{"id":15959,"date":"2021-11-25T15:22:09","date_gmt":"2021-11-25T15:22:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=15959"},"modified":"2021-12-09T08:46:21","modified_gmt":"2021-12-09T08:46:21","slug":"kymriah-thisagenle-nucleus","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/kymriah-thisagenle-nucleus\/","title":{"rendered":"Kymriah &#8211; Thisagenle nucleus uses, dose and side effects"},"content":{"rendered":"\n<p>1.2 x 10\u00a0<sup>6<\/sup>\u00a0&#8211; 6 x 10\u00a0<sup>8<\/sup>\u00a0cells\u00a0infusion fluid\u00a0,\u00a0dispersion<br>thisagentle nucleus (CAR + viable\u00a0T cells\u00a0)a<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Kymriah is and what it is used for<\/h2>\n\n\n\n<p><strong>What Kymriah is<\/strong><\/p>\n\n\n\n<p>Kymriah, also called thisagenlekleucel, is made up of a number of your white blood cells&nbsp;called&nbsp;T cells.&nbsp;T cells are important for your immune system to function normally.<\/p>\n\n\n\n<p><strong>How does Kymriah work?<\/strong><\/p>\n\n\n\n<p>To make Kymriah,&nbsp;T&nbsp;cells are taken&nbsp;from your blood and a new gene is placed in the&nbsp;T cells&nbsp;so that they can target the cancer cells in your body.&nbsp;When you receive Kymriah via an infusion into the bloodstream, the modified&nbsp;T cells will&nbsp;find and kill the cancer cells.<\/p>\n\n\n\n<p><strong>What Kymriah is used for<\/strong><\/p>\n\n\n\n<p>Kymriah is used to treat:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>acute&nbsp;lymphoblastic&nbsp;B cell leukemia (B-cell ALL)<\/strong>&nbsp;&#8211; a cancer affecting certain&nbsp;white blood cells&nbsp;.&nbsp;It can be used in children and young adults up to the age of 25 who have this type of cancer.<\/li><li><strong>diffuse large-cell B-cell lymphoma (DLBCL)<\/strong>&nbsp;&#8211; another form of cancer that affects certain types of&nbsp;white blood cells&nbsp;, most often in the lymph nodes.&nbsp;It can be used in adults (from the age of 18) who have this type of cancer.<\/li><\/ul>\n\n\n\n<p>Ask your doctor if you are wondering how Kymriah works or why the medicine has been prescribed for you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given Kymriah<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not be given Kymriah:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to any of the ingredients of this medicine (listed in section 6).&nbsp;Ask your doctor if you think you may be allergic.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Kymriah is made from your white blood cells&nbsp;and should be given to you only.<\/p>\n\n\n\n<p><strong>Before you are given Kymriah, tell your doctor about:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have had a&nbsp;stem cell transplant&nbsp;in the last 4 months.&nbsp;Your doctor will check if you have any signs or symptoms of a&nbsp;graft&nbsp;\u2011for \u2011 host \u2011 disease.&nbsp;This means that the transplanted cells attack your body and cause symptoms such as skin rash, nausea, vomiting, diarrhea and blood-mixed stools.<\/li><li>you have problems with your lungs, heart or&nbsp;blood pressure&nbsp;(low or high).<\/li><li>you notice that the symptoms of your cancer are getting worse.&nbsp;If you have&nbsp;leukemia&nbsp;, this may include having a fever, feeling weak, having bleeding gums or getting bruises.&nbsp;If you have&nbsp;lymphoma&nbsp;, it may include you getting a fever for no apparent reason, feeling weak, sweating at night or suddenly losing weight<\/li><li>you have an&nbsp;infection&nbsp;.&nbsp;Infection&nbsp;one will be treated before you get Kymriah.<\/li><li>you have had an&nbsp;infection&nbsp;with&nbsp;hepatitis&nbsp;B,&nbsp;hepatitis&nbsp;C or human immunodeficiency virus (&nbsp;HIV&nbsp;).<\/li><li>you are pregnant, think you may be pregnant, or are planning to become pregnant (see sections \u201cPregnancy and breast-feeding\u201d and \u201cContraceptives for women and men\u201d below).<\/li><li>you have been vaccinated in the last 6 weeks or are planning a vaccination in the next few months.