{"id":15688,"date":"2021-11-13T10:37:50","date_gmt":"2021-11-13T10:37:50","guid":{"rendered":"https:\/\/zeepedia.com\/?p=15688"},"modified":"2021-11-19T18:07:53","modified_gmt":"2021-11-19T18:07:53","slug":"juluca","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/juluca\/","title":{"rendered":"Juluca &#8211; Dolutegravir \/ rilpivirine uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg \/ 25 mg&nbsp;film-coated tablets<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tivicay\/\">dolutegravir<\/a> \/ rilpivirine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Juluca is and what it is used for<\/h2>\n\n\n\n<p>Juluca is a medicine that contains two active substances that are used to treat human immunodeficiency virus (&nbsp;HIV&nbsp;) infection: dolutegravir and rilpivirine.&nbsp;Dolutegravir belongs to a group of antiretroviral medicines called&nbsp;<em>integrase inhibitors&nbsp;&nbsp;(INI&nbsp;) and rilpivirine belongs to a group of antiretroviral medicines called&nbsp;non-nucleoside reverse transcriptase inhibitors (NNRTIs)<\/em>.<\/p>\n\n\n\n<p>Juluca is used to treat&nbsp;HIV&nbsp;in adults from the age of 18 who are taking other antiretroviral medicines and whose&nbsp;HIV-&nbsp;1&nbsp;infection&nbsp;has been under control for at least 6 months.&nbsp;Juluca replaces the antiretroviral medicines you are taking now.<\/p>\n\n\n\n<p>Juluca keeps the amount of&nbsp;HIV&nbsp;&#8211;&nbsp;the virus&nbsp;in the body at a low level.&nbsp;It helps maintain the number of CD4 cells in your blood.&nbsp;CD4 cells are a type of&nbsp;white blood cell&nbsp;that is important for the body&#8217;s ability to fight&nbsp;infections.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Juluca<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Juluca:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to dolutegravir or rilpivirine or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p><strong>Do not take Juluca if you are taking any of the following medicines<\/strong>&nbsp;as they may affect the way Juluca works:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fampridine (also called dalfampridine; used for&nbsp;multiple sclerosis&nbsp;).<\/li><li>carbamazepine, oxcarbazepine, phenobarbital,&nbsp;phenytoin&nbsp;(medicines used to treat&nbsp;epilepsy&nbsp;and to prevent seizures)<\/li><li>rifampicin, rifapentine (medicines used to treat certain bacterial infections, such as&nbsp;tuberculosis&nbsp;)<\/li><li>omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole (medicines to prevent and treat&nbsp;stomach ulcers&nbsp;, heartburn or&nbsp;reflux disease&nbsp;)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a> (a&nbsp;corticosteroid&nbsp;used in many conditions such as&nbsp;inflammation&nbsp;and allergic reactions) when taken orally or injected, with the exception of treatment as a single dose<\/li><li>herbal medicines containing&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) (used for mild depression and mild anxiety).<\/li><\/ul>\n\n\n\n<p>If you are taking any of the above medicines, ask your doctor for alternatives.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Juluca.<\/p>\n\n\n\n<p>Allergy&nbsp;to reactions<\/p>\n\n\n\n<p>Juluca contains dolutegravir.&nbsp;Dolutegravir can cause a severe&nbsp;allergic reaction, a so-called&nbsp;hypersensitivity reaction.&nbsp;You need to know the important signs and symptoms to be aware of while taking Juluca.<\/p>\n\n\n\n<p><strong>\u2192 Read the information<\/strong>&nbsp;under &#8220;Allergic reactions&#8221; in section 4 of this leaflet.<\/p>\n\n\n\n<p>Liver problems including&nbsp;hepatitis&nbsp;B and\/or C<\/p>\n\n\n\n<p>Tell your doctor if you have or have had&nbsp;<strong>liver problems<\/strong>, including&nbsp;hepatitis&nbsp;B and\/or C. Your doctor may need to assess the severity of your liver disease before deciding if you can be treated with Juluca.