{"id":16147,"date":"2021-12-01T09:19:29","date_gmt":"2021-12-01T09:19:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16147"},"modified":"2021-12-09T07:25:46","modified_gmt":"2021-12-09T07:25:46","slug":"lanvis","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lanvis\/","title":{"rendered":"Lanvis &#8211; Thioguanine uses, dose and side effects"},"content":{"rendered":"\n<p>40 mg&nbsp;thioguanine&nbsp;tablets<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lanvis is and what it is used for<\/h2>\n\n\n\n<p>Lanvis tablets contain a medicine called thioguanine.\u00a0It belongs to a group of medicines called cytotoxic medicines (also called\u00a0chemotherapy\u00a0).\u00a0Lanvis is used for certain blood problems and cancers of the blood.\u00a0It works by reducing the number of new\u00a0blood cells\u00a0your body produces.<\/p>\n\n\n\n<p>Lanvis is used for acute (fast-growing)\u00a0leukemias, especially these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Acute&nbsp;myelogenous&nbsp;leukemia&nbsp;<\/strong>(also called<strong>&nbsp;acute myeloid leukemia<\/strong>&nbsp;or<strong>&nbsp;AML<\/strong>&nbsp;) &#8211; a fast-growing disease that increases the number of abnormal&nbsp;white blood cells&nbsp;produced by&nbsp;bone marrow&nbsp;.&nbsp;This can cause&nbsp;infection&nbsp;and bleeding.<\/li><li><strong>Acute lymphoblastic leukemia<\/strong>&nbsp;(also called<strong>&nbsp;acute&nbsp;lymphocytic&nbsp;leukemia<\/strong>&nbsp;or<strong>&nbsp;ALL<\/strong>&nbsp;) &#8211; a fast-growing disease that increases the number of immature&nbsp;white blood cells&nbsp;.&nbsp;These immature&nbsp;white blood cells&nbsp;cannot grow and function properly.&nbsp;They can therefore not fightyou&nbsp;infection&nbsp;, but they can cause bleeding.<\/li><\/ul>\n\n\n\n<p>Ask your doctor if you want to know more about these diseases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Lanvis<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Lanvis<\/h2>\n\n\n\n<p>if you are allergic to thioguanine or any of the other ingredients of this medicine (listed in section 6)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are breast-feeding, see the section \u201cPregnancy, breast-feeding and fertility\u201d.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Lanvis:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have been taking this medicine for a long time.&nbsp;This can increase the risk of&nbsp;side effects&nbsp;, such as liver problems<\/li><li>if you have a condition where your body produces too little of something called TPMT or &#8220;thiopurine methyltransferase&#8221;<\/li><li>if you have &#8220;Lesch-Nyhan&#8217;s syndrome&#8221;.&nbsp;This is a rare, inherited condition caused by a deficiency of something called HPRT or &#8216;hypoxanthine-&nbsp;guanine&nbsp;phosphoribosyltransferase&#8217;.<\/li><\/ul>\n\n\n\n<p>If you are not sure if any of the above applies to you, contact your doctor, nurse, or pharmacist before taking Lanvis.<\/p>\n\n\n\n<p><em>NUDT15 gene mutation<\/em><\/p>\n\n\n\n<p>If you have a hereditary\u00a0mutation\u00a0in the NUDT15 gene (a gene that is involved in the breakdown of Lanvis in the body), then the risk is higher for you to get\u00a0infection\u00a0and hair loss and the doctor can in this case give you a lower\u00a0dose.<\/p>\n\n\n\n<p><strong>Lanvis and the sun<\/strong><\/p>\n\n\n\n<p>While taking Lanvis, you may be sensitive to sunlight which may cause a rash or discoloration of the skin.\u00a0Be sure to avoid too much sun, wear opaque clothing, and use sunscreen.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Lanvis<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>In particular, tell your doctor or pharmacist if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>olsalzine, balsalazide or mesalazine &#8211; used for a bowel problem called&nbsp;ulcerative colitis<\/li><li>sulfasalazine &#8211; used for&nbsp;rheumatoid arthritis&nbsp;or&nbsp;ulcerative colitis<\/li><li>drugs that can have a detrimental effect on&nbsp;bone marrow&nbsp;, such as other&nbsp;chemotherapy&nbsp;or radiation therapy.&nbsp;This can lead to bone marrow damage and&nbsp;dose&nbsp;one of Lanvis may need to be reduced.<\/li><\/ul>\n\n\n\n<p><strong>Get vaccines while you are taking Lanvis<\/strong><\/p>\n\n\n\n<p>If you are about to be vaccinated, talk to your doctor or nurse before doing so.\u00a0The reason is that some vaccines (such as polio, measles, mumps, and rubella) can give you an\u00a0infection\u00a0if you take them while taking Lanvis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.\u00a0Reliable contraceptives must be used to avoid pregnancy while you or your partner are taking these tablets.\u00a0This applies to both men and women.\u00a0Thioguanine can damage your semen or eggs.<\/p>\n\n\n\n<p>Breast-feeding should be discontinued during treatment with Lanvis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0A description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lanvis contains lactose&nbsp;&nbsp;<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking Lanvis tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Lanvis&nbsp;<\/h2>\n\n\n\n<p>Lanvis should only be given to you by a specialist doctor who has experience in treating blood problems.<\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.\u00a0You must take the tablets at the right time.\u00a0The label on the package indicates how many tablets to take and how often to take them.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swallow the tablets whole with a glass of water.<\/li><li>If you need to break the tablet into two parts, make sure you do not inhale any tablet powder.&nbsp;Wash your hands afterwards.&nbsp;The notch is only for you to be able to divide the tablet if you have difficulty swallowing it whole.<\/li><li>While you are taking Lanvis, your doctor will take blood samples at regular intervals.