{"id":16143,"date":"2021-12-01T09:16:27","date_gmt":"2021-12-01T09:16:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16143"},"modified":"2021-12-09T07:26:37","modified_gmt":"2021-12-09T07:26:37","slug":"lantus","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lantus\/","title":{"rendered":"Lantus &#8211; Glargine uses, dose and side effects"},"content":{"rendered":"\n<p>100 units\/ml\u00a0solution for injection\u00a0in a\u00a0vial of<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toujeo-2\/\">insulin\u00a0glargine<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lantus is and what it is used for<\/h2>\n\n\n\n<p>Lantus contains\u00a0insulin\u00a0glargine.\u00a0This is a modified\u00a0insulin, very similar to human insulin.<\/p>\n\n\n\n<p>Lantus is used to treat\u00a0diabetes mellitus\u00a0in adults, adolescents, and children from 2 years of age.\u00a0Diabetes mellitus\u00a0is a disease in which the body does not produce enough\u00a0insulin\u00a0to control blood sugar levels.\u00a0Insulin\u00a0glargine has a long and even blood sugar lowering effect.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Lantus<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Lantus<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to&nbsp;insulin&nbsp;glargine or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Lantus.<\/p>\n\n\n\n<p>Be sure to follow the dosing instructions and instructions for control (of blood and urine), diet, and physical activities (physical work and exercise) as discussed with your doctor.\u00a0Follow the\u00a0hypoglycaemic\u00a0information\u00a0(see box at the end of the package leaflet) if your blood sugar is too low (hypoglycemia).<\/p>\n\n\n\n<p>Skin changes at the injection site:<\/p>\n\n\n\n<p>To prevent skin changes, e.g.&nbsp;nodules under the skin, you should constantly change the injection site.&nbsp;It may be that&nbsp;insulin&nbsp;et not work as well if you inject in an area of nodules (see How to use Lantus).&nbsp;Contact your doctor before changing the injection site if you are currently injecting in an area with lumps.&nbsp;Your doctor may advise you to check your blood sugar more often and to adjust your insulin dose or the&nbsp;dose&nbsp;of other diabetes medicines.<\/p>\n\n\n\n<p>Travel<\/p>\n\n\n\n<p>Consult your doctor before traveling.&nbsp;You may need to raise questions about:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>the availability of your&nbsp;insulin&nbsp;in the country you are visiting,<\/li><li>the availability of&nbsp;insulin&nbsp;, syringes, etc.,<\/li><li>the storage of&nbsp;insulin&nbsp;during the journey,<\/li><li>times for meals and insulin use during the trip,<\/li><li>possible consequences of travel to other time zones,<\/li><li>any new health risks in the countries you visit,<\/li><li>What to do in an emergency if you feel unwell or become ill.<\/li><\/ul>\n\n\n\n<p>Diseases and injuries<\/p>\n\n\n\n<p>In the following situations, the management of your&nbsp;diabetes&nbsp;may require extra care (for example, adjustment of insulin dose, blood and urine tests):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are ill or have a serious accident, your blood sugar level may rise (&nbsp;hyperglycaemia&nbsp;).<\/li><li>If you do not eat enough, your blood sugar level may become too low (&nbsp;hypoglycaemia&nbsp;).<\/li><\/ul>\n\n\n\n<p>In most cases, you will need medical attention.&nbsp;<strong>Contact a doctor at an early stage.<\/strong><\/p>\n\n\n\n<p>If you have\u00a0type 1\u00a0diabetes\u00a0(insulin-dependent\u00a0diabetes mellitus\u00a0), you should not stop\u00a0taking insulin\u00a0and you should continue to add enough carbohydrates.\u00a0Always tell those who see you or treat you that you need\u00a0insulin.<\/p>\n\n\n\n<p>Insulin treatment can cause the body to make&nbsp;antibodies&nbsp;against&nbsp;insulin&nbsp;(substances that react with&nbsp;insulin&nbsp;).&nbsp;Only in very rare cases is a change in insulin dose required.