{"id":16075,"date":"2021-11-30T09:57:53","date_gmt":"2021-11-30T09:57:53","guid":{"rendered":"https:\/\/zeepedia.com\/?p=16075"},"modified":"2021-12-09T07:31:59","modified_gmt":"2021-12-09T07:31:59","slug":"lanoxin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/lanoxin\/","title":{"rendered":"Lanoxin &#8211; Digoxin uses, dose and side effects"},"content":{"rendered":"\n<p>50 micrograms \/ ml&nbsp;oral&nbsp;solution<br>Digoxin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Lanoxin is and what it is used for<\/h2>\n\n\n\n<p>Lanoxin contains the active substance&nbsp;digoxin&nbsp;which is a so-called cardiac glycoside.&nbsp;Digoxin increases the contractile force of the heart and reduces the number of heartbeats per minute.<\/p>\n\n\n\n<p>Lanoxin is used in the treatment of&nbsp;heart failure&nbsp;and in irregular heartbeats e.g.&nbsp;atrial fibrillation&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Lanoxin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Lanoxin:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;digoxin&nbsp;or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have certain types of heart rhythm disorder such as Wolff-Parkinson-White syndrome or&nbsp;AV block<\/li><li>if you have obstructive&nbsp;cardiomyopathy&nbsp;(a disease of the heart muscle)<\/li><li>if you have arrhythmias caused by cardiac glycoside poisoning<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Lanoxin if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>acute&nbsp;myocardial infarction<\/li><li>congenital heart disease (Fallot&#8217;s tetrad)<\/li><li>decreased oxygen content in the body tissues (&nbsp;hypoxia&nbsp;)<\/li><li>renal impairment<\/li><li>decreased circulation in the coronary arteries of the heart<\/li><li>myocarditis (&nbsp;myocarditis&nbsp;)<\/li><li>pericarditis (constrictive pericarditis)<\/li><li>used cardiac glycosides in the last two weeks<\/li><li>severe lung disease<\/li><li>abnormally low levels of&nbsp;potassium&nbsp;, abnormally low levels of&nbsp;magnesium&nbsp;or elevated levels of&nbsp;calcium&nbsp;in the blood<\/li><li>underactive or overactive&nbsp;thyroid gland<\/li><li>malabsorption syndrome or have a reconstructed gastrointestinal tract (that is, you have a reduced ability to absorb the nutrients in your food).<\/li><\/ul>\n\n\n\n<p>Digoxin poisoning can lead to various types of arrhythmias, and some of them may be similar to the arrhythmias for which this medicine has been prescribed.<\/p>\n\n\n\n<p>In some cases (in case of a sick sinus node, so-called Sick Sinus Syndrome), Lanoxin can make the heart beat slower.<\/p>\n\n\n\n<p>If you are having an&nbsp;ECG&nbsp;(&nbsp;electrocardiogram&nbsp;)&nbsp;test&nbsp;, tell the person performing the test that you are using Lanoxin as it may affect the interpretation of the results.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Lanoxin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines \/ herbal medicines can affect or be affected by treatment with Lanoxin, eg:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diuretics&nbsp;(antihypertensive drugs)<\/li><li>spironolactone&nbsp;(a medicine that increases the amount of urine you produce to reduce swelling (&nbsp;edema&nbsp;) or lower&nbsp;blood pressure&nbsp;)<\/li><li>certain medicines for irregular heartbeat such as&nbsp;amiodarone&nbsp;,&nbsp;flecainide&nbsp;,&nbsp;propafenone&nbsp;,&nbsp;quinidine&nbsp;, dronedarone<\/li><li>Certain medications used to treat cardiovascular disease such as high&nbsp;blood pressure&nbsp;,&nbsp;heart failure&nbsp;and angina.