{"id":16447,"date":"2021-12-09T09:11:02","date_gmt":"2021-12-09T09:11:02","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16447"},"modified":"2021-12-11T10:17:17","modified_gmt":"2021-12-11T10:17:17","slug":"lergigan-comp-2","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lergigan-comp-2\/","title":{"rendered":"Lergigan comp &#8211; Prometazine hydrochloride \/ caffeine \/ ephedrine sulphate uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg \/ 50 mg \/ 10 mg&nbsp;tablet<br>prometazine hydrochloride \/ <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">caffeine<\/a> \/ ephedrine sulphate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lergigan comp is and what it is used for<\/h2>\n\n\n\n<p>Lergigan comp contains promethazine, caffeine, and\u00a0ephedrine\u00a0and belongs to the group of\u00a0antihistamines.\u00a0Promethazine blocks the effect of\u00a0histamine, a substance found in the body&#8217;s\u00a0tissues\u00a0that, among other things, triggers\u00a0itching\u00a0in allergic reactions.\u00a0Promethazine means that Lergigan comp also has a calming effect.\u00a0Ephedrine\u00a0and caffeine enhance the effects of motion sickness and pregnancy nausea.<\/p>\n\n\n\n<p>Lergigan comp is used against:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tension and anxiety in nervous disorders.<\/li><li>Alcohol abuse and drug addiction.<\/li><li>Sleep disorders.<\/li><li>Severe anxiety and as a sedative before surgery and dental procedures.<\/li><li>Motion sickness, such as seasickness.<\/li><li>Skin itching and&nbsp;allergies&nbsp;.<\/li><li>Nausea and dizziness<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Lergigan comp<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Lergigan comp<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to prometazine, caffeine, ephedrine sulphate or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Lergigan comp:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you suffer from an enlarged&nbsp;prostate<\/li><li>if you suffer from narrowing of the urethra<\/li><li>if you suffer from narrowing of the lower&nbsp;gastrointestinal tract&nbsp;and&nbsp;duodenum&nbsp;(pyloroduodenal&nbsp;obstruction&nbsp;)<\/li><li>if you have jaundice (&nbsp;hepatitis&nbsp;)<\/li><li>if you have&nbsp;myasthenia gravis&nbsp;(severe muscle weakness)<\/li><li>if you suffer from cardiovascular disease or changes in heart rhythm<\/li><li>if you have a risk of cerebral haemorrhage (&nbsp;stroke&nbsp;)<\/li><li>if you have high&nbsp;blood pressure<\/li><\/ul>\n\n\n\n<p>Due to\u00a0dry mouth\u00a0(which is a common side effect), there is a risk of tooth and oral mucosal damage, especially with prolonged use.\u00a0You should therefore brush your teeth thoroughly with fluoride toothpaste twice daily.<\/p>\n\n\n\n<p>Treatment with Lergigan comp can cause problems for contact lens wearers due to reduced tear flow.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Lergigan comp<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0This also applies to over-the-counter medicines and herbal medicines.<\/p>\n\n\n\n<p>Lergigan comp may affect or be affected if taken concomitantly with certain other medicinal substances against:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cardiac drugs given directly into the bloodstream (eg&nbsp;adenosine&nbsp;)<\/li><li>infection&nbsp;(eg&nbsp;ciprofloxacin&nbsp;, norfloxacin)<\/li><li>depression (&nbsp;tricyclic antidepressants&nbsp;)<\/li><li>allergic nasal congestion (eg phenylpropanolamine)<\/li><li>epilepsy&nbsp;(eg carbamazepine)<\/li><li>certain psychiatric conditions (eg lithium and&nbsp;neuroleptics&nbsp;such as&nbsp;haloperidol&nbsp;, clozapine and&nbsp;risperidone&nbsp;)<\/li><li>anxiety (eg&nbsp;diazepam&nbsp;)<\/li><li>high&nbsp;blood pressure&nbsp;(eg&nbsp;beta-blockers&nbsp;and&nbsp;alpha-&nbsp;blockers&nbsp;)<\/li><li>arrhythmias in the heart (eg flecainide and&nbsp;amiodarone&nbsp;)<\/li><li>certain&nbsp;antibiotics&nbsp;(moxifloxacin and erythromycin)<\/li><li>pain conditions (eg&nbsp;methadone&nbsp;)<\/li><li>malaria drug (meflokin)<\/li><li>intestinal disease (eg cisapride)<\/li><\/ul>\n\n\n\n<p>Avoid concomitant treatment with certain diuretics (thiazide diuretics), as these may reduce the level of potassium in the blood and thus increase the risk of arrhythmias in the heart.