<\/p>\n\n\n\n<p>Some patients with long-standing\u00a0diabetes mellitus\u00a0type 2 and heart disease or previous\u00a0stroke, treated with pioglitazone (a drug against\u00a0diabetes\u00a0taken by mouth for the treatment of\u00a0diabetes mellitus\u00a0type 2),\u00a0insulin, developed\u00a0heart failure.\u00a0Tell your doctor as soon as possible if you get signs of\u00a0heart failure\u00a0such as increased shortness of breath, rapid weight gain, or local swelling (\u00a0edema\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>There is no experience with the use of Lantus in children under 2 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Lantus<\/h2>\n\n\n\n<p>Some medicines affect the blood sugar level (lowering the blood sugar, raising the blood sugar, or both, depending on the circumstances).\u00a0In any case, it may be necessary to adjust your insulin dose to prevent your blood sugar levels from becoming either too low or too high.\u00a0Keep this in mind when you start or stop taking another medicine.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0Before taking any medicine, consult your doctor if it may affect your blood sugar level and if so, what to do.<\/p>\n\n\n\n<p><strong>Drugs that can lower your blood sugar (hypoglycemia) include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>all other medicines used to treat&nbsp;diabetes&nbsp;,<\/li><li>ACE inhibitors&nbsp;(used to treat certain heart conditions or high&nbsp;blood pressure&nbsp;),<\/li><li>disopyramide&nbsp;(used to treat certain heart conditions),<\/li><li>fluoxetine&nbsp;(used to treat depression),<\/li><li>fibrates (used to lower high levels of blood fats),<\/li><li>MAO inhibitors&nbsp;(used to treat depression),<\/li><li>pentoxifylline, propoxyphene, salicylates (eg&nbsp;acetylsalicylic acid&nbsp;used as painkillers and antipyretics),<\/li><li>sulfonamide antibiotics.<\/li><\/ul>\n\n\n\n<p><strong>Drugs that can raise your blood sugar (hyperglycemia) include:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>corticosteroids&nbsp;(eg&nbsp;cortisone&nbsp;used to treat&nbsp;inflammation&nbsp;),<\/li><li>danazol (medicines that affect ovulation),<\/li><li>diazoxide (used to treat high&nbsp;blood pressure&nbsp;),<\/li><li>diuretics&nbsp;(used to treat high&nbsp;blood pressure&nbsp;or if you have accumulated too much fluid),<\/li><li>glucagon (pancreatic hormone used to treat severe&nbsp;hypoglycaemia&nbsp;),<\/li><li>isoniazid&nbsp;(used to treat&nbsp;tuberculosis&nbsp;),<\/li><li>estrogens&nbsp;and progestogens (eg&nbsp;birth control pills&nbsp;used for birth control),<\/li><li>phentiazine derivatives (used to treat mental illness),<\/li><li>somatropin (&nbsp;growth hormone&nbsp;),<\/li><li>sympathomimetics&nbsp;(eg&nbsp;epinephrine&nbsp;(&nbsp;adrenaline&nbsp;) or&nbsp;salbutamol&nbsp;,&nbsp;terbutaline&nbsp;used in the treatment of&nbsp;asthma&nbsp;),<\/li><li>thyroid hormones (used in the treatment of thyroid disease),<\/li><li>atypical&nbsp;psychotropic drugs&nbsp;(eg clozapine, olanzapine),<\/li><li>protease inhibitor&nbsp;(used in the treatment of&nbsp;HIV&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Blood sugar levels can sometimes increase and sometimes decrease if you use:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>beta-blockers&nbsp;(used to treat high&nbsp;blood pressure&nbsp;),<\/li><li>clonidine&nbsp;(used to treat high&nbsp;blood pressure&nbsp;),<\/li><li>lithium salts (used in the treatment of mental illness)<\/li><\/ul>\n\n\n\n<p>Pentamidine (used to treat certain\u00a0infections\u00a0caused by parasites) can cause\u00a0hypoglycemia,\u00a0which can sometimes be followed by\u00a0hyperglycemia.<\/p>\n\n\n\n<p>In addition, beta-blockers,\u00a0as well as other sympatholytic drugs (eg\u00a0clonidine, guanethidine, and reserpine), may cause the first warning signs that make you recognize\u00a0hypoglycemia to be\u00a0weakened or absent.