caffeine<\/a> habits can also change the effect of Leponex.<\/p>\n\n\n\nPregnancy and breastfeeding<\/h2>\n\n\n\n
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.\u00a0Your doctor will discuss the benefits and possible risks for you of using this medicine during pregnancy.\u00a0Tell your doctor immediately if you become pregnant during treatment with Leponex.<\/p>\n\n\n\n
The following symptoms may occur in newborns of mothers who have used Leponex during the last trimester (last three months of pregnancy): tremors, muscle stiffness and\/or weakness, drowsiness, anxiety, difficulty breathing, and difficulty eating.\u00a0If your child has any of these symptoms, you may need to consult a doctor.<\/p>\n\n\n\n
Some women who take medication to treat mental illness have irregular periods or none at all. If you have been affected in this way, your periods may return when you are treated with Leponex. This means that you must use an effective contraceptive method.<\/p>\n\n\n\n
Do not breastfeed during treatment with Leponex.\u00a0Clozapine, the active substance in Leponex, may pass into your breast milk and affect your baby.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Do not drive or use any tools or machines as Leponex may cause fatigue, drowsiness, and cramps, especially at the beginning of treatment.<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Leponex contains lactose<\/h2>\n\n\n\n
If you have been told by your doctor that you have an intolerance to some sugars, talk to your doctor before taking Leponex.<\/p>\n\n\n\n
How to take Leponex<\/h2>\n\n\n\n
To reduce the risk of low\u00a0blood pressure, seizures, and drowsiness, it is necessary for your doctor to increase the\u00a0dose\u00a0gradually.\u00a0Always take Leponex exactly as your doctor has told you.\u00a0Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n
You mustn’t change your\u00a0dose\u00a0or stop taking Leponex without consulting your doctor first.<\/p>\n\n\n\n
Keep taking the tablets for as long as your doctor tells you to. If you are 60 years of age or older, your doctor may start with the lower dose and gradually increase it as you are at greater risk of developing any side effects (See section 2 \u201cWhat you need to know before taking Leponex\u201d).<\/p>\n\n\n\n
If the dose one you have been prescribed cannot be achieved with this strength on the tablet, there are other strengths of this medicine that may make it possible to achieve dose one.<\/p>\n\n\n\n
Treatment of schizophrenia<\/strong><\/p>\n\n\n\nThe usual starting dose is 12.5 mg (half a 25 mg tablet) once or twice on the first day followed by 25 mg once or twice daily on the second day. Swallow the tablet with water. If you tolerate this well, your doctor will gradually increase the dose one by one in 25 mg-50 mg over the next 2-3 weeks until a dose of 300 mg per day is reached. Thereafter, if necessary, the daily dose may be increased in increments of 50 to 100 mg twice a week or preferably at weekly intervals.<\/p>\n\n\n\n
The effective daily\u00a0dose\u00a0is usually between 200 mg and 450 mg, divided into several single doses per day.\u00a0Some patients may need a higher\u00a0dose.\u00a0A daily\u00a0dose\u00a0of up to 900 mg is allowed.\u00a0Increased\u00a0side effects\u00a0(especially seizures) may occur with daily\u00a0doses\u00a0above 450 mg.\u00a0Always take the lowest\u00a0dose\u00a0that is effective for you.\u00a0Most people take part of their\u00a0dose\u00a0in the morning and the other part in the evening.\u00a0Your doctor will tell you exactly how to distribute the daily\u00a0dose.\u00a0About your daily\u00a0dose of only 200 mg, you can take it as a single dose in the evening.\u00a0Once you have taken Leponex with good results for some period, your doctor may try a lower\u00a0dose.\u00a0You need to take Leponex for at least 6 months.<\/p>\n\n\n\n
