{"id":16323,"date":"2021-12-06T10:03:46","date_gmt":"2021-12-06T10:03:46","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16323"},"modified":"2021-12-09T07:12:05","modified_gmt":"2021-12-09T07:12:05","slug":"lecigon","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lecigon\/","title":{"rendered":"Lecigon &#8211; Levodopa \/ carbidopamonohydrate \/ entacapone uses, dose and side effects"},"content":{"rendered":"\n<p>20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml intestinal gel<br>levodopa \/ carbidopamonohydrate \/ entacapone<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lecigon is and what it is used for<\/h2>\n\n\n\n<p>Lecigon is used to treat\u00a0Parkinson&#8217;s disease.\u00a0It is used in severe illness when oral drugs (drugs taken by mouth) have not given sufficient effect.<\/p>\n\n\n\n<p>Lecigon is a&nbsp;gel&nbsp;for&nbsp;continuous&nbsp;supply that is given through a pump and a probe (tube) directly into the small intestine.&nbsp;Lecigon contains three active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>levodopa<\/li><li>carbidopa (in the form of carbidopamonohydrate)<\/li><li>entakapon<\/li><\/ul>\n\n\n\n<p><strong>How Lecigon works<\/strong><\/p>\n\n\n\n<p>In\u00a0Parkinson&#8217;s disease, the levels of the substance\u00a0dopamine\u00a0in the brain are low.\u00a0Levodopa is\u00a0converted to\u00a0dopamine\u00a0in the brain, thus relieving the symptoms of\u00a0Parkinson&#8217;s disease.\u00a0Carbidopa and entacapone improve the effect of\u00a0levodopa\u00a0on\u00a0Parkinson&#8217;s disease.<\/p>\n\n\n\n<p>Levodopa \/ carbidopa monohydrate\/entacapone contained in Lecigon may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Lecigon<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Lecigon if you:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>is allergic to&nbsp;levodopa&nbsp;, carbidopa, entacapone or any of the other ingredients of this medicine (listed in section 6).<\/li><li>have an eye disease called&nbsp;narrow-angle glaucoma&nbsp;(a type of&nbsp;glaucoma&nbsp;that is&nbsp;acute&nbsp;).<\/li><li>have severe&nbsp;heart failure&nbsp;.<\/li><li>have severe&nbsp;cardiac arrhythmia&nbsp;(irregular heartbeat).<\/li><li>recently had a&nbsp;stroke&nbsp;.<\/li><li>have a serious liver disease.<\/li><li>take certain antidepressants, so-called selective MAO-A inhibitors (such as moclobemide) and non-selective&nbsp;MAO inhibitors&nbsp;(such as phenelzine).&nbsp;Treatment with these drugs must be stopped at least two weeks before starting treatment with Lecigon.&nbsp;See also section &#8220;Other medicines and Lecigon&#8221;.<\/li><li>have&nbsp;pheochromocytoma&nbsp;(&nbsp;tumor&nbsp;of the adrenal gland that leads to overproduction of&nbsp;adrenaline&nbsp;and&nbsp;norepinephrine&nbsp;).<\/li><li>have Cushing&#8217;s syndrome (overproduction of&nbsp;cortisol&nbsp;).<\/li><li>have&nbsp;hyperthyroidism&nbsp;(overproduction of thyroid hormone).<\/li><li>previously suffered from malignant neuroleptic syndrome (a severe, rare, reaction that may occur during treatment or&nbsp;discontinuation&nbsp;of certain drugs).<\/li><li>previously afflicted with&nbsp;rhabdomyolysis&nbsp;(a serious, rare, muscular disease with renal impairment).&nbsp;have previously had skin cancer, or if you have any abnormal birthmarks or rashes on the skin that have not been examined by a doctor.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><em>Talk to your doctor&nbsp;<strong>before using<\/strong>&nbsp;<\/em>Lecigon if you have or have had:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart attack or other cardiovascular disease including angina and irregular heartbeat.<\/li><li>asthma&nbsp;or other lung disease.<\/li><li>kidney or liver disease.<\/li><li>hormonal disease.<\/li><li>stomach ulcer&nbsp;.<\/li><li>seizures.<\/li><li>severe mental illness, such as&nbsp;psychosis&nbsp;.<\/li><li>an eye disease called wide-angle glaucoma (a type of&nbsp;glaucoma&nbsp;).<\/li><li>underwent surgery in the upper abdomen.<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor immediately if you get any of the following symptoms during treatment with Lecigon:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Malignant neuroleptic syndrome:<\/strong>A severe condition with a combination of muscle stiffness, cramps, tremors, sweating, fever, rapid&nbsp;pulse&nbsp;, sharp blood pressure fluctuations, extravagant behavior, confusion, unconsciousness.