&nbsp;Examples are prazosin, carvedilol, verapamil,&nbsp;diltiazem&nbsp;, felodipine, nifedipine, eplerone, ranolazine,&nbsp;beta blockers&nbsp;, angiotensin receptor blockers eg <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tolura\/\">telmisartan<\/a> and&nbsp;ACE inhibitors&nbsp;eg&nbsp;captopril<\/li><li>kanagliflozin (used to treat type 2&nbsp;diabetes&nbsp;)<\/li><li>daclatasvir (used in combination with other medicines to treat&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;)<\/li><li>flibanserin (used in the treatment of low sex drive in women who are still menstruating, ie who have not yet undergone&nbsp;menopause&nbsp;)<\/li><li>lithium salts (medicines for manic-depressive illness)<\/li><li>corticosteroids&nbsp;(medicines that reduce&nbsp;inflammation&nbsp;)<\/li><li>carbenoxolone (an agent used to treat ulcers in the gastrointestinal tract)<\/li><li>certain&nbsp;antibiotics&nbsp;(medicines for&nbsp;infections&nbsp;)<\/li><li>isavuconazole (used to treat fungal infections)<\/li><li>itraconazole (used to treat fungal infections)<\/li><li>ivakaftor (used in the treatment of&nbsp;cystic fibrosis&nbsp;)<\/li><li>alprazolam (a sedative that can be used to treat anxiety)<\/li><li>quinine (an anti-&nbsp;malarial&nbsp;drug&nbsp;)<\/li><li>mirabegron (used to treat overactive&nbsp;bladder&nbsp;that causes a sudden need to urinate and involuntary urine leakage)<\/li><li>propantheline (used to prevent muscle spasms)<\/li><li>nefazodone (an antidepressant)<\/li><li>atorvastatin, cholestyramine (medicines that lower blood fats)<\/li><li>ciclosporin (immune-suppressing drug commonly used to prevent post-transplant rejection)<\/li><li>epoprostenol (used to treat high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs)<\/li><li>tolvaptan (used to treat low sodium levels in the blood)<\/li><li>ritonavir \/ ritonavir containing treatments (used to treat&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;)<\/li><li>taleprevir (used to treat&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;)<\/li><li>lapatinib (used to treat breast cancer)<\/li><li>tikagrelor (used to prevent blood clots)<\/li><li>antacids (used to treat heartburn and acid reflux)<\/li><li>certain bulking agents (fiber-containing&nbsp;laxatives&nbsp;)<\/li><li>kaolin pectin (used to treat diarrhea)<\/li><li>acarbose (used to treat certain types of&nbsp;diabetes&nbsp;)<\/li><li>certain&nbsp;chemotherapy drugs&nbsp;(used to treat cancer)<\/li><li>metoclopramide (used to treat nausea and vomiting)<\/li><li>sulfasalazine (medicine for&nbsp;rheumatoid arthritis&nbsp;and inflammatory bowel disease)<\/li><li>adrenaline&nbsp;(used to treat severe allergic reactions)<\/li><li>salbutamol&nbsp;(a medicine used to treat&nbsp;asthma&nbsp;)<\/li><li>phenytoin&nbsp;, phenobarbital, carbamazepine (used to treat&nbsp;epilepsy&nbsp;)<\/li><li>St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;)<\/li><li>non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;such as indomethacin,&nbsp;ibuprofen&nbsp;) (used to treat pain and&nbsp;inflammation&nbsp;)<\/li><li>cyclooxygenase&nbsp;-2&nbsp;enzyme&nbsp;(&nbsp;COX-2&nbsp;) inhibitors (used to treat pain and&nbsp;inflammation&nbsp;)<\/li><li>sennosides (for temporary constipation)<\/li><li>simeprevir (used in combination with other medicines to treat&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;)<\/li><li>calcium&nbsp;(used for example in case of&nbsp;calcium&nbsp;deficiency&nbsp;)<\/li><li>rifampicin (medicine for turberculosis)<\/li><li>thyroid hormones (drugs for thyroid dysfunction)<\/li><li>velpatasvir (used in combination with other medicines to treat&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;)<\/li><li>vandetanib (used to treat certain types of thyroid cancer)<\/li><li>venetoclax (used to treat certain types of&nbsp;leukemia&nbsp;(blood cancer))<\/li><li>vemurafenib (used to treat metastatic&nbsp;melanoma&nbsp;(skin cancer))<\/li><li>proton pump inhibitors&nbsp;(eg omeprazole) (used to treat heartburn and&nbsp;stomach ulcers&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>No significant&nbsp;adverse reactions&nbsp;were observed in fetuses or neonates when maternal levels of&nbsp;digoxin&nbsp;were maintained within the normal range.