<\/p>\n\n\n\n<p>If you are not sure if you are taking any of these medicines, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lantus with alcohol<\/h2>\n\n\n\n<p>Your blood sugar can either be raised or lowered if you drink alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<p>Tell your doctor if you intend to become pregnant or if you are already pregnant.\u00a0The insulin dose may need to be adjusted during pregnancy and after delivery.\u00a0For the sake of the child, it is especially important that your\u00a0diabetes\u00a0is monitored and that\u00a0hypoglycemia is\u00a0prevented.<\/p>\n\n\n\n<p>If you are breastfeeding, your insulin dose and diet may need to be adjusted.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Your ability to concentrate or react may be impaired if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you get&nbsp;hypoglycaemia&nbsp;(low blood sugar),<\/li><li>you get&nbsp;hyperglycemia&nbsp;(elevated blood sugar levels),<\/li><li>you have vision problems.<\/li><\/ul>\n\n\n\n<p>Always remember the risk of this in all situations where you may&nbsp;expose&nbsp;yourself and others to danger (eg when driving or using machines).&nbsp;Contact your doctor for advice on driving if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you often have episodes of&nbsp;hypoglycaemia&nbsp;,<\/li><li>if the first warning signs that make you recognize&nbsp;hypoglycaemia&nbsp;are weakened or absent.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of Lantus<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie essentially &#8216;sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Lantus<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Although Lantus contains the same active substance as <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toujeo-2\/\">Toujeo<\/a> (\u00a0insulin\u00a0glargine 300 units\/ml), these medicines are not interchangeable.\u00a0Switching from one insulin treatment to another requires a prescription, medical monitoring, and blood sugar control.\u00a0Consult a physician for further information.<\/p>\n\n\n\n<p><strong>Dose<\/strong><\/p>\n\n\n\n<p>Depending on your lifestyle and the results of your blood glucose (&nbsp;glucose&nbsp;) test and your previous insulin treatment, your doctor will:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>determine how much Lantus you will need per day and at what time of day,<\/li><li>tell you when to check your blood sugar level and if you need to take a urine sample,<\/li><li>tell you when you may need to increase or decrease the&nbsp;dose of&nbsp;a Lantus.<\/li><\/ul>\n\n\n\n<p>Lantus is a long-acting\u00a0insulin.\u00a0Your doctor may\u00a0prescribe\u00a0it in combination with fast-acting\u00a0insulin\u00a0or with tablets to treat high blood sugar.<\/p>\n\n\n\n<p>Many factors can affect blood sugar levels.\u00a0You need to know these factors to be able to react correctly when the blood sugar level changes and to prevent the level from becoming too high or too low.\u00a0See the box at the end of the package leaflet for further information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Lantus can be used in adolescents and children from 2 years of age.&nbsp;Use this medicine exactly as your doctor has told you.<\/p>\n\n\n\n<p><strong>Time of&nbsp;administration<\/strong><\/p>\n\n\n\n<p>You will need one&nbsp;injection&nbsp;of Lantus daily, at the same time.<\/p>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<p>Lantus is injected under the skin.\u00a0NEVER inject Lantus into a blood vessel, as it would alter the effect and may cause\u00a0hypoglycemia.<\/p>\n\n\n\n<p>Your doctor will show you in which area of \u200b\u200bskin you should inject Lantus.\u00a0Change the injection site each time in the area of \u200b\u200bthe skin that you use for\u00a0injection.<\/p>\n\n\n\n<p><strong>Handling of vials<\/strong><\/p>\n\n\n\n<p>Check the vial before use.\u00a0The only transparent and colorless water-like solution, without visible solid particles may be used.