<\/li><li><strong>Rhabdomyolysis:<\/strong>&nbsp;A severe condition with unexplained muscle pain, muscle cramps or muscle weakness.&nbsp;Rhabdomyolysis&nbsp;can be caused by malignant neuroleptic syndrome.<ul><li>For more information on malignant neuroleptic syndrome and&nbsp;rhabdomyolysis&nbsp;, see section 3 &#8220;If you stop using Lecigon or lower your dose&#8221; and section 4 &#8220;Possible side effects&#8221;.<\/li><\/ul><\/li><li><strong>Problems from the probe or operation:<\/strong>Stomach pain, nausea or vomiting.&nbsp;This may be due to serious problems caused by the probe or surgery e.g.&nbsp;blockages, ulcers or injuries in the intestine.<\/li><\/ul>\n\n\n\n<p><em>Talk to your doctor if you are&nbsp;<strong>being treated<\/strong>&nbsp;with Lecigon:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feeling&nbsp;<strong>depressed<\/strong>&nbsp;, having&nbsp;<strong>suicidal thoughts<\/strong>&nbsp;or noticing other&nbsp;<strong>mental changes<\/strong>&nbsp;.<\/li><li>Detects&nbsp;<strong>abnormal birthmarks<\/strong>&nbsp;or rashes on the skin that you have not seen before or that have changed.<\/li><li>get&nbsp;<strong>involuntary movements<\/strong>&nbsp;(&nbsp;dyskinesia&nbsp;).&nbsp;If you have not been treated with entacapone before (one of the active substances in Lecigon), the symptoms may be due to the fact that entacapone enhances the effect of&nbsp;levodopa&nbsp;and carbidopa (active substances that are also included in Lecigon).&nbsp;Your doctor may need to reduce your&nbsp;dose&nbsp;.<\/li><li>experience that the&nbsp;<strong>effect of the treatment suddenly or gradually deteriorates<\/strong>&nbsp;, e.g.&nbsp;that you have difficulty moving \/ slow movements (&nbsp;bradykinesia&nbsp;).&nbsp;This may be because the probe has jumped out of position in the small intestine, it has become clogged or the pump is not working properly.<\/li><li>gets&nbsp;<strong>diarrhea<\/strong>&nbsp;.&nbsp;Your weight may need to be monitored to avoid any significant weight loss or treatment may need to be stopped.&nbsp;Prolonged or persistent diarrhea can be a sign of&nbsp;inflammation&nbsp;in the intestine and your doctor will then need to review your treatment with Lecigon.<\/li><li>experiences&nbsp;<strong>loss of appetite<\/strong>&nbsp;that worsens over time,&nbsp;<strong>weakness<\/strong>&nbsp;and&nbsp;<strong>weight loss<\/strong>&nbsp;within a short period of time.&nbsp;A general medical examination including examination of liver function may be needed.<\/li><\/ul>\n\n\n\n<p>In case of impaired ability to handle the pump and probe, you must seek the help of a healthcare provider (eg nurse, health care assistant, or relative) to avoid complications (problems).<\/p>\n\n\n\n<p><em>Disrupted impulse control &#8211; changes in your behavior<\/em><\/p>\n\n\n\n<p>Tell your doctor if you, your family, or caregivers notice that you develop urges or desires that make you behave in ways that are unusual for you or if you can not resist the impulse, drive, or temptation to perform certain activities that may harm you or others.\u00a0These behaviors are called &#8220;disturbed impulse control&#8221; and may include gambling addiction, compulsive eating or spending of money, abnormally high sex drive or an increase in sexual thoughts or feelings.\u00a0<em>Your doctor may need to adjust your\u00a0dose\u00a0or discontinue your treatment.\u00a0<\/em>For more information, see section 4 &#8220;Possible side effects&#8221;.<\/p>\n\n\n\n<p><em>Dopaminergic dysregulation syndrome<\/em><\/p>\n\n\n\n<p>Tell your doctor if you or your family\/caregiver notice that you are developing addictive symptoms that lead to a craving for higher\u00a0doses\u00a0of Lecigon and other medicines used to treat\u00a0Parkinson&#8217;s disease.<\/p>\n\n\n\n<p><em>Regular checks<\/em><\/p>\n\n\n\n<p>During long-term treatment with Lecigon, your doctor may need to have regular check-ups of liver and kidney function, blood counts, heart and blood\u00a0vessels,\u00a0and examine the skin to detect any skin changes.