&nbsp;The use of Lanoxin during pregnancy should be considered if the benefits outweigh the potential risks to the fetus.<\/p>\n\n\n\n<p>Digoxin&nbsp;given to the mother has been used to treat abnormally fast heartbeats and&nbsp;heart failure&nbsp;in fetuses.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Lanoxin is excreted in breast milk, but is unlikely to affect breast-fed infants.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>As&nbsp;central nervous system&nbsp;and visual&nbsp;disturbances&nbsp;have been reported, caution should be exercised when driving vehicles, using machines or engaging in hazardous activities.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Lanoxin contains methyl parahydroxybenzoate (E218), sucrose, sodium and ethanol<\/h2>\n\n\n\n<p><em>Methyl parahydroxybenzoate (E218)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>May cause allergic reactions (possibly delayed).<\/li><\/ul>\n\n\n\n<p><em>Sucrose:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking Lanoxin.&nbsp;Because Lanoxin&nbsp;oral&nbsp;solution contains sucrose, it can be harmful to the teeth.<\/li><\/ul>\n\n\n\n<p><em>Sodium:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This medicine contains 0.0551 mmol&nbsp;sodium&nbsp;per 1 ml&nbsp;oral&nbsp;solution.&nbsp;Depending on&nbsp;dose&nbsp;one, the amount of&nbsp;sodium&nbsp;may vary.&nbsp;This should be considered by patients on a low-salt diet.<\/li><\/ul>\n\n\n\n<p><em>Ethanol:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This medicine contains less than 8.5% v \/ w&nbsp;ethanol&nbsp;(alcohol) in a&nbsp;dose&nbsp;of 5 ml, equivalent to 12.5 ml beer or 4.5 ml wine.&nbsp;The amount of&nbsp;ethanol&nbsp;varies depending on the size of the dose.&nbsp;Harmful to people suffering from alcoholism.&nbsp;This information should be considered for pregnant or lactating women, children and high-risk groups such as patients with liver disease or&nbsp;epilepsy&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Lanoxin<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p>The difference between the effective&nbsp;dose&nbsp;and the&nbsp;dose&nbsp;that causes&nbsp;side effects&nbsp;is usually small.&nbsp;It is therefore important to follow the doctor&#8217;s&nbsp;prescription&nbsp;.<\/p>\n\n\n\n<p>Lanoxin&nbsp;oral&nbsp;solution comes with a graduated&nbsp;pipette&nbsp;to be used to measure all&nbsp;doses&nbsp;.<\/p>\n\n\n\n<p>Lanoxin&nbsp;oral&nbsp;solution should not be diluted.<\/p>\n\n\n\n<p><em>Recommended maintenance dose to:<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Adults and children over 10 years of age are 0.125 and 0.25 mg (2.5-5 ml) of&nbsp;oral&nbsp;solution daily.<\/li><li>Children under the age of 10 are determined on the basis of the child&#8217;s weight and are usually between 0.005 and 0.01 mg \/ kg (0.1-0.2 ml \/ kg) body weight.<\/li><\/ul>\n\n\n\n<p>A lower&nbsp;dose&nbsp;may be needed in case of impaired renal function.<\/p>\n\n\n\n<p>Sometimes treatment with Lanoxin is started with a slightly higher&nbsp;dose&nbsp;for a few days (so-called digitization).&nbsp;This is done to achieve a certain level (concentration) of&nbsp;digoxin&nbsp;in the body, which is then maintained with a lower maintenance dose.<\/p>\n\n\n\n<p>When using Lanoxin, you may have to take blood samples regularly.&nbsp;This is to be able to determine how you respond to the treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Lanoxin than you should<\/h2>\n\n\n\n<p>If you have taken too large a&nbsp;dose of&nbsp;medicine or if e.g.&nbsp;If a child has ingested the medicine by mistake, contact a doctor, hospital or the Poison Information Center (tel. 112) for risk assessment and advice.<\/p>\n\n\n\n<p>The signs of Lanoxin poisoning can be heart rhythm disturbances, nausea, vomiting, headache, fatigue, confusion, altered consciousness, hallucinations, seizures, blurred vision, disturbed color vision.