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lergigan comp with food, drink and alcohol<\/h2>\n\n\n\n<p>Concomitant use of alcohol or central suppressants should be avoided due to the risk of enhanced drug effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p><em>Promethazine and&nbsp;ephedrine<\/em><\/p>\n\n\n\n<p>No known hazards during use.<\/p>\n\n\n\n<p><em>Caffeine<\/em><\/p>\n\n\n\n<p>Pregnant women are advised to limit their caffeine intake as available data suggest a possible risk to the fetus.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Caffeine passes into breast milk but probably does not affect breastfed babies.\u00a0There is no information on whether promethazine and\u00a0ephedrine\u00a0pass into breast milk.\u00a0Therefore, consult a physician before regular use during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>During treatment with Lergigan comp, the ability to react may be reduced.&nbsp;This should be taken into account when sharper attention is required, eg when driving a car.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lergigan comp contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Lergigan comp<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Dose\u00a0one is determined by the physician, who adjusts it individually for each patient.\u00a0The usual\u00a0dose\u00a0is:<\/p>\n\n\n\n<p>1 tablet 1-2 times daily.<\/p>\n\n\n\n<p>Nausea and vomiting can be avoided if the tablets are taken with a meal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Lergigan comp can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):\u00a0<\/em>Dry mouth.<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em>\u00a0Dizziness, headache, difficulty throwing water.\u00a0Constipation.\u00a0Difficulties for the eye to switch between near and far vision.\u00a0Reduced tear flow.\u00a0Nausea, vomiting, sweating, thirst, palpitations, muscle weakness, tremors, anxiety, ringing in the ears, and flicker of the eyes may occur at high\u00a0doses.<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em>\u00a0Jaundice without signs of liver damage, effects on heart rhythm, irregular heartbeat, and\u00a0ECG\u00a0changes associated with it.\u00a0Cardiac arrest.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lergigan comp<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><em>The active substances are:<\/em>&nbsp;promethazine hydrochloride 10 mg, caffeine 50 mg and&nbsp;ephedrine&nbsp;10 mg.<\/li><li><em>The other ingredients are:<\/em>&nbsp;titanium dioxide (E171),&nbsp;glycerol&nbsp;, vanilla aroma, magnesium stearate, anhydrous&nbsp;colloidal&nbsp;silica, calcium hydrogen phosphate dihydrate, microcrystalline cellulose, ethylcellulose, hydroxypropylcellulose, macrogol, sodium starch glycolate, sorbitanoleate.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Lergigan comp film-coated tablets are 9 mm in diameter, white and round, cupped with embossing LC within arches.<\/p>\n\n\n\n<p>Plastic jar with child-resistant lid: 30 tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder:<\/h2>\n\n\n\n<p>Meda AB<\/p>\n\n\n\n<p>Box 906<\/p>\n\n\n\n<p>170 09 Solna<\/p>\n\n\n\n<p>Phone: 08-630 19 00<\/p>\n\n\n\n<p>Email: info@meda.se<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lergigan comp contains promethazine, caffeine and ephedrine and belongs to the group of antihistamines . Prometazine blocks the effect of histamine , a substance found in the body&#8217;s tissues that, among other things, triggers itching in allergic reactions. Prometazine means that Lergigan comp also has a calming effect. Ephedrine and caffeine enhance the effects of motion sickness and pregnancy nausea.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15600,11915,15604,15595,15729,15599,15728,15601,11916,15605,15596,15602,15597],"class_list":["post-16447","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-lergigan-comp","tag-caffeine","tag-ephedrine-sulphate","tag-lergigan-comp","tag-lergigan-comp-dosage","tag-lergigan-comp-side-effects","tag-lergigan-comp-tablet","tag-prometazine-hydrochloride","tag-what-is-caffeine","tag-what-is-ephedrine-sulphate","tag-what-is-lergigan-comp","tag-what-is-prometazine-hydrochloride","tag-what-lergigan-comp-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16447"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16447\/revisions"}],"predecessor-version":[{"id":16535,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16447\/revisions\/16535"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}