<\/p>\n\n\n\n<p>Pay attention to important symptoms<\/p>\n\n\n\n<p>Some people take medicines for&nbsp;HIV&nbsp;&#8211;&nbsp;infection, other problems can be serious.&nbsp;These include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Symptoms of&nbsp;infection&nbsp;you and&nbsp;inflammation&nbsp;you<\/li><li>joint pain, stiffness and skeletal problems.<\/li><\/ul>\n\n\n\n<p>You need to know the important signs and symptoms to be aware of while taking Juluca.<\/p>\n\n\n\n<p>\u2192&nbsp;&nbsp;<strong>Read the<\/strong>&nbsp;&#8221;&nbsp;<strong>Other possible&nbsp;side effect&nbsp;are<\/strong>&nbsp;&#8221;&nbsp;<strong>in section 4 of this leaflet.<\/strong><\/p>\n\n\n\n<p>Protect others<\/p>\n\n\n\n<p>HIV&nbsp;&#8211;&nbsp;infection&nbsp;is spread by sexual contact with an infected person, or by transfer of infected blood (e.g., by sharing needles).&nbsp;You can still transmit&nbsp;HIV&nbsp;infection when you take this medicine, even if the risk is reduced with effective&nbsp;antiretroviral&nbsp;therapy.&nbsp;Discuss with your doctor what steps you need to take to avoid infecting others.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine is not intended for use in children or adolescents below 18 years of age as it has not been studied in these patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Juluca<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p><strong>Juluca must not be taken<\/strong>&nbsp;with certain other medicines (see &#8220;Do not take Juluca&#8221; above in section 2).<\/p>\n\n\n\n<p>Some medicines may affect the way Juluca works, or increase the risk of&nbsp;side effects.&nbsp;Juluca may also affect the way some other medicines work.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you are taking any of the medicines&nbsp;<em>listed below<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Metformin&nbsp;, for the treatment of&nbsp;<strong>diabetes<\/strong>&nbsp;.<\/li><li>Drugs that can cause life-threatening irregular heartbeat (&nbsp;<em>torsade de pointes&nbsp;)<\/em>&nbsp;.&nbsp;As many different medicines can cause this condition, you should ask your doctor or pharmacist if you are unsure.<\/li><li>Medicines called&nbsp;<strong>antacids<\/strong>&nbsp;and used for&nbsp;<strong>indigestion<\/strong>&nbsp;and&nbsp;<strong>heartburn<\/strong>&nbsp;.&nbsp;<strong>Do not take antacids<\/strong>&nbsp;for 6 hours before taking Juluca, or for the next 4 hours after taking Juluca (see also section 3, \u201cHow to take Juluca\u201d).<\/li><li><strong>Calcium supplements, iron supplements and multivitamins<\/strong>&nbsp;should be taken at the same time as Juluca with meals.&nbsp;If you can not take these supplements at the same time as Juluca&nbsp;<strong>, do not&nbsp;<\/strong>&nbsp;<strong>take calcium supplements, iron supplements or multivitamins<\/strong>&nbsp;for 6 hours before taking Juluca, or for the next 4 hours after taking Juluca (see also section 3 &#8220;How to take Juluca&#8221; ).<\/li><li>Drugs called&nbsp;<strong>H&nbsp;<sub>2<\/sub>&nbsp;-receptor antagonists<\/strong>&nbsp;(eg cimetidine, famotidine, nizatidine, ranitidine) to treat&nbsp;<strong>stomach ulcers<\/strong>&nbsp;or to relieve&nbsp;<strong>heartburn caused by&nbsp;reflux disease<\/strong>&nbsp;.&nbsp;<strong>Do not take these medicines<\/strong>&nbsp;for 12 hours before taking Juluca, or for the next 4 hours after taking Juluca (see also section 3, &#8220;How to take Juluca&#8221;).<\/li><li>Any medicine to treat&nbsp;<strong>HIV&nbsp;&#8211;&nbsp;infection<\/strong>&nbsp;.<\/li><li>Rifabutin, for the treatment of&nbsp;tuberculosis&nbsp;(TB) and other&nbsp;<strong>bacterial infections.&nbsp;<\/strong>If you take rifabutin, your doctor may give you another&nbsp;dose&nbsp;of rilpivirine to treat your&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(see section 3, &#8220;How to take Juluca&#8221;).