<\/p>\n\n\n\n<p><em>Lecigon and cancer<\/em><\/p>\n\n\n\n<p>Lecigon contains hydrazine, which is formed during the breakdown of carbidopa (an active substance in Lecigon).\u00a0Hydrazine can be harmful to the genes and this can cause cancer.\u00a0It is not known whether the amount of hydrazine added at the recommended\u00a0dose\u00a0of Lecigon can cause injury or illness.<\/p>\n\n\n\n<p><em>Operation<\/em><\/p>\n\n\n\n<p>If you need to have surgery, including dental surgery, tell your doctor or dentist that you are using Lecigon.<\/p>\n\n\n\n<p><em>Urine sample<\/em><\/p>\n\n\n\n<p>The active substances&nbsp;levodopa&nbsp;and carbidopa may cause misleading results in urine tests.&nbsp;Therefore, mention that you are taking Lecigon if you are taking a urine sample.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Lecigon should not be given to children or adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Lecigon<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p><em>Do&nbsp;<strong>not<\/strong>&nbsp;use Lecigon if you are taking&nbsp;<strong>:<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain antidepressants, so-called selective MAO-A inhibitors (such as moclobemide) and non-selective&nbsp;MAO inhibitors&nbsp;(such as phenelzine).&nbsp;Treatment with these drugs must be stopped at least two weeks before starting treatment with Lecigon.<\/li><\/ul>\n\n\n\n<p>Lecigon may&nbsp;<em>potentiate the effects and&nbsp;side effects&nbsp;of other&nbsp;<\/em><em>medicines<\/em>&nbsp;and other medicines may&nbsp;<em>increase the effects and&nbsp;side effects&nbsp;of Lecigon.&nbsp;<\/em>Talk to your doctor if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>certain antidepressants, so-called tricyclic drugs (such as clomipramine, amitriptyline and nortriptyline).&nbsp;Other types of antidepressants could also affect or be affected by Lecigon.<\/li><li>certain other medicines for&nbsp;Parkinson&#8217;s disease&nbsp;, so-called selective MAO-B inhibitors (such as&nbsp;selegiline&nbsp;), amantadine and dopamine agonists (such as piribedil) and anticholinergics (such as biperiden).<\/li><li>drugs for urinary incontinence (such as oxybutynin),&nbsp;asthma&nbsp;and&nbsp;chronic obstructive pulmonary disease&nbsp;, COPD (such as ipratropium and <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiogiva\/\">tiotropium<\/a>).&nbsp;These are so-called anticholinergic drugs.<\/li><li>certain&nbsp;asthma&nbsp;and allergy medicines (such as&nbsp;salbutamol&nbsp;and&nbsp;terbutaline&nbsp;) and&nbsp;adrenaline&nbsp;.&nbsp;These are so-called sympathomimetic drugs.<\/li><li>antihypertensive drugs.&nbsp;Concomitant use with Lecigon may cause a drop in blood pressure when you get up from a sitting or lying position.&nbsp;The dose of&nbsp;one of the antihypertensive drugs may need to be adjusted.<\/li><li>warfarin&nbsp;(a medicine to prevent blood clots).&nbsp;If you are being treated, started, stopped or changed treatment with Lecigon, the effect of&nbsp;warfarin&nbsp;should be monitored&nbsp;.<\/li><\/ul>\n\n\n\n<p>Some medicines may&nbsp;<em>reduce the effect<\/em>&nbsp;of Lecigon.&nbsp;Talk to your doctor if you are taking:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>oral iron preparations (tablets, capsules, solution).&nbsp;Iron may impair the absorption of&nbsp;levodopa&nbsp;from the gastrointestinal tract (and vice versa).&nbsp;You should therefore take Lecigon and iron supplements at least 2-3 hours apart.&nbsp;If you do not use the pump during the night, you can take the iron preparation before bedtime.<\/li><li>drugs for&nbsp;psychosis&nbsp;(such as phenothiazines, butyrophenones (eg,&nbsp;haloperidol&nbsp;) and&nbsp;risperidone&nbsp;).<\/li><li>antiemetic drugs (such as metoclopramide).<\/li><li>antiepileptic&nbsp;drugs&nbsp;(such as clonazepam and&nbsp;phenytoin&nbsp;).<\/li><li>sedatives and hypnotics, so-called&nbsp;benzodiazepines&nbsp;(such as&nbsp;diazepam&nbsp;,&nbsp;oxazepam&nbsp;and nitrazepam).<\/li><li>drugs against&nbsp;tuberculosis&nbsp;(&nbsp;isoniazid&nbsp;).<\/li><li>medicines for convulsions in the gastrointestinal tract (papaverine).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Lecigon with food, drink and alcohol<\/h2>\n\n\n\n<p>Lecigon is less well absorbed immediately after consuming protein-rich foods (eg meat, fish, dairy products, nuts, and seeds).