{"id":14455,"date":"2021-10-01T05:42:11","date_gmt":"2021-10-01T05:42:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14455"},"modified":"2021-10-12T07:48:27","modified_gmt":"2021-10-12T07:48:27","slug":"invanz","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/invanz\/","title":{"rendered":"Invanz &#8211; Ertapenem uses, dose and side effects"},"content":{"rendered":"\n<p>1 g of&nbsp;powder to concentrate for&nbsp;infusion&nbsp;solution<br>ertapenem<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. WHAT INVANCE IS AND WHAT IT IS USED FOR<\/h2>\n\n\n\n<p>INVANZ contains ertapenem, an&nbsp;antibiotic&nbsp;belonging to the&nbsp;beta-lactam&nbsp;group.&nbsp;It has the ability to kill a large number of different bacteria (&nbsp;microorganisms&nbsp;) that cause&nbsp;infection&nbsp;in different parts of the body.<\/p>\n\n\n\n<p>INVANZ can be given to individuals who are three months and older.<\/p>\n\n\n\n<p>Treatment:<\/p>\n\n\n\n<p>Your doctor has prescribed INVANZ because you or your child have one (or more) of the following types of infections:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Infection&nbsp;of the abdomen<\/li><li>Infection&nbsp;affecting the lungs (&nbsp;pneumonia&nbsp;)<\/li><li>Gynecological&nbsp;infection&nbsp;er.<\/li><li>Skin infections of the foot in diabetics.<\/li><\/ul>\n\n\n\n<p>Prophylaxis:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Prophylaxis&nbsp;against&nbsp;infection&nbsp;is in adults in the area where the surgery was performed after surgery in the colon or rectum.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you get INVANZ<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use INVANZ<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to the active substance (ertapenem) or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to&nbsp;antibiotics&nbsp;such as&nbsp;penicillins&nbsp;,&nbsp;cephalosporins&nbsp;or carbapenems (used to treat various&nbsp;infections&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking INVANZ<\/p>\n\n\n\n<p>If you get an&nbsp;allergic reaction&nbsp;during treatment&nbsp;(such as swelling of the face, tongue, or throat, difficulty breathing or swallowing, rash), you should contact your doctor as soon as possible as you may need medical treatment immediately.<\/p>\n\n\n\n<p>Although&nbsp;antibiotics,&nbsp;including INVANZ, kill certain bacteria, other bacteria and fungi can continue to grow more than normal.&nbsp;This is called overgrowth.&nbsp;Your doctor will monitor you for overgrowth and, if necessary, give you treatment.<\/p>\n\n\n\n<p>It is important that you tell your doctor if you have diarrhea before, during, or after your treatment with INVANZ.&nbsp;This is because you may have a condition called&nbsp;colitis&nbsp;(inflammation&nbsp;of the colon).&nbsp;Do not take any medicine to treat diarrhea without first discussing it with your doctor.<\/p>\n\n\n\n<p>Tell your doctor if you are taking the medicines&nbsp;valproic acid&nbsp;or sodium valproate (see&nbsp;<strong>Other medicines and INVANZ<\/strong>&nbsp;below).<\/p>\n\n\n\n<p>Tell your doctor about the diseases you have or have had:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kidney disease.&nbsp;It is especially important that your doctor knows if you have kidney disease and if you are undergoing dialysis treatment.<\/li><li>Drug allergies, including to&nbsp;antibiotics&nbsp;.<\/li><li>Diseases of the&nbsp;central nervous system&nbsp;, such as limited tremors or seizures.<\/li><\/ul>\n\n\n\n<p><strong>Children and adolescents (3 months to 17 years of age)<\/strong><br>Experience with INVANZ in children younger than two years is limited.&nbsp;For this age group, the doctor makes an assessment of the possible benefits of the treatment.&nbsp;There is no experience in children under 3 months of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and INVANZ<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Tell your doctor, nurse, or pharmacist if you are taking medicines containing&nbsp;valproic acid&nbsp;or sodium valproate (used to treat&nbsp;epilepsy,&nbsp;bipolar disorder,&nbsp;migraine,&nbsp;and schizophrenia).&nbsp;This is because INVANZ can affect the way other medicines work.