{"id":15964,"date":"2021-11-25T15:37:12","date_gmt":"2021-11-25T15:37:12","guid":{"rendered":"https:\/\/zeepedia.com\/?p=15964"},"modified":"2022-12-03T14:14:27","modified_gmt":"2022-12-03T14:14:27","slug":"kyntheum","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/kyntheum\/","title":{"rendered":"Kyntheum &#8211; Brodalumab Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong><strong>Kyntheum 210 mg<\/strong>&nbsp;Solution for injection&nbsp;in a Pre Filled&nbsp;Syringe of Brodalumab<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Kyntheum Is And What It Is Used For<\/h2>\n\n\n\n<p>Kyntheum is a medicine that contains the active substance brodalumab.&nbsp;Brodalumab is a monoclonal&nbsp;antibody, a special type of&nbsp;protein&nbsp;that recognizes and attaches to certain&nbsp;proteins&nbsp;in your body.<\/p>\n\n\n\n<p><strong>kyntheum brodalumab<\/strong> belongs to a group of medicines called\u00a0interleukin\u00a0(IL) inhibitors.\u00a0This drug works by blocking the activity of IL-17\u00a0proteins, which occur in elevated levels in diseases such as\u00a0psoriasis.<\/p>\n\n\n\n<p>Kyntheum is used to treat a skin disease called plaque psoriasis, which causes&nbsp;inflammation&nbsp;and scaly plaque formation in the skin.&nbsp;Kyntheum is used in adults with moderate to severe plaque psoriasis that affects large areas of the body.<\/p>\n\n\n\n<p>The use of Kyntheum will improve skin healing and reduce the signs and symptoms of&nbsp;psoriasis, such as&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Itching<\/li><li>Redness<\/li><li>Scaling<\/li><li>Burning<\/li><li>Tingling<\/li><li>Cracking<\/li><li>Flaking<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">Pain<\/a><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Kyntheum<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Kyntheum<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to <strong><em>kyntheum brodalumab <\/em><\/strong>or any of the other ingredients of this medicine (listed in section 6).\u00a0If you think you may be allergic, ask your doctor for advice before using Kyntheum<\/li><li>If you have active\u00a0Crohn&#8217;s disease<\/li><li>If you have an\u00a0infection\u00a0that your doctor considers important (for example, active\u00a0tuberculosis\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have an\u00a0inflammatory\u00a0disease of the gastrointestinal tract called\u00a0Crohn&#8217;s disease<\/li><li>If you have an\u00a0inflammation\u00a0of the colon called\u00a0ulcerative colitis<\/li><li>If you have ever had or still have suicidal thoughts, depression, anxiety or mood problems or have committed suicide<\/li><li>If you have an active\u00a0infection\u00a0or if you often get\u00a0infections\u00a0you<\/li><li>If you have a long-term (\u00a0chronic\u00a0)\u00a0infection<\/li><li>If you have\u00a0tuberculosis\u00a0, have tested positive for\u00a0tuberculosis\u00a0or have been in close contact with someone who has\u00a0tuberculosis\u00a0.\u00a0You may need to be treated with another medicine for\u00a0tuberculosis\u00a0before starting treatment with this medicine.<\/li><li>If you have recently received or have a planned vaccination.\u00a0You should not be given certain types of vaccines (so-called &#8220;live vaccines&#8221;) while you are being treated with Kyntheum.<\/li><li>If you have used Kyntheum during the last three months of pregnancy, talk to your doctor before vaccinating your baby.<\/li><li>If you are receiving any other treatment for\u00a0psoriasis\u00a0, such as another immunosuppressive drug or light therapy with ultraviolet (UV) light.<\/li><\/ul>\n\n\n\n<p>After starting treatment with this medicine, tell your doctor, pharmacist, or nurse immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If your doctor tells you that you have developed&nbsp;Crohn&#8217;s disease<\/li><li>If you feel depressed, anxious or have suicidal thoughts, or have unusual mood swings<\/li><li>If you get an&nbsp;infection&nbsp;or get any signs of&nbsp;infection&nbsp;listed in section 4 \u201cPossible side effects\u201d<\/li><li>If you are told you have&nbsp;tuberculosis&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Inflammatory&nbsp;bowel disease (&nbsp;Crohn&#8217;s disease&nbsp;or&nbsp;ulcerative colitis&nbsp;)<\/strong><\/p>\n\n\n\n<p>Stop using IL \u2011 17 \u2011 inhibitors, such as Kyntheum, and contact a doctor or seek medical attention immediately if you experience stomach cramps and pain, diarrhea, weight loss, or blood in the stool (signs of bowel problems).<\/p>\n\n\n\n<p><strong>Be aware of allergic reactions<\/strong><\/p>\n\n\n\n<p>Kyntheum can cause serious&nbsp;side effects, including allergic reactions.&nbsp;Be aware of signs of these conditions while using Kyntheum.<\/p>\n\n\n\n<p>Stop using this medicine and contact a doctor or seek medical attention immediately if you notice any signs of an\u00a0allergic reaction.