&nbsp;The reason is to check the number and type of&nbsp;blood cells&nbsp;and to ensure that your liver is functioning properly.&nbsp;Your doctor may sometimes change your&nbsp;dose&nbsp;as a result.<\/li><\/ul>\n\n\n\n<p>The&nbsp;dose&nbsp;of Lanvis that you are given is determined by your doctor based on:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your body size (surface area)<\/li><li>the result of the blood tests<\/li><li>which disease is being treated.<\/li><\/ul>\n\n\n\n<p>The usual\u00a0dose\u00a0is between 60 and 200 mg \/ m\u00a0<sup>2<\/sup>\u00a0body surface area\/day.\u00a0If you have kidney or liver problems, you can get a lower\u00a0dose\u00a0of Lanvis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Lanvis<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, contact your doctor.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you get any of these\u00a0side effects, talk to your healthcare provider immediately or consult a hospital.\u00a0These\u00a0side effects\u00a0are very common (affects more than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs of fever or&nbsp;infection&nbsp;(sore throat, sore mouth or difficulty urinating)<\/li><li><strong>unexpected<\/strong>&nbsp;bruising or bleeding, as this can mean that too few&nbsp;blood cells&nbsp;of a certain type are produced<\/li><li>if you&nbsp;<strong>suddenly<\/strong>&nbsp;feel unwell (even if you do not have a fever)<\/li><li>yellowing of the whites of the eyes or skin (jaundice), fatigue and nausea, followed by&nbsp;itching&nbsp;, dark urine and may include rash or fever (severe liver damage).<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if you get any of the following&nbsp;side effects&nbsp;that may also occur with this medicine:<\/p>\n\n\n\n<p><strong>Very common (affects more than 1 in 10&nbsp;<\/strong><strong>people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased number of&nbsp;blood cells&nbsp;and&nbsp;platelets<\/li><li>jaundice (skin and whites of the eyes turn yellow) and severe liver damage (symptoms are fatigue and nausea, followed by&nbsp;itching&nbsp;, dark urine and may include rash or fever) &#8211; with long-term use or high&nbsp;doses&nbsp;of Lanvis.&nbsp;This can also show up in your blood tests.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;<\/strong><strong>(affects less than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver damage that can cause enlarged liver (a swelling under the chest) &#8211; with short-term use of Lanvis.&nbsp;This can also show up in your blood tests<\/li><li>nausea or vomiting, diarrhea and cold sores<\/li><li>increased concentration of&nbsp;uric acid&nbsp;in the blood (hyperuricemia), which can sometimes lead to impaired kidney function.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong><strong>(&nbsp;<\/strong><strong>affects&nbsp;<\/strong><strong>less than 1 in 100&nbsp;<\/strong><strong>people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver damage that can cause jaundice (skin and whites of the eyes turn yellow).<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;<\/strong><strong>(affects&nbsp;<\/strong><strong>less than 1 in&nbsp;<\/strong><strong>1,000 people)<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a problem with the intestines called&nbsp;necrotizing&nbsp;colitis&nbsp;, which can cause severe stomach pain, vomiting, diarrhea and fever<\/li><li>severe liver damage when Lanvis is used with other chemotherapeutic drugs,&nbsp;birth control pills&nbsp;and alcohol.<\/li><\/ul>\n\n\n\n<p><strong>Unknown frequency<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity to light.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lanvis<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Store the jar in the outer carton.&nbsp;Sensitive to light<\/li><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d \/ \u201cEXP\u201d.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is thioguanine.&nbsp;Each tablet contains 40 mg of thioguanine.<\/p>\n\n\n\n<p>The other ingredients are\u00a0lactose monohydrate, potato starch, acacia, stearic acid, and magnesium stearate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Lanvis tablets are white to off-white tablets, round, biconvex with a scoreline and embossed with T40 on the front, without a score and embossing on the back.<\/p>\n\n\n\n<p>The medicine is supplied in a brown glass jar with a child-resistant lid containing 25 tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive<\/p>\n\n\n\n<p>Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Excella GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Nurnberger Strasse 12<\/p>\n\n\n\n<p>90537 Moisture<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Agent<\/strong><\/p>\n\n\n\n<p>Questions about medical information:<\/p>\n\n\n\n<p>Tel: 0046 856642572<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lanvis tablets contain a medicine called thioguanine. It belongs to a group of medicines called cytotoxic medicines (also called chemotherapy ). Lanvis is used for certain blood problems and cancers of the blood. It works by reducing the number of new blood cells your body produces.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15368,15362,15363,15367,15366,15357,15361,15360,15364,15358,15365,15359],"class_list":["post-16147","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-lanvis","tag-benefits-of-thioguanine","tag-lanvis","tag-lanvis-side-effects","tag-lanvis-tablet","tag-thioguanine","tag-thioguanine-side-effects","tag-thioguanine-tablet","tag-what-is-lanvis","tag-what-is-thioguanine","tag-what-lanvis-is-used-for","tag-what-thioguanine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16147"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16147\/revisions"}],"predecessor-version":[{"id":16177,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16147\/revisions\/16177"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}