<\/li><li>Artemeter \/ lumefantrine used to prevent&nbsp;malaria&nbsp;.<\/li><li>Clarithromycin and erythromycin, for the treatment of&nbsp;<strong>bacterial infections.<\/strong><\/li><li>Methadone&nbsp;, which is used to treat opioid addiction.<\/li><li>Dabigatran etexilate, which is used to treat or prevent&nbsp;<strong>blood clots<\/strong>&nbsp;.<\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;&nbsp;<strong>Tell<\/strong>&nbsp;your&nbsp;<strong>doctor or pharmacist<\/strong>&nbsp;if you are taking any of these medicines.&nbsp;Your doctor may decide that you need to have more check-ups.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you are pregnant, think you may be pregnant or are planning to have a baby:<\/p>\n\n\n\n<p><strong>\u2192 The use of Juluca is not recommended.&nbsp;Consult a doctor<\/strong>.<\/p>\n\n\n\n<p>Taking Juluca at the time of conception or during the first six weeks of pregnancy can also increase the risk of a type of malformation called a neural tube defect, e.g.&nbsp;spina bifida (malformed spinal cord).<\/p>\n\n\n\n<p>If you could get pregnant while getting Juluca:<\/p>\n\n\n\n<p><strong>\u2192 Talk to your doctor<\/strong>&nbsp;and discuss whether you need to use contraception, such as condoms or&nbsp;pills.<\/p>\n\n\n\n<p>Tell your doctor immediately if you become pregnant or are planning to become pregnant.&nbsp;Your doctor will review your treatment.&nbsp;Do not stop taking Juluca without consulting your doctor as this may harm you and your unborn baby.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p><strong>Women who are&nbsp;HIV&nbsp;-positive must not breastfeed<\/strong>&nbsp;because&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;can be transferred to the baby through breast milk.<\/p>\n\n\n\n<p>A small amount of the ingredient dolutegravir in Juluca may pass into your breast milk.&nbsp;It is not known if the other ingredient rilpivirine can pass into your breast milk.<\/p>\n\n\n\n<p>If you are breast-feeding or considering starting breastfeeding:<\/p>\n\n\n\n<p><strong>\u2192 Talk to your doctor immediately.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Juluca can make you dizzy, tired, or drowsy and cause other&nbsp;side effects&nbsp;that diminish your attention.<\/p>\n\n\n\n<p>\u2192 Do not drive or use machines unless you are sure you are affected by them.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Juluca contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Juluca<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;of Juluca is&nbsp;<strong>one tablet daily<\/strong>&nbsp;.&nbsp;Juluca&nbsp;<strong>must be taken with a meal<\/strong>&nbsp;.&nbsp;The meal is important for you to get the right level of medicine in your body.&nbsp;A protein-rich nutritional drink alone does not replace a meal.<\/li><li>Do not chew, crush or divide the tablet, to ensure that the full&nbsp;dose is&nbsp;taken.<\/li><\/ul>\n\n\n\n<p>Rifabutin<\/p>\n\n\n\n<p>Rifabutin, a drug used to treat certain bacterial infections, can reduce the amount of Juluca in the body so that it has a worse effect.<\/p>\n\n\n\n<p>If you are taking rifabutin, your doctor may need to give you an extra&nbsp;dose of&nbsp;rilpivirine.&nbsp;Take the rilpivirine tablet while you are taking Juluca.<\/p>\n\n\n\n<p>\u2192 Talk to your doctor for more information about treatment with rifabutin with Juluca.<\/p>\n\n\n\n<p>Antacids<\/p>\n\n\n\n<p>Antacids, which are used for indigestion and heartburn, can prevent Juluca from being absorbed by the body and therefore have a worse effect.<\/p>\n\n\n\n<p>Do not take antacids for 6 hours before taking Juluca, or for the next 4 hours after taking Juluca.<\/p>\n\n\n\n<p>\u2192 Talk to your doctor for further information about taking antacids with Juluca.