\u00a0Talk to your doctor if you are on a high protein diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Lecigon is not recommended during pregnancy or in women of childbearing potential not using contraception unless the doctor considers that the benefits to the mother outweigh the potential risks to the fetus.<\/p>\n\n\n\n<p>You should not breastfeed while being treated with Lecigon.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Lecigon can have a significant effect on the ability to drive and use machines.&nbsp;Do not drive or use machines until you know how Lecigon affects you.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lecigon can make you feel very sleepy, or sometimes you suddenly fall asleep (sleep attacks).<\/li><li>Lecigon can cause a drop in blood pressure e.g.&nbsp;when getting up from a sitting or lying position as well as dizziness.<\/li><\/ul>\n\n\n\n<p>Wait until you feel properly awake or do not feel dizzy before driving, using tools or machines, or performing other activities where diminished attention may&nbsp;put&nbsp;you or others at risk.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Lecigon<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Lecigon<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor, nurse or pharmacist has told you.\u00a0If you are not sure, talk to your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<p><strong>How Lecigon is given<\/strong><\/p>\n\n\n\n<p>Lecigon is a\u00a0gel\u00a0that is given through a portable pump (Crono LECIG) and a probe directly into the upper part of the small intestine.\u00a0Gel\u00a0one is provided in a\u00a0cartridge\u00a0that is connected to the pump.\u00a0The pump is connected to a probe that has been operated on in the intestine via the abdominal wall.<\/p>\n\n\n\n<p>During the day, a small\u00a0dose is\u00a0added\u00a0continuously.\u00a0This means that the level of drugs in the blood becomes more even and the risk of\u00a0side effects, such as movement disorders, is less compared to drugs taken by mouth.<\/p>\n\n\n\n<p>Before the probe is inserted into the small intestine, the doctor can choose to check if the treatment with Lecigon works for you.\u00a0A gel\u00a0is then given via a probe that goes through the nose, pharynx, and stomach to the small intestine.<\/p>\n\n\n\n<p><em>A manual with instructions for using the pump is supplied with the pump.<\/em><\/p>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>The doctor will adjust the&nbsp;doses&nbsp;individually to you based on previous medication.&nbsp;Dosage&nbsp;one may need to be fine-tuned during the first few weeks of treatment.<\/p>\n\n\n\n<p>In the morning when the treatment is started, a larger&nbsp;dose&nbsp;is given&nbsp;to quickly reach the right drug levels in the blood (so-called&nbsp;bolus dose&nbsp;).&nbsp;Thereafter, a&nbsp;continuous&nbsp;maintenance&nbsp;dose is given&nbsp;during the waking hours (usually about 16 hours).&nbsp;If necessary, your doctor may decide to give you Lecigon for up to 24 hours a day.<\/p>\n\n\n\n<p>If necessary, extra doses can also be given.&nbsp;Individuals may also need to increase or decrease the continuous maintenance dose during the day.&nbsp;How and when you take these extra doses or adjust the&nbsp;dose&nbsp;during the day will be decided by your doctor in consultation with you.<\/p>\n\n\n\n<p>The total daily dose, including morning dose (\u00a0bolus dose\u00a0), maintenance dose, and extra dose, should not exceed 100 ml (equivalent to 2000 mg\u00a0levodopa, 500 mg carbidopa, and 2000 mg entacapone).<\/p>\n\n\n\n<p>If the user has dementia, the doctor may decide that the pump should only be handled by a healthcare professional or relative.\u00a0The pump can be locked to avoid\u00a0accidentally exceeding\u00a0the daily recommended\u00a0dose.<\/p>\n\n\n\n<p><em>Started&nbsp;cartridge<\/em><\/p>\n\n\n\n<p>Ampoules\u00a0with medicines are for single use only and should not be used for more than 24 hours, even if there are medicines left.\u00a0Dosing pump with mounted\u00a0ampoule\u00a0can be carried close to the body for up to 16 hours and during treatment at night, the pump should not be carried next to the body but can e.g.\u00a0be stored on the bedside table.