{"id":16397,"date":"2021-12-07T09:56:01","date_gmt":"2021-12-07T09:56:01","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16397"},"modified":"2023-01-02T16:05:22","modified_gmt":"2023-01-02T16:05:22","slug":"lepheton","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lepheton\/","title":{"rendered":"Lepheton | Ethylmorphine Hydrochloride, Ephedrine Hydrochloride | Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Lepheton ethylmorphine hydrochloride, ephedrine hydrochloride oral&nbsp;solution<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lephetone Is And What Lepheton Used For<\/h2>\n\n\n\n<p>Lephetone contains ethylmorphine, which has an antitussive and mild sedative effect, and\u00a0ephedrine,\u00a0which has a mucosal\u00a0decongestant and bronchodilator effect.<\/p>\n\n\n\n<p>Lephetone is used for the short-term treatment of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">whooping cough<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before You Use Lepheton<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Lepheton<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to ethylmorphine,\u00a0ephedrine\u00a0or any of the other ingredients of this medicine (listed in section 6),<\/li><li>To children and adolescents (0-18 years) who have obstructive sleep apnea syndrome or are undergoing or are planning to undergo removal of tonsils or\u00a0polyps,<\/li><li>If you know that you very quickly convert ethyl morphine to morphine.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Lepheton<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have cardiovascular disease,<\/li><li>If you have an overactive\u00a0thyroid gland\u00a0(\u00a0hyperthyroidism\u00a0),<\/li><li>If you have an enlarged\u00a0prostate,<\/li><li>If you have\u00a0diabetes,<\/li><li>If you have\u00a0glaucoma,\u00a0<\/li><li>If you have\u00a0asthma.\u00a0Ethylmorphine can worsen breathing problems.<\/li><\/ul>\n\n\n\n<p>Due to its content of&nbsp;ephedrine,&nbsp;lephetone may&nbsp;increase blood pressure, which is why patients with high&nbsp;blood pressure&nbsp;should consult a doctor before starting treatment with lephetone.<\/p>\n\n\n\n<p>There is a certain risk of developing addiction in high&nbsp;doses&nbsp;and long-term use.<\/p>\n\n\n\n<p>As&nbsp;dry mouth&nbsp;occurs, careful oral hygiene (brushing with fluoride toothpaste twice a day) during the use of Lepheton is important.<\/p>\n\n\n\n<p>Ethyl morphine is converted to morphine in the liver by an\u00a0enzyme.\u00a0It is morphine that gives the <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a> suppressant effect.\u00a0The ability to convert ethylmorphine differs between different people, and one can be affected differently.\u00a0Some people have an increased risk of serious\u00a0side effects\u00a0because a large amount of morphine can be formed quickly in the liver.\u00a0Get any of the following side effects. You must stop taking this medicine and contact a doctor immediately: <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Slow or shallow breathing<\/li><li>Confusion<\/li><li>Drowsiness<\/li><li>Small\u00a0pupils<\/li><li>Nausea<\/li><li>Vomiting<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/constipation\/\">Constipation<\/a><\/li><li>Loss of appetite<\/li><\/ul>\n\n\n\n<p>If you have previously reacted strongly to medicines containing ethylmorphine of\u00a0codeine,\u00a0you should tell your doctor before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Lephetone should not be used in children under 2 years of age.<\/p>\n\n\n\n<p>Use in children with respiratory problems. Ethylmorphine is not recommended for children with respiratory problems that may occur in, for example, neuromuscular diseases, severe heart and respiratory conditions, or severe\u00a0infections\u00a0of the upper respiratory tract or lungs, as the symptoms of morphine poisoning may be more severe in these children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Lephetone<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Concomitant use of Lepheton and certain medicines increase the risk of <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/fatigue-syndrome\/\">fatigue<\/a>, impaired breathing (&nbsp;respiratory depression&nbsp;), and unconsciousness and can be life-threatening.