2.5 mg \/ 850 mg film-coated tablets
saxagliptin \/ metformin hydrochloride<\/p>\n\n\n\n
This medicine contains two different substances called:<\/p>\n\n\n\n
saxagliptin, which belongs to a class of drugs called DPP-4 inhibitors (dipeptidyl peptidase 4 inhibitors), and<\/p>\n\n\n\n
metformin, which belongs to a class of drugs called biguanides.<\/p>\n\n\n\n
Both belong to a group of medicines called oral diabetes medicines.<\/p>\n\n\n\n
What Komboglyze is used for<\/strong><\/p>\n\n\n\n This medicine is used to treat a type of diabetes called “type 2 diabetes”.<\/p>\n\n\n\n How Komboglyze works<\/strong><\/p>\n\n\n\n Saxagliptin and\u00a0metformin\u00a0work by regulating your blood sugar together.\u00a0They increase the levels of\u00a0insulin\u00a0after a meal.\u00a0They also lower the amount of sugar that is formed in your body.\u00a0Together with diet and exercise, this helps to lower your blood sugar.\u00a0This medicine can be used alone or in combination with other diabetes medicines, including\u00a0insulin.<\/p>\n\n\n\n To control your\u00a0diabetes, you still need to diet and exercise, even while taking this medicine.\u00a0Therefore, you must follow the advice on diet and exercise that you receive from your doctor or nurse.<\/p>\n\n\n\n Do not take this medicine if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking this medicine.<\/p>\n\n\n\n Risk of lactic acidosis<\/strong><\/p>\n\n\n\n KOMBOGLYZE can cause the very rare, but very serious\u00a0side effect\u00a0of\u00a0lactic acidosis, particularly if your kidneys are not working properly.\u00a0The risk of developing\u00a0lactic acidosis\u00a0is also increased in uncontrolled\u00a0diabetes, severe\u00a0infections, prolonged fasting or alcohol intake, dehydration (see more information below), liver problems, and conditions where part of the body has reduced oxygen supply (including\u00a0acute\u00a0severe heart disease).<\/p>\n\n\n\n If any of the above apply to you, talk to your doctor for further information.<\/p>\n\n\n\n Stop\u00a0taking Komboglyze for a short time if you have a condition that may be associated with dehydration,<\/strong>\u00a0such as severe vomiting, diarrhea, fever, exposure to heat, or if you drink less fluid than normal.\u00a0Talk to a doctor for further instructions.<\/p>\n\n\n\n Stop\u00a0taking Komboglyze and contact a doctor or nearest hospital immediately if you get any of the symptoms of\u00a0lactic acidosis<\/strong>\u00a0as the condition may lead to\u00a0coma.<\/p>\n\n\n\n The symptoms of lactic acidosis include:<\/p>\n\n\n\n Lactic acidosis is an acute medical condition that must be treated in a hospital.<\/p>\n\n\n\n Talk to your doctor or pharmacist before taking Komboglyze:<\/p>\n\n\n\n Diabetic skin lesions are a common complication of\u00a0diabetes.\u00a0Skin rash has been seen with saxagliptin and with certain antidiabetic drugs in the same class as saxagliptin.\u00a0Follow the skin and foot care recommendations given to you by your doctor or nurse.\u00a0Contact your doctor if you have blisters on your skin as it may be a sign of a condition called bullous\u00a0pemphigoid.\u00a0Your doctor may ask you to stop taking Komboglyze.<\/p>\n\n\n\n If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before taking this medicine.<\/p>\n\n\n\n Kidney tests or kidney checks<\/strong><\/p>\n\n\n\n During treatment with this medicine, your doctor will check your kidney function at least once a year or more often if you are older and\/or if your kidney function is deteriorating.<\/p>\n\n\n\n Komboglyze is not recommended for children and adolescents under 18 years of age. It is not known if this medicine is safe and effective for use in children and adolescents under 18 years of age.<\/p>\n\n\n\n If you need to get an\u00a0injection\u00a0into your blood with a contrast agent that contains iodine, for example in connection with X-rays or\u00a0computed tomography, you must stop taking Komboglyze before or at the time of\u00a0injection.\u00a0Your doctor will decide when you need to stop taking Komboglyze and when you should start taking it again.<\/p>\n\n\n\n Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n You may need to have more blood sugar and kidney function tests, or your doctor may need to adjust the dose of Komboglyze.\u00a0You must mention the following:<\/p>\n\n\n\n If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before taking this medicine.