{"id":16491,"date":"2021-12-10T10:20:30","date_gmt":"2021-12-10T10:20:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16491"},"modified":"2021-12-11T10:13:42","modified_gmt":"2021-12-11T10:13:42","slug":"letrozole-bluefish","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/letrozole-bluefish\/","title":{"rendered":"Letrozole Bluefish &#8211; Letrozole uses, dose and side effects"},"content":{"rendered":"\n<p>2.5 mg&nbsp;film-coated tablets<br>letrozole<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Letrozole Bluefish is and what it is used for<\/h2>\n\n\n\n<p><em>What Letrozole Bluefish is<\/em><\/p>\n\n\n\n<p>Letrozole Bluefish contains an active substance called letrozole.\u00a0Letrozole Bluefish belongs to a group of medicines called aromatase inhibitors.\u00a0It is a hormonal (or &#8220;endocrine&#8221;) treatment for breast cancer.\u00a0The growth of breast tumors is often stimulated by the female sex hormone\u00a0estrogen.\u00a0Letrozole reduces the amount of\u00a0estrogen\u00a0by blocking an\u00a0enzyme\u00a0(&#8220;aromatase&#8221;) that participates in the production of\u00a0estrogen\u00a0and can therefore stop the growth of breast tumors that need\u00a0estrogen\u00a0to grow.\u00a0This slows or stops the growth of tumor cells and their spread to other parts of the body.<\/p>\n\n\n\n<p><em>What Letrozole Bluefish is used for<\/em><\/p>\n\n\n\n<p>Letrozole Bluefish is used to treat breast cancer in women who have undergone\u00a0menopause, ie.\u00a0no longer have menstruation.<\/p>\n\n\n\n<p>It is used to prevent the recurrence of cancer.\u00a0It can be used as first treatment before breast surgery when immediate surgery is not appropriate, or as first treatment after breast surgery or after five years of treatment with tamoxifen.\u00a0Letrozole Bluefish is also used to prevent breast tumors from spreading to other parts of the body in patients with advanced breast cancer.<\/p>\n\n\n\n<p>Ask your doctor if you are wondering how Letrozole Bluefish works or why you have been prescribed it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Letrozole Bluefish<\/h2>\n\n\n\n<p>Carefully follow your doctor&#8217;s instructions.&nbsp;They may deviate from the general instructions in this leaflet.<\/p>\n\n\n\n<p><strong>Do not take Letrozole Bluefish<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to letrozole or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are still menstruating ie if you have not yet undergone&nbsp;menopause&nbsp;one<\/li><li>if you are pregnant<\/li><li>if you are breast-feeding<\/li><\/ul>\n\n\n\n<p>If any of these apply to you,\u00a0<strong>do not take this medicine and talk to your doctor<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Letrozole Bluefish<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have severe kidney disease<\/li><li>if you have severe liver disease<\/li><li>if you have or have had osteoporosis or&nbsp;fractures&nbsp;(see also &#8220;Checks during treatment with Letrozole Bluefish&#8221; in section 3).<\/li><\/ul>\n\n\n\n<p>If any of these apply to you,&nbsp;<strong>tell your doctor.&nbsp;<\/strong>Your doctor will take this into account during your treatment with Letrozole Bluefish.<\/p>\n\n\n\n<p>Letrozole may cause&nbsp;tendon&nbsp;inflammation&nbsp;or tendon damage (see section 4).&nbsp;In case of any sign of sensory pain or swelling &#8211; rest the painful area and consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and adolescents (under 18 years)<\/h2>\n\n\n\n<p>Children and adolescents should not use this medicine.<\/p>\n\n\n\n<p><strong>Elderly people (from 65 years)<\/strong><\/p>\n\n\n\n<p>People who are 65 years or older can use this drug in the same&nbsp;dose&nbsp;as other adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Letrozole Bluefish<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>You should only take Letrozole Bluefish after you have had a&nbsp;menopause&nbsp;(ie you are no longer menstruating).