{"id":16462,"date":"2021-12-09T09:31:09","date_gmt":"2021-12-09T09:31:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16462"},"modified":"2021-12-11T10:13:47","modified_gmt":"2021-12-11T10:13:47","slug":"letrozole-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/letrozole-accord\/","title":{"rendered":"Letrozole Accord &#8211; Letrozole uses, dose and side effects"},"content":{"rendered":"\n<p>2.5 mg&nbsp;film-coated tablet<br>letrozole<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Letrozole Accord is and what it is used for<\/h2>\n\n\n\n<p><strong>What Letrozole Accord is and how it works<\/strong><\/p>\n\n\n\n<p>Letrozole Accord contains an active substance called letrozole.\u00a0It belongs to a group of medicines called aromatase inhibitors.\u00a0It is a hormonal (or &#8220;endocrine&#8221;) treatment for breast cancer.\u00a0The growth of breast tumors is often stimulated by the female sex hormone\u00a0estrogen.\u00a0Letrozole Accord reduces the amount of\u00a0estrogen\u00a0by blocking an\u00a0enzyme\u00a0(&#8220;aromatase&#8221;) that participates in the production of\u00a0estrogen\u00a0and can therefore stop the growth of breast tumors that need\u00a0estrogen\u00a0to grow.\u00a0This slows or stops the growth of tumor cells and their spread to other parts of the body.<\/p>\n\n\n\n<p><strong>What Letrozole Accord is used for<\/strong><\/p>\n\n\n\n<p>Letrozole Accord is used to treat breast cancer in women who have undergone\u00a0menopause, ie.\u00a0no longer have menstruation.<\/p>\n\n\n\n<p>It is used to prevent the recurrence of cancer.\u00a0It can be used as first treatment before breast surgery when immediate surgery is not appropriate, or as first treatment after breast surgery or after five years of treatment with tamoxifen.\u00a0Letrozole Accord is also used to prevent breast tumors from spreading to other parts of the body in patients with advanced breast cancer.<\/p>\n\n\n\n<p>Ask your doctor if you are wondering how Letrozole Accord works or why you have been prescribed it.<\/p>\n\n\n\n<p>Letrozole contained in Letrozole Accord may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Letrozole Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Letrozole Accord<\/h2>\n\n\n\n<p>Follow your doctor&#8217;s instructions carefully.&nbsp;They may differ from the general information contained in this leaflet.<\/p>\n\n\n\n<p><strong>Do not use Letrozole Accord<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to letrozole or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you still have menstruation ie.&nbsp;if you have not yet undergone&nbsp;menopause&nbsp;one,<\/li><li>if you are pregnant,<\/li><li>if you are breast-feeding.<br>If any of these apply to you, do not take this medicine and talk to your doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Letrozole Accord<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have a serious kidney disease,<\/li><li>if you have severe liver disease,<\/li><li>if you have problems with brittle bones (&nbsp;osteoporosis&nbsp;) and bone fractures (see also section 1 &#8220;Monitoring during treatment with Letrozole Accord&#8221;).<\/li><\/ul>\n\n\n\n<p>Letrozole may cause&nbsp;tendon&nbsp;inflammation&nbsp;or tendon damage (see section 4).&nbsp;In case of any sign of sensory pain or swelling &#8211; rest the painful area and consult a doctor.<\/p>\n\n\n\n<p>If any of these apply to you,\u00a0<strong>tell your doctor<\/strong>.\u00a0Your doctor will take this into account during your treatment with Letrozole Accord.<\/p>\n\n\n\n<p><strong>Children and adolescents (under 18 years)<\/strong><\/p>\n\n\n\n<p>Children and adolescents should not use this medicine.<\/p>\n\n\n\n<p><strong>Elderly people (from 65 years)<\/strong><\/p>\n\n\n\n<p>People 65 years of age or older can use this medicine at the same&nbsp;dose&nbsp;as other adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Letrozole Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You should only take Letrozole Accord after you have had a&nbsp;menopause&nbsp;(ie you are no longer menstruating).&nbsp;However, your doctor should talk to you about using an effective method of contraception as you may still become pregnant during treatment with Letrozole Accord.<\/li><li>You must not take Letrozole Accord if you are pregnant or breast-feeding as it may harm your baby.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you feel dizzy, tired, drowsy, or generally unwell, do not drive or use any tools or machines until you feel normal again.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Letrozole Accord contains lactose<\/h2>\n\n\n\n<p>Letrozole Accord contains&nbsp;lactose&nbsp;(milk sugar).