Treatment of severe thought disorders in patients with Parkinson’s disease<\/strong><\/p>\n\n\n\nThe usual starting dose is 12.5 mg (half a 25 mg tablet) in the evening. Swallow the tablet with water.<\/p>\n\n\n\n
Your doctor will then gradually increase the\u00a0dose\u00a0one step by 12.5 mg, not faster than 2 steps in a week, all the way up to a maximum\u00a0dose\u00a0of 50 mg at the end of the second week.\u00a0Increases in\u00a0dosage\u00a0should be discontinued or postponed if you feel dizzy, dizzy, or confused.\u00a0To avoid such symptoms, your\u00a0blood pressure\u00a0will be measured during the first few weeks of treatment.<\/p>\n\n\n\n
The effective dose is usually between 25 mg and 37.5 mg, it is taken as a dose in the evening. Doses of 50 mg per day should only be exceeded in exceptional cases. The maximum daily dose is 100 mg. Always take the lowest dose that is effective for you.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, Leponex can cause side effects, although not everybody gets them.<\/p>\n\n\n\n
Some side effects may be serious and require immediate medical attention:<\/strong><\/p>\n\n\n\nTell your doctor immediately before taking the next Leponex tablet if you experience any of the following:<\/strong><\/p>\n\n\n\nVery common<\/strong> ( may affect more than 1 user in 10<\/em> ):<\/p>\n\n\n\n- severe constipation<\/strong> . Your doctor will treat this to avoid further complications.<\/li>
- fast heartbeat.<\/li><\/ul>\n\n\n\n
Common<\/strong> ( <\/em>may affect up to 1 in 10 people<\/em> ):<\/p>\n\n\n\n- signs of cold, fever, flu-like symptoms, sore throat or any other infection<\/strong> . Then you will need to take a blood test quickly to check if your symptoms are related to your medicine.<\/li>
- seizures.<\/li>
- suddenly faints or loses consciousness at the same time as you become muscle weak ( syncope ).<\/li><\/ul>\n\n\n\n
Uncommon<\/strong> ( may affect up to 1 in 100 people<\/em> ):<\/p>\n\n\n\n- a sudden rapid increase in body temperature, stiff muscles, which can lead to unconsciousness (malignant neuroleptic syndrome) as this can be a serious side effect that requires immediate treatment.<\/li>
- dizzy, dizzy or faint when standing up from a sitting or lying position as these may increase the risk of falling.<\/li><\/ul>\n\n\n\n
Rare<\/strong> ( may affect up to 1 in 1,000 people<\/em> ):<\/p>\n\n\n\n- signs of respiratory infection or pneumonia such as fever, cough, difficulty breathing or wheezing.<\/li>
- severe, burning, pain in the upper abdomen extending to the back as well as nausea and vomiting (due to inflammation of the pancreas).<\/li>
- faints and \/ or becomes muscle weak due to a sharp drop in blood pressure.<\/li>
- difficulty swallowing (which may cause you to put food in the trachea).<\/li>
- nausea, vomiting<\/strong> and \/ or loss of appetite<\/strong> . In these cases, your doctor needs to check your liver.<\/li>
- signs of becoming overweight or increasing obesity.<\/li>
- respiratory arrest with or without snoring during sleep.<\/li><\/ul>\n\n\n\n
Rare<\/strong> ( may affect up to 1 in 1,000 people<\/em> ) or Very rare<\/strong> ( may affect up to 1 in 10,000 users<\/em> ):<\/p>\n\n\n\n- rapid and irregular heartbeat<\/strong> even at rest, palpitations, difficulty breathing, chest pain<\/strong> or unexplained fatigue<\/strong> . Your doctor will need to examine your heart and, if necessary, refer you immediately to a cardiologist.<\/li><\/ul>\n\n\n\n
Very rare<\/strong> ( <\/em>may affect up to 1 in 10,000 people<\/em> ):<\/p>\n\n\n\n- persistent painful erection of the penis, if you are a man. This is called priapism. If you have an erection that lasts for more than 4 hours, immediate medical treatment may be necessary to avoid further complications.<\/li>
