{"id":15823,"date":"2021-11-20T09:43:19","date_gmt":"2021-11-20T09:43:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=15823"},"modified":"2021-11-23T08:03:16","modified_gmt":"2021-11-23T08:03:16","slug":"kabiven","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/kabiven\/","title":{"rendered":"Kabiven uses, dose and side effects"},"content":{"rendered":"\n<p>infusion solution,&nbsp;emulsion<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Kabiven is and what it is used for<\/h2>\n\n\n\n<p>The kabiven consists of a\u00a0three-chamber bag\u00a0with an outer bag.\u00a0Kabiven contains\u00a0amino acids\u00a0(building blocks of proteins), fats,\u00a0glucose,\u00a0and salts.\u00a0When you can not eat normally, this drug provides energy (in the form of sugar and fat) and\u00a0amino acids\u00a0directly into your blood.<\/p>\n\n\n\n<p>Kabiven works as part of a balanced\u00a0intravenous\u00a0nutrition supply which, together with additional salts, trace elements, and\u00a0vitamins, satisfies your entire need for nutrition.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given Kabiven<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not get Kabiven<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to any of the active substances or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to products containing&nbsp;<strong>eggs, soy or peanuts<\/strong><\/li><li>if you have too high levels of fats (like&nbsp;cholesterol&nbsp;) in your blood<\/li><li>if you have severe&nbsp;<strong>liver failure<\/strong><\/li><li>if you are in&nbsp;<strong>acute&nbsp;shock<\/strong>&nbsp;(due to severe blood loss or&nbsp;allergic reaction&nbsp;)<\/li><li>if you have a&nbsp;<strong>defect&nbsp;in the blood coagulation system<\/strong>&nbsp;(haemophagocytic syndrome) or if you have problems that affect the&nbsp;<strong>blood&#8217;s ability to coagulate<\/strong><\/li><li>if you have a disorder of your body&#8217;s ability to convert and break down&nbsp;<strong>proteins&nbsp;and&nbsp;amino acids<\/strong><\/li><li>if you suffer from&nbsp;<strong>kidney failure<\/strong><\/li><li>if you have&nbsp;hyperglycaemia&nbsp;(&nbsp;<strong>too much blood sugar<\/strong>&nbsp;) that requires treatment with more than 6 units of&nbsp;insulin&nbsp;per hour<\/li><li>if you have&nbsp;<strong>elevated levels of salts<\/strong>&nbsp;(&nbsp;electrolytes&nbsp;) in your blood<\/li><li>if you suffer from&nbsp;<strong>metabolic&nbsp;acidosis&nbsp;<\/strong>(the amount of acid in the body fluids and&nbsp;tissues&nbsp;is too large)<\/li><li>in case of&nbsp;<strong>overhydration<\/strong>&nbsp;(hyperhydration)<\/li><li>if you have&nbsp;<strong>fluid in your lungs<\/strong>&nbsp;(&nbsp;acute&nbsp;pulmonary edema&nbsp;)<\/li><li>if you are in&nbsp;<strong>a coma<\/strong><\/li><li>in&nbsp;<strong>heart disease<\/strong><\/li><li>if you are&nbsp;<strong>dehydrated<\/strong>&nbsp;and have low salinity in your blood<\/li><li>in&nbsp;<strong>severe&nbsp;sepsis<\/strong>&nbsp;(a condition in which the body fights a serious&nbsp;infection&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before giving Kabiven if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>impaired&nbsp;<strong>liver function<\/strong><\/li><li>untreated&nbsp;<strong>diabetes<\/strong><\/li><li>problems with the body&#8217;s ability to&nbsp;<strong>use fat<\/strong><\/li><li><strong>kidney problems<\/strong><\/li><li>problems with the&nbsp;<strong>pancreas<\/strong><\/li><li><strong>thyroid<\/strong>&nbsp;problems&nbsp;&#8211;&nbsp;hypothyroidism&nbsp;(&nbsp;toxic goiter&nbsp;)<\/li><li><strong>blood poisoning<\/strong>&nbsp;(&nbsp;sepsis&nbsp;, a condition in which the body fights a serious&nbsp;infection&nbsp;)<\/li><li>problems getting rid of salts (&nbsp;electrolytes&nbsp;)<\/li><li>a condition where there is&nbsp;<strong>not enough oxygen<\/strong>&nbsp;for your body cells<\/li><li>increased osmotic pressure in the blood (&nbsp;serum&nbsp;)<\/li><\/ul>\n\n\n\n<p>If you\u00a0develop\u00a0a fever, rash, chills, or shortness of breath\u00a0during\u00a0an infusion,\u00a0tell your healthcare provider immediately, as these symptoms may be due to an\u00a0allergic reaction\u00a0or that you have been given too much medicine (see section 4).