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor before taking Kymriah.<\/p>\n\n\n\n<p><strong>Samples and examinations<\/strong><\/p>\n\n\n\n<p><strong>Before you are given Kymriah, your&nbsp;<\/strong>&nbsp;<strong>doctor will check the following:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lungs, heart and&nbsp;blood pressure&nbsp;.<\/li><li>Signs of&nbsp;infection&nbsp;.&nbsp;In that case,&nbsp;infection&nbsp;one is&nbsp;treated&nbsp;before you get Kymriah.<\/li><li>If your&nbsp;lymphoma&nbsp;or&nbsp;leukemia&nbsp;has worsened.<\/li><li>Any signs of&nbsp;graft&nbsp;\u2011about \u2011 host \u2011 disease, which may occur after a transplant.<\/li><li>If you have&nbsp;uric acid&nbsp;in&nbsp;your&nbsp;blood and how many cancer cells you have in your blood.&nbsp;This shows if there is a risk that you will get so-called tumor light syndrome.&nbsp;You can get medicine to reduce the risk of it.<\/li><li>If you have&nbsp;hepatitis&nbsp;B,&nbsp;hepatitis&nbsp;C or&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>After you&#8217;ve got Kymriah<\/strong><\/p>\n\n\n\n<p><strong>Tell your doctor or nurse immediately if you have any of the following:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever, which can be a symptom of an&nbsp;infection&nbsp;.&nbsp;Your doctor will check your blood levels regularly, as the number of&nbsp;blood cells&nbsp;and other blood components may decrease.<\/li><li>Measure your temperature twice a day for 3-4 weeks after&nbsp;administering&nbsp;Kymriah.&nbsp;Contact a doctor immediately if your temperature is elevated.<\/li><li>Extreme fatigue, weakness and shortness of breath, which can be symptoms of a lack of&nbsp;red blood cells&nbsp;.<\/li><li>You bleed or bruise more easily which can be a symptom of low levels of a type of&nbsp;blood cell&nbsp;in the blood called&nbsp;platelets&nbsp;.<\/li><\/ul>\n\n\n\n<p>The results of certain types of&nbsp;HIV&nbsp;tests may be affected &#8211; ask your doctor about this.<\/p>\n\n\n\n<p>Your doctor will regularly check your blood counts after you have received Kymriah as the number of&nbsp;blood cells&nbsp;and other components in your blood may decrease.<\/p>\n\n\n\n<p>Do not donate blood, organs,&nbsp;tissues, sperm, scars, or cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>No formal studies have been performed in children under 3 years of age with B-cell ALL.<\/li><li>Kymriah should not be used for the treatment of DLBCL in children and adolescents under 18 years of age.&nbsp;Kymriah has not been studied in this age group.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Kymriah<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.&nbsp;Other medicines may affect the way Kymriah works.<\/p>\n\n\n\n<p>You mustn&#8217;t be given certain vaccines called live vaccines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>for 6 weeks before you receive the short chemotherapy treatment (so-called lymphocyte-&nbsp;reducing chemotherapy&nbsp;), which prepares your body for the Kymriah cells<\/li><li>during the Kymriah treatment<\/li><li>after treatment while the immune system recovers.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if you need to be vaccinated.<\/p>\n\n\n\n<p>Before you are given Kymriah, tell your doctor or nurse if you are taking any medicines that weaken the immune system such as&nbsp;corticosteroids&nbsp;(&#8220;cortisone&#8221;).&nbsp;These medicines may affect the effect of Kymriah.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.&nbsp;The effects of Kymriah on pregnant or breastfeeding women are not known and could harm an unborn baby or a newborn baby\/infant.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you become pregnant or think you may be pregnant after treatment with Kymriah, talk to a doctor immediately.<\/li><li>Before starting treatment, a pregnancy test is performed.&nbsp;Kymriah should only be given if the results show that you are not pregnant.<\/li><\/ul>\n\n\n\n<p><strong>Contraceptives for women and men<\/strong><\/p>\n\n\n\n<p>Talk to your doctor about pregnancy if you have had Kymriah.