&nbsp;Your doctor will decide if you should use INVANZ at the same time as any of these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>INVANZ has not been studied in pregnant women.&nbsp;INVANZ should not be used during pregnancy unless your doctor considers that the potential benefit outweighs the potential risk to the fetus.<\/p>\n\n\n\n<p>Because INVANZ has been found in breast milk, women receiving INVANZ should not breastfeed as the breast-fed baby may be affected.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use machines until you know how you react to the medicine.&nbsp;Certain&nbsp;side effects, such as dizziness and drowsiness, have been reported with INVANZ, which may affect some patients&#8217; ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">INVANZ contains sodium<\/h2>\n\n\n\n<p>This medicine contains approximately 137 mg of&nbsp;sodium&nbsp;(the main ingredient in table salt\/table salt) per&nbsp;dose&nbsp;of 1.0 g. This corresponds to 6.85% of the maximum recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use INVANZ<\/h2>\n\n\n\n<p>INVANZ will always be mixed and given to you&nbsp;intravenously&nbsp;(into a vein) by a doctor or other healthcare professional.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;of INVANZ for adults and adolescents 13 years of age or older is 1 gram (g) once daily.&nbsp;The recommended&nbsp;dose&nbsp;for children between 3 months and 12 years of age is 15 mg\/kg given twice daily (1 g \/ day must not be exceeded).&nbsp;Your doctor will decide how many days you need to receive treatment.<\/p>\n\n\n\n<p>In&nbsp;prophylaxis&nbsp;against&nbsp;infection&nbsp;in the area where the surgery was performed after surgery in the colon or rectum, the usual&nbsp;dose is&nbsp;1 g and is given&nbsp;intravenously&nbsp;as a single dose one hour before the operation.<\/p>\n\n\n\n<p>It is very important that you continue to receive INVANZ for as long as your doctor prescribes it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more INVANZ than you should<\/h2>\n\n\n\n<p>If you are concerned that you may have received too much INVANZ, contact your doctor or other healthcare professional immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you miss a dose of INVANZ<\/h2>\n\n\n\n<p>If you are concerned that you may have missed a&nbsp;dose, contact your doctor or other healthcare professional immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong><em>Adults 18 years or older<\/em><\/strong><\/p>\n\n\n\n<p>Since the drug was introduced to the market, severe allergic reactions (&nbsp;anaphylaxis&nbsp;) and hypersensitivity syndromes (allergic reactions with rash, fever, and abnormal blood tests) have been reported.&nbsp;The first signs of a severe&nbsp;allergic reaction&nbsp;may be swelling of the face and\/or throat.&nbsp;If these signs of illness occur, contact your doctor as soon as possible as you may need medical treatment immediately.<\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 people)&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Diarrhea, nausea, vomiting<\/li><li>Rash,&nbsp;itching<\/li><li>Problems with the vein in which the medicine is given (including&nbsp;inflammation&nbsp;, lump formation, swelling at the injection site or leakage of fluid into the&nbsp;tissue&nbsp;and skin around the injection site).<\/li><li>Increased&nbsp;platelet count<\/li><li>Altered liver function values.<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people)&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness, drowsiness, difficulty sleeping, confusion, seizures<\/li><li>Low&nbsp;blood pressure&nbsp;, slow heart rate<\/li><li>Shortness of breath, sore throat<\/li><li>Constipation, yeast infection in the mouth, diarrhea associated with antibiotic treatment, acid reflux,&nbsp;dry mouth&nbsp;, impaired digestion, loss of appetite<\/li><li>Reddening of the skin<\/li><li>Discharges and irritation in the abdomen<\/li><li>Stomach pain, fatigue, fungal infection, fever, edema \/ swelling, chest pain, altered taste experience.<\/li><li>Alteration of certain blood and urine samples.