- spontaneous bleeding or bruising, which may be a sign of decreased platelet count .<\/li>
- symptoms due to uncontrolled blood sugar levels (such as nausea or vomiting, stomach pain, increased thirst, urination abnormally and often, confusion).<\/li>
- stomach pain, cramps, bloated stomach, vomiting, constipation and problems with gas in the gastrointestinal tract which may be signs and symptoms of intestinal obstruction (intestinal obstruction).<\/li>
- poor appetite, swollen stomach, stomach pain, yellow skin, severe weakness and malaise. These symptoms may be a sign that you have started to develop a liver disease that can lead to cell death in the liver ( fulminant liver necrosis).<\/li>
- nausea, vomiting, fatigue, weight loss that may be symptoms of inflammation of the kidneys.<\/li><\/ul>\n\n\n\n
Has been reported<\/strong> ( <\/em>occurs in an unknown number of users<\/em> ):<\/p>\n\n\n\n- oppressive chest pain, feeling of tightness in the chest (chest pain may radiate to the left arm, jaw, neck and upper abdomen), difficulty breathing, sweating, weakness, dizziness, nausea, vomiting and palpitations (signs of heart attack), which may be life-threatening. Seek emergency medical treatment immediately.<\/li>
- pressure over the chest, heaviness, tightness, burning or suffocating sensation (signs of insufficient blood flow and oxygen to the heart muscle), which can be life-threatening. Your doctor will need to check your heart.<\/li>
- periodic “throbbing”, “throbbing” or “fluttering” sensation in the chest (palpitations).<\/li>
- rapid and irregular heartbeat ( atrial fibrillation ). It can cause symptoms such as temporary palpitations, fainting, shortness of breath or chest pain. Your doctor will need to check your heart.<\/li>
- symptoms of low blood pressure such as dizziness, dizziness, fainting, blurred vision, unusual tiredness, cold and damp \/ sticky skin and nausea.<\/li>
- signs of blood clots in the veins, especially in the legs, (symptoms are swelling, pain and redness of the legs), which can be transported via the blood vessels to the lungs and cause chest pain and difficulty breathing.<\/li>
- diagnosed or suspected infection together with fever or low body temperature, abnormally fast breathing, fast heart rate, altered alertness and consciousness, drop in blood pressure (symptoms of sepsis ).<\/li>
- heavy sweating, headache, nausea, vomiting and diarrhea (symptoms of cholinergic syndrome).<\/li>
- severely decreased urine production (signs of kidney failure ).<\/li>
- allergic reaction (swelling mainly of the face, mouth and throat, as well as the tongue, which may be itchy or painful).<\/li>
- poor appetite, swollen stomach, stomach pain, yellow skin, severe weakness and malaise. It can be a sign of a kind of liver disease which means that normal liver tissue is replaced with scar tissue. This leads to reduced liver function, including liver effects that have life-threatening consequences such as liver failure (which can lead to death), liver damage (damage to liver cells, bile ducts in the liver or both) and liver transplantation.<\/li>
- burning pain in the upper abdomen, especially between meals, early in the morning, or after drinking acidic beverages; tar-like, black, or bloody stools; bloating, heartburn, nausea or vomiting, early feeling of satiety (intestinal ulcers in the stomach and \/ or intestines), which can be life-threatening.<\/li>
- severe abdominal pain aggravated by movement; nausea, vomiting, including bloody vomiting (coffee-like); tense abdomen with residual tenderness spreading across the abdomen; fever and \/ or chills (broken stomach or intestines), which can be life-threatening.<\/li>
