{"id":14568,"date":"2021-10-04T15:55:43","date_gmt":"2021-10-04T15:55:43","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14568"},"modified":"2021-10-09T16:24:12","modified_gmt":"2021-10-09T16:24:12","slug":"isoptin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/isoptin\/","title":{"rendered":"Isoptin &#8211; Verapamil hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>40 mg and 80 mg\u00a0film-coated tablets<br>verapamil hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Isoptin is and what it is used for<\/h2>\n\n\n\n<p>Isoptin lowers&nbsp;blood pressure&nbsp;by dilating certain blood vessels so that vascular resistance decreases.&nbsp;Isoptin also increases blood flow in the coronary arteries of the heart and thus counteracts angina (&nbsp;angina pectoris&nbsp;). Isoptin is used for high&nbsp;blood pressure&nbsp;and angina, and as a preventive treatment after the acute phase of a heart attack to reduce the risk of a new heart attack.&nbsp;Isoptin is also used in an irregular heartbeat.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Isoptin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Isoptin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to verapamil hydrochloride or any of the other ingredients of this medicine (listed in section 6).<\/li><li>in certain serious heart diseases such as&nbsp;heart failure&nbsp;or heart block (disorders of the heart&#8217;s conduction system).<\/li><li>in&nbsp;acute&nbsp;myocardial infarction with concomitant slow heart activity, markedly low&nbsp;blood pressure&nbsp;or impaired left ventricular function.<\/li><li>in atrial fibrillation \/ flutter with concomitant&nbsp;WPW syndrome&nbsp;(irregular heartbeat).<\/li><li>in connection with overdose of drugs containing&nbsp;digitalis&nbsp;.<\/li><li>if you are&nbsp;taking&nbsp;medicines containing&nbsp;ivabradine&nbsp;(used to treat certain heart problems).<\/li><\/ul>\n\n\n\n<p>Isoptin should also not be used as a preventive treatment after a heart attack if you have a very low&nbsp;heart rate, if you are also taking certain medicines for high&nbsp;blood pressure&nbsp;(&nbsp;beta-blockers&nbsp;) or if you are receiving verapamil&nbsp;intravenously.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Those with the following conditions should consult a physician before starting treatment with Isoptin:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>slow heart rate (&nbsp;pulse&nbsp;)<\/li><li>narrowing of the great carotid artery<\/li><li>salt balance disorders (especially reduced blood potassium)<\/li><li>poor left ventricular function<\/li><li>hepatic impairment<\/li><li>renal impairment<\/li><li>heart block (disorders of the cardiac conduction system)<\/li><li>heart failure<\/li><li>neuromuscular diseases (nerve diseases with muscle influence, eg muscle weakness).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Isoptin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Isoptin should not be used with medicines containing&nbsp;ivabradine&nbsp;(used to treat certain heart problems).<\/p>\n\n\n\n<p>Isoptin may reduce the glucose-lowering effect of&nbsp;metformin&nbsp;(used to treat&nbsp;diabetes&nbsp;).<\/p>\n\n\n\n<p>Isoptin can affect or be affected by treatment with, among other things, certain drugs against:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>asthma&nbsp;(theophylline)<\/li><li>blood clots (dabigatran and other direct-acting anticoagulants such as apixapan and rivaroxaban &#8211; medicines to prevent blood clots from forming)<\/li><li>cancer (paclitaxel, doxorubicin)<\/li><li>epilepsy&nbsp;(&nbsp;phenytoin&nbsp;, phenobarbital, carbamazepine)<\/li><li>heart disease (eg&nbsp;beta-receptor blockers&nbsp;,&nbsp;diuretics&nbsp;and digitoxin)<\/li><li>high blood fats (so-called statins