{"id":14445,"date":"2021-10-01T05:33:02","date_gmt":"2021-10-01T05:33:02","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14445"},"modified":"2021-10-13T07:40:15","modified_gmt":"2021-10-13T07:40:15","slug":"integrilin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/integrilin\/","title":{"rendered":"Integrilin &#8211; Eptifibatide uses, dose and side effects"},"content":{"rendered":"\n<p>0.75 mg \/ ml&nbsp;Infusion&nbsp;solution<br>eptifibatide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Integrilin is and what it is used for<\/h2>\n\n\n\n<p>Integrilin is a platelet aggregation inhibitor.&nbsp;This means that it helps to prevent the platelets from clotting.<\/p>\n\n\n\n<p>It is used in adults with signs of severe&nbsp;heart failure&nbsp;defined as spontaneous and recently experienced chest pain with&nbsp;ECG&nbsp;changes or biological changes.&nbsp;It is usually given together with&nbsp;acetylsalicylic acid&nbsp;and unfractionated&nbsp;heparin.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you take Integrilin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You can not get Integrilin:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to eptifibatide or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have recently had a bleeding from the stomach, intestines, bladder or other organs, for example if you have seen blood in the stool or urine (with the exception of menstrual bleeding) in the last 30 days<\/li><li>if you have had a stroke in the last 30 days or some form of cerebral haemorrhage (also make sure your doctor knows if you have ever had a stroke)<\/li><li>if you have had a brain tumor or any disease that affects the blood vessels in the brain<\/li><li>if you have undergone major surgery or suffered a serious injury in the last 6 weeks<\/li><li>if you have or have had bleeding problems<\/li><li>if you have or have had coagulation disorders or a low&nbsp;platelet count<\/li><li>if you have or have had severe&nbsp;hypertension&nbsp;(high&nbsp;blood pressure&nbsp;)<\/li><li>if you have or have had severe kidney or liver problems<\/li><li>if you have been treated with another medicine of the same type as Integrilin.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you have had any of these conditions.&nbsp;If you have any further questions, ask your doctor, hospital pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Take special care with Integrilin:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Integrilin is only recommended for use in adult inpatients in cardiology departments.<\/li><li>Integrilin is not intended for use in children or adolescents below 18 years.<\/li><li>Before and during treatment with Integrilin, blood tests will be taken as a precautionary measure to limit the risk of unexpected bleeding.<\/li><li>When you receive Integrilin, you will be closely monitored for signs of unusual or unexpected bleeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Integrilin<\/h2>\n\n\n\n<p>To avoid the risk of&nbsp;interacting&nbsp;with other medicines, tell your doctor, hospital pharmacist, or nurse if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.&nbsp;Particularly:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood thinners (oral&nbsp;anticoagulants&nbsp;) or<\/li><li>medicines that prevent the blood from clotting, including&nbsp;warfarin&nbsp;, dipyridamole, ticlopidine,&nbsp;acetylsalicylic acid&nbsp;(with the exception of those that you may receive as part of your Integrilin treatment).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Integrilin is not usually recommended for use during pregnancy.&nbsp;Tell your doctor if you are pregnant, think you may be pregnant, or are planning to have a baby.&nbsp;Your doctor will weigh the benefits for you against the risks to your baby when using Integrilin during your pregnancy.<\/p>\n\n\n\n<p>If you are breastfeeding, you should stop breastfeeding during the treatment period.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Integrilin contains sodium<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>This medicine contains 161 mg of&nbsp;sodium&nbsp;(the main ingredient in table salt \/ table salt) per 100 ml&nbsp;vial&nbsp;.&nbsp;This corresponds to 8.1% of the highest recommended daily intake of&nbsp;sodium&nbsp;for adults.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Integrilin<\/h2>\n\n\n\n<p>Integrilin is given into a vein by direct&nbsp;injection&nbsp;followed by an&nbsp;infusion&nbsp;(drip solution).&nbsp;Dose&nbsp;one is calculated according to your body weight.&nbsp;The recommended&nbsp;dose&nbsp;is 180 micrograms\/kg given as a&nbsp;bolus&nbsp;(rapid&nbsp;intravenous&nbsp;injection&nbsp;), followed by an&nbsp;infusion&nbsp;(drip solution) of 2 micrograms\/kg\/minute for up to 72 hours.&nbsp;If you have any kidney disease, the&nbsp;dose&nbsp;may be reduced to 1 microgram\/kg\/minute.<\/p>\n\n\n\n<p>If catheterization procedures (PCI) are performed during treatment with Integrilin, the intravenous solution may be given for up to 96 hours.<\/p>\n\n\n\n<p>You must also receive&nbsp;acetylsalicylic acid&nbsp;and&nbsp;heparin&nbsp;(unless&nbsp;contraindicated&nbsp;in your case).