<\/p>\n\n\n\n Avoid high alcohol intake while taking Komboglyze as alcohol may increase the risk of lactic acidosis (see section “Warnings and precautions”).<\/p>\n\n\n\n Do not take this medicine if you are pregnant or could become pregnant, as it may affect your baby.<\/p>\n\n\n\n Do not take this medicine if you are breastfeeding or planning to breastfeed, as\u00a0metformin\u00a0in small amounts passes into breast milk.<\/p>\n\n\n\n Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n Saxagliptin and\u00a0metformin\u00a0have a negligible effect on the ability to drive and use tools or machines.\u00a0Low blood sugar (hypoglycemia) can affect your ability to drive and use machines or work without a secure foothold, and there is a risk of\u00a0hypoglycemia\u00a0if you take this medicine in combination with medicines known to cause low blood sugar, such as\u00a0insulin\u00a0and sulphonylureas.<\/p>\n\n\n\n Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n If your doctor prescribes this medicine together with sulphonylurea or\u00a0insulin, to get the best results for your health, remember to take the other medicine as prescribed by your doctor.<\/p>\n\n\n\n How much to take<\/strong><\/p>\n\n\n\n If you have impaired kidney function, your doctor may prescribe a lower\u00a0dose.<\/p>\n\n\n\n How to take this medicine<\/strong><\/p>\n\n\n\n Diet and exercise<\/strong><\/p>\n\n\n\n To control your\u00a0diabetes, you still need to diet and exercise, even while taking this medicine.\u00a0Therefore, you must follow the advice on diet and exercise that you receive from your doctor or nurse.\u00a0In particular, if you are following a diabetic weight control diet, you should continue with this medicine while taking this medicine.<\/p>\n\n\n\n If you take more than this medicine, talk to a doctor or go to a hospital straight away. Take the medicine pack with you.<\/p>\n\n\n\n Keep taking this medicine until your doctor tells you to stop. This is to keep your blood sugar under control.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n Stop <\/strong>taking this medicine and contact your doctor immediately if you get any of the following serious side effects:<\/strong><\/p>\n\n\n\n You should contact your doctor if you get the following side effect:<\/p>\n\n\n\n Other side effects of Komboglyze are:<\/strong><\/p>\n\n\n\n Common (may affect up to 1 in 10 people)<\/p>\n\n\n\n Uncommon (may affect up to 1 in 100 people)<\/p>\n\n\n\n Side effects\u00a0are seen with saxagliptin alone:<\/strong><\/p>\n\n\n\n Usual<\/p>\n\n\n\n Side effects\u00a0are seen with saxagliptin alone or in combination:<\/strong>\u00a0No known frequency (can not be calculated from the available data)<\/p>\n\n\n\n Some patients have had a slight decrease in the number of a type of white blood cell ( lymphocyte ) that appears in a blood test when saxagliptin is used alone or in combination. In addition, some patients have reported rash and skin reactions (hypersensitivity) when taking saxagliptin.<\/p>\n\n\n\n When used after the approval of saxagliptin, additional\u00a0side effects have\u00a0been reported which include severe allergic reactions (\u00a0anaphylaxis\u00a0), as well as swelling of the face, lips, tongue, and throat, which may make it difficult to breathe or swallow.\u00a0If you get an\u00a0allergic reaction, stop taking this medicine and call your doctor or nurse immediately.\u00a0Your doctor may\u00a0prescribe\u00a0a medicine to treat your allergic reaction and another medicine for your\u00a0diabetes.<\/p>\n\n\n\n Side effects\u00a0are seen with metformin alone:<\/strong><\/p>\n\n\n\n Very common (may affect more than 1 in 10 people)<\/p>\n\n\n\n Usual<\/p>\n\n\n\n Very rare<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the blister and carton after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Do not store above 25 \u00b0 C.<\/p>\n\n\n\n Do not use this medicine if the package is damaged or shows signs of tampering.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n The active substances are saxagliptin and metformin hydrochloride.<\/p>\n\n\n\n Each film-coated tablet contains 2.5 mg saxagliptin (as hydrochloride) and 850 mg metformin hydrochloride.<\/p>\n\n\n\n Other ingredients (excipients) are:<\/p>\n\n\n\n Not all pack sizes may be marketed.