eg&nbsp;simvastatin&nbsp;, atorvastatin, lovastatin)<\/li><li>infection&nbsp;is (rifampicin, clarithromycin, erythromycin, telithromycin)<\/li><li>stomach upset (cimetidine)<\/li><li>manic depressive illness (lithium)<\/li><li>irregular heartbeat (&nbsp;digoxin&nbsp;,&nbsp;quinidine&nbsp;,&nbsp;flecainide&nbsp;)<\/li><li>pain (&nbsp;acetylsalicylic acid&nbsp;)<\/li><li>anxiety (buspirone)<\/li><li>rejection after transplantation (cyclosporine, sirolimus, tacrolimus)<\/li><li>anesthesia before surgery (inhalation anesthetics, midazolam, neuromuscular blockers)<\/li><li>gout&nbsp;(colchicine, sulfinpyrazine)<\/li><li>the herbal medicine&nbsp;St. John&#8217;s wort&nbsp;.<\/li><li>high&nbsp;blood pressure&nbsp;(prazosin)<\/li><li>benign prostatic hyperplasia (terazosin).<\/li><\/ul>\n\n\n\n<p>This is why treating physicians need to be aware of such concomitant medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Isoptin with food and drink<\/h2>\n\n\n\n<p>Grapefruit juice may increase the effect of Isoptin.&nbsp;In some patients, Isoptin affects the effects of alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>There is a risk that the fetus is affected.<\/p>\n\n\n\n<p>Isoptin passes into breast milk.&nbsp;You should not breastfeed during treatment with Isoptin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><br>In some people, the ability to drive or use machines may be affected by treatment with Isoptin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Isoptin contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie it is essentially &#8216;sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Isoptin<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Dose&nbsp;one should be determined by a doctor, who will tailor it individually for you.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adults is 240-480 mg Isoptin per day divided into 2-4 dosing times.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for children:<\/p>\n\n\n\n<p>Isoptin: 4-10 mg \/ kg \/ day divided into 2-3&nbsp;doses&nbsp;for infants.&nbsp;For older children, a lower&nbsp;dose&nbsp;, 3-6 mg \/ kg \/ day&nbsp;should be&nbsp;given.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Isoptin than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Isoptin<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Isoptin<\/h2>\n\n\n\n<p>Always consult a doctor before stopping Isoptin.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p>Stop taking Isoptin and contact a doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n<p>\u2022 swelling of the face, tongue, or throat<\/p>\n\n\n\n<p>\u2022 difficulty swallowing<\/p>\n\n\n\n<p>\u2022&nbsp;hives&nbsp;and difficulty breathing.<\/p>\n\n\n\n<p>These symptoms are signs of&nbsp;angioedema&nbsp;which is a very rare side effect (affects less than 1 in 10,000 people).<\/p>\n\n\n\n<p><em>Common (affects more than 1 user in 100)<\/em><\/p>\n\n\n\n<p>Constipation, nausea.&nbsp;Slow pulse.&nbsp;Heart failure&nbsp;or worsening of&nbsp;heart failure, low&nbsp;blood pressure.&nbsp;Headache, dizziness, fatigue.&nbsp;Swollen ankles.&nbsp;Itching, hives.&nbsp;Feeling of heat and&nbsp;redness&nbsp;on the face.<\/p>\n\n\n\n<p><em>Uncommon (affects less than 1 user in 100)<\/em><\/p>\n\n\n\n<p>Chest pain, increased&nbsp;heart rate.&nbsp;Impact on heart rhythm, palpitations.&nbsp;Change in certain liver values.&nbsp;Impaired sexual ability.&nbsp;Loss of appetite.&nbsp;Skin rash, ant crawling, or numbness.&nbsp;Diarrhea, abdominal pain, muscle cramps, tremors, confusion, sleep disturbances, frequent urination.<\/p>\n\n\n\n<p><em>Rare (affects less than 1 user in 1,000)<\/em><\/p>\n\n\n\n<p>Hypersensitivity reaction.&nbsp;Fainting attack.&nbsp;Hormone changes (elevated prolactin levels).&nbsp;Running breasts.&nbsp;Vomiting.