&nbsp;However, your doctor should talk to you about using an effective method of contraception as you may still become pregnant during treatment with Letrozole Bluefish.<\/li><li>You must not take Letrozole Bluefish if you are pregnant or breast-feeding as it may harm your baby.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you feel dizzy, tired, drowsy, or generally unwell, do not drive or use any tools or machines until you feel normal again.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Letrozole Bluefish contains lactose<\/h2>\n\n\n\n<p>Letrozole Bluefish contains&nbsp;lactose&nbsp;(milk sugar).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<p><strong>Letrozole Bluefish contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>Letrozole Bluefish contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per 2.5 mg film-coated tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Letrozole Bluefish<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is one tablet once a day.&nbsp;Taking Letrozole Bluefish at the same time each day will make it easier to remember when to take the tablet.<\/p>\n\n\n\n<p>The tablet can be taken with or without food and should be swallowed whole with a glass of water or other beverage.<\/p>\n\n\n\n<p><strong>How long to take Letrozole Bluefish<\/strong><\/p>\n\n\n\n<p>Continue to take Letrozole Bluefish every day for as long as your doctor prescribes it.&nbsp;You may need to take it for months or even years.&nbsp;Talk to your doctor if you are wondering how long to continue taking Letrozole Bluefish.<\/p>\n\n\n\n<p><strong>Check during treatment with Letrozole Bluefish<\/strong><\/p>\n\n\n\n<p>You should only take this medicine under the supervision of a doctor.&nbsp;Your doctor will regularly check your condition to make sure the treatment is having the right effect.<\/p>\n\n\n\n<p>Letrozole Bluefish may cause osteoporosis (\u00a0osteoporosis\u00a0) because of the reduced amount of\u00a0estrogen\u00a0in the body.\u00a0Your doctor may decide to measure your bone density (a way to check if you have\u00a0osteoporosis\u00a0) before, during, and after treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Most of the&nbsp;side effects&nbsp;are mild to moderate and generally go away after a few days to a few weeks of treatment.<\/p>\n\n\n\n<p>Some of these\u00a0side effects, such as hemorrhages, hair loss, and vaginal bleeding can be due to estrogen deficiency in the body.<\/p>\n\n\n\n<p>Do not let this list of possible&nbsp;side effects&nbsp;worry you.&nbsp;You may not get any of them.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious:<\/strong><\/p>\n\n\n\n<p><strong>Rare or uncommon&nbsp;<\/strong>side effects&nbsp;(may affect up to 1 in 100 people in 10,000):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weakness, paralysis or loss of sensation in any part of the body (especially an arm or a leg), impaired coordination, nausea, speech or breathing difficulties (signs of brain effects such as&nbsp;stroke&nbsp;)<\/li><li>sudden oppressive chest pain (signs of heart disease)<\/li><li>difficulty breathing, chest pain, fainting, rapid&nbsp;pulse&nbsp;, bluish discoloration of the skin or sudden pain in an arm, leg or foot (signs that a blood clot may have formed)<\/li><li>swelling and&nbsp;redness&nbsp;along a vein that is very tender and possibly painful to the touch<\/li><li>high fever, chills or cold sores due to&nbsp;infection&nbsp;(lack of&nbsp;white blood cells&nbsp;)<\/li><li>severe, persistent blurred vision.<\/li><li>Uncommon &#8211;&nbsp;inflammation&nbsp;of a tendon or&nbsp;tendinitis&nbsp;(connective tissue that connects muscles to the skeleton)<\/li><li>Rare &#8211; rupture of a tendon (connective tissue that connects muscles to the skeleton)<\/li><\/ul>\n\n\n\n<p><strong>If you experience any of these symptoms, tell your doctor immediately<\/strong>.