{"id":14570,"date":"2021-10-04T15:57:22","date_gmt":"2021-10-04T15:57:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14570"},"modified":"2021-10-09T16:23:46","modified_gmt":"2021-10-09T16:23:46","slug":"isoptin-retard","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/isoptin-retard\/","title":{"rendered":"Isoptin Retard &#8211; Verapamil hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>120, 180, and 240 mg&nbsp;prolonged-release tablets&nbsp;are<br>verapamil hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What ISOPTIN RETARD is and what it is used for<\/h2>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;lowers&nbsp;blood pressure&nbsp;by dilating certain blood vessels so that vascular resistance decreases.&nbsp;Isoptin&nbsp;Retard also&nbsp;increases blood flow in the coronary arteries of the heart and thus counteracts angina (&nbsp;angina pectoris&nbsp;).&nbsp;Isoptin&nbsp;Retard&nbsp;is used for high&nbsp;blood pressure&nbsp;and angina.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking ISOPTIN RETARD<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Isoptin Retard<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to verapamil hydrochloride or any of the other ingredients of this medicine (listed in section 6).<\/li><li>in certain serious heart diseases such as&nbsp;heart failure&nbsp;or heart block (disorders of the heart&#8217;s conduction system).<\/li><li>in&nbsp;acute&nbsp;myocardial infarction with concomitant slow heart activity, markedly low&nbsp;blood pressure&nbsp;or impaired left ventricular function.<\/li><li>in atrial fibrillation \/ flutter with concomitant&nbsp;WPW syndrome&nbsp;(irregular heartbeat).<\/li><li>in connection with overdose of drugs containing&nbsp;digitalis&nbsp;.<\/li><li>if you are&nbsp;taking&nbsp;medicines containing&nbsp;ivabradine&nbsp;(used to treat certain heart problems).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Those with the following conditions should consult a physician before starting treatment with Isoptin&nbsp;Retard&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>slow heart rate (&nbsp;pulse&nbsp;)<\/li><li>narrowing of the great carotid artery<\/li><li>poor left ventricular function<\/li><li>hepatic impairment<\/li><li>renal impairment<\/li><li>heart block (disorders of the cardiac conduction system)<\/li><li>heart failure<\/li><li>neuromuscular diseases (nerve diseases with muscle influence, eg muscle weakness).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and ISOPTIN RETARD<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;should not be used with medicines containing&nbsp;ivabradine&nbsp;(used to treat certain heart problems).<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;may reduce the glucose-lowering effect of&nbsp;metformin&nbsp;(used to treat&nbsp;diabetes&nbsp;).<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;can affect or be affected by treatment with, among other things, certain drugs against:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>asthma&nbsp;(theophylline)<\/li><li>blood clots (dabigatran and other direct-acting anticoagulants such as apixapan and rivaroxaban &#8211; medicines to prevent blood clots from forming)<\/li><li>cancer (paclitaxel, doxorubicin)<\/li><li>epilepsy&nbsp;(&nbsp;phenytoin&nbsp;, phenobarbital, carbamazepine)<\/li><li>heart disease (eg&nbsp;beta-receptor blockers&nbsp;,&nbsp;diuretics&nbsp;and digitoxin)<\/li><li>high blood fats (so-called statins eg&nbsp;simvastatin&nbsp;, atorvastatin, lovastatin)<\/li><li>infection&nbsp;is (rifampicin, clarithromycin, erythromycin, telithromycin)<\/li><li>stomach upset (cimetidine)<\/li><li>manic depressive illness (lithium)<\/li><li>irregular heartbeat (&nbsp;digoxin&nbsp;,&nbsp;quinidine&nbsp;,&nbsp;flecainide&nbsp;)<\/li><li>pain (&nbsp;acetylsalicylic acid&nbsp;)<\/li><li>anxiety (buspirone)<\/li><li>rejection after transplantation (cyclosporine, sirolimus, tacrolimus)<\/li><li>anesthesia before surgery (inhalation anesthetics, midazolam, neuromuscular blockers)<\/li><li>gout&nbsp;(colchicine, sulfinpyrazine)<\/li><li>the herbal medicine&nbsp;St. John&#8217;s wort<\/li><li>high&nbsp;blood pressure&nbsp;(prazosin)<\/li><li>benign prostatic hyperplasia (terazosin).