have a\u00a0stroke\u00a0over 5 years.<\/p>\n\n\n\n For women in their 50s who have taken Livial for more than 5 years, 7 out of 1,000 users are expected to have a stroke (ie 4 extra cases).<\/p>\n\n\n\n For women in their 60s who do not take Livial, an average of 11 out of 1,000 people are expected to have a\u00a0stroke\u00a0over 5 years.\u00a0For women in their 60s who have taken Livial, the figure is 24 out of 1,000 users (ie 13 extra cases).<\/p>\n\n\n\n \u2022 This relative risk is not dependent on age or the duration of treatment, but as the baseline risk is strongly dependent on age, the overall risk of stroke in women using HRT or tibolone will increase with age (see section 4.4).<\/p>\n\n\n\n \u2022 A 2.9-year randomized controlled trial has estimated a 2.2-fold increase in the risk of stroke in women (mean age 68) who used 1.25 mg tibolone (28\/2 249) compared with placebo (13 \/ 2 257). The majority (80%) of these strokes were ischemic.<\/p>\n\n\n\n \u2022 The underlying risk of\u00a0stroke\u00a0is strongly age-dependent.\u00a0However, the underlying\u00a0incidence is\u00a0estimated\u00a0over five years to 3 per 1,000 women aged 50-59 years resp.\u00a011 per 1,000 women aged 60-69.<\/p>\n\n\n\n \u2022 For women using tibolone for 5 years, the number of additional cases is expected to be approximately 4 per 1,000 users aged 50-59 years and 13 per 1,000 users aged 60-69 years.<\/p>\n\n\n\n Other conditions<\/strong><\/p>\n\n\n\n Using HRT does not prevent memory loss. The risk of memory loss may be slightly higher in women who start using HRT after the age of 65. Consult your doctor.<\/p>\n\n\n\n Some medicines can affect the effect of Livial, which can lead to irregular bleeding. The following applies:<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal remedies.<\/p>\n\n\n\n Results from blood test analyze<\/strong><\/p>\n\n\n\n If you need to take a blood sample, tell your doctor, or the person taking the blood sample, that you are taking Livial as it may affect the results of some tests.<\/p>\n\n\n\n Livial is intended for women whose menstruation has stopped. If you become pregnant, stop taking Livial and consult a doctor.<\/p>\n\n\n\n No effects on the ability to drive and use machines have been observed.<\/p>\n\n\n\n Livial tablets contain\u00a0lactose monohydrates.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n The recommended dose is 1 tablet daily. You should take the tablet at about the same time each day and swallow it with some liquid.<\/p>\n\n\n\n You should take the first tablet on the tablet map on a mark that corresponds to the current day of the week. Then follow the day markings and take one tablet daily until the map is blank.<\/p>\n\n\n\n Your doctor will strive to\u00a0give you\u00a0the lowest\u00a0dose, which will give you relief of symptoms, and to use Livial for the shortest possible time.\u00a0Talk to your doctor if you do not get any relief from the symptoms, or feel that the\u00a0dose\u00a0is too high.<\/p>\n\n\n\n The following diseases are more common in women who take HRT than those who do not:<\/p>\n\n\n\n See section 2 for more information on these\u00a0side effects.<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0Most\u00a0side effects\u00a0are usually mild to moderate and do not usually mean that women need to stop taking their tablets.<\/p>\n\n\n\n Illegal bleeding (breakthrough bleeding\/spotting) may occur during the first months of treatment.\u00a0You should contact your doctor if the irregular bleeding lasts longer than a few months or if it starts to occur after a period of treatment, or if it continues after the end of treatment, as the cause may need to be investigated further.<\/p>\n\n\n\n Common (\u22651 \/ 100, <1\/10):<\/em>\u00a0abdominal pain, pelvic pain, weight gain, chest tightness, unnatural hair growth, abdominal problems such as discharge,\u00a0itching, bleeding, spotting,\u00a0inflammation,\u00a0and fungal infection.<\/p>\n\n\n\n Uncommon (\u22651 \/ 1,000, <1\/100):<\/em>\u00a0fluid retention, gastrointestinal upset, acne, and nipple pain.<\/p>\n\n\n\n Rare (\u22651 \/ 10,000, <1 \/ 1,000): <\/em>pruritus<\/p>\n\n\n\n Dizziness, headaches,\u00a0migraines, depression, skin problems, visual disturbances, joint pain, muscle aches, and altered liver values \u200b\u200bhave also been reported.<\/p>\n\n\n\n There have been reports of breast cancer and an increase in cell growth or cancer of the uterine lining in women using Livial.<\/p>\n\n\n\n The following side effects have been reported for other HRTs:<\/p>\n\n\n\n If you get\u00a0any side effects, talk to your doctor.\u00a0This also applies to any\u00a0side effects\u00a0not mentioned in this information.<\/p>\n\n\n\n Do not store above 25 \u00b0 C. Store in the original package. Sensitive to light.<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Livial tablets are white, round, flat, and marked MK 2 on one side and ORGANON * on the other.<\/p>\n\n\n\n NV Organon<\/p>\n\n\n\n Kloosterstraat 6<\/p>\n\n\n\n 5349 AB Oss<\/p>\n\n\n\n Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":" Livial is a preparation used for hormonal substitution therapy ( Hormone Replacement Therapy , HRT ). Livial is used for women whose menstruation has stopped ( menopause ), at least 12 months after their last natural menstruation.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[16263,16257,16258,16261,16252,16256,16255,16259,16253,16260,16254],"class_list":["post-16874","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-livial","tag-benefits-of-tibolone","tag-livial","tag-livial-tablet","tag-tibolone","tag-tibolone-side-effects","tag-tibolone-tablet","tag-what-is-livial","tag-what-is-tibolone","tag-what-livial-is-used-for","tag-what-tibolone-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16874","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16874"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16874\/revisions"}],"predecessor-version":[{"id":16945,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16874\/revisions\/16945"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16874"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16874"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What you need to know before taking Livial<\/h2>\n\n\n\n
Do not use Livial<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Other drugs and Livial<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Livial contains lactose monohydrate<\/h2>\n\n\n\n
How to take Livial<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
How to store Livial<\/h2>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n