&nbsp;Dimsyn.&nbsp;Tinnitus&nbsp;(ringing in the ears, ringing in the ears).&nbsp;Heavy sweating.<\/p>\n\n\n\n<p><em>Very rare (affects less than 1 user in 10,000)<\/em><\/p>\n\n\n\n<p>Dizziness.&nbsp;Enlargement of the mammary glands in men.&nbsp;Swelling of the gums.&nbsp;Blocked intestinal passage (intestinal knot).&nbsp;Photosensitivity that causes allergic reactions.&nbsp;Reddening of the skin and small bleeding in the skin due to&nbsp;inflammation&nbsp;of the blood vessels.&nbsp;Skin and mucosal changes (sometimes severe).&nbsp;Muscle pain, joint pain.<\/p>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<p>Hair loss.&nbsp;Movement disorders such as tremors, involuntary movements, muscle stiffness, inner anxiety, and inability to stand still (extrapyramidal syndrome).&nbsp;Serious disorders of the heart rhythm.&nbsp;High levels of&nbsp;potassium&nbsp;in the blood.&nbsp;Kidney failure.<\/p>\n\n\n\n<p>Only in rare cases does treatment need to be stopped due to&nbsp;side effects.&nbsp;Constipation usually occurs at the beginning of treatment and can be counteracted with a high-fiber diet or a mild laxative (contact your doctor for advice).<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Isoptin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is verapamil hydrochloride 40 mg and 80 mg respectively per tablet.<\/li><li>The other ingredients are calcium hydrogen phosphate dihydrate, microcrystalline cellulose, anhydrous&nbsp;colloidal&nbsp;silica, croscarmellose sodium, magnesium stearate, hypromellose, sodium lauryl sulphate, macrogol 6000, talc, the dye titanium dioxide (E 171).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>40 mg white, cupped \u00d8 7mm, marked 40 and with tuber triangle<\/p>\n\n\n\n<p>80 mg white, cupped \u00d8 9 mm marked Isoptin 80 \/ Knoll, with notch<\/p>\n\n\n\n<p>The switch is not for dividing the tablet into equal&nbsp;doses, but only for easier swallowing.<\/p>\n\n\n\n<p><em>40 mg tablets:<\/em>&nbsp;100 pcs (blister)<\/p>\n\n\n\n<p><em>80 mg tablets:<\/em>&nbsp;100 pcs (blister)<\/p>\n\n\n\n<p>Not all pack sizes may be marketed<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n<p>BGP Products AB<\/p>\n\n\n\n<p>Box 23033<\/p>\n\n\n\n<p>104 35 Stockholm<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>AbbVie Deutschland GmbH Co.&nbsp;KG, Ludwigshafen, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>FAMAR AVE Anthoussa, Attiki, Greece<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Isoptin lowers blood pressure by dilating certain blood vessels so that vascular resistance decreases. Isoptin also increases blood flow in the coronary arteries of the heart and thus counteracts angina ( angina pectoris ). Isoptin is used for high blood pressure and angina, and as a preventive treatment after the acute phase of a heart attack to reduce the risk of a new heart attack. Isoptin is also used in an irregular heartbeat.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[12116,2200],"tags":[12253,12257,12256,12247,2210,12243,12246,12254,12244,12255,12245],"class_list":["post-14568","post","type-post","status-publish","format-standard","hentry","category-i","category-medicines","tag-isoptin","tag-isoptin-side-effects","tag-isoptin-tablet","tag-side-effects-of-verapamil-hydrochloride","tag-tablet","tag-verapamil-hydrochloride","tag-verapamil-hydrochloride-tablet","tag-what-is-isoptin","tag-what-is-verapamil-hydrochloride","tag-what-isoptin-is-used-for","tag-what-verapamil-hydrochloride-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14568"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14568\/revisions"}],"predecessor-version":[{"id":14738,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14568\/revisions\/14738"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}