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You must not drive, use machines, or engage in any activity that requires concentration and attention as Kymriah may cause problems such as altered or impaired consciousness, confusion, and seizures for 8 weeks after&nbsp;infusion.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Kymriah contains sodium, dimethyl sulfoxide (DMSO) and dextran 40.<\/h2>\n\n\n\n<p>This medicine contains 24.3 to 121.5 mg of&nbsp;sodium&nbsp;per&nbsp;dose.&nbsp;This corresponds to 1 to 6% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.&nbsp;If you have not been in contact with dextran or DMSO before, you should be kept under close observation during the first minutes of the infusion period.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Kymriah<\/h2>\n\n\n\n<p>Kymriah is always given by a doctor at a qualified clinic.<\/p>\n\n\n\n<p>Kymriah contains human&nbsp;blood cells.&nbsp;The physician handling Kymriah will therefore take appropriate precautions (use gloves and goggles) to avoid the potential transmission of infectious diseases.<\/p>\n\n\n\n<p><strong>Donate blood for the making of Kymriah<\/strong><\/p>\n\n\n\n<p>Kymriah is made from your white blood cells.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will collect a quantity of your blood through a&nbsp;catheter&nbsp;that is placed in a vein.&nbsp;A number of your&nbsp;white blood cells&nbsp;will then be separated from your blood, the rest of the blood being returned to your vein.&nbsp;The procedure is called&nbsp;leukapheresis&nbsp;and can take 3 to 6 hours and may need to be repeated again.<\/li><li>Your&nbsp;white blood cells&nbsp;are frozen and sent away for the production of Kymriah.&nbsp;It usually takes 3 to 4 weeks to make Kymriah, but the time may vary.<\/li><li>Kymriah is a treatment that is made specifically for you.&nbsp;There may be times when the production of Kymriah is not successful and it can not be given to you.&nbsp;In some cases, a second attempt to make Kymriah may be made.<\/li><\/ul>\n\n\n\n<p>Before you receive Kymriah, your doctor may give you a type of treatment called lymphocyte-reducing chemotherapy&nbsp;for a few days to prepare your body.<\/p>\n\n\n\n<p><strong>Treatment of cancer while Kymriah is being manufactured<\/strong><\/p>\n\n\n\n<p>During the period of manufacture of Kymriah, your&nbsp;lymphoma&nbsp;or&nbsp;leukemia&nbsp;may worsen and&nbsp;your&nbsp;doctor may decide to use an additional treatment (a type of&nbsp;chemotherapy&nbsp;called &#8220;bridging treatment&#8221;) to stabilize your cancer by stopping the formation of new cancer cells.&nbsp;This treatment can lead to&nbsp;side effects&nbsp;that can be serious or life-threatening.&nbsp;Your doctor will inform you about the possible&nbsp;side effects&nbsp;of this treatment.<\/p>\n\n\n\n<p><strong>Medicines are given immediately before treatment with Kymriah<\/strong><\/p>\n\n\n\n<p>For 30-60 minutes before receiving Kymriah, you may be given other medicines to prevent infusion reactions and fever.&nbsp;You can get medicines such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Paracetamol<\/li><li>An&nbsp;antihistamine&nbsp;such as&nbsp;diphenhydramine.<\/li><\/ul>\n\n\n\n<p><strong>How to give Kymriah<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will check that the patient information on the infusion bag with Kymriah matches your information.<\/li><li>The doctor will give you Kymriah as an&nbsp;infusion&nbsp;, ie.&nbsp;you get the drug as a drip through a tube into a vein.&nbsp;It usually takes less than 1 hour.<\/li><li>Kymriah is a one-time treatment.<\/li><\/ul>\n\n\n\n<p><strong>Once you&#8217;ve got Kymriah<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For at least 4 weeks after receiving Kymriah, you must plan to stay within 2 hours of travel distance from the hospital where you were treated.&nbsp;Your doctor will recommend that you come to the hospital daily for at least 10 days and will consider whether you need to be hospitalized for the first 10 days after&nbsp;infusion&nbsp;one.