<\/li><\/ul>\n\n\n\n<p>This is why treating physicians need to be aware of such concomitant medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ISOPTIN RETARD with food, drink and alcohol<\/h2>\n\n\n\n<p>Grapefruit juice may increase the effect of Isoptin&nbsp;Retard.&nbsp;In some patients, Isoptin&nbsp;Retard&nbsp;affects the&nbsp;effects of alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>There is a risk that the fetus is affected.<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;passes into breast milk.&nbsp;You should not breastfeed during treatment with Isoptin&nbsp;Retard.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p>In some people, the ability to drive or use machines may be affected by treatment with Isoptin&nbsp;Retard.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ISOPTIN RETARD contains sodium<\/h2>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;120 mg contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free.<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;180 mg contains 27.9 mg&nbsp;sodium&nbsp;(the main ingredient in table salt\/table salt) per tablet.&nbsp;This corresponds to 1.4% of the highest recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;240 mg contains 37.1 mg&nbsp;sodium&nbsp;(the main ingredient in table salt\/table salt) per tablet.&nbsp;This corresponds to 1.9% of the maximum recommended daily&nbsp;sodium&nbsp;intake&nbsp;for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take ISOPTIN RETARD<\/h2>\n\n\n\n<p>Always take Isoptin&nbsp;Retard&nbsp;exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The dose&nbsp;should be determined by a doctor, who will tailor it individually for you.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adults is 120-240 mg Isoptin&nbsp;Retard&nbsp;1-2 times a day.<\/p>\n\n\n\n<p><em>Use for children and adolescents<\/em><\/p>\n\n\n\n<p>There are no data on the use of Isoptin&nbsp;Retard&nbsp;in children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more ISOPTIN RETARD than you should&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;If a child has ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use ISOPTIN RETARD<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using ISOPTIN RETARD<\/h2>\n\n\n\n<p>Always consult a doctor before stopping Isoptin&nbsp;Retard.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Stop taking Isoptin&nbsp;Retard&nbsp;and contact your doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n<p>\u2022 swelling of the face, tongue, or throat<\/p>\n\n\n\n<p>\u2022 difficulty swallowing<\/p>\n\n\n\n<p>\u2022&nbsp;hives&nbsp;and difficulty breathing.<\/p>\n\n\n\n<p>These symptoms are signs of&nbsp;angioedema&nbsp;which is a very rare side effect (affects less than 1 in 10,000 people).<\/p>\n\n\n\n<p><em>Common (affects more than 1 user in 100):<\/em><\/p>\n\n\n\n<p>Constipation, nausea.&nbsp;Slow&nbsp;pulse.&nbsp;Heart failure&nbsp;or worsening of&nbsp;heart failure, low&nbsp;blood pressure.&nbsp;Headache, dizziness, fatigue.&nbsp;Swollen ankles.&nbsp;Itching, hives. Feeling of heat and&nbsp;redness&nbsp;on the face.<\/p>\n\n\n\n<p><em>Uncommon (affects less than 1 user in 100):<\/em><\/p>\n\n\n\n<p>Chest pain, increased&nbsp;heart rate.&nbsp;Impact on heart rhythm, palpitations.&nbsp;Change in certain liver values.&nbsp;Impaired sexual ability.&nbsp;Loss of appetite.&nbsp;Skin rash, ant crawling, or numbness.&nbsp;Diarrhea, abdominal pain, muscle cramps, tremors, confusion, sleep disturbances, frequent urination.<\/p>\n\n\n\n<p><em>Rare (affects less than 1 user in 1,000):<\/em><\/p>\n\n\n\n<p>Hypersensitivity reaction.&nbsp;Fainting attack.&nbsp;Hormone changes (elevated prolactin levels).&nbsp;Running breasts.&nbsp;Vomiting.&nbsp;Tamsyn.&nbsp;Tinnitus&nbsp;(ringing in the ears, ringing in the ears).&nbsp;Heavy sweating.<\/p>\n\n\n\n<p><em>Very rare (affects less than 1 user in 10,000):<\/em><\/p>\n\n\n\n<p>Dizziness.&nbsp;Enlargement of the mammary glands in men.&nbsp;Swelling of the gums.&nbsp;Blocked intestinal passage (intestinal knot).&nbsp;Photosensitivity that causes allergic reactions.&nbsp;Reddening of the skin and small bleeding in the skin due to&nbsp;inflammation&nbsp;of the blood vessels.