{"id":15662,"date":"2021-11-13T10:22:55","date_gmt":"2021-11-13T10:22:55","guid":{"rendered":"https:\/\/zeepedia.com\/?p=15662"},"modified":"2021-11-19T18:25:07","modified_gmt":"2021-11-19T18:25:07","slug":"javlor","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/javlor\/","title":{"rendered":"Javlor &#8211; Vinflunine uses, dose and side effects"},"content":{"rendered":"\n<p>25 mg \/ mL&nbsp;concentrate for&nbsp;infusion&nbsp;solution<br>vinflunine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Javlor is and what it is used for<\/h2>\n\n\n\n<p>Javlor contains the active substance vinflunine which belongs to a group of cancer drugs called vinca alkaloids.&nbsp;These drugs affect the growth of cancer cells by interrupting cell division, leading to cell death (cytotoxicity).<\/p>\n\n\n\n<p>Javlar is used to treat advanced or metastatic cancer of the bladder and urinary tract when previous treatment with platinum-containing drugs has not been effective.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Javlor<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Javlor<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to vinflunine or any other wine alkaloid (vinblastine, vincristine, vindesine, vinorelbine).<\/li><li>if you have, or within the last two weeks have had, a serious&nbsp;infection&nbsp;.<\/li><li>if you are breast-feeding.<\/li><li>if you have low levels of&nbsp;white blood cells&nbsp;and \/ or&nbsp;platelets&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Javlor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any problems with your liver, kidneys or heart.<\/li><li>if you have any neurological symptoms such as headache, altered mood that can lead to confusion and&nbsp;coma&nbsp;, seizures, blurred vision and high&nbsp;blood pressure&nbsp;because you may then need to stop treatment.<\/li><li>if you are taking other medicines mentioned under the heading \u201cUsing other medicines\u201d below.<\/li><li>if you are constipated, if you are being treated with painkillers (&nbsp;opioids&nbsp;), if you have stomach cancer or if you have had surgery on your stomach.<\/li><li>if you are male and planning to have children (see section \u201cPregnancy, breast-feeding and fertility\u201d below).<\/li><\/ul>\n\n\n\n<p>The number of&nbsp;blood cells&nbsp;in your blood will be checked regularly before and during treatment because low&nbsp;blood cell count&nbsp;is a very common&nbsp;side effect&nbsp;of Javlor.<\/p>\n\n\n\n<p>Constipation is a very common&nbsp;side effect&nbsp;of Javlor.&nbsp;To prevent constipation, you may be given&nbsp;laxatives.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Javlar is not intended for children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines and Javlor<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>You must tell your doctor if you are taking medicines that contain any of the following active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ketoconazole&nbsp;and itraconazole, for the treatment of fungal infections.<\/li><li>opioids&nbsp;, for the treatment of pain.<\/li><li>ritonavir for the treatment of&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;.<\/li><li>doxorubicin and pegylated liposomal doxorubicin, for the treatment of certain cancers.<\/li><li>rifampicin, for the treatment of&nbsp;tuberculosis&nbsp;or&nbsp;meningitis&nbsp;.<\/li><li>natural remedy containing&nbsp;St. John&#8217;s wort&nbsp;(Hypericum perforatum), for the treatment of mild to moderate depression.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Javler with food and drink<\/h2>\n\n\n\n<p>You should tell your doctor if you usually drink grapefruit juice as it may increase the effect of Javlor.<\/p>\n\n\n\n<p>You should also drink water and eat foods high in fiber.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>If you are a woman or a man of&nbsp;childbearing&nbsp;age should use reliable contraception during treatment and for 3 months after your last Javlor-&nbsp;dose.<\/p>\n\n\n\n<p>You should not be treated with Javlor if you are pregnant unless it is necessary.<\/p>\n\n\n\n<p>You must not breastfeed during treatment with Javlor.<\/p>\n\n\n\n<p>If you are a man and want to have children, you should consult your doctor.&nbsp;You may also want to consult about the possibility of preserving sperm before starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Javlar can cause&nbsp;side effects&nbsp;such as fatigue and dizziness.&nbsp;If you experience&nbsp;side effects&nbsp;that affect your ability to concentrate and react, do not drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Javlor<\/h2>\n\n\n\n<p><strong>Dosage<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adult patients is 320 mg \/ m&nbsp;<sup>2<\/sup>&nbsp;body surface area (calculated by your doctor based on your weight and height).&nbsp;The treatment will be repeated every three weeks.<\/p>\n\n\n\n<p>Your doctor will adjust the starting dose of Javlor based on your age and physical condition and in special situations:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have previously had radiation treatment of the pelvis.<\/li><li>if you have moderate or severe kidney problems.<\/li><li>if you have liver problems.<\/li><\/ul>\n\n\n\n<p>During treatment, your doctor may lower the&nbsp;dose&nbsp;of Javlor, postpone or discontinue treatment if you experience any&nbsp;side effects.<\/p>\n\n\n\n<p><strong>How Javlor is given<\/strong><\/p>\n\n\n\n<p>Javlar will be given by qualified healthcare professionals as an&nbsp;intravenous&nbsp;infusion&nbsp;(in the form of a drip into a vein) for 20 minutes.&nbsp;Javler should not be given intrathecally (in the spinal cord).&nbsp;Javlor is a concentrate that must be diluted before use.