&nbsp;Your doctor needs to check that the treatment is working and help you if you get&nbsp;any side effects&nbsp;.<\/li><\/ul>\n\n\n\n<p>If you miss an appointment, call your doctor or hospital as soon as possible to rebook.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell<\/strong>&nbsp;your&nbsp;<strong>doctor immediately if<\/strong>&nbsp;you get any of the following&nbsp;side effects&nbsp;after Kymriah&nbsp;infusion.&nbsp;They usually occur during the first 8 weeks after&nbsp;infusion&nbsp;but can also develop later:<\/p>\n\n\n\n<p><strong>Very common:&nbsp;<\/strong>&nbsp;<strong>may affect more than 1 in 10 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high fever and chills.&nbsp;These can be symptoms of a serious condition called cytokine release syndrome which can be life threatening or fatal.&nbsp;Other symptoms of cytokine release syndrome include difficulty breathing, nausea, vomiting, diarrhea, loss of appetite, fatigue, muscle aches, joint pain, swelling, low&nbsp;blood pressure&nbsp;, headache, heart, lung and&nbsp;kidney failure&nbsp;and liver damage or dizziness \/ fainting.&nbsp;These symptoms almost always occur during the first 10 days after&nbsp;infusion&nbsp;one.<\/li><li>problems such as changes in thinking or decreased level of consciousness, lost perception of reality, confusion, agitation, seizures, difficulty speaking or understanding speech, difficulty walking.<\/li><li>you feel hot, have a fever, chill or start shivering, have a sore throat or cold sore &#8211; this may be a sign of an&nbsp;infection&nbsp;.&nbsp;Some&nbsp;infections&nbsp;can be life-threatening or fatal.<\/li><\/ul>\n\n\n\n<p><strong>Common:&nbsp;<\/strong>&nbsp;<strong>may affect up to 1 in 10 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rapid degradation of tumor cells, which causes its contents to spread in the bloodstream.&nbsp;This can interfere with the function of various organs in the body, in particular the kidneys, heart and nervous system (tumor lysis syndrome)<\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;are listed below.&nbsp;If these&nbsp;side effects&nbsp;become severe, tell your doctor immediately<\/p>\n\n\n\n<p><strong>Very common:&nbsp;<\/strong>&nbsp;<em>may affect more than 1 in 10 people<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pale skin, weakness, shortness of breath due to low&nbsp;red blood cell count&nbsp;or low hemoglobin value<\/li><li>heavy or prolonged bleeding or bruising due to low&nbsp;platelet count<\/li><li>fever with a dangerously low&nbsp;white blood cell count<\/li><li>increased risk of&nbsp;infection&nbsp;due to an abnormally low number of&nbsp;white blood cells<\/li><li>frequent and persistent&nbsp;infection&nbsp;due to reduced number of&nbsp;antibodies&nbsp;in the blood<\/li><li>weakness, abnormal heart rhythm, muscle spasms \/ cramps due to low levels of salts in the blood including phosphorus,&nbsp;calcium&nbsp;,&nbsp;potassium&nbsp;,&nbsp;magnesium<\/li><li>high levels of liver enzyme or&nbsp;creatinine&nbsp;in the blood indicating that the liver or kidneys are not functioning normally<\/li><li>anxiety, irritability<\/li><li>fast or irregular heartbeat<\/li><li>high&nbsp;blood pressure<\/li><li>shortness of breath, labored breathing, increased respiratory rate, fluid in the lungs<\/li><li>cough<\/li><li>abdominal pain, constipation<\/li><li>rash<\/li><li>difficulty sleeping<\/li><li>swollen ankles, arms, legs and face<\/li><\/ul>\n\n\n\n<p><strong>Common:&nbsp;<\/strong><em>may affect up to 1 in 10 people<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fever, malaise, enlarged liver, yellow skin or eyes, low&nbsp;blood cell count&nbsp;due to severe immune activation<\/li><li>dizziness or fainting,&nbsp;redness&nbsp;, rash,&nbsp;itching&nbsp;, fever, shortness of breath or vomiting, abdominal pain, diarrhea due to a reaction to&nbsp;infusion&nbsp;.