\u00a0Examples of such signs are listed under &#8220;Serious side effects&#8221; in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>This medicine is not recommended for children and adolescents (under 18 years of age) as it has not been studied in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Kyntheum<\/h2>\n\n\n\n<p>Tell a doctor or pharmacist:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are taking, have recently taken or might take any other medicines<\/li><li>If you have recently been vaccinated or if you or your infant should be vaccinated soon, see &#8220;Warnings and Precautions&#8221; in section &#8220;2.&nbsp;What you need to know before using Kyntheum \u201d.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.\u00a0Kyntheum has not been tested on pregnant women and it is not known if this medicine can harm your unborn baby.\u00a0It is, therefore, best to avoid using Kyntheum during pregnancy.\u00a0If you are a woman of\u00a0childbearing potential, you should avoid becoming pregnant and must use effective contraception during treatment with Kyntheum and for at least 12 weeks after the last\u00a0dose of\u00a0this medicine.<\/p>\n\n\n\n<p>It is not known if brodalumab is converted to breast milk.\u00a0Tell your doctor if you are breastfeeding or planning to breastfeed.\u00a0Your doctor will then help you decide whether to stop breastfeeding or stop using Kyntheum.\u00a0Together you will consider the benefits of breastfeeding for the baby and the benefits of this medicine for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Kyntheum does not affect your ability to drive and use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Use Kyntheum<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Kyntheum should be prescribed to you by a doctor who has experience in diagnosing and treating&nbsp;psoriasis.<\/li><li>Always use this medicine exactly as your doctor, pharmacist or nurse has told you.&nbsp;If you are not sure, talk to your doctor, pharmacist, or nurse.<\/li><\/ul>\n\n\n\n<p><strong>How much kyntheum injection<\/strong> <strong>is given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will decide how much Kyntheum you need and for how long.\u00a0The recommended\u00a0dose\u00a0is 210 mg (one\u00a0injection\u00a0).<\/li><li>After the first\u00a0dose\u00a0one you need to get a weekly\u00a0injection\u00a0week 1 (one week after the first\u00a0dose\u00a0one) and week 2 (two weeks after the first\u00a0dose\u00a0one).\u00a0Then you need to get an\u00a0injection\u00a0every two weeks.<\/li><li>Kyntheum is intended for long-term treatment.\u00a0Your doctor will regularly check your condition to make sure the treatment is having the desired effect.\u00a0Talk to your doctor if you do not feel that your signs and symptoms of\u00a0psoriasis\u00a0improve after receiving <strong>kyntheum injection<\/strong>.<\/li><\/ul>\n\n\n\n<p><strong>How Kyntheum is given<\/strong><\/p>\n\n\n\n<p>This medicine is given as an\u00a0injection\u00a0under the skin (it is called a\u00a0subcutaneous\u00a0injection\u00a0).<\/p>\n\n\n\n<p><strong>Instructions on how to give yourself the medicine<\/strong><\/p>\n\n\n\n<p><strong>See the detailed \u201cInstructions for Use\u201d<\/strong>&nbsp;that come with this medicine for information on how to store, prepare and&nbsp;administer the injections&nbsp;properly at home.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If the doctor decides that you or a carer can give the\u00a0injections\u00a0at home, you or the carer should receive training in the correct way to prepare and inject Kyntheum.\u00a0Do not try to inject Kyntheum until your doctor or nurse has shown you or your healthcare provider how to inject Kyntheum.<\/li><li>Do not shake the pre-filled syringe before use.<\/li><li>This medicine is injected into the upper part of the legs (thighs) or stomach (abdomen) by you or a caregiver.\u00a0A caregiver can also give you an\u00a0injection\u00a0in the outside of the upper arm.<\/li><li>Do not inject into an area with bruising or where the skin is sore, red, hard or into an area of \u200b\u200bskin with\u00a0psoriasis\u00a0.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Kyntheum Than You Should\u00a0<\/h2>\n\n\n\n<p><strong>kyntheum usage<\/strong><\/p>\n\n\n\n<p>If you have used more of this medicine than&nbsp;you should&nbsp;or if you have taken a&nbsp;dose&nbsp;earlier than required, tell your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Kyntheum<\/h2>\n\n\n\n<p>kyntheum usage<\/p>\n\n\n\n<p>If you forget to inject one\u00a0dose\u00a0of this medicine, inject the next\u00a0dose\u00a0as soon as you can.\u00a0Then contact your doctor to discuss when to inject the next\u00a0dose.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Using Kyntheum<\/h2>\n\n\n\n<p>You should not stop using this medicine without talking to your doctor first.\u00a0If you stop treatment, your psoriasis symptoms may return.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible kyntheum Side Effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious\u00a0kyntheum side effects<\/strong> <strong>are<\/strong><\/p>\n\n\n\n<p>Stop using this medicine and contact a doctor or seek medical attention immediately if you get any of the following\u00a0side effects.\u00a0Your doctor will decide if and when you can resume treatment.