\u00a0It should not be shaken or mixed before use.<br>It is important to make sure that\u00a0insulin is\u00a0not contaminated with alcohol, other disinfectants, or other substances.\u00a0Do not dilute it.\u00a0Do not mix Lantus with any other\u00a0insulin\u00a0or drugs.\u00a0Mixing\u00a0or diluting may alter the effect of Lantus.<\/p>\n\n\n\n<p>Always take a new\u00a0vial\u00a0if you notice that your blood sugar control is unexpectedly deteriorating.\u00a0You should do this because\u00a0insulin\u00a0may have lost some of its effects.\u00a0If you suspect you have a problem with Lantus, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Insulin confusions<\/strong><\/p>\n\n\n\n<p>You must always check the insulin label before each\u00a0injection, to avoid confusing Lantus with other\u00a0insulins.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Lantus than you should<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have&nbsp;<strong>injected too much Lantus<\/strong>&nbsp;,&nbsp;<strong>your<\/strong>&nbsp;blood sugar level may become too low (&nbsp;hypoglycaemia&nbsp;).&nbsp;Check your blood sugar often.&nbsp;To avoid&nbsp;hypoglycaemia&nbsp;, you usually need to eat more food and control your blood sugar.&nbsp;For information on the treatment of&nbsp;hypoglycaemia&nbsp;, see the box at the end of the leaflet.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Lantus<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you&nbsp;<strong>miss&nbsp;<\/strong><strong>a&nbsp;dose of&nbsp;Lantus<\/strong>&nbsp;or if you have&nbsp;<strong>not injected enough&nbsp;insulin<\/strong>&nbsp;, your blood sugar level may become too high (&nbsp;hyperglycaemia&nbsp;).&nbsp;Check your blood sugar often.<br>For information on treating&nbsp;hyperglycaemia&nbsp;, see the box at the end of this leaflet.<\/li><li>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Lantus<\/h2>\n\n\n\n<p>This can lead to severe\u00a0hyperglycemia\u00a0(very high blood sugar) and\u00a0ketoacidosis\u00a0(accumulation of acid in the blood because the body breaks down fat instead of sugar).\u00a0Do not stop treatment with Lantus without consulting your doctor, who will tell you what needs to be done.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you notice that your blood sugar is getting too low (hypoglycemia<\/strong>),\u00a0take immediate action to raise\u00a0your blood\u00a0sugar (see the box at the end of this leaflet).\u00a0Hypoglycemia\u00a0(low blood sugar) can be very serious and is very common with insulin therapy (may affect more than 1 in 10 people).\u00a0Low blood sugar means that there is not enough sugar in your blood.\u00a0If your blood sugar level gets too low, you may faint (become unconscious).\u00a0Severe\u00a0hypoglycemia\u00a0can cause brain damage and can be life-threatening.\u00a0For more information, see the box at the end of this leaflet.<\/p>\n\n\n\n<p><strong>Severe\u00a0allergic reaction<\/strong>\u00a0(rare, may affect up to 1 in 1,000 people) &#8211; symptoms may include widespread skin reactions (rash and\u00a0itching\u00a0all over the body), severe swelling of the skin or mucous membranes (\u00a0angioedema\u00a0), shortness of breath, drop in blood pressure with rapid heartbeat and sweating.\u00a0Severe\u00a0allergic reactions\u00a0to\u00a0insulin\u00a0may be life-threatening.\u00a0Contact a doctor immediately if you notice signs of severe allergic reactions.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skin changes at the injection site:<\/strong>If you inject&nbsp;insulin&nbsp;too often in the same place, the skin may either shrink (lipoatrophy) (&nbsp;<em>may occur in up to 1 in 100 people<\/em>&nbsp;) or thicken (lipohypertrophy) (&nbsp;<em>may occur in up to 1 in 10 people<\/em>&nbsp;).&nbsp;Nodules under the skin can also be caused by the accumulation of a&nbsp;protein&nbsp;called amyloid (&nbsp;cutaneous&nbsp;amyloidosis. How often this occurs is not known).