<\/li><li>rash, nausea, vomiting, diarrhea including bloody stools (possible symptoms of&nbsp;graft-&nbsp;versus-host disease which is when transplanted cells attack your cells)<\/li><li>joint pain due to high levels of&nbsp;uric acid<\/li><li>abnormal results on blood tests (high levels of phosphorus,&nbsp;potassium&nbsp;,&nbsp;calcium&nbsp;,&nbsp;magnesium&nbsp;and&nbsp;sodium&nbsp;, an&nbsp;enzyme&nbsp;called alkaline phosphatase that helps detect liver disease,&nbsp;fibrin&nbsp;d-dimer,&nbsp;serum ferritin&nbsp;, low levels of: a&nbsp;protein&nbsp;in the blood called albumin,&nbsp;sodium&nbsp;)<\/li><li>convulsions, seizures<\/li><li>involuntary or uncontrollable movements<\/li><li>tingling or numbness, difficulty moving due to nerve damage<\/li><li>visual impairment<\/li><li>thirst<\/li><li>weight loss<\/li><li>nerve pain<\/li><li>shortness of breath, difficulty lying in a supine position, swollen feet or legs (possible symptoms of&nbsp;heart failure&nbsp;), cardiac arrest<\/li><li>swelling and pain due to blood clots<\/li><li>swelling due to leakage of fluid from blood vessels to surrounding&nbsp;tissue&nbsp;.<\/li><li>bloating and discomfort (distended abdomen) due to an accumulation of fluid in the abdomen<\/li><li>dry mouth&nbsp;, pain in the mouth, bleeding in the mouth,&nbsp;inflammation&nbsp;of the gums<\/li><li>yellow skin and yellow eyes due to abnormally high levels of&nbsp;bilirubin&nbsp;in the blood<\/li><li>itching<\/li><li>heavy sweating, night sweats<\/li><li>leg and back pain<\/li><li>flu-like illness<\/li><li>multiple organ failure<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:&nbsp;<\/strong><em>(may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>weakness or paralysis of the arms or legs or of the face, speech difficulties (possible symptoms of stroke as a result of reduced blood supply)<\/li><li>hot skin or sudden&nbsp;redness<\/li><li>mucus cough or sometimes bloody cough, fever, cough that produces mucus or sometimes blood, fever, shortness of breath or difficulty breathing<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Kymriah<\/h2>\n\n\n\n<p><strong>The following information is for physicians only.<\/strong><\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the infusion bag label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store and transport below \u2011120 \u00b0 C.&nbsp;Do not thaw the product until it is ready to use.<\/p>\n\n\n\n<p>Do not use this medicine if the infusion bag is damaged or leaking.<\/p>\n\n\n\n<p>This medicine contains genetically modified blood cells.&nbsp;Local guidelines for the management of biological waste must be followed for unused medicines and waste.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance in Kymriah is thisagenlekleucel.&nbsp;Each&nbsp;Kymriah&nbsp;infusion&nbsp;bag contains thisagen leucleucle cell dispersion with a batch-dependent concentration of autologous&nbsp;T cells&nbsp;that have been genetically modified to express a chimeric antigen receptor (CAR) directed against CD19 (CAR-positive viable&nbsp;T cells&nbsp;).&nbsp;1 or more bags containing a total of 1.2 X 10&nbsp;<sup>6<\/sup>&nbsp;&#8211; 6 x 10&nbsp;<sup>8<\/sup>&nbsp;CAR + viable&nbsp;T cell&nbsp;s<\/li><li>The other ingredients are:&nbsp;glucose&nbsp;, sodium chloride,&nbsp;human&nbsp;albumin solution, dextran 40 for&nbsp;injection&nbsp;, dimethylsulfoxide, sodium gluconate, sodium acetate, potassium chloride, magnesium chloride,&nbsp;sodium-&nbsp;N-acetyltryptophan, sodium caprylate, aluminum and water for injections.&nbsp;See section 2, &#8220;Kymriah contains&nbsp;sodium&nbsp;, dimethyl sulfoxide (DMSO) and dextran 40&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Kymriah is a cell dispersion for&nbsp;infusion.&nbsp;It is supplied in an&nbsp;infusion bag&nbsp;containing a cloudy to clear, colorless to light yellow&nbsp;dispersion&nbsp;of cells.&nbsp;Each bag contains 10 ml to 50 ml of&nbsp;dispersion.