- constipation, abdominal pain, abdominal tenderness, fever, bloating, bloody diarrhea. This may indicate a possible megacolon (enlargement of the intestines) or a blood clot in the blood vessels of the intestines (intestinal infarction \/ ischemia \/ necrosis), which can be life-threatening. Your doctor will need to examine you.<\/li>
- sharp chest pain with shortness of breath with or without cough<\/li>
- increased or new muscle weakness, muscle spasms, muscle pain. This may indicate a possible muscle disease ( rhabdomyolysis ). Your doctor will need to examine you.<\/li>
- sharp chest or abdominal pain with shortness of breath and with or without cough or fever.<\/li>
- Extremely intense and severe skin reactions, such as rash with eosinophilia and systemic symptoms (DRESS syndrome), have been reported with clozapine. Side effect can manifest itself as a rash with or without blisters. Skin irritation, edema , fever and flu-like symptoms may occur. Symptoms of DRESS syndrome usually occur about 2-6 weeks (possibly up to 8 weeks) after starting treatment.<\/li><\/ul>\n\n\n\n
If you get any of these\u00a0side effects, talk to your doctor immediately before taking your next Leponex tablet.<\/p>\n\n\n\n
Other side effects are<\/strong><\/p>\n\n\n\nVery common<\/strong> ( <\/em>may affect more than 1 user in 10<\/em> ):<\/p>\n\n\n\nDrowsiness, dizziness, increased saliva flow.<\/p>\n\n\n\n
Common<\/strong> ( may affect up to 1 in 10 people<\/em> ):<\/p>\n\n\n\nIncreased\u00a0white blood cell count\u00a0(\u00a0leukocytosis\u00a0), increased number of a specific type of\u00a0white blood cell count\u00a0(\u00a0eosinophilia\u00a0), weight gain, blurred vision, headache, tremors, stiffness, internal anxiety, twitching of arms and legs, muscle twitching, abnormal movements, inability to initiate movement, inability to remain immobile, changes in\u00a0ECG, high\u00a0blood pressure, fainting when getting up quickly, nausea, vomiting, loss of appetite,\u00a0dry mouth, slightly elevated values \u200b\u200bin liver tests, urinary incontinence, difficulty urinating, fatigue, fever, sweating, increased body temperature (speech difficulties, speech difficulties eg slurred speech).<\/p>\n\n\n\n
Uncommon<\/strong> ( may affect up to 1 in 100 people<\/em> ):<\/p>\n\n\n\nDecreased white blood cell count ( agranulocytosis ), speech difficulties (eg stuttering).<\/p>\n\n\n\n
Rare<\/strong> ( <\/em>may affect up to 1 in 1,000 people<\/em> ):<\/p>\n\n\n\nReduced number of\u00a0red cells\u00a0(\u00a0anemia\u00a0),\u00a0restlessness, excitement, confusion, irregular heartbeat,\u00a0inflammation\u00a0of the heart muscle (\u00a0myocarditis\u00a0) or\u00a0membrane\u00a0surrounding the heart muscle (pericarditis), fluid retention around the pericardial sac (pericardial effusion), high blood sugar levels in the blood,\u00a0diabetes mellitus, blood clots in the lungs (\u00a0thromboembolism\u00a0),\u00a0inflammation\u00a0of the liver (hepatitis), liver disease causing yellowing of the skin \/ dark urine\/itching, elevated levels of an\u00a0enzyme\u00a0called creatinine phosphokinase in the blood.<\/p>\n\n\n\n
Very rare<\/strong> ( <\/em>may affect up to 1 in 10,000 people<\/em> ):<\/p>\n\n\n\nIncreased numbers of\u00a0platelets\u00a0with the risk of blood clots, involuntary twitching of the arms and legs, obsessive thoughts and compulsive repetitive behavior (signs of obsessive-compulsive disorder), skin reactions, swelling in front of the ear (enlargement of the parotid glands), difficulty in breathing, very high levels of\u00a0triglycerides\u00a0you or\u00a0cholesterol\u00a0in the blood, heart muscle disease (\u00a0cardiomyopathy\u00a0), cardiac arrest, sudden unexplained death.<\/p>\n\n\n\n