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Letrozole Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is one tablet of Letrozole Accord once a day.&nbsp;Taking Letrozole Accord at the same time each day will make it easier to remember when to take the tablet.<\/p>\n\n\n\n<p>The tablet can be taken with or without food and should be swallowed whole with a glass of water or other beverage.<\/p>\n\n\n\n<p><strong>How long to use Letrozole Accord<\/strong><\/p>\n\n\n\n<p>Continue to take Letrozole Accord every day for as long as your doctor prescribes it.&nbsp;You may need to take it for months or even years.&nbsp;Talk to your doctor if you are wondering how long to continue taking Letrozole Accord.<\/p>\n\n\n\n<p><strong>Check during treatment with Letrozole Accord<\/strong><\/p>\n\n\n\n<p>You should only take this medicine under the supervision of a doctor.&nbsp;Your doctor will regularly check your condition to make sure the treatment is having the right effect.<\/p>\n\n\n\n<p>Letrozole Accord may cause osteoporosis (\u00a0osteoporosis\u00a0) because of the reduced amount of\u00a0estrogen\u00a0in the body.\u00a0Your doctor may decide to measure your bone density (a way to check if you have\u00a0osteoporosis\u00a0) before, during, and after treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Most\u00a0side effects\u00a0are mild to moderate and usually, go away within a few days or a few weeks after starting treatment.<\/p>\n\n\n\n<p>Some of these\u00a0side effects, such as hemorrhages, hair loss, and vaginal bleeding, may be due to estrogen deficiency in the body.<\/p>\n\n\n\n<p>Do not let this list of&nbsp;side effects&nbsp;worry you.&nbsp;You may not get any of them.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;can be serious:<\/strong><\/p>\n\n\n\n<p><strong>Rare or uncommon&nbsp;side effects&nbsp;(ie may affect 1 to 100 users in 10,000):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Weakness, paralysis or loss of sensation in any part of the body (especially an arm or a leg), impaired coordination, nausea, speech or breathing difficulties (signs of brain effects, eg&nbsp;stroke&nbsp;).<\/li><li>Sudden oppressive chest pain (signs of heart disease).<\/li><li>Difficulty breathing, chest pain, fainting, increased&nbsp;heart rate&nbsp;, bluish discoloration of the skin or sudden pain in an arm, leg or foot (signs that a blood clot may have formed).<\/li><li>Swelling and&nbsp;redness&nbsp;along a blood vessel that is very tender and possibly painful to the touch.<\/li><li>High fever, chills, sores in the oral cavity caused by&nbsp;infection&nbsp;(lack of&nbsp;white blood cells&nbsp;).<\/li><li>Difficult, persistent blurred vision.<\/li><li>Inflammation&nbsp;of a tendon (connective tissue that connects muscles to the skeleton).<\/li><li>Rupture of a tendon (connective tissue that connects muscles to the skeleton).<\/li><\/ul>\n\n\n\n<p><strong>If you experience any of these symptoms, tell your doctor immediately.<\/strong><\/p>\n\n\n\n<p>You should also inform your doctor immediately if you experience any of the following symptoms during treatment with Letrozole Accord:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling, mainly on the face and neck (signs of an&nbsp;allergic reaction&nbsp;).<\/li><li>Yellow skin and yellow whites of the eyes, nausea, decreased appetite, dark urine (signs of&nbsp;hepatitis&nbsp;).<\/li><li>Skin rash, red skin, blisters on the lips, eyes or mouth, skin rash, fever (signs of a skin disease).<\/li><\/ul>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are very common&nbsp;<\/strong><strong>(may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hemorrhoids<\/li><li>Elevated cholesterol (&nbsp;hypercholesterolemia&nbsp;)<\/li><li>Fatigue<\/li><li>Increased sweating<\/li><li>Pain in the bones and joints (&nbsp;arthralgia&nbsp;)<\/li><\/ul>\n\n\n\n<p>If any of these\u00a0side effects\u00a0gets serious, or if you notice\u00a0any\u00a0side effects\u00a0not listed in this\u00a0leaflet, please tell your doctor.<\/p>\n\n\n\n<p><strong>Some&nbsp;side effects&nbsp;are common&nbsp;<\/strong><strong>(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rash<\/li><li>Headache<\/li><li>Dizziness<\/li><li>General malaise<\/li><li>Gastrointestinal disorders such as nausea, vomiting, indigestion, constipation, diarrhea<\/li><li>Increased or decreased appetite<\/li><li>Muscle aches<\/li><li>Brittle bones (&nbsp;osteoporosis&nbsp;), which in some cases leads to&nbsp;fracture&nbsp;s (see also &#8220;Controls during treatment with Letrozole Accord&#8221; in Section 3).