&nbsp;Examples of these drugs are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Strong painkillers (opioid drugs)<\/li><li>Sedatives and hypnotics (eg\u00a0benzodiazepines\u00a0and certain\u00a0antihistamines\u00a0)<\/li><li>Anaesthetics for anaesthesia before e.g.\u00a0an operation<\/li><li>Certain medicines for mental illness (phenothiazines)<\/li><li>Muscle relaxants<\/li><li>Some medicines used to prevent blood clots (eg clopidogrel, prasugrel, ticagrelor) may have a delayed or reduced effect when taken with opium.<\/li><\/ul>\n\n\n\n<p>Due to this, concomitant use of Lepheton and the above medicines should only be considered by your doctor when other treatment options are not possible.\u00a0If your doctor prescribes Lepheton at the same time as any of the above medicines, your\u00a0dose\u00a0and treatment time\u00a0should be\u00a0limited by your doctor.\u00a0Tell your doctor if you are taking any of the above medicines, and follow your doctor&#8217;s dose recommendations.\u00a0It may be helpful to inform friends or relatives about being aware of the signs and symptoms listed above.\u00a0Contact your doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>The treatment effect can also be affected if Lepheton is taken at the same time as certain other medicines, such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Certain antidepressants (moclobemide, selegelin),<\/li><li>Dexamethasone (an\u00a0asthma\u00a0medicine\u00a0),<\/li><li>Certain other medicines may affect or be affected by treatment with Lepheton,<\/li><li>Other preparations, including dietary supplements containing\u00a0ephedrine, should not be used during treatment with Lepheton.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Lepheton With Alcohol<\/h2>\n\n\n\n<p>Alcohol consumption should be avoided during treatment with Lepheton.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding And Fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Lephetone should not be used during pregnancy. Ephedrine\u00a0and ethyl morphine passes into breast milk.\u00a0Lephetone should not be used during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>During treatment with Lepheton, dizziness may occur.\u00a0Reactivity can also be reduced.\u00a0This should be considered when sharper attention is required, e.g.\u00a0while driving.<\/p>\n\n\n\n<p>You are responsible for assessing whether you can drive a motor vehicle or perform work requiring sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lephetone Contains sorbitol, Sodium And Macrogol Glycerol Hydroxystearate.<\/h2>\n\n\n\n<p>This medicine contains 560 mg sorbitol per ml.\u00a0Sorbitol is a source of fructose.\u00a0If you (or your child) do not tolerate certain sugars, or if you (or your child) have been diagnosed with\u00a0hereditary\u00a0fructose intolerance, a rare, inherited disease that\u00a0prevents fructose\u00a0from being broken down, consult a doctor before using this medicine.\u00a0Sorbitol may cause gastrointestinal discomfort and may have a mild laxative effect.<br>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per ml, essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<p>Lephetone contains macrogol glycerol hydroxy stearate, which may cause stomach upset and diarrhoea.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Use Lepheton<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always take this medicine exactly as your doctor has told you.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0Do not exceed the\u00a0dose\u00a0specified by your doctor.<\/li><li>Overdose increases the risk of fatigue, impaired breathing (\u00a0respiratory depression\u00a0), and unconsciousness.\u00a0Overdose can be life-threatening.<\/li><li>Not for long-term treatment.<\/li><li>Dose\u00a0one is determined by the doctor, who adjusts it individually for you.<\/li><li>The recommended\u00a0dose\u00a0for adults is 20 ml 3 times daily.<\/li><li>The recommended\u00a0dose\u00a0for children 11-12 years (30-40 kg) is 10 ml 3 times daily.<\/li><li>The recommended\u00a0dose\u00a0for children 6-10 years (20-30 kg) is 7.5 ml 3 times daily.<\/li><li>The recommended\u00a0dose\u00a0for children 3-5 years (15-20 kg) is 5 ml 3 times daily.<\/li><li>The recommended\u00a0dose\u00a0for children 2 years (13-15 kg) is 2.5 ml 3 times daily.