Has been reported<\/strong> ( occurs in an unknown number of users<\/em> ) :<\/em><\/p>\n\n\n\nChanges in brain activity (seen on electroencephalogram \/ EEC), diarrhea, stomach pain, heartburn, stomach pain after the meal, muscle weakness, muscle cramps, muscle aches, nasal congestion, nocturnal bedwetting, sudden, uncontrollable increase in\u00a0blood pressure\u00a0(pseudopheochromocytoma)\u00a0(<\/em>\u00a0pleurothotonus), disturbed ejaculation in men which means that semen enters the bladder instead of ejaculation through the penis (dry orgasm or\u00a0retrograde\u00a0ejaculation),\u00a0rash,\u00a0purplish-red spots, fever or\u00a0itching\u00a0due to\u00a0inflammation\u00a0of blood vessels,\u00a0inflammation in the colon that causes diarrhea, abdominal pain, fever, changes in skin color, redness of the face, joint pain, muscle aches, fever and fatigue (lupus erythematosus\u00a0).\u00a0<\/strong>Restless legs syndrome (<\/em>\u00a0compulsive need to move your legs or arms. This is usually accompanied by unpleasant sensations during times of rest, especially in the evening or at night, and is temporarily relieved by movement).<\/p>\n\n\n\nIn the elderly with dementia, a small increase in the number of deaths has been reported for patients who have been treated with antipsychotics compared with those who have not been treated.<\/p>\n\n\n\n
How to store Leponex<\/h2>\n\n\n\n- Keep this medicine out of the sight and reach of children.<\/li>
- Do not use Leponex after the expiry date which is stated on the blister \/ jar and carton. The expiration date is the last day of the specified month.<\/li>
- No special storage instructions.<\/li>
- Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n- The active substance is clozapine. Each tablet contains 25 mg clozapine resp. 100 mg clozapine.<\/li>
- The other ingredients are magnesium stearate, colloidal silicic acid, povidone K30, talc, corn starch, lactose monohydrate .<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Both strengths of Leponex are available in PVC \/ PVDC \/ aluminum or PVC \/ PE \/ PVDC \/ aluminum blister packs containing 7, 14, 20, 28, 30, 40, 50, 60, 84, 98, 100, 500 (10×50) or 5000 ( 100×50) tablets.<\/p>\n\n\n\n
PVC \/ PVDC \/ Aluminum or PVC \/ PE \/ PVDC \/ Aluminum, perforated single-dose blister containing 7 x 1, 14 x 1, 20 x 1, 28 x 1, 30 x 1, 40 x 1, 50 x 1, 60 x 1, 84 x 1.98 x 1, 100 x 1, 500 (10 x 50 x 1) and 5000 (100 x 50 x 1) tablets and in white plastic jars containing 100 or 500 tablets.<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder:<\/em><\/p>\n\n\n\nBGP Products AB<\/p>\n\n\n\n
Box 23033<\/p>\n\n\n\n
104 35 Stockholm<\/p>\n\n\n\n
Manufacturer:<\/em><\/p>\n\n\n\nMylan Hungary Kft.<\/p>\n\n\n\n
Mylan UTC 1<\/p>\n\n\n\n
Kom\u00e1rom 2900<\/p>\n\n\n\n
Hungary<\/p>\n\n\n\n
Alternative manufacturers<\/strong><\/p>\n\n\n\nMcDermott Laboratories Limited T \/ A Gerard Laboratories T \/ A Mylan Dublin<\/p>\n\n\n\n
Unit 35\/36 Baldoyle Industrial Estate, Grange Road, Dublin 13, Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"
The active substance in Leponex is clozapine which belongs to a group of medicines called antipsychotic medicines, which are used to treat specific mental conditions e.g. psychos .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15662,15668,2304,2430,6864,15663,15667,15666,15661,6863,15664,15665],"class_list":["post-16400","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefit-of-clozapine","tag-benefits-of-leponex","tag-clozapine","tag-clozapine-side-effects","tag-clozapine-tablet","tag-leponex","tag-leponex-side-effects","tag-leponex-tablet","tag-what-clozapine-is-used-for","tag-what-is-clozapine","tag-what-is-leponex","tag-what-leponex-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16400"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16400\/revisions"}],"predecessor-version":[{"id":16441,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16400\/revisions\/16441"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}