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact a doctor immediately<\/strong>&nbsp;if you get any of the following symptoms while being treated with Javlor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever and \/ or chills, which may be a sign of an&nbsp;infection&nbsp;.<\/li><li>Chest pain, which may be a sign of a heart attack.<\/li><li>Constipation, which is not relieved by&nbsp;laxatives&nbsp;.<\/li><li>Headache, altered mood that can lead to confusion and&nbsp;coma&nbsp;, seizures, blurred vision and high&nbsp;blood pressure&nbsp;.&nbsp;This may be a sign of a neurological disease such as \u201cposterior reversible encephalopathy syndrome\u201d (see section 2 \u201cWarnings and precautions\u201d).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur:<\/strong><\/p>\n\n\n\n<p><strong>Very typ&nbsp;IgA&nbsp;(can occur in more than 1 in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abdominal pain, nausea, vomiting<\/li><li>constipation, diarrhea,<\/li><li>inflammation&nbsp;of the lining of the mouth<\/li><li>fatigue, muscle pain<\/li><li>loss of sensation<\/li><li>weight loss, loss of appetite<\/li><li>hair loss<\/li><li>injection site reactions (pain,&nbsp;redness&nbsp;, swelling)<\/li><li>fever<\/li><li>low level of&nbsp;white blood cells&nbsp;,&nbsp;red blood cells&nbsp;and \/ or&nbsp;platelets&nbsp;(seen in blood tests)<\/li><li>low level of&nbsp;sodium&nbsp;in the blood (&nbsp;hyponatremia&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>chills, increased sweating<\/li><li>allergies&nbsp;, dehydration, headaches, rashes,&nbsp;itching<\/li><li>digestive problems, pain in the mouth, on the tongue and toothache, taste change<\/li><li>muscle weakness, jaw pain, pain in the&nbsp;extremities&nbsp;, back pain, joint pain, muscle aches, leg pain, earache<\/li><li>dizziness, difficulty sleeping, transient loss of consciousness<\/li><li>difficulties with certain body movements<\/li><li>fast&nbsp;heart rate&nbsp;, high&nbsp;blood pressure&nbsp;, low&nbsp;blood pressure<\/li><li>difficulty breathing, cough, chest pain<\/li><li>swelling in arms, hands, feet, ankles, legs or other body parts<\/li><li>inflammation of the veins (&nbsp;phlebitis&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>visual disturbances<\/li><li>dry skin, reddening of the skin<\/li><li>problems with muscle contractions<\/li><li>sore throat, gum problems<\/li><li>weight gain<\/li><li>urinary tract problems<\/li><li>ringing or buzzing sound in the ears (&nbsp;tinnitus&nbsp;)<\/li><li>increased levels of liver enzymes (seen in blood tests)<\/li><li>inadequate&nbsp;antidiuretic hormone&nbsp;(&nbsp;ADH&nbsp;)&nbsp;secretion&nbsp;( &#8220;syndrome of inappropiate antidiuretic&nbsp;hormone&nbsp;secretion&#8221; SIADH), which is a condition that causes low sodium levels in the blood<\/li><li>tumor pain.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to Store Javlor<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the vial after EXP and the carton after EXP.&nbsp;data.<\/p>\n\n\n\n<p>It is unlikely that you will be responsible for the storage of this medicine.&nbsp;Storage instructions are given in the section intended for healthcare professionals.<\/p>\n\n\n\n<p><em>Unopened vial:<\/em><\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p><em>Diluted solution:<\/em><\/p>\n\n\n\n<p>A diluted solution should be used immediately.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is vinflunine.&nbsp;Each ml of concentrate contains 25 mg of vinflunine (as ditartrate).A&nbsp;vial&nbsp;of 2 ml contains 50 mg of vinflunine (as ditartrate).<br>One&nbsp;vial&nbsp;each of 4 ml contains 100 mg of vinflunine (as ditartrate).A&nbsp;vial&nbsp;of 10 ml contains 250 mg of vinflunine (as ditartrate).<br><\/li><li>The other ingredient is water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Javlor is a clear, colorless to the pale yellow solution, which is supplied in clear glass vials containing 2 ml, 4 ml, or 10 ml of concentrate sealed with a rubber stopper.&nbsp;Each pack contains 1 or 10 vials.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Pierre Fabre Medicine<\/p>\n\n\n\n<p>45 place Abel Gance<\/p>\n\n\n\n<p>F-92100 Boulogne<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Pierre Fabre Medicine Production<\/p>\n\n\n\n<p>Establishment Aquitaine Pharm International<\/p>\n\n\n\n<p>Avenue du B\u00e8arn<\/p>\n\n\n\n<p>F-64320 Idron<\/p>\n\n\n\n<p>France<\/p>\n","protected":false},"excerpt":{"rendered":"<p>25 mg \/ mL&nbsp;concentrate for&nbsp;infusion&nbsp;solutionvinflunine What Javlor is and what it is used for Javlor contains the active substance vinflunine which belongs to a group of cancer drugs called vinca alkaloids.&nbsp;These drugs affect the growth of cancer cells by interrupting cell division, leading to cell death (cytotoxicity). Javlar is used to treat advanced or metastatic [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12117],"tags":[14929,14924,14925,14928,14920,14923,14926,14921,14927,14922],"class_list":["post-15662","post","type-post","status-publish","format-standard","hentry","category-medicines","category-j","tag-benefits-of-javlor","tag-benefits-of-vinflunine","tag-javlor","tag-javlor-side-effects","tag-vinflunine","tag-vinflunine-side-effects","tag-what-is-javlor","tag-what-is-vinflunine","tag-what-javlor-is-used-for","tag-what-vinflunine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=15662"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15662\/revisions"}],"predecessor-version":[{"id":15815,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/15662\/revisions\/15815"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=15662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=15662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=15662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}