&nbsp;Skin and mucous membrane changes (sometimes severe).&nbsp;Muscle pain, joint pain.<\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<p>Hair loss.&nbsp;Movement disorders such as tremors, involuntary movements, muscle stiffness, internal anxiety, and inability to be still (extrapyramidal syndrome).Severe disorders of the heart rhythm.&nbsp;High levels of&nbsp;potassium&nbsp;in the blood.&nbsp;Kidney failure.<\/p>\n\n\n\n<p>Only in rare cases does treatment need to be stopped due to&nbsp;side effects.&nbsp;Constipation usually occurs at the beginning of treatment and can be counteracted with a high-fiber diet or a mild laxative (contact your doctor for advice).<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store ISOPTIN RETARD<\/h2>\n\n\n\n<p><em>Prolonged-release<\/em> tablet&nbsp;s 120 mg, 180 mg,<em> and 240 mg blisters:<\/em>&nbsp;Store at 25\u00baC.<\/p>\n\n\n\n<p><em>Prolonged-release tablet&nbsp;180 mg in a glass jar:<\/em>&nbsp;No special storage instructions<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is verapamil hydrochloride 120 mg, 180 mg, and 240 mg per&nbsp;prolonged-release tablet&nbsp;respectively.<\/p>\n\n\n\n<p>The other ingredients are sodium alginate, microcrystalline cellulose, povidone, magnesium stearate, purified water, talc, hypromellose, Makrogol 400, Makrogol 6000, montanglycol wax.<\/p>\n\n\n\n<p>dye in:<\/p>\n\n\n\n<p><em>Isoptin&nbsp;Retard&nbsp;120 mg:<\/em>&nbsp;titanium dioxide (E171).<\/p>\n\n\n\n<p><em>Isoptin&nbsp;Retard&nbsp;180 mg:<\/em>&nbsp;titanium dioxide (E171), iron oxide (E172)<\/p>\n\n\n\n<p><em>Isoptin&nbsp;Retard&nbsp;240 mg:<\/em>&nbsp;titanium dioxide (E171), quinoline yellow (E104), indigo carmine (E132)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;120 mg: white, round, hilly&nbsp;prolonged-release tablet.&nbsp;The tablets have a diameter of 10 mm and are marked KNOLL, 120 SR<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;180 mg: pink, oval&nbsp;prolonged-release tablet&nbsp;with scored and marked KNOLL \/ SR 180<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;240 mg: yellow-green, oblong, cupped&nbsp;prolonged-release tablet.<\/p>\n\n\n\n<p>The switch is not for dividing the tablet into equal&nbsp;doses, but only for easier swallowing.<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;120 mg: 28 pcs and 98 pcs (&nbsp;calendar pack&nbsp;)<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;180 mg: 28 pcs and 98 pcs (&nbsp;calendar pack&nbsp;and glass jar)<\/p>\n\n\n\n<p>Isoptin&nbsp;Retard&nbsp;240 mg: 28 pcs and 98 pcs (&nbsp;calendar pack&nbsp;)<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>BGP Products AB, Box 23033, 104 35 Stockholm<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>AbbVie Deutschland GmbH &amp; Co.&nbsp;KG, Ludwigshafen, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>FAMAR AVE Anthoussa, Attiki, Greece<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Isoptin Retard lowers blood pressure by dilating certain blood vessels so that vascular resistance decreases. Isoptin Retard also increases blood flow in the coronary arteries of the heart and thus counteracts angina ( angina pectoris ). Isoptin Retard is used for high blood pressure and angina.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[12116,2200],"tags":[12248,12252,12251,12247,2210,12243,12246,12249,12244,12250,12245],"class_list":["post-14570","post","type-post","status-publish","format-standard","hentry","category-i","category-medicines","tag-isoptin-retard","tag-isoptin-retard-side-effects","tag-isoptin-retard-tablet","tag-side-effects-of-verapamil-hydrochloride","tag-tablet","tag-verapamil-hydrochloride","tag-verapamil-hydrochloride-tablet","tag-what-is-isoptin-retard","tag-what-is-verapamil-hydrochloride","tag-what-isoptin-retard-is-used-for","tag-what-verapamil-hydrochloride-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14570"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14570\/revisions"}],"predecessor-version":[{"id":14737,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14570\/revisions\/14737"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14570"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14570"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}