<\/p>\n\n\n\n<p>This medicine may affect the results of other tests that you undergo.\u00a0You must tell your doctor if you are undergoing any tests while taking Kabiven.<\/p>\n\n\n\n<p>Your doctor may need to take regular blood tests to make sure that Kabiven treatment is working properly.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Kabiven should not be given to newborns or children under two years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Kabiven<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor if you are taking<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a drug called&nbsp;heparin&nbsp;which is used to prevent the formation and facilitate the dissolution of blood clots<\/li><li>the drug&nbsp;warfarin&nbsp;because&nbsp;Vitamin&nbsp;K1 found in soybean oil can affect blood clotting ability<\/li><li>insulin&nbsp;for the treatment of&nbsp;diabetes<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>There is no experience with the use of Kabiven during pregnancy and lactation.&nbsp;Kabiven should therefore only be given to pregnant or lactating women if the doctor deems it necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Kabiven is not expected to affect your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Kabiven is given<\/h2>\n\n\n\n<p>This medicine will only be given to you by\u00a0infusion\u00a0into a central vein.\u00a0Your body weight in kilograms and your body&#8217;s ability to use fat and sugar determine the\u00a0dosage of\u00a0one of Kabiven and the bag size used.\u00a0Kabiven will be slowly given into a blood vessel for 12-24 hours.\u00a0Your doctor will determine the correct\u00a0dosage\u00a0for you or your child.\u00a0You may be monitored during treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children<\/h2>\n\n\n\n<p>Kabiven is not adapted for the treatment of newborns or children under two years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Kabiven than you should<\/h2>\n\n\n\n<p>It is unlikely that you will receive too much medicine, as healthcare professionals will monitor you during treatment.\u00a0The effects of an overdose can be nausea, vomiting, sweating, and fluid retention.\u00a0Hyperglycaemia\u00a0(too much sugar in the blood) and disturbances in the salt balance have also been reported.\u00a0In the event of an overdose, there is a risk of absorbing too much fat.\u00a0This is called &#8220;fat overload syndrome&#8221;.\u00a0See section 4 \u201cPossible side effects\u201d for more information.\u00a0If you experience any of the symptoms described above or think you have had too much Kabiven, tell your doctor or nurse immediately.\u00a0Infusion\u00a0one will be discontinued or\u00a0dosage\u00a0one will be reduced.\u00a0Usually, the symptoms disappear when the\u00a0infusion\u00a0is stopped or dosage\u00a0and reduced.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, nurse, or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><strong>Kabiven can cause an&nbsp;allergic reaction<\/strong>&nbsp;(very rare, may affect up to 1 in 10,000 users).&nbsp;<strong>Tell your doctor immediately if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you get lumpy and itchy rashes on the body<\/li><li>you get a high fever<\/li><li>you have difficulty breathing<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;include:<\/p>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>small increase in body temperature.