<\/li><\/ul>\n\n\n\n<p><strong>Small\u00a0doses\u00a0(2.5\u20135 ml) should be given with a dosing syringe to obtain an exact\u00a0dosage<\/strong>.\u00a0Use a 5 ml dosing syringe with a <strong>graduation of 0.5 ml.<\/strong><\/p>\n\n\n\n<p><strong>NOTE: dosing syringe is not included in the package but is available from the pharmacy.<\/strong><\/p>\n\n\n\n<p><strong>How to measure and give a&nbsp;dose&nbsp;with a dosing syringe<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Unscrew the cap from the bottle.<\/li><li>Attach the syringe adapter to the neck of the bottle and make sure it is firmly seated.<\/li><li>Make sure that the plunger on the dosing syringe is depressed.\u00a0Then push the tip of the dosing syringe into the hole on the syringe adapter.<\/li><li>Turn the bottle upside down.\u00a0Slowly pull the plunger out of the syringe to the number of ml to be given.<\/li><li>Turn the bottle right again and remove the dosing syringe from the bottle.<\/li><li>Insert the dosing syringe into the baby&#8217;s mouth, point the dosing syringe at the inside of the cheek, and slowly push the plunger in until the baby has swallowed everything.<\/li><li>Remove the adapter and put the cap back on the bottle.<\/li><li>Clean the dosing syringe and adapter with water after use.<\/li><\/ol>\n\n\n\n<ul class=\"wp-block-list\"><li>In diabetics, there is some risk of temporarily rising <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar levels<\/a>, but it is uncommon to take this medicine.<\/li><li>Keep this medicine out of sight and reach of children.<\/li><li>Do not use this medicine after the expiry date stated on the bottle after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines that are no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Lepheton Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em>\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficulty urinating<\/li><li>Especially in older men with an enlarged\u00a0prostate<\/li><li>Dizziness<\/li><li>Headache<\/li><li>Nausea<\/li><li>Constipation<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em>\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sweating<\/li><li>Palpitations<\/li><li>Tremors<\/li><li>Anxiety<\/li><li>Insomnia<\/li><li>Dry mouth<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em>\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Muscle weakness<\/li><li>Bile problems<\/li><li>Hallucinations<\/li><li>Hives<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Pack And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are ethylmorphine hydrochloride 0.82 mg\/ml and ephedrine hydrochloride 2.05 mg\/ml.<\/li><li>The other ingredients are macrogol glycerol hydroxy stearate, citric acid, sodium citrate, sorbic acid (\u00a0preservative\u00a0E 200), and purified water.\u00a0Sweetening: sorbitol 560 mg\/ml, saccharin sodium 0.30 mg\/ml.\u00a0Flavours: anise oil, honey aroma, orange aroma.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Colourless to slightly yellow,\u00a0viscous\u00a0solution.<\/li><li>Pack sizes: 250 ml, 500 ml, and 1000 ml in a brown glass bottle with a child-resistant lid in white plastic.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Meda AB<\/p>\n\n\n\n<p>Box 906<\/p>\n\n\n\n<p>170 09 Solna<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Unimedic AB<\/p>\n\n\n\n<p>Box 91<\/p>\n\n\n\n<p>864 21 Matfors<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ephedrine\/ethylmorphine (Lepheton) is a mixture of medications used as an antitussive.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15636,4685,15631,15632,15637,15635,15638,2212,15633,15634],"class_list":["post-16397","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-lepheton","tag-ephedrine-hydrochloride","tag-ethylmorphine-hydrochloride","tag-lepheton","tag-lepheton-dosage","tag-lepheton-side-effects","tag-lepheton-uses","tag-medicine","tag-what-is-lepheton","tag-what-lepheton-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16397"}],"version-history":[{"count":37,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16397\/revisions"}],"predecessor-version":[{"id":42653,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16397\/revisions\/42653"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}