<\/p>\n\n\n\n<p>Calcium supplements, iron supplements, and multivitamins<\/p>\n\n\n\n<p>Calcium&nbsp;and iron supplements or multivitamins can prevent Juluca from being absorbed by the body and therefore have a worse effect.<\/p>\n\n\n\n<p>Calcium&nbsp;and iron supplements or multivitamins should be taken at the same time as Juluca.&nbsp;Juluca should be taken with a meal.<\/p>\n\n\n\n<p>If you can not take these supplements at the same time as Juluca, do not take&nbsp;calcium&nbsp;&#8211; or iron supplements or multivitamins for 6 hours before taking Juluca, or for the next 4 hours after taking Juluca.<\/p>\n\n\n\n<p>\u2192 Talk to your doctor for more information on how to take calcium supplements, iron supplements, or multivitamins with Juluca.<\/p>\n\n\n\n<p>H&nbsp;<sub>2<\/sub>&nbsp;-receptor antagonists (eg cimetidine, famotidine, nizatidine, ranitidine)<\/p>\n\n\n\n<p>H&nbsp;<sub>2<\/sub>&nbsp;-receptor antagonists can prevent Juluca from being absorbed by the body and therefore have a worse effect.<\/p>\n\n\n\n<p>Do not take such medicines for 12 hours before taking Juluca, or for the next 4 hours after taking Juluca.<\/p>\n\n\n\n<p>\u2192 Talk to your doctor for more information on how to take these medicines with Juluca.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Juluca than you should<\/h2>\n\n\n\n<p>If you have taken too many Juluca tablets<strong>, contact your doctor or pharmacist immediately.&nbsp;<\/strong>Show them if possible the Juluca packaging.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Juluca<\/h2>\n\n\n\n<p>If you notice that you have missed a&nbsp;dose&nbsp;within 12 hours from the time you usually take Juluca, you must take the tablet as soon as possible.&nbsp;You must take Juluca with a meal.&nbsp;Then take the next&nbsp;dose&nbsp;as usual.&nbsp;If you notice it later than after 12 hours, skip the missed&nbsp;dose&nbsp;and take the next&nbsp;dose&nbsp;as usual.<\/p>\n\n\n\n<p>\u2192&nbsp;<strong>Do not take a double&nbsp;dose<\/strong>&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<p>If you vomit less than 4 hours after taking Juluca, take a new tablet with a meal.&nbsp;If you vomit more than 4 hours after taking Juluca, you do not need to take a new tablet until you take the next scheduled&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Do not stop taking Juluca without talking to your doctor<\/h2>\n\n\n\n<p>Take Juluca for as long as your doctor recommends.&nbsp;Do not stop unless your doctor tells you to.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;<strong>Therefore, it is very important that you talk to your doctor if your health should change in any way.<\/strong><\/p>\n\n\n\n<p><strong>Allergic reactions<\/strong><\/p>\n\n\n\n<p>Juluca contains dolutegravir.&nbsp;Dolutegravir can cause a severe&nbsp;allergic reaction&nbsp;called&nbsp;a hypersensitivity reaction.&nbsp;It is a less common (may affect up to 1 in 100 people) reaction in people taking raltegravir.&nbsp;If you get any of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rash<\/li><li>high temperature (&nbsp;<em>fever<\/em>&nbsp;)<\/li><li>lack of energy (&nbsp;<em>weakness<\/em>&nbsp;)<\/li><li>swelling, sometimes in the face and mouth (&nbsp;<em>angioedema<\/em>&nbsp;), which causes difficulty breathing<\/li><li>muscle or joint pain.<\/li><\/ul>\n\n\n\n<p><strong>\u2192 Seek medical attention immediately.&nbsp;<\/strong>Your doctor may decide to take samples to check your liver, kidneys, or blood and possibly to stop taking Juluca.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>more than 1 in 10 users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>dizziness<\/li><li>diarrhea<\/li><li>nausea<\/li><li>difficulty sleeping (&nbsp;<em>insomnia<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;that may show up in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated liver enzyme values \u200b\u200b(aminotransferases)<\/li><li>elevated&nbsp;cholesterol<\/li><li>elevated pancreatic amylase (a digestive enzyme).