<\/li><\/ul>\n\n\n\n<p><strong>Less common&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>overindulge<\/li><li>fatigue<\/li><li>magont<\/li><li>headache<\/li><li>nausea and vomiting<\/li><li>elevated liver levels in the blood (your doctor will tell you if this happens)<\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side effects&nbsp;are<\/strong>&nbsp;(may affect up to 1 in 10 000 users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low or high&nbsp;blood pressure<\/li><li>respiratory distress<\/li><li>prolonged, painful&nbsp;erection&nbsp;in men<\/li><li>problem with the blood<\/li><\/ul>\n\n\n\n<p><strong>Fat overload syndrome<\/strong><br>This can occur when your body has problems using fat because you have received too much Kabiven.\u00a0It can also occur when your condition suddenly changes (such as in kidney problems or an\u00a0infection\u00a0).\u00a0Possible symptoms are fever, increased fat levels in the blood, cells, and\u00a0tissues, disorders of various organs, and\u00a0coma.\u00a0All these symptoms disappear if the\u00a0infusion is\u00a0stopped.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Kabiven<\/h2>\n\n\n\n<p><strong>Keep this medicine out of the sight and reach of children.<\/strong><\/p>\n\n\n\n<p>The medical staff is responsible for the correct storage, use, and disposal of Kabiven.<br>Do not store above 25 \u00b0 C.\u00a0Do not freeze.\u00a0Always store in the outer bag.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label of the sachet and the outer carton.<\/p>\n\n\n\n<p>Do not use it if the bag leaks.<\/p>\n\n\n\n<p>For single use only.&nbsp;Any remaining&nbsp;mixture&nbsp;should be discarded.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The kabiven consists of a\u00a0three-chamber bag.\u00a0Each bag contains the following different volumes depending on the package size:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>&nbsp;<\/td><td><em>2566 ml<\/em><\/td><td><em>2053 ml<\/em><\/td><td><em>1540 ml<\/em><\/td><td><em>1026 ml<\/em><\/td><\/tr><tr><td>Glucose&nbsp;(&nbsp;Glucose&nbsp;190 mg \/ ml)<\/td><td>1316 ml<\/td><td>1053 ml<\/td><td>790 ml<\/td><td>526 ml<\/td><\/tr><tr><td>Amino acids\u00a0and\u00a0electrolytes\u00a0(Vitamin 18 Novum)<\/td><td>750 ml<\/td><td>600 ml<\/td><td>450 ml<\/td><td>300 ml<\/td><\/tr><tr><td>Fat emulsion (Intralipid 200 mg \/ ml)<\/td><td>500 ml<\/td><td>400 ml<\/td><td>300 ml<\/td><td>200 ml<\/td><\/tr><tr><td><br>The active substances are:<\/td><\/tr><tr><td>Soybean oil, purified<\/td><td>100 g<\/td><td>80 g<\/td><td>60 g<\/td><td>40 g<\/td><\/tr><tr><td>Glucose monohydrate<\/td><td>275 g<\/td><td>220 g<\/td><td>165 g<\/td><td>110 g<\/td><\/tr><tr><td>&nbsp;&nbsp;&nbsp;-equivalent&nbsp;glucose&nbsp;(anhydrous)<\/td><td>250 g<\/td><td>200 g<\/td><td>150 g<\/td><td>100 g<\/td><\/tr><tr><td>Alanine<\/td><td>12.0 g<\/td><td>9.6 g<\/td><td>7.2 g<\/td><td>4.8 g<\/td><\/tr><tr><td>Arginine<\/td><td>8.5 g<\/td><td>6.8 g<\/td><td>5.1 g<\/td><td>3.4 g<\/td><\/tr><tr><td>Aspartic acid<\/td><td>2.6 g<\/td><td>2.0 g<\/td><td>1.5 g<\/td><td>1.0 g<\/td><\/tr><tr><td>Phenylalanine<\/td><td>5.9 g<\/td><td>4.7 g<\/td><td>3.6 g<\/td><td>2.4 g<\/td><\/tr><tr><td>Glutamic acid<\/td><td>4.2 g<\/td><td>3.4 g<\/td><td>2.5 g<\/td><td>1.7 g<\/td><\/tr><tr><td>Glycine<\/td><td>5.9 g<\/td><td>4.7 g<\/td><td>3.6 g<\/td><td>2.4 g<\/td><\/tr><tr><td>Histidine<\/td><td>5.1 g<\/td><td>4.1 g<\/td><td>3.1 g<\/td><td>2.0 g<\/td><\/tr><tr><td>Isoleucine<\/td><td>4.2 g<\/td><td>3.4 g<\/td><td>2.5 g<\/td><td>1.7 g<\/td><\/tr><tr><td>Leucine<\/td><td>5.9 g<\/td><td>4.7 g<\/td><td>3.6 g<\/td><td>2.4 g<\/td><\/tr><tr><td>Lysine hydrochloride<\/td><td>8.5 g<\/td><td>6.8 g<\/td><td>5.1 g<\/td><td>3.4 g<\/td><\/tr><tr><td>&nbsp;&nbsp;&nbsp;-corresponding&nbsp;lysine<\/td><td>6.8 g<\/td><td>5.4 g<\/td><td>4.1 g<\/td><td>2.7 g<\/td><\/tr><tr><td>Methionine<\/td><td>4.2 g<\/td><td>3.4 g<\/td><td>2.5 g<\/td><td>1.7 g<\/td><\/tr><tr><td>Proline<\/td><td>5.1 