<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people)&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased&nbsp;white blood cell count&nbsp;, decreased&nbsp;platelet count<\/li><li>Low blood sugar<\/li><li>Upset, anxiety, depression, tremors<\/li><li>Irregular heartbeat, high&nbsp;blood pressure&nbsp;, bleeding, fast heartbeat<\/li><li>Nasal congestion, cough, nosebleeds,&nbsp;pneumonia&nbsp;, altered breathing sounds, wheezing<\/li><li>Inflammation&nbsp;of the gallbladder, difficulty swallowing, fecal incontinence, jaundice, liver disease<\/li><li>Skin inflammation, fungal infection of the skin, skin flaking,&nbsp;infection&nbsp;of the wound after surgery<\/li><li>Muscle cramps, shoulder pain<\/li><li>Urinary tract infection, kidney problems<\/li><li>Miscarriage, abdominal bleeding<\/li><li>Allergy&nbsp;, malaise,&nbsp;inflammation&nbsp;of the pelvic floor, changes in the white part of the eye, fainting<\/li><li>The skin may become hard at the injection site<\/li><li>Swollen blood vessels in the skin.<\/li><\/ul>\n\n\n\n<p>Adverse reactions&nbsp;reported without known frequency (frequency can not be calculated from the available data) are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hallucinations<\/li><li>Decreased level of consciousness<\/li><li>Changed mood (including aggression,&nbsp;delirium&nbsp;, disorientation, changes in mood)<\/li><li>Abnormal movements<\/li><li>Muscle weakness<\/li><li>Unsteady gait<\/li><li>Discoloration of teeth.<\/li><\/ul>\n\n\n\n<p>There have also been reports of changes in certain laboratory values.<\/p>\n\n\n\n<p>If you experience raised or fluid-filled skin spots all over your body, talk to your doctor or nurse immediately.<\/p>\n\n\n\n<p><strong><em>Children and adolescents (3 months to 17 years old)<\/em><\/strong><\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 people)&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea<\/li><li>Diaper rash<\/li><li>Pain at the infusion site<\/li><li>Change in the number of&nbsp;white blood cells<\/li><li>Altered liver function values.<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people)&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Hot flashes, high&nbsp;blood pressure&nbsp;, red or reddish-purple flat dots as big as pinheads under the skin<\/li><li>Discolored stools, black tar-like stools<\/li><li>Reddening of the skin, itchy skin<\/li><li>Burning sensation,&nbsp;itching&nbsp;,&nbsp;redness&nbsp;and heat at the infusion&nbsp;site&nbsp;,&nbsp;redness&nbsp;at the injection site<\/li><li>Increased&nbsp;platelet count<\/li><li>Alteration of certain blood samples.<\/li><\/ul>\n\n\n\n<p>Adverse reactions&nbsp;reported without known frequency (frequency can not be calculated from the available data) are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hallucinations<\/li><li>Changed mood (including aggression).<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store INVANZ<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The first 2 digits show the month and the following 4 digits show the year.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance in INVANZ is ertapenem 1 g.<\/p>\n\n\n\n<p>The other ingredients are Sodium bicarbonate (E500) and sodium hydroxide (E524).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>INVANZ is a white to off-white lyophilised powder for concentrate for&nbsp;solution&nbsp;for&nbsp;infusion.<\/p>\n\n\n\n<p>The color of INVANZ solutions ranges from colorless to pale yellow.&nbsp;Variations within this color scale do not affect the strength of the drug.<\/p>\n\n\n\n<p>INVANZ is supplied in packs of 1&nbsp;vial&nbsp;or 10 vials.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Merck Sharp &amp; Dohme BV<br>Waarderweg 39<br>2031 BN Haarlem The&nbsp;<br>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>FAREVA Mirabel<\/p>\n\n\n\n<p>Route de Marsat, Riom<\/p>\n\n\n\n<p>63963 Clermont-Ferrand Cedex 9<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgique \/ Belgi\u00eb \/ Belgien<\/strong>MSD Belgium BVBA \/ SPRLTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><td><strong>Lithuania<\/strong>UAB Merck Sharp &amp; DohmeTel.&nbsp;+ 370 5 278 02 47msd_lietuva@merck.