\u00a0If you have had a break in treatment during the night, you can continue to use the started\u00a0ampoule the\u00a0next day, but only for up to 24 hours after it was first opened.\u00a0Do not\u00a0remove the ampoule\u00a0from the pump before using it (ie either after 24 hours after opening or when it is closed, whichever comes first).<\/p>\n\n\n\n<p>Gel\u00a0one may turn pale yellow\/reddish at the end of the shelf life.\u00a0This does not affect the effectiveness of the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0To reduce the risk of\u00a0side effects, it is important to adjust the\u00a0dose\u00a0of the drug individually with the appropriate setting of the pump.<\/p>\n\n\n\n<p><strong><em>Serious&nbsp;side effects&nbsp;are with Lecigon<\/em><\/strong><\/p>\n\n\n\n<p><strong>Contact a&nbsp;<\/strong><strong>doctor&nbsp;<\/strong><strong>immediately&nbsp;<\/strong><strong>if you get any of the following symptoms during treatment with Lecigon &#8211; you may need&nbsp;emergency&nbsp;medical treatment:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Itching&nbsp;,&nbsp;hives&nbsp;, swelling of the face, lips, tongue or throat, which may make it difficult to breathe or swallow.&nbsp;Drop in blood pressure.&nbsp;This may be a sign of a severe&nbsp;<strong>allergic reaction<\/strong>&nbsp;<em>&nbsp;(rare side effect).<\/em><\/li><li>A combination of muscle stiffness, cramps, tremors, sweating, fever, rapid&nbsp;pulse&nbsp;, sharp blood pressure fluctuations, extravagant behavior, confusion, unconsciousness.&nbsp;These can be symptoms of a serious condition called&nbsp;<strong>malignant neuroleptic syndrome&nbsp;<\/strong>&nbsp;<em>(occurring in an unknown number of users).<\/em><\/li><li>Unexplained muscle pain, muscle cramps or muscle weakness which may be signs of&nbsp;<strong>rhabdomyolysis<\/strong>&nbsp;, a serious, rare, muscle disease with breakdown of muscle cells and which may cause severe kidney damage&nbsp;<em>(no known frequency (can not be calculated from the available data))<\/em>&nbsp;.&nbsp;Rhabdomyolysis&nbsp;can be caused by malignant neuroleptic syndrome.<br>For more information on neuroleptic malignant syndrome and&nbsp;rhabdomyolysis,&nbsp;see section 3 &#8220;If you stop using Lecigon or lower your dose&#8221;.<\/li><li>Stomach pain, nausea or vomiting.&nbsp;This may be due to&nbsp;<strong>serious problems caused by the probe or surgery<\/strong>&nbsp;e.g.&nbsp;blockages, ulcers or injuries in the intestine&nbsp;<em>(common side effect)<\/em>&nbsp;.<\/li><li>Infection&nbsp;with symptoms such as fever with severely deteriorating general condition or fever with local infection symptoms such as sore throat \/ throat \/ mouth or difficulty urinating.&nbsp;This may be a sign that the white&nbsp;blood cells&nbsp;are affected, so-called&nbsp;<strong>agranulocytosis&nbsp;<\/strong><em>(no known frequency &#8211; can not be calculated from the available data)<\/em>&nbsp;.&nbsp;Your doctor will take a blood test to check this.<\/li><li>Suicidal ideation or suicide attempt&nbsp;<em>(less common side effect)<\/em>&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong><em>Other&nbsp;side effects&nbsp;that may occur with Lecigon:<\/em><\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Weight loss.<\/li><li>Anxiety, anxiety, depression, insomnia.<\/li><li>Involuntary movements (&nbsp;dyskinesia&nbsp;).<\/li><li>Exacerbated symptoms of&nbsp;Parkinson&#8217;s disease&nbsp;.<\/li><li>Dizziness when getting up from a sitting or lying position (&nbsp;orthostatic&nbsp;hypotension&nbsp;) due to a drop in blood pressure.<\/li><li>Nausea, constipation, diarrhea.<\/li><li>Pain in muscles, connective tissue and skeleton.<\/li><li>Abnormal color of the urine (chromatury).<\/li><li>Risk of falling.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anemia&nbsp;.<\/li><li>Elevated levels of&nbsp;amino acids&nbsp;(eg&nbsp;homocysteine&nbsp;) in the blood, deficiency of&nbsp;vitamins&nbsp;B6 and B12.<\/li><li>Decreased appetite, weight gain.<\/li><li>Nightmares, extravagant behavior, restlessness, confusion, hallucinations, psychosis.<\/li><li>Sleep attacks, drowsiness, sleep disorders.<\/li><li>Dizziness, fainting, headache.<\/li><li>Decreased sensation when touching, feeling of tingling or numbness in the skin.