<\/p>\n\n\n\n AstraZeneca AB<\/p>\n\n\n\n SE-151 85 S\u00f6dert\u00e4lje<\/p>\n\n\n\n Sweden<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n AstraZeneca AB<\/p>\n\n\n\n G\u00e4rtunav\u00e4gen<\/p>\n\n\n\n SE-151 85 S\u00f6dert\u00e4lje<\/p>\n\n\n\n Sweden<\/p>\n\n\n\n AstraZeneca GmbH<\/p>\n\n\n\n Tinsdaler Weg 183<\/p>\n\n\n\n 22880 Wedel<\/p>\n\n\n\n Germany<\/p>\n\n\n\n AstraZeneca UK Limited<\/p>\n\n\n\n Silk Road Business Park<\/p>\n\n\n\n Macclesfield<\/p>\n\n\n\n Cheshire<\/p>\n\n\n\n SK10 2NA<\/p>\n\n\n\n UK<\/p>\n\n\n\n Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n This medicine contains two different substances called:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12118],"tags":[15126,14317,15132,15121,15125,15124,3466,3469,4837,15127,15131,15130,15122,4836,15128,15123,14316,15129],"class_list":["post-15903","post","type-post","status-publish","format-standard","hentry","category-medicines","category-k","tag-benefits-of-komboglyze","tag-benefits-of-metformin-hydrochloride","tag-benefits-of-saxagliptin","tag-komboglyze","tag-komboglyze-side-effects","tag-komboglyze-tablet","tag-metformin-hydrochloride","tag-metformin-hydrochloride-side-effects","tag-metformin-hydrochloride-tablet","tag-saxagliptin","tag-saxagliptin-side-effects","tag-saxagliptin-tablet","tag-what-is-komboglyze","tag-what-is-metformin-hydrochloride","tag-what-is-saxagliptin","tag-what-komboglyze-is-used-for","tag-what-metformin-hydrochloride-is-used-for","tag-what-saxagliptin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=15903"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15903\/revisions"}],"predecessor-version":[{"id":15953,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15903\/revisions\/15953"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=15903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=15903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=15903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}What you need to know before you take Komboglyze<\/h2>\n\n\n\n
Do not take Komboglyze<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Other medicines and Komboglyze<\/h2>\n\n\n\n
Comboglyze with alcohol<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
How to take Komboglyze<\/h2>\n\n\n\n
If you take more Komboglyze than you should<\/h2>\n\n\n\n
If you forget to take Komboglyze<\/h2>\n\n\n\n
If you stop taking Komboglyze<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
How to store Komboglyze<\/h2>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n
Belgium \/ Belgique \/ Belgien<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td> Lithuania<\/strong>UAB AstraZeneca LietuvaTel: +370 5 2660550<\/td><\/tr> Bulgaria<\/strong>Australia Bulgaria \u0415\u041e\u041e\u0414Tel: +359 (2) 44 55 000<\/td> Luxembourg \/ Luxemburg<\/strong>AstraZeneca SA \/ NVTel: +32 2 370 48 11<\/td><\/tr> Czech Republic<\/strong>AstraZeneca Czech Republic sroTel: +420 222 807 111<\/td> Hungary<\/strong>AstraZeneca Kft.Tel .: +36 1 883 6500<\/td><\/tr> Denmark<\/strong>AstraZeneca A \/ STel: +45 43 66 64 62<\/td> Malta<\/strong>Associated Drug Co. Ltd.Tel: +356 2277 8000<\/td><\/tr> Germany<\/strong>AstraZeneca GmbHTel: +49 41 03 7080<\/td> The Netherlands<\/strong>AstraZeneca BVTel: +31 79 363 2222<\/td><\/tr> Eesti<\/strong>AstraZenecaTel: + 372 6549 600<\/td> Norway<\/strong>AstraZeneca ASTel: +47 21 00 64 00<\/td><\/tr> Greece<\/strong>AstraZeneca AE:\u0397\u03bb: +30 2 106871500<\/td> Austria<\/strong>AstraZeneca \u00d6sterreich GmbHTel: +43 1 711 31 0<\/td><\/tr> Spain<\/strong>AstraZeneca Pharmac\u00e9utica Spain, SATel: +34 91 301 91 00<\/td> Poland<\/strong>AstraZeneca Pharma Poland Sp. z ooTel .: +48 22 245 73 00<\/td><\/tr> France<\/strong>AstraZenecaTel: +33 1 41 29 40 00<\/td> Portugal<\/strong>AstraZeneca Pharmaceutical Products, Lda.Tel: +351 21 434 61 00<\/td><\/tr> Croatia<\/strong>AstraZeneca dooTel: + 385 1 4628 000<\/td> Romania<\/strong>AstraZeneca Pharma SRLTel: +40 21 317 60 41<\/td><\/tr> Ireland<\/strong>AstraZeneca Pharmaceuticals (Ireland) DACTel: +353 1609 7100<\/td> Slovenia<\/strong>AstraZeneca UK LimitedTel: +386 1 51 35 600<\/td><\/tr> Iceland<\/strong>Vistor hf.Phone: + 354 535 7000<\/td> Slovak Republic<\/strong>AstraZeneca AB, ozTel: +421 2 5737 7777<\/td><\/tr> Italy<\/strong>AstraZeneca SpATel: +39 02 9801 1<\/td> Finland \/ Finland<\/strong>AstraZeneca OyPuh \/ Tel: +358 10 23 010<\/td><\/tr> .\u03a0\u03c1\u03bf\u03c2<\/strong>Alexander the Great:\u0397\u03bb: +357 22490305<\/td> Sweden<\/strong>AstraZeneca ABTel: +46 8 553 26 000<\/td><\/tr> Latvia<\/strong>SIA AstraZeneca LatvijaTel: + 371 67377100<\/td> United Kingdom<\/strong>AstraZeneca UK LtdTel: +44 1582 836 836<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"