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Novartis Europharm Limited<\/p>\n\n\n\n<p>Vista Building<\/p>\n\n\n\n<p>Elm Park, Merrion Road<\/p>\n\n\n\n<p>Dublin 4<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Novartis Pharma GmbH<\/p>\n\n\n\n<p>Roonstrasse 25<\/p>\n\n\n\n<p>90429 Nuremberg<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>CELLFORCURE<\/p>\n\n\n\n<p>ZA de Courtab\u0153uf<\/p>\n\n\n\n<p>11 avenue des Tropiques<\/p>\n\n\n\n<p>91940 Les Ulis<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><td><strong>Lithuania<\/strong>SIA Novartis Baltics Lithuanian branchesTel: +370 5 269 16 50<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Novartis Bulgaria EOODTel: +359 2 489 98 28<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>Novartis Pharma NVTel: +32 2 246 16 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Novartis sroTel: +420 225 775 111<\/td><td><strong>Hungary<\/strong>Novartis Hungary Kft.Tel .: +36 1 457 65 00<\/td><\/tr><tr><td><strong>Denmark<\/strong>Novartis Healthcare A \/ STel: +45 39 16 84 00<\/td><td><strong>Malta<\/strong>Novartis Pharma Services Inc.Tel: +356 2122 2872<\/td><\/tr><tr><td><strong>Germany<\/strong>Novartis Pharma GmbHTel: +49 911 273 0<\/td><td><strong>The Netherlands<\/strong>Novartis Pharma BVTel: +31 88 04 52<\/td><\/tr><tr><td><strong>Eesti<\/strong>SIA Novartis Baltics Eesti subsidiaryTel: +372 66 30 810<\/td><td><strong>Norway<\/strong>Novartis Norge ASTel: +47 23 05 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Novartis (Hellas) AEBE:\u0397\u03bb: +30 210 281 17 12<\/td><td><strong>Austria<\/strong>Novartis Pharma GmbHTel: +43 1 86 6570<\/td><\/tr><tr><td><strong>Spain<\/strong>Novartis Pharmac\u00e9utica, SATel: +34 93 306 42 00<\/td><td><strong>Poland<\/strong>Novartis Poland Sp.&nbsp;z ooTel .: +48 22 375 4888<\/td><\/tr><tr><td><strong>France<\/strong>Novartis Pharma SASTel: +33 1 55 47 66 00<\/td><td><strong>Portugal<\/strong>Novartis Farma &#8211; Pharmaceutical Products, SATel: +351 21 000 8600<\/td><\/tr><tr><td><strong>Croatia<\/strong>Novartis Hrvatska dooTel.&nbsp;+385 1 6274 220<\/td><td><strong>Romania<\/strong>Novartis Pharma Services Romania SRLTel: +40 21 31299 01<\/td><\/tr><tr><td><strong>Ireland<\/strong>Novartis Ireland LimitedTel: +353 1 260 12 55<\/td><td><strong>Slovenia<\/strong>Novartis Pharma Services Inc.Tel: +386 1 300 75 50<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Novartis Slovakia sroTel: +421 2 5542 5439<\/td><\/tr><tr><td><strong>Italy<\/strong>Novartis Farma SpATel: +39 02 96 54 1<\/td><td><strong>Finland \/ Finland<\/strong>Novartis Finland OyPuh \/ Tel: +358 (0) 10 6133 200<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Novartis Pharma Services Inc.:\u0397\u03bb: +357 22 690 690<\/td><td><strong>Sweden<\/strong>Novartis Sverige ABTel: +46 8 732 32 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Novartis BalticsTel: +371 67 887 070<\/td><td><strong>United Kingdom<\/strong>Novartis Pharmaceuticals UK Ltd.Tel: +44 1276 698370<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Kymriah, also called thisagenlekleucel, is made up of a number of your white blood cells called T cells. T cells are important for your immune system to function normally.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12118],"tags":[15182,15177,15178,15181,15173,15176,15179,15174,15180,15175],"class_list":["post-15959","post","type-post","status-publish","format-standard","hentry","category-medicines","category-k","tag-benefits-of-kymriah","tag-benefits-of-thisagenle-nucleus","tag-kymriah","tag-kymriah-side-effects","tag-thisagenle-nucleus","tag-thisagenle-nucleus-side-effects","tag-what-is-kymriah","tag-what-is-thisagenle-nucleus","tag-what-kymriah-is-used-for","tag-what-thisagenle-nucleus-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=15959"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15959\/revisions"}],"predecessor-version":[{"id":15976,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15959\/revisions\/15976"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=15959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=15959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=15959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}