<\/li><li>Nerve disease with discomfort, pain and numbness mainly in the feet (&nbsp;polyneuropathy&nbsp;).<\/li><li>Involuntary persistent muscle contractions that lead to twisting repeated movements or abnormal posture (&nbsp;dystonia&nbsp;), excessive movements (hyperkinesia), tremors (&nbsp;tremor&nbsp;).<\/li><li>Changes in the effect on Parkinson&#8217;s symptoms (on-off episodes).<\/li><li>Dimsyn.<\/li><li>Irregular heart rhythm, coronary heart disease other than myocardial infarction (eg angina).<\/li><li>High or low&nbsp;blood pressure&nbsp;.<\/li><li>Shortness of breath,&nbsp;pneumonia&nbsp;due to foreign matter in the lungs.<\/li><li>Pain in the mouth or throat.<\/li><li>Stretched abdomen, abdominal pain, abdominal discomfort, sensitive stomach with, among other things, pain, heartburn, gas tension in the abdomen, vomiting.<\/li><li>Dry mouth&nbsp;, altered taste experience.<\/li><li>Difficulty swallowing, pain in the throat.<\/li><li>Contact dermatitis,&nbsp;itching&nbsp;, rash.<\/li><li>Heavy sweating.<\/li><li>Pain, joint pain, neck pain, muscle spasms.<\/li><li>Urinary leakage (urinary incontinence), difficulty urinating, urinary tract infection.<\/li><li>Weakness, fatigue, chest pain.<\/li><li>Gait disorder.<\/li><li>Swelling in legs or feet.<\/li><\/ul>\n\n\n\n<p><strong>Disrupted impulse control &#8211; changes in your behavior.&nbsp;<\/strong>This is a common&nbsp;side effect&nbsp;(&nbsp;<em>may affect up to 1 in 10 people<\/em>&nbsp;).<\/p>\n\n\n\n<p>Inability to resist the impulse to perform an act that may be harmful, which may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>strong impulse to excessive gambling despite serious consequences for you or your family.<\/li><li>altered or increased sexual interest and behavior that significantly disturbs you or others, e.g.&nbsp;an increased sexual drive.<\/li><li>uncontrollable and excessive need to buy things and spend money.<\/li><li>binge eating (eating large amounts of food in a short time) or compulsive eating (eating more food than normal and more than is needed to satisfy your hunger).<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you, your family, or carers notice any of these behaviors.\u00a0The doctor will discuss ways to manage or reduce the symptoms.<\/p>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduction in the number of&nbsp;white blood cells&nbsp;or&nbsp;platelets&nbsp;in the blood which can lead to bleeding.<\/li><li>Suicide.<\/li><li>Confusion, feeling of elation, fear, nightmares.<\/li><li>Difficulty coordinating muscle movements, seizures.<\/li><li>Twitching or cramping of the eyelids that can make it difficult to open the eyes, double vision, damage to the&nbsp;optic nerve&nbsp;,&nbsp;narrow-angle glaucoma&nbsp;(&nbsp;acute&nbsp;elevated pressure in the eye).<\/li><li>Palpitations, heart attack.<\/li><li>Inflammation&nbsp;of veins.<\/li><li>Voice change.<\/li><li>Inflammation&nbsp;of the colon, bleeding in the gastrointestinal tract.<\/li><li>Abnormally large saliva production.<\/li><li>Deviating results from liver function tests.<\/li><li>Reddening of the skin,&nbsp;hives&nbsp;.<\/li><li>Hair loss, discoloration of nails, skin, hair or sweat.<\/li><li>Feeling sick.<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Abnormal thoughts.<\/li><li>Abnormal breathing pattern.<\/li><li>Tooth grinding, pain in the tongue, discoloration of saliva.<\/li><li>Hiccup.<\/li><li>Skin cancer (malignant&nbsp;melanoma&nbsp;) (see section 2, \u201cDo not use Lecigon\u201d).<\/li><li>Persistent and painful&nbsp;erection&nbsp;.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in the unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the liver (&nbsp;hepatitis&nbsp;).<\/li><li>Deviating laboratory values \u200b\u200bfrom blood and urine samples.<\/li><li>Impairment of memory, dementia.<\/li><li>Ask for a higher&nbsp;dose&nbsp;of Lecigon that is greater than that required to control motor systems, known as dopaminergic dysregulation syndrome.&nbsp;Some patients experience severe abnormal involuntary movements (&nbsp;dyskinesias&nbsp;), mood swings or other&nbsp;side effects&nbsp;after taking larger&nbsp;doses&nbsp;of Lecigon.<\/li><\/ul>\n\n\n\n<p><strong><em>Side effects\u00a0of the pump, probe, or operation:<\/em><\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach pain<\/li><li>Infection&nbsp;in the wound after surgery.