<\/p>\n\n\n\n<p><strong>Severe&nbsp;allergic reaction&nbsp;(may affect up to 1 in 1,000 people), signs of this may be:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Difficult to breathe or swallow<\/li><li>Low&nbsp;blood pressure&nbsp;, which can cause dizziness or fainting<\/li><li>Swelling of the face, lips, tongue or throat<\/li><li>Severe skin itching with red rash or raised bumps<\/li><\/ul>\n\n\n\n<p><strong>Any serious&nbsp;infection&nbsp;(may affect up to 1 in 100 people), signs of this may be:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cold\/\">Fever<\/a><\/li><li>Flu-like symptoms<\/li><li>Night sweats<\/li><li>Fatigue<\/li><li>Shortness of breath<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">Cough<\/a> that does not go away<\/li><li>Hot, red and painful skin<\/li><li>Painful rash with blisters<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0side effects<\/strong> <strong>have been reported<\/strong><\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><li>Nausea<\/li><li>Redness<\/li><li>Pain<\/li><li>Itching<\/li><li>Bruising<\/li><li>Bleeding at the injection site<\/li><li>Fatigue<\/li><li>Pain in mouth or throat<\/li><li>Fungal infection (&nbsp;tinea&nbsp;) in the skin (including on feet and groin)<\/li><li>Influenza<\/li><li>Headache<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/joint-pain\/\">Joint pain<\/a><\/li><li>Muscle <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">aches<\/a><\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fungal infection (&nbsp;candida&nbsp;) in the mouth<\/li><li>Throat or genitals<\/li><li>Watery eyes with&nbsp;itching<\/li><li>Redness&nbsp;and swelling (&nbsp;conjunctivitis&nbsp;)<\/li><li>Low&nbsp;white blood cell count&nbsp;<\/li><\/ul>\n\n\n\n<p>Most of these&nbsp;side effects&nbsp;are mild to moderate.&nbsp;If any of these&nbsp;side effects&nbsp;gets serious, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach cramps and pain<\/li><li>Diarrhea<\/li><li>Weight loss<\/li><li>Blood in the stool <\/li><\/ul>\n\n\n\n<p>(signs of bowel problems) have also been reported with IL \u2011 17 \u2011 inhibitors, such as Kyntheum.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Kyntheum<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the outer carton and label on the pre-filled syringe after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in the outer carton.\u00a0Sensitive to light.<\/li><li>Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).\u00a0Do not freeze.<\/li><li>This medicine can be stored at room temperature up to 25 \u00b0 C in the outer carton for 14 days.\u00a0Discard this medicine if not used within 14 days at room temperature.<\/li><li>Do not use this medicine if the solution is cloudy or discolored or contains lumps, flakes, or particles.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Pack And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is brodalumab.&nbsp;Each pre-filled&nbsp;syringe&nbsp;contains 210 mg brodalumab in 1.5 ml solution.<\/li><li>The other ingredients are&nbsp;<ul><li>Proline<\/li><li>Glutamate<\/li><li>Polysorbate<\/li><li>Water for injections<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Anthem is a&nbsp;solution for injection, which is a clear to slightly pearlescent, colorless to pale yellow liquid, without particles.<\/li><li>Anthem is available in packs containing 2 pre-filled syringes and in multipacks containing 6 (3 packs of 2) pre-filled syringes.&nbsp;Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>LEO Pharma A \/ S<\/p>\n\n\n\n<p>Industrial Park 55<\/p>\n\n\n\n<p>DK-2750 Ballerup<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>LEO Laboratories<\/p>\n\n\n\n<p>39 Route de Chartres<\/p>\n\n\n\n<p>28500 Vernouillet<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>LEO Pharma A \/ S<\/p>\n\n\n\n<p>Industrial Park 55<\/p>\n\n\n\n<p>DK \u2011 2750 Ballerup<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kyntheum is used to treat plaque psoriasis, a disease causing red, scaly patches on the skin. It is used in adults with moderate to severe disease and requires systemic treatment (with medicines given by mouth or injection). <\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12118],"tags":[15167,15172,15163,15166,15168,15171,15165,15164,15169,15170],"class_list":["post-15964","post","type-post","status-publish","format-standard","hentry","category-medicines","category-k","tag-benefits-of-brodalumab","tag-benefits-of-kyntheum","tag-brodalumab","tag-brodalumab-side-effects","tag-kyntheum","tag-kyntheum-side-effects","tag-what-brodalumab-is-used-for","tag-what-is-brodalumab","tag-what-is-kyntheum","tag-what-kyntheum-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=15964"}],"version-history":[{"count":76,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15964\/revisions"}],"predecessor-version":[{"id":37971,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15964\/revisions\/37971"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=15964"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=15964"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=15964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}