&nbsp;It may be that&nbsp;insulin&nbsp;et not work as well if you inject in an area with nodules.&nbsp;Change the injection site for each&nbsp;injection&nbsp;to prevent these skin changes.<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are reported as common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skin side effects and allergic reactions at the injection site<\/strong><br>Reactions may include&nbsp;redness&nbsp;, unusually intense pain during&nbsp;injection&nbsp;,&nbsp;itching&nbsp;,&nbsp;hives&nbsp;, swelling and&nbsp;inflammation&nbsp;.&nbsp;These reactions may spread around the injection site.&nbsp;Most less severe insulin reactions usually go away within a few days to a few weeks.<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are reported as rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Visual impact<\/strong>A marked change (improvement or deterioration) in blood sugar control may temporarily impair your eyesight.&nbsp;If you have&nbsp;proliferative&nbsp;retinopathy&nbsp;(an eye disease associated with&nbsp;diabetes&nbsp;), severe hypoglycaemic attacks can cause temporary loss of vision.<\/li><li><strong>General symptoms<\/strong>In rare cases, insulin treatment may cause temporary storage of water in the body, with swelling of the calves and ankles.<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;are reported as very rare<\/strong>&nbsp;(may affect up to 1 in 10,000 people)<br>In very rare cases,&nbsp;dysgeusia&nbsp;(taste change) and&nbsp;myalgia&nbsp;(muscle pain) may occur.<\/p>\n\n\n\n<p><strong>Use in children and adolescents<\/strong><\/p>\n\n\n\n<p>In general, the&nbsp;side effects&nbsp;in children and adolescents who are 18 years or younger are similar to those seen in adults.<br>Complaints of injection site reactions (injection site pain, injection site reactions) and skin reactions (rash,&nbsp;hives&nbsp;) are comparatively more frequently reported in children and adolescents 18 years of age or younger than in adults.<\/p>\n\n\n\n<p>There is no experience of use in children younger than 2 years.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lantus<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and the vial label after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Unopened vials<\/strong><\/p>\n\n\n\n<p>Store in a refrigerator (2\u00baC-8\u00baC).<br>Do not freeze or store in direct contact with the freezer compartment or cooling lamp.<br>Keep the vial in the outer carton.\u00a0Sensitive to light.<\/p>\n\n\n\n<p><strong>Opened vials<\/strong><\/p>\n\n\n\n<p>The 5 ml vial currently in use can be stored for a maximum of 4 weeks at a maximum of 25 \u00b0 C in the outer carton and protection against direct heat and direct light.<\/p>\n\n\n\n<p>The 10 ml vial currently in use can be stored for a maximum of 4 weeks at a maximum of 30\u00baC in the outer carton and protection against direct heat and direct light.<\/p>\n\n\n\n<p>After this period, the drug should not be used.&nbsp;Feel free to write down the date on the label for the first use.<\/p>\n\n\n\n<p>Do not use Lantus if you see particles in it.\u00a0Only use Lantus if the solution is clear, colorless, and water-like.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;insulin&nbsp;glargine.&nbsp;Each ml of solution contains 100 units of&nbsp;insulin&nbsp;glargine (equivalent to 3.64 mg).<\/li><li>The other ingredients are: zinc chloride, metacresol,&nbsp;glycerol&nbsp;, sodium hydroxide (see section 2 &#8220;Important information about some of the ingredients of Lantus&#8221;) and&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;adjustment), polysorbate 20 (only 10 ml&nbsp;vial&nbsp;) and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Lantus 100 Units\/ml\u00a0solution for injection\u00a0in a\u00a0vial\u00a0is a clear, colorless, and water-like solution.<br>Each\u00a0vial\u00a0contains 5 ml of\u00a0solution for injection\u00a0(equivalent to 500 units) or 10 ml of\u00a0solution for injection\u00a0(equivalent to 1000 units).