<\/li><li>Thick scarring at the site of incision.<\/li><li>Problems with tube insertion such as pain or swelling in the mouth or throat, difficulty swallowing, stomach discomfort, pain or swelling, damage to the throat, mouth or stomach, internal bleeding, vomiting, gas tension in the stomach, anxiety.<\/li><li>Problems with incisions,&nbsp;redness&nbsp;, sores, ostomy leaks, pain or irritation.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach upset, pain in the upper abdomen.<\/li><li>Infection&nbsp;at the surgical incision or in the intestine,&nbsp;infection&nbsp;after surgery when the probe has been placed in the intestine.<\/li><li>Peritonitis.<\/li><li>The probe changes position from the intestine to, for example, the stomach or becomes blocked &#8211; which can lead to a worsened treatment response.<\/li><li>Problems in the digestive tract because of the stoma (where the probe is inserted into the abdomen), pain at the incision, stop magtarmr\u00f6relse&nbsp;RNA&nbsp;after surgery and problems, pain or bleeding as a result of the treatment procedure.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the colon or pancreas.<\/li><li>Inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;).<\/li><li>The probe passes through the colon wall.<\/li><li>Stops in the intestines, bleeding or ulcers on the small intestine.<\/li><li>A part of the intestine is inserted into another, adjacent part of the intestine (invagination).<\/li><li>Blockage of the probe due to undigested food stuck around the probe.<\/li><li>Abscess after insertion of the probe into the intestine.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in the unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduced blood flow in the small intestine.<\/li><li>The probe passes through the stomach wall or small intestine.<\/li><\/ul>\n\n\n\n<p><strong>The side effect is\u00a0when the substances\u00a0levodopa\u00a0and carbidopa are taken by mouth<\/strong><\/p>\n\n\n\n<p>The following car effects have been reported when&nbsp;levodopa&nbsp;and carbidopa (two of the active substances found in Lecigon) are taken orally.&nbsp;These&nbsp;side effects&nbsp;may also occur with Lecigon.<\/p>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anemia&nbsp;due to increased degradation of&nbsp;red blood cells&nbsp;.<\/li><li>Inability to open mouth completely.<\/li><li>Symptoms from one half of the face with drooping eyelids (Horner&#8217;s syndrome).<\/li><li>Enlargement of the&nbsp;pupil,&nbsp;a spasmodic movement of the eyeballs into a fixed position, usually upwards.<\/li><li>Inflammation&nbsp;of small blood vessels that, among other things, cause small raised bruises (Henoch-Sch\u00f6nlein&#8217;s purpura).<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Altered blood levels.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lecigon<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><em>Unopened cartridge:<\/em>&nbsp;Store in a refrigerator (2&nbsp;<sup>\u00b0<\/sup>&nbsp;C &#8211; 8&nbsp;<sup>\u00b0<\/sup>&nbsp;C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p><em>Opened cartridge:<\/em>\u00a0Use immediately.\u00a0The product can be used for up to 24 hours when taken out of the refrigerator.\u00a0The dosing pump with a mounted\u00a0cartridge\u00a0can be carried close to the body for up to 16 hours.\u00a0During treatment at night, the pump should not be carried next to the body but can e.g.\u00a0be stored on the bedside table.\u00a0Discard any unused amount after 24 hours.<\/p>\n\n\n\n<p>The cylinder cartridge\u00a0is for single use only.\u00a0Do not reuse an opened\u00a0cartridge.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are&nbsp;levodopa&nbsp;, carbidopamonohydrate and entacapone.&nbsp;1 ml contains 20 mg&nbsp;levodopa&nbsp;, 5 mg carbidopamonohydrate and 20 mg entacapone.<\/li><li>The other ingredients are caramel sodium,&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment), sodium hydroxide (for&nbsp;pH&nbsp;adjustment) and purified water.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Lecigon\u00a0intestinal\u00a0gel\u00a0is a yellow or yellow-reddish opaque viscous\u00a0gel.<\/p>\n\n\n\n<p>The medicament container is called\u00a0cartridge\u00a0of plastic and contains 47 ml of\u00a0intestinal\u00a0gel.