<\/p>\n\n\n\n<p>You should also tell your doctor immediately if you get any of the following symptoms during treatment with Letrozole Bluefish:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the face and neck in particular (signs of&nbsp;allergic reaction&nbsp;).<\/li><li>Yellow skin and eyes, nausea, decreased appetite, dark urine (signs of jaundice).<\/li><li>Skin rash, redness of the skin, blisters on the lips, eyes or mouth, skin rash, fever (signs of skin disease).<\/li><\/ul>\n\n\n\n<p><strong>Some\u00a0side effects\u00a0are very common<\/strong><em>.\u00a0<\/em>These\u00a0side effects\u00a0may affect more than 10 in 100 patients:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hot flashes<\/li><li>elevated cholesterol (&nbsp;hypercholesterolemia&nbsp;)<\/li><li>fatigue<\/li><li>increased sweating<\/li><li>skeletal or joint pain (&nbsp;arthralgia&nbsp;).<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if the&nbsp;side effects&nbsp;are perceived as serious.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are common.&nbsp;<\/strong>These&nbsp;side effects&nbsp;may affect 1 to 10 users in 100.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>headache<\/li><li>dizziness<\/li><li>general malaise<\/li><li>gastrointestinal disorders such as nausea, vomiting, indigestion, constipation, diarrhea<\/li><li>increased or decreased appetite<\/li><li>muscle aches<\/li><li>bone loss (&nbsp;osteoporosis&nbsp;) which in some cases may lead to&nbsp;fracture&nbsp;s (see also &#8220;Monitoring during treatment with Letrozole Blue Fish&#8221; in section 3)<\/li><li>swelling of hands, arms, feet and ankles (&nbsp;edema&nbsp;)<\/li><li>Depression<\/li><li>weight gain<\/li><li>hair loss<\/li><li>high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>abdominal pain<\/li><li>dry skin<\/li><li>vaginal bleeding<\/li><li>palpitation&nbsp;er, fast heart rate<\/li><li>joint stiffness (&nbsp;arthritis&nbsp;)<\/li><li>chest pain.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if the&nbsp;side effects&nbsp;are perceived as serious.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are less common.&nbsp;<\/strong>These&nbsp;side effects&nbsp;may affect 1 to 10 users in 1,000:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nervous conditions such as anxiety, nervousness, irritability, drowsiness, memory problems, drowsiness, insomnia<\/li><li>pain or a burning sensation in the hands or wrists (&nbsp;carpal tunnel syndrome&nbsp;)<\/li><li>impaired sensation, especially sensitivity to touch<\/li><li>eye problems such as blurred vision, eye irritation<\/li><li>skin problems such as&nbsp;itching&nbsp;(&nbsp;hives&nbsp;)<\/li><li>vaginal discharge&nbsp;or dryness<\/li><li>chest pain<\/li><li>fever<\/li><li>thirst, taste disturbances,&nbsp;dry mouth<\/li><li>dry mucous membranes<\/li><li>weight loss<\/li><li>urinary tract infection, more frequent need to urinate<\/li><li>cough.<\/li><li>elevated levels of&nbsp;enzyme&nbsp;er<\/li><li>yellowing of the skin or eyes<\/li><li>high levels of&nbsp;bilirubin&nbsp;in the blood (a breakdown product of&nbsp;red blood cells&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>The side effect is\u00a0without any known frequency<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Trigger finger, ie a condition where some finger or thumb locks in a bent position.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if the&nbsp;side effects&nbsp;are perceived as serious.<\/p>\n\n\n\n<p>If you get\u00a0any side effects, talk to your doctor, pharmacist, or nurse.\u00a0This also applies to\u00a0side effects\u00a0that are not mentioned in this information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Letrozole Bluefish<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton or blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not use damaged or opened packaging.