<\/li><li>Swelling of arms, hands, feet, ankles (&nbsp;edema&nbsp;)<\/li><li>Depression<\/li><li>Weight gain<\/li><li>Hair loss<\/li><li>High&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>Abdominal pain<\/li><li>Dry skin<\/li><li>Vaginal bleeding<\/li><li>Palpitation&nbsp;is, fast heart rate<\/li><li>Joint stiffness (&nbsp;arthritis&nbsp;)<\/li><li>Chest pain&nbsp;<\/li><\/ul>\n\n\n\n<p>If any of these\u00a0side effects\u00a0gets serious, or if you notice\u00a0any\u00a0side effects\u00a0not listed in this\u00a0leaflet, please tell your doctor.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are less common.&nbsp;<\/strong>These&nbsp;side effects&nbsp;may affect 1 to 10 users in 1,000:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nervous conditions such as anxiety, worry, irritability, drowsiness, memory problems, drowsiness, difficulty sleeping, numbness, tingling or burning sensation<\/li><li>Pain or burning sensation in hands or wrists (&nbsp;carpal tunnel syndrome&nbsp;)<\/li><li>Impaired sensation, especially sensitivity to touch<\/li><li>Eye problems such as blurred vision, eye irritation<\/li><li>Skin problems such as&nbsp;itching&nbsp;(&nbsp;hives&nbsp;)<\/li><li>Vaginal&nbsp;discharge and dryness<\/li><li>Chest pain<\/li><li>Fever<\/li><li>Thirst, taste changes,&nbsp;dry mouth<\/li><li>Dry mucous membranes<\/li><li>Weight loss<\/li><li>Urinary tract infection, more frequent need to urinate<\/li><li>Cough<\/li><li>Elevated levels of&nbsp;enzyme&nbsp;s<\/li><li>Yellowing of the skin or eyes<\/li><li>High levels of&nbsp;bilirubin&nbsp;in the blood (a breakdown product of&nbsp;red blood cells&nbsp;)<\/li><\/ul>\n\n\n\n<p>If any of these\u00a0side effects\u00a0gets serious, or if you notice\u00a0any\u00a0side effects\u00a0not listed in this\u00a0leaflet, please tell your doctor.<\/p>\n\n\n\n<p><strong>Side effects&nbsp;that occur in an unknown number of users:<\/strong><\/p>\n\n\n\n<p>Trigger finger, ie.&nbsp;a condition in which a finger or thumb gets stuck in a bent position.<\/p>\n\n\n\n<p>If you get\u00a0any side effects, talk to your doctor or pharmacist.\u00a0This also applies to any\u00a0side effects\u00a0not mentioned in this information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Letrozole Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Store in the original package.&nbsp;Moisture sensitive.<\/li><li>Do not use damaged or opened packaging.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is letrozole.&nbsp;Each film-coated tablet contains 2.5 mg letrozole.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>Tablet core:\u00a0lactose monohydrate,\u00a0maize\u00a0starch, hypromellose (E464), sodium starch glycolate, microcrystalline cellulose (E460), anhydrous\u00a0colloidal\u00a0silica (E551), magnesium stearate (E572).<\/p>\n\n\n\n<p>Coating film: hypromellose (E464), titanium dioxide (E171), yellow iron oxide (E172), macrogol 400, and talc (E553b).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Letrozole Accord 2.5 mg tablets are yellow, round, biconvex, film-coated tablets, unlabeled on both sides.&nbsp;Pack sizes: 10 tablets, 14 tablets, 28 tablets, 30 tablets, 50 tablets, 60 tablets, 84 tablets, 90 tablets, 98 tablets, 98 tablets, 100 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 kV Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited<em>,<\/em>\u00a0Sage House, 319, Pinner Road, North Harrow, Middlesex, HA1 4HF, UK<\/p>\n\n\n\n<p>Accord Healthcare BV<br>Winthontlaan 200<br>3526 kV Utrecht The<br>Netherlands<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Letrozole Accord contains an active substance called letrozole. It belongs to a group of medicines called aromatase inhibitors. It is a hormonal (or &#8220;endocrine&#8221;) treatment for breast cancer. The growth of breast tumors is often stimulated by the female sex hormone estrogen . Letrozole Accord reduces the amount of estrogen by blocking an enzyme (&#8220;aromatase&#8221;) that participates in the production of estrogen and can therefore stop the growth of breast tumors that need estrogen to grow. This slows or stops the growth of tumor cells and their spread to other parts of the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15672,15708,3110,15703,15707,15706,3113,15671,15669,15704,15705,15670],"class_list":["post-16462","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-letrozole","tag-benefits-of-letrozole-accord","tag-letrozole","tag-letrozole-accord","tag-letrozole-accord-side-effects","tag-letrozole-accord-tablet","tag-letrozole-side-effects","tag-letrozole-tablet","tag-what-is-letrozole","tag-what-is-letrozole-accord","tag-what-letrozole-accord-is-used-for","tag-what-letrozole-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16462"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16462\/revisions"}],"predecessor-version":[{"id":16531,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16462\/revisions\/16531"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}