<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 10&nbsp;<\/strong><strong>users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of appetite<\/li><li>rash<\/li><li>itching&nbsp;(&nbsp;<em>pruritus<\/em>&nbsp;)<\/li><li>vomiting<\/li><li>abdominal pain (abdominal&nbsp;<em>pain<\/em>&nbsp;) or stomach upset<\/li><li>gas production (&nbsp;<em>flatulence<\/em>&nbsp;)<\/li><li>drowsiness<\/li><li>difficulty sleeping<\/li><li>abnormal dreams<\/li><li>lack of energy (&nbsp;<em>weakness<\/em>&nbsp;)<\/li><li>depression (deep sadness and feelings of inferiority)<\/li><li>Depression<\/li><li>anxiety<\/li><li>dry mouth&nbsp;.<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;that can show up in blood tests are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>increased amount of&nbsp;enzymes&nbsp;produced in the muscles (creatine phosphokinase)<\/li><li>decreased number of&nbsp;platelets&nbsp;involved in blood&nbsp;coagulation<\/li><li>decreased&nbsp;white blood cell count<\/li><li>decreased hemoglobin value<\/li><li>increased content of&nbsp;triglycerides&nbsp;(a type of fat)<\/li><li>increased content of&nbsp;lipase&nbsp;(an&nbsp;enzyme&nbsp;involved in fat breakdown)<\/li><li>increased levels of&nbsp;bilirubin&nbsp;(a test of liver function) in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 100 users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction&nbsp;(&nbsp;<em>hypersensitivity<\/em>&nbsp;) (see &#8220;allergic reactions&#8221; earlier in this section)<\/li><li>inflammation&nbsp;of the liver (&nbsp;<em>hepatitis<\/em>&nbsp;)<\/li><li>suicidal ideation and behavior (especially in patients with a history of depression or mental health problems)<\/li><li>joint pain<\/li><li>muscle pain.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;are<\/strong>&nbsp;<\/p>\n\n\n\n<p>These can occur in&nbsp;<strong>up to 1 in 1000 users<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>liver failure (signs include yellow skin and whites of the eyes or unusually dark-colored urine).<\/li><\/ul>\n\n\n\n<p><strong>Has been reported<\/strong><\/p>\n\n\n\n<p>Occurs in an unknown number of users:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>signs or symptoms of&nbsp;inflammation&nbsp;or&nbsp;infection&nbsp;, such as fever, chills, sweating (&nbsp;<em>immune reactivation syndrome<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>People taking combination therapy for&nbsp;HIV&nbsp;may experience other&nbsp;side effects.<\/p>\n\n\n\n<p><strong>Symptoms of&nbsp;infection&nbsp;you and&nbsp;inflammation&nbsp;you<\/strong><\/p>\n\n\n\n<p>People with advanced&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;(&nbsp;AIDS&nbsp;) have weak immune systems, and the risk is greater that they have a serious&nbsp;infection&nbsp;(&nbsp;<em>opportunistic&nbsp;infection&nbsp;s<\/em>&nbsp;).&nbsp;Infectious symptoms can develop caused by old&nbsp;infections&nbsp;that flare up again when the body begins to fight them.&nbsp;The symptoms usually consist of&nbsp;<strong>fever<\/strong>&nbsp;and some of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>abdominal pain<\/li><li>breathing difficulties.<\/li><\/ul>\n\n\n\n<p>When the immune system becomes stronger, it can even in rare cases attack healthy body tissues (&nbsp;autoimmune&nbsp;disease).&nbsp;Symptoms of&nbsp;autoimmune&nbsp;disease can develop several months after starting treatment for your&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Symptoms may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>palpitations (rapid or irregular heartbeat) and tremors<\/li><li>hyperactivity (excessive restlessness and movement)<\/li><li>weakness that begins in the hands and feet and then moves towards the torso.<\/li><\/ul>\n\n\n\n<p><strong>If you get symptoms of an&nbsp;infection<\/strong>&nbsp;or if you notice any of the symptoms mentioned above:<\/p>\n\n\n\n<p><strong>\u2192 Tell your doctor immediately<\/strong>.