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is letrozole.&nbsp;One film-coated tablet contains 2.5 mg letrozole.<\/p>\n\n\n\n<p>The other ingredients in the tablet are\u00a0lactose monohydrate, corn starch, microcrystalline cellulose, sodium starch\u00a0glycolate\u00a0(type A), anhydrous\u00a0colloidal\u00a0silica, magnesium stearate.<\/p>\n\n\n\n<p>The film coating contains macrogol, hypromellose, talc, titanium dioxide (E 171), iron oxide yellow (E172), and iron oxide red (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Letrozole Bluefish are yellow, round, 6.1 mm (\u00b1 0.2 mm) in diameter, biconvex film-coated tablets.<\/p>\n\n\n\n<p>The tablets are packed in blister packs of 30, 100 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder<\/p>\n\n\n\n<p>Bluefish Pharmaceuticals AB<\/p>\n\n\n\n<p>PO Box 49013<\/p>\n\n\n\n<p>100 28 Stockholm<\/p>\n\n\n\n<p>Sweden<\/p>\n\n\n\n<p>Manufacturer<\/p>\n\n\n\n<p>Bluefish Pharmaceuticals AB<\/p>\n\n\n\n<p>G\u00e4vlegatan 22<\/p>\n\n\n\n<p>113 30 Stockholm<\/p>\n\n\n\n<p>Sweden<\/p>\n\n\n\n<p>Genepharm SA<\/p>\n\n\n\n<p>18th Marathonos Avenue<\/p>\n\n\n\n<p>153 51 Pallini Attikis<\/p>\n\n\n\n<p>Greece<\/p>\n\n\n\n<p><strong>This medicine is authorized in the EFA member countries under the following names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Member State<\/strong><\/td><td><strong>Product name<\/strong><\/td><\/tr><tr><td>Denmark<\/td><td>Letrozole Bluefish<\/td><\/tr><tr><td>Finland<\/td><td>Letrozole Bluefish 2.5 mg tablets, calvap\u00e4\u00e4llysteineLetrozole Bluefish 2.5 mg film-coated tablets<\/td><\/tr><tr><td>France<\/td><td>Letrozole Bluefish 2.5 mg compressed tablets<\/td><\/tr><tr><td>Ireland<\/td><td>Letrozole Bluefish 2.5 mg film-coated tablets<\/td><\/tr><tr><td>Iceland<\/td><td>Letrozole Bluefish 2.5 mg film-coated tablets<\/td><\/tr><tr><td>Italy<\/td><td>Brestoral 2.5 mg compress rivestite with film<\/td><\/tr><tr><td>Poland<\/td><td>Letrozole Bluefish<\/td><\/tr><tr><td>Spain<\/td><td>Letrozole Bluefish 2.5 mg compresses recovered with film<\/td><\/tr><tr><td>Sweden<\/td><td>Letrozole Bluefish 2.5 mg film-coated\u00a0tablets<\/td><\/tr><tr><td>Germany<\/td><td>Letrozole Bluefish 2.5 mg film tablets<\/td><\/tr><tr><td>Austria<\/td><td>Letrozole Bluefish 2.5 mg film tablets<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Letrozole Bluefish contains an active substance called letrozole. Letrozole Bluefish belongs to a group of medicines called aromatase inhibitors. It is a hormonal (or &#8220;endocrine&#8221;) treatment for breast cancer. The growth of breast tumors is often stimulated by the female sex hormone estrogen . Letrozole reduces the amount of estrogen by blocking an enzyme (&#8220;aromatase&#8221;) that participates in the production of estrogen and can therefore stop the growth of breast tumors that need estrogen to grow. This slows or stops the growth of tumor cells and their spread to other parts of the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15672,15702,3110,15697,15701,15700,3113,15671,15669,15698,15699,15670],"class_list":["post-16491","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-letrozole","tag-benefits-of-letrozole-bluefish","tag-letrozole","tag-letrozole-bluefish","tag-letrozole-bluefish-side-effects","tag-letrozole-bluefish-tablet","tag-letrozole-side-effects","tag-letrozole-tablet","tag-what-is-letrozole","tag-what-is-letrozole-bluefish","tag-what-letrozole-bluefish-is-used-for","tag-what-letrozole-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16491"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16491\/revisions"}],"predecessor-version":[{"id":16530,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16491\/revisions\/16530"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}