g<\/td><td>4.1 g<\/td><td>3.1 g<\/td><td>2.0 g<\/td><\/tr><tr><td>Serine<\/td><td>3.4 g<\/td><td>2.7 g<\/td><td>2.0 g<\/td><td>1.4 g<\/td><\/tr><tr><td>Troponin<\/td><td>4.2 g<\/td><td>3.4 g<\/td><td>2.5 g<\/td><td>1.7 g<\/td><\/tr><tr><td>Tryptophan<\/td><td>1.4 g<\/td><td>1.1 g<\/td><td>0.86 g<\/td><td>0.57 g<\/td><\/tr><tr><td>Tyrosine<\/td><td>0.17 g<\/td><td>0.14 g<\/td><td>0.10 g<\/td><td>0.07 g<\/td><\/tr><tr><td>Valin<\/td><td>5.5 g<\/td><td>4.4 g<\/td><td>3.3 g<\/td><td>2.2 g<\/td><\/tr><tr><td>Calcium chloride 2 H&nbsp;<sub>2<\/sub>&nbsp;O<\/td><td>0.74 g<\/td><td>0.59 g<\/td><td>0.44 g<\/td><td>0.29 g<\/td><\/tr><tr><td>&nbsp;&nbsp;&nbsp;-equivalent calcium chloride<\/td><td>0.56 g<\/td><td>0.44 g<\/td><td>0.33 g<\/td><td>0.22 g<\/td><\/tr><tr><td>Sodium glycerophosphate (anhydrous)<\/td><td>3.8 g<\/td><td>3.0 g<\/td><td>2.3 g<\/td><td>1.5 g<\/td><\/tr><tr><td>Magnesium sulfate 7 H&nbsp;<sub>2<\/sub>&nbsp;O<\/td><td>2.5 g<\/td><td>2.0 g<\/td><td>1.5 g<\/td><td>0.99 g<\/td><\/tr><tr><td>\u00a0\u00a0\u00a0-corresponding magnesium sulfate<\/td><td>1.2 g<\/td><td>0.96 g<\/td><td>0.72 g<\/td><td>0.48 g<\/td><\/tr><tr><td>Potassium chloride<\/td><td>4.5 g<\/td><td>3.6 g<\/td><td>2.7 g<\/td><td>1.8 g<\/td><\/tr><tr><td>Sodium acetate 3 H&nbsp;<sub>2<\/sub>&nbsp;O<\/td><td>6.1 g<\/td><td>4.9 g<\/td><td>3.7 g<\/td><td>2.5 g<\/td><\/tr><tr><td>&nbsp;&nbsp;&nbsp;-equivalent sodium acetate<\/td><td>3.7 g<\/td><td>2.9 g<\/td><td>2.2 g<\/td><td>1.5 g<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Other ingredients are<\/p>\n\n\n\n<p>purified egg phospholipids,<\/p>\n\n\n\n<p>glycerol,<\/p>\n\n\n\n<p>sodium hydroxide,<\/p>\n\n\n\n<p>acetic acid,<\/p>\n\n\n\n<p>water for injections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>The glucose\u00a0and amino acid solutions are clear, colorless, or faintly yellow and the fat emulsion is white.\u00a0The kabiven consists of a\u00a0three-chamber bag\u00a0and an outer bag.\u00a0An oxygen absorber is placed between the inner bag and the outer bag, which must be discarded before use.\u00a0The inner bag is separated into three chambers by openable weak welds (closures).\u00a0The contents of the three chambers must be mixed before use, by opening the weak welds.<\/p>\n\n\n\n<p><strong>Pack sizes:<\/strong><\/p>\n\n\n\n<p>1 x 1026 ml, 4 x 1026 ml<\/p>\n\n\n\n<p>1 x 1540 ml, 4 x 1540 ml<\/p>\n\n\n\n<p>1 x 2053 ml, 4 x 2053 ml<\/p>\n\n\n\n<p>1 x 2566 ml, 3 x 2566 ml<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Fresenius Kabi AB<\/p>\n\n\n\n<p>751 74 Uppsala<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Fresenius Kabi AB, 751 74 Uppsala, Sweden<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The kabiven consists of a three-chamber bag with an outer bag. Kabiven contains amino acids (building blocks of proteins), fats, glucose and salts. When you can not eat normally, this drug provides energy (in the form of sugar and fat) and amino acids directly into your blood.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12118],"tags":[15056,2860,15052,15057,15055,15058,2212,15053,15054],"class_list":["post-15823","post","type-post","status-publish","format-standard","hentry","category-medicines","category-k","tag-benefits-of-kabiven","tag-emulsion","tag-kabiven","tag-kabiven-dosage","tag-kabiven-side-effects","tag-kabiven-uses","tag-medicine","tag-what-is-kabiven","tag-what-kabiven-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=15823"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15823\/revisions"}],"predecessor-version":[{"id":15896,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15823\/revisions\/15896"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=15823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=15823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=15823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}