&nbsp;Do not take other medicines for&nbsp;infection&nbsp;without your doctor&#8217;s recommendation.<\/p>\n\n\n\n<p><strong>Joint pain, stiffness, and bone problems<\/strong><\/p>\n\n\n\n<p>Some people who take combination therapy for&nbsp;HIV&nbsp;suffer from&nbsp;<em>osteonecrosis<\/em>.&nbsp;This means that parts of the skeletal tissue die because the blood supply to the skeleton decreases.&nbsp;People are at increased risk of developing this condition:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if they have been taking the combination treatment for a long time<\/li><li>if they are also taking anti-inflammatory medicines called&nbsp;corticosteroids&nbsp;s<\/li><li>if they drink alcohol<\/li><li>if their immune system is very weak<\/li><li>if they are overweight.<\/li><\/ul>\n\n\n\n<p><strong>Signs of&nbsp;osteonecrosis&nbsp;are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>stiffness in the joints<\/li><li>aches and pains in the joints (especially in the hips, knees or shoulders)<\/li><li>difficulty moving.<\/li><\/ul>\n\n\n\n<p>If you get any of these symptoms:<\/p>\n\n\n\n<p><strong>\u2192 Tell your doctor.<\/strong><\/p>\n\n\n\n<p><strong>Effects on weight, blood fats, and blood sugar<\/strong><\/p>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of blood fats and blood sugar may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood fats, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Juluca<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and jar after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.&nbsp;Keep the jar tightly closed.&nbsp;Do not remove the desiccant.<\/p>\n\n\n\n<p>No special temperature instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are dolutegravir and rilpivirine.&nbsp;Each film-coated tablet contains dolutegravir sodium equivalent to 50 mg dolutegravir and rilpivirine hydrochloride equivalent to 25 mg rilpivirine.<\/li><li>The other ingredients are mannitol (E421), magnesium stearate, microcrystalline cellulose, povidone (K29 \/ 32), sodium&nbsp;starch glycolate&nbsp;, sodium stearyl fumarate, lactose&nbsp;monohydrate&nbsp;, croscarmellose sodium, povidone (K30), polysorbate 17, titanium dioxide, microhydrolene cellulose macrogol, talc, yellow iron oxide (E172), red iron oxide (E172).<\/li><li>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;dose&nbsp;, which is essentially &#8216;sodium-free&#8217;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Juluca film-coated tablets are pink, oval, biconvex tablets marked with SV J3T \u201don one side.<\/p>\n\n\n\n<p>The film-coated tablets are supplied in jars with child-resistant lids.<\/p>\n\n\n\n<p>Each jar contains 30 film-coated tablets and a desiccant to reduce moisture.&nbsp;Once the jar has been opened, leave the desiccant in the jar, do not remove it.<\/p>\n\n\n\n<p>There are also multi-packs of 90 film-coated tablets (3 packs of 30 film-coated tablets).<\/p>\n\n\n\n<p>Not all pack sizes may be available in your country.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>ViiV Healthcare BV<\/p>\n\n\n\n<p>Van Asch van Wijckstraat 55H<\/p>\n\n\n\n<p>3811 LP Amersfoort<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Glaxo Wellcome, SA<br>Avda.