<\/p>\n\n\n\n<p>Packs of 1, 2, 5, and 10 vials of 5 ml or 1 vial of 10 ml.<br>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorization Holder:<br>Sanofi-Aventis Deutschland GmbH, D-65926 Frankfurt, Germany.<\/p>\n\n\n\n<p>Manufacturer:<br>Sanofi-Aventis Deutschland GmbH,<br>D-65926 Frankfurt am Main,<br>Germany.<\/p>\n\n\n\n<p>Sanofi SpA,<br>Valcanello, 4<br>03012 Anagni (FR),<br>Italy.<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Sanofi BelgiumTel: +32 (0) 2 710 54 00<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Sanofi- BelgiumPhone: +32 (0) 2 710 54 00 (Belgium \/ Belgium)<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>SANOFI BULGARIA EOODTel: +359 (0) 2 970 53 00<\/td><td><strong>Hungary<\/strong>SANOFI-AVENTIS Zrt.Tel .: +36 1 505 0050<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>sanofi-aventis, sroTel: +420 233 086 111<\/td><td><strong>Malta<\/strong>Sanofi Srl<br>Tel: +39 02 39394275<\/td><\/tr><tr><td><strong>Denmark<\/strong>Sanofi A \/ STel: +45 45 16 70 00<\/td><td><strong>The Netherlands<\/strong>Genzyme Europe BVTel: +31 20 245 4000<\/td><\/tr><tr><td><strong>Germany<\/strong>Tel .: 0800 52 52 010Tel.&nbsp;from abroad: +49 69 305 21 131<\/td><td><strong>Norway<\/strong>sanofi-aventis Norge ASTel: +47 67 10 71 00<\/td><\/tr><tr><td><strong>Eesti<\/strong>sanofi-aventis Estonia O\u00dcTel: +372 627 34 88<\/td><td><strong>Austria<\/strong>sanofi-aventis GmbHTel: +43 1 80 185 &#8211; 0<\/td><\/tr><tr><td><strong>Greece<\/strong>sanofi-aventis AEBE:\u0397\u03bb: +30 210 900 16 00<\/td><td><strong>Poland<\/strong>sanofi-aventis Sp.&nbsp;z ooTel .: +48 22 280 00 00<\/td><\/tr><tr><td><strong>Spain<\/strong>sanofi-aventis, SATel: +34 93 485 94 00<\/td><td><strong>Portugal<\/strong>Sanofi &#8211; Pharmaceutical Products, LdaTel: +351 21 35 89 400<\/td><\/tr><tr><td><strong>France<\/strong>sanofi-aventis FranceTel: 0 800 222 555Call from abroad:+33 1 57 63 23 23<\/td><td><strong>Romania<\/strong>Sanofi Romania SRLTel: +40 (0) 21 317 31 36<\/td><\/tr><tr><td><strong>Croatia<\/strong>sanofi-aventis Croatia dooTel: +385 1 600 34 00<\/td><td><\/td><\/tr><tr><td><strong>Ireland<\/strong>sanofi-aventis Ireland Ltd.&nbsp;T \/ A SANOFITel: +353 (0) 1 403 56 00<\/td><td><strong>Slovenia<\/strong>sanofi-aventis dooTel: +386 1 560 48 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>sanofi-aventis Slovakia sroTel: +421 2 33 100 100<\/td><\/tr><tr><td><strong>Italy<\/strong>Sanofi SrlTel: 800 13 12 12 (technical type domande)800.536389 (altre domande)<\/td><td><strong>Finland \/ Finland<\/strong>Sanofi OyPuh \/ Tel: +358 (0) 201 200 300<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>sanofi-aventis Cyprus Ltd.:\u0397\u03bb: +357 22 871600<\/td><td><strong>Sweden<\/strong>Sanofi ABTel: +46 (0) 8 634 50 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>sanofi-aventis Latvia SIATel: +371 67 33 24 51<\/td><td><strong>United Kingdom<\/strong>SanofiTel: +44 (0) 845 372 7101<\/td><\/tr><tr><td><strong>Lithuania<\/strong>UAB \u00abSANOFI-AVENTIS LIETUVA\u00bbTel: +370 5 2755224<\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Lantus contains insulin glargine. This is a modified insulin , very similar to human insulin.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15373,15383,15369,15372,15379,15382,15371,15370,15380,15381],"class_list":["post-16143","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-glargine","tag-benefits-of-lantus","tag-glargine","tag-glargine-side-effects","tag-lantus","tag-lantus-side-effects","tag-what-glargine-is-used-for","tag-what-is-glargine","tag-what-is-lantus","tag-what-lantus-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16143"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16143\/revisions"}],"predecessor-version":[{"id":16179,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16143\/revisions\/16179"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}