<\/p>\n\n\n\n<p>One pack contains 7\u00a0cartridges.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>LobSor Pharmaceuticals AB<\/p>\n\n\n\n<p>K\u00e5ls\u00e4ngsgr\u00e4nd 10 D<\/p>\n\n\n\n<p>753 19 Uppsala<\/p>\n\n\n\n<p>info@lobsor.se<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Bioglan AB<\/p>\n\n\n\n<p>Borrgatan 31<\/p>\n\n\n\n<p>211 24 Malm\u00f6, Sweden<\/p>\n\n\n\n<p><strong>Information provided by:<\/strong><\/p>\n\n\n\n<p>NordicInfu Care AB<\/p>\n\n\n\n<p>Box 14026<\/p>\n\n\n\n<p>167 14 Bromma<\/p>\n\n\n\n<p>info@infucare.se<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Belgium Lecigimon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml,&nbsp;intestinal&nbsp;gel<\/p>\n\n\n\n<p>Lecigimon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;gel&nbsp;for intestinal use<\/p>\n\n\n\n<p>Lecigimon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;Gel&nbsp;for&nbsp;intestinal&nbsp;use<\/p>\n\n\n\n<p>Bulgaria Chession 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml gel for taking in cervix<\/p>\n\n\n\n<p>Denmark Lecigon enteral gel<\/p>\n\n\n\n<p>Finland Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml yellow suolene<\/p>\n\n\n\n<p>France Lecigimon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml,&nbsp;intestinal&nbsp;gel<\/p>\n\n\n\n<p>Ireland Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;intestinal&nbsp;gel<\/p>\n\n\n\n<p>Italy Lecigimon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;intestinal&nbsp;gel<\/p>\n\n\n\n<p>Croatia Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml intestinal&nbsp;gel<\/p>\n\n\n\n<p>Netherlands Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;gel&nbsp;for intestinal use<\/p>\n\n\n\n<p>Norway Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml intestinal gel<\/p>\n\n\n\n<p>Poland Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml gel dojelitowy<\/p>\n\n\n\n<p>Portugal Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;intestinal&nbsp;gel<\/p>\n\n\n\n<p>Romania Lecigon 20 mg \/ 5 mg \/ 20 mg \/ ml&nbsp;gel&nbsp;intestinal<\/p>\n\n\n\n<p>Slovakia Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml intestinal gel<\/p>\n\n\n\n<p>Slovenia Lecigon 20 mg \/ 5 mg \/ 20 mg in 1 ml intestinal&nbsp;gel<\/p>\n\n\n\n<p>Spain Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;intestinal&nbsp;gel<\/p>\n\n\n\n<p>Czech Lecigimon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml intestinal&nbsp;gel<\/p>\n\n\n\n<p>Germany Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;Gel&nbsp;for&nbsp;intestinal&nbsp;and application<\/p>\n\n\n\n<p>Hungary Lecigon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml intestinal gel<\/p>\n\n\n\n<p>Austria Lecigimon 20 mg \/ ml + 5 mg \/ ml + 20 mg \/ ml&nbsp;Gel&nbsp;for&nbsp;intestinal&nbsp;use<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lecigon is used to treat Parkinson&#8217;s disease . It is used in severe illness when oral drugs (drugs taken by mouth) have not given sufficient effect.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15565,15558,15560,15563,4174,4176,15553,15556,15557,2808,2811,15562,15564,15561,4175,15554,5040,15555,15559],"class_list":["post-16323","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-entacapone","tag-benefits-of-lecigon","tag-carbidopamonohydrate","tag-carbidopamonohydrate-side-effects","tag-entacapone","tag-entacapone-side-effects","tag-lecigon","tag-lecigon-gel","tag-lecigon-side-effects","tag-levodopa","tag-levodopa-side-effects","tag-what-carbidopamonohydrate-is-used-for","tag-what-entacapone-is-used-for","tag-what-is-carbidopamonohydrate","tag-what-is-entacapone","tag-what-is-lecigon","tag-what-is-levodopa","tag-what-lecigon-is-used-for","tag-what-levodopa-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16323","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16323"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16323\/revisions"}],"predecessor-version":[{"id":16389,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16323\/revisions\/16389"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16323"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16323"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16323"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}