&nbsp;Extremadura, 3<br>09400 Aranda De Duero<br>Burgos<br>Spain<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine: Show larger<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>ViiV Healthcare srl \/ bv&nbsp;Tel: + 32 (0) 10 85 65 00<\/td><td><strong>Lithuania<\/strong>ViiV Healthcare BVTel: + 370 80000334<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>ViiV Healthcare BVTel: + 359 80018205<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>ViiV Healthcare srl \/ bv&nbsp;Belgium \/ BelgiumTel: + 32 (0) 10 85 65 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline, sroTel: + 420 222 001 111cz.info@gsk.com<\/td><td><strong>Hungary<\/strong>ViiV Healthcare BVTel .: + 36 80088309<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A \/ STel: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>ViiV Healthcare BVTel: + 356 80065004<\/td><\/tr><tr><td><strong>Germany<\/strong>ViiV Healthcare GmbHTel .: + 49 (0) 89 203 0038-10viiv.med.info@viivhealthcare.com&nbsp;<\/td><td><strong>The Netherlands<\/strong>ViiV Healthcare BVTel: + 31 (0) 33 2081199<\/td><\/tr><tr><td><strong>Eesti<\/strong>ViiV Healthcare BVTel: + 372 8002640<\/td><td><strong>Norway<\/strong>GlaxoSmithKline ASTel: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>GlaxoSmithKline A\u03bf\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03b7 AEBE:\u0397\u03bb: + 30 210 68 82 100<\/td><td><strong>\u00d6&nbsp;<\/strong><strong>sterreich<\/strong>GlaxoSmithKline Pharma GmbHTel: + 43 (0) 1 97075 0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Laboratories ViiV Healthcare, SLTel: + 34 900 923 501es-ci@viivhealthcare.com<\/td><td><strong>Poland<\/strong>GSK Services Sp.&nbsp;z ooTel .: + 48 (0) 22 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>ViiV Healthcare SASTel .: + 33 (0) 1 39 17 69 69Infomed@viivhealthcare.com<\/td><td><strong>Portugal<\/strong>VIIVHIV HEALTHCARE, UNIPESSOAL, LDATel: + 351 21 094 08 01viiv.fi.pt@viivhealthcare.com<\/td><\/tr><tr><td><strong>Croatia<\/strong>ViiV Healthcare BVTel: + 385 800787089<\/td><td><strong>Romania<\/strong>ViiV Healthcare BVTel: +40 800672524<\/td><\/tr><tr><td><strong>Ireland<\/strong>GlaxoSmithKline (Ireland) LimitedTel: + 353 (0) 1 4955000<\/td><td><strong>Slovenia<\/strong>ViiV Healthcare BVTel: + 386 80688869<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>ViiV Healthcare BVTel: + 421 800500589<\/td><\/tr><tr><td><strong>Italy<\/strong>ViiV Healthcare Srl&nbsp;Tel: + 39 (0) 45 7741600<\/td><td><strong>Finland \/ Finland<\/strong>GlaxoSmithKline OyPuh \/ Tel: + 358 (0) 10 30 30 30Finland.tuoteinfo@gsk.com<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>ViiV Healthcare BV:\u0397\u03bb: + 357 80070017<\/td><td><strong>Sweden<\/strong>GlaxoSmithKline ABTel: + 46 (0) 8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>ViiV Healthcare BVTel: + 371 80205045<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>ViiV Healthcare BVTel: + 44 (0) 800 221441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Juluca is a medicine that contains two active substances that are used to treat human immunodeficiency virus ( HIV ) infection: dolutegravir and rilpivirine. Dolutegravir belongs to a group of antiretroviral medicines called integrase inhibitors  (INI ) and rilpivirine belongs to a group of antiretroviral medicines called non-nucleoside reverse transcriptase inhibitors (NNRTIs) .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12117],"tags":[14841,14839,5221,5223,5224,3394,3397,4738,14840,5222,4737,14838],"class_list":["post-15688","post","type-post","status-publish","format-standard","hentry","category-medicines","category-j","tag-benefits-of-dolutegravir","tag-benefits-of-rilpivirine","tag-dolutegravir","tag-dolutegravir-side-effects","tag-dolutegravir-tablet","tag-rilpivirine","tag-rilpivirine-side-effects","tag-rilpivirine-tablet","tag-what-dolutegravir-is-used-for","tag-what-is-dolutegravir","tag-what-is-rilpivirine","tag-what-rilpivirine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=15688"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15688\/revisions"}],"predecessor-version":[{"id":15798,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15688\/revisions\/15798"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=15688"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=15688"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=15688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}