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Lanoxin<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/p>\n\n\n\n<p><strong>If you stop using Lanoxin<\/strong><\/p>\n\n\n\n<p>Do not stop treatment without consulting a doctor.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>If&nbsp;side effects&nbsp;occur, they are almost always signs of overdose.&nbsp;Contact a doctor if&nbsp;side effects&nbsp;occur.<\/p>\n\n\n\n<p><em>Common<\/em>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<p>&#8211; Impact on the&nbsp;central nervous system&nbsp;, dizziness.<\/p>\n\n\n\n<p>&#8211; Visual disturbance (blurred vision, yellow-green vision).<\/p>\n\n\n\n<p>&#8211; Irregular heartbeat, disturbance in the heart&#8217;s conduction system (eg too low&nbsp;pulse&nbsp;).<\/p>\n\n\n\n<p>&#8211; Nausea, vomiting, diarrhea.<\/p>\n\n\n\n<p>&#8211; Skin rash similar to&nbsp;hives&nbsp;.<\/p>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(may affect up to 1 in 100 people)&nbsp;<\/p>\n\n\n\n<p>&#8211; Depression.<\/p>\n\n\n\n<p><em>Very rare<\/em>&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<p>&#8211; Decreased number of&nbsp;platelets&nbsp;(&nbsp;blood cells&nbsp;that cause the blood to clot), increased number of&nbsp;white blood cells&nbsp;(&nbsp;blood cells&nbsp;that participate in the body&#8217;s infection defense).<\/p>\n\n\n\n<p>&#8211; Loss of appetite<\/p>\n\n\n\n<p>&#8211; Severe psychological influence (&nbsp;psychosis&nbsp;), indifference, confusion.<\/p>\n\n\n\n<p>&#8211; Headache.<\/p>\n\n\n\n<p>&#8211; Abnormal heartbeat<\/p>\n\n\n\n<p>&#8211; Stomach pain, caused by lack of blood supply to the intestines or damage to them, which can lead to tissue death.<\/p>\n\n\n\n<p>&#8211; Enlargement of the mammary glands (&nbsp;gynecomastia&nbsp;).<\/p>\n\n\n\n<p>&#8211; Fatigue, a general feeling of discomfort, weakness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Lanoxin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;digoxin&nbsp;50 micrograms \/ ml.<\/li><li>The other ingredients are anhydrous disodium phosphate, citric acid monohydrate, methyl parahydroxybenzoate (&nbsp;preservative&nbsp;E 218), sucrose, quinoline yellow (dye E 104), lime (flavoring),&nbsp;ethanol&nbsp;96%, propylene glycol and purified water.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Glass bottle with measuring pipette containing 60 ml&nbsp;oral&nbsp;solution.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Agent<\/h2>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive,<\/p>\n\n\n\n<p>Citywest Business Campus,<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p>0046 856642572<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lanoxin contains the active substance digoxin which is a so-called cardiac glycoside. Digoxin increases the contractile force of the heart and reduces the number of heartbeats per minute.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15579],"tags":[15286,15291,5604,5606,15287,15290,15285,5605,15288,15289],"class_list":["post-16075","post","type-post","status-publish","format-standard","hentry","category-medicines","category-l","tag-benefits-of-digoxin","tag-benefits-of-lanoxin","tag-digoxin","tag-digoxin-side-effects","tag-lanoxin","tag-lanoxin-side-effects","tag-what-digoxin-is-used-for","tag-what-is-digoxin","tag-what-is-lanoxin","tag-what-lanoxin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16075","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=16075"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16075\/revisions"}],"predecessor-version":[{"id":16124,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/16075\/revisions\/16124"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=16075"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=16075"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=16075"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}