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Mark Harp and Doom Bulgaria BulgariaTel: +359 2 819 3737info-msdbg@merck.com<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>MSD Belgium BVBA \/ SPRLTel: +32 (0) 27766211dpoc_belux@merck.com<\/td><\/tr><tr><td><strong>Czech Republic<br><\/strong>Merck Sharp &amp; Dohme sroTel .: +420 233 010 111dpoc_czechslovak@merck.com<\/td><td><strong>Hungary<\/strong>MSD Pharma Hungary Kft.Tel .: +361 888 53 00hungary_msd@merck.com<\/td><\/tr><tr><td><strong>Denmark<\/strong>MSD Danmark ApSTel: +45 44 82 40 00dkmail@merck.com<\/td><td><strong>Malta<\/strong>Merck Sharp &amp; Dohme Cyprus LimitedTel: 8007 4433 (+356 99917558)malta_info@merck.com<\/td><\/tr><tr><td><strong>Germany<\/strong>INFECTOPHARMArzneimittel und Consilium GmbHTel.&nbsp;+49 (0) 6252 \/ 95-7000kontakt@infectopharm.com<\/td><td><strong>The Netherlands<\/strong>Merck Sharp &amp; Dohme BVTel: 0800 9999000(+31 (0) 23 5153153)medicalinfo.nl@merck.com<\/td><\/tr><tr><td><strong>Eesti<\/strong>Merck Sharp &amp; Dohme O\u00dcTel .: +372 6144 200msdeesti@merck.com<\/td><td><strong>Norway<\/strong>MSD (Norway) ASTel: +47 32 20 73 00msdnorge@msd.no<\/td><\/tr><tr><td><strong>Elad<\/strong>MSD \u0391.\u03a6.\u0392.\u0395.\u0395:\u0397\u03bb: + 30-210 98 97 300dpoc_greece@merck.com<\/td><td><strong>Austria<\/strong>Merck Sharp &amp; Dohme Ges.mbHTel: +43 (0) 1 26 044msd-medizin@merck.com<\/td><\/tr><tr><td><strong>Spain<\/strong>Merck Sharp &amp; Dohme de Espa\u00f1a, SATel: +34 91 321 06 00msd_info@merck.com<\/td><td><strong>Poland<\/strong>MSD Polska Sp.z ooTel .: +48 22 549 51 00msdpolska@merck.com<\/td><\/tr><tr><td><strong>France<\/strong>MSD FranceTel: + 33 (0) 1 80 46 40 40<\/td><td><strong>Portugal<\/strong>Merck Sharp &amp; Dohme, LdaTel: +351 21 4465700inform_pt@merck.com<\/td><\/tr><tr><td><strong>Croatia<\/strong>Merck Sharp &amp; Dohme dooTel: + 385 1 6611 333croatia_info@merck.com<\/td><td><strong>Romania<\/strong>Merck Sharp &amp; Dohme Romania SRLTel: + 4021 529 29 00msdromania@merck.com<\/td><\/tr><tr><td><strong>Ireland<\/strong>Merck Sharp &amp; Dohme Ireland (&nbsp;Human&nbsp;Health) LimitedTel: +353 (0) 12998700medinfo_ireland@merck.com<\/td><td><strong>Slovenia<\/strong>Merck Sharp &amp; Dohme, innovative zdravila dooTel: + 386 1 5204201msd_slovenia@merck.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000ISmail@merck.com<\/td><td><strong>Slovak Republic<\/strong>Merck Sharp &amp; Dohme, sro Tel .: +421 2 58282010dpoc_czechslovak@merck.com<\/td><\/tr><tr><td><strong>Italy<\/strong>MSD Italia SrlTel: +39 06 361911medicalinformation.it@merck.com<\/td><td><strong>Finland \/ Finland<\/strong>MSD Finland OyPuh \/ Tel: +358 (0) 9 804650info@msd.fi<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>Merck Sharp &amp; Dohme Cyprus Limited.:\u0397\u03bb .: 80000 673 (+357 22866700)cyprus_info@merck.com<\/td><td><strong>Sweden<\/strong>Merck Sharp &amp; Dohme (Sweden) ABTel: +46 (0) 77 5700488medicinskinfo@merck.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA \u201cMerck Sharp &amp; Dohme Latvija\u201dTel: +371 67364 224msd_lv@merck.com.<\/td><td><strong>United Kingdom<\/strong>Merck Sharp &amp; Dohme LimitedTel: +44 (0) 1992 467272medicalinformationuk@msd.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>INVANZ contains ertapenem, an antibiotic belonging to the beta-lactam group. It has the ability to kill a large number of different bacteria ( microorganisms ) that cause infection in different parts of the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[12546,12550,3891,3893,12547,12551,12545,12549,3892,12548],"class_list":["post-14455","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-ertapenem","tag-benefits-of-invanz","tag-ertapenem","tag-ertapenem-side-effects","tag-invanz","tag-side-effects-of-invanz","tag-what-ertapenem-is-used-for","tag-what-invanz-is-used-for","tag-what-is-ertapenem","tag-what-is-invanz"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14455"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14455\/revisions"}],"predecessor-version":[{"id":14836,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14455\/revisions\/14836"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14455"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14455"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}