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, hospital pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effect<\/strong><\/p>\n\n\n\n<p><em>Occurs in more than 1 in 10 individuals<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>minor or major bleeding (eg blood in the urine, blood in the stool, blood in connection with vomiting or bleeding in connection with surgery)<\/li><li>anemia&nbsp;(decreased number of&nbsp;red blood cells&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effect<\/strong><\/p>\n\n\n\n<p><em>Occurs in up to 1 in 10 individuals<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>inflammation&nbsp;of blood vessels.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effect<\/strong><\/p>\n\n\n\n<p><em>Occurs in up to 1 in 100 individuals<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;(&nbsp;blood cells&nbsp;needed for blood coagulation)<\/li><li>reduced blood supply to the brain.<\/li><\/ul>\n\n\n\n<p><strong>Very rare&nbsp;side effect<\/strong><\/p>\n\n\n\n<p><em>Occurs in up to 1 in 10,000 individuals<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe bleeding (eg bleeding inside the abdomen, brain or lungs)<\/li><li>bleeding leading to death<\/li><li>sharp decrease in the number of&nbsp;platelets&nbsp;(&nbsp;blood cells&nbsp;needed for blood coagulation)<\/li><li>skin rash (&nbsp;hives&nbsp;)<\/li><li>sudden severe&nbsp;allergic reaction&nbsp;.<\/li><\/ul>\n\n\n\n<p>If you notice any signs of bleeding, contact your doctor, hospital pharmacist, or nurse immediately.&nbsp;In very rare cases, bleeding has become severe and even fatal.<br>Precautions to prevent this from happening to include blood tests and careful checks performed by the healthcare professional who cares for you.<\/p>\n\n\n\n<p>If you get a severe&nbsp;allergic reaction&nbsp;or hives, contact your doctor, hospital pharmacist, or nurse immediately.<\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur in patients who require this type of treatment include those associated with the disease you are being treated for, such as rapid or irregular heartbeat, low&nbsp;blood pressure,&nbsp;shock,&nbsp;or cardiac arrest.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Integrilin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date (EXP) on the outer carton and infusion bottle.&nbsp;The expiration date is the last day of the month specified.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).<\/p>\n\n\n\n<p>Store the infusion bottle in the outer carton.&nbsp;Sensitive to light.&nbsp;However, the integrilin solution does not need to be protected from light during&nbsp;administration.<\/p>\n\n\n\n<p>The contents of the bottle should be checked before use.<\/p>\n\n\n\n<p>Do not use Integrilin if it contains particles or is discolored.<\/p>\n\n\n\n<p>Any remaining medicine in the bottle should be discarded.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your hospital pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is eptifibatide.&nbsp;Each ml of&nbsp;solution for infusion&nbsp;contains 0.75 mg of entifibatide.&nbsp;One 100 ml&nbsp;vial&nbsp;contains 75 mg of eptifibatide.<\/li><li>The other ingredients are citric acid monohydrate, sodium hydroxide and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Integrilin&nbsp;solution&nbsp;for&nbsp;infusion: 100 ml&nbsp;infusion&nbsp;bottle, pack of one&nbsp;infusion bottle.<\/p>\n\n\n\n<p>The clear, colorless liquid is supplied in a 100 ml&nbsp;glass&nbsp;infusion&nbsp;bottle, which is sealed with a butyl rubber stopper and sealed with an aluminum seal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorization Holder:<br>GlaxoSmithKline (Ireland) Limited, 12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>GlaxoSmithKline Manufacturing SPA, Strada Provinciale Asolana No.&nbsp;90, San Polo di Torrile 43056, Parma, Italy<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>GlaxoSmithKline Pharmaceuticals sa \/ nvTel: + 32 (0) 10 85 52 00<\/td><td><strong>Lithuania<\/strong>GlaxoSmithKline Lithuania UABTel: + 370 5 264 90 00info.lt@gsk.com<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>The GlaxoSmithKlein \u0415\u041e\u041e\u0414Tel .: + 359 2 953 10 34<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>&nbsp;GlaxoSmithKline Pharmaceuticals sa \/ nvBelgium \/ BelgiumTel: + 32 (0) 10 85 52 00<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>GlaxoSmithKline sroTel: + 420 222 001 111cz.info@gsk.com<\/td><td><strong>Hungary<\/strong>GlaxoSmithKline Kft.Tel .: + 36 1 225 5300<\/td><\/tr><tr><td><strong>Denmark<\/strong>GlaxoSmithKline Pharma A \/ STel: + 45 36 35 91 00dk-info@gsk.com<\/td><td><strong>Malta<\/strong>GlaxoSmithKline (Malta) LimitedTel: + 356 21 238131<\/td><\/tr><tr><td><strong>Germany<\/strong>GlaxoSmithKline GmbH &amp; Co.&nbsp;KGTel .: + 49 (0) 89 36044 8701produkt.info@gsk.com<\/td><td><strong>The Netherlands<\/strong>GlaxoSmithKline BVTel: + 31 (0) 33 2081100<\/td><\/tr><tr><td><strong>Eesti<\/strong>GlaxoSmithKline Eesti O\u00dcTel: + 372 6676 900estonia@gsk.com<\/td><td><strong>Norway<\/strong>GlaxoSmithKline ASTel: + 47 22 70 20 00<\/td><\/tr><tr><td><strong>Greece<\/strong>&nbsp;GlaxoSmithKline A\u03bf\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03b7 AEBE:\u0397\u03bb: + 30 210 68 82 100<\/td><td><strong>Austria<\/strong>&nbsp;GlaxoSmithKline Pharma GmbHTel: + 43 (0) 1 97075 0at.info@gsk.com<\/td><\/tr><tr><td><strong>Spain<\/strong>GlaxoSmithKline, SATel: + 34 900 202 700es-ci@gsk.com<\/td><td><strong>Poland<\/strong>&nbsp;GSK Services Sp.&nbsp;z ooTel .: + 48 (0) 22 576 9000<\/td><\/tr><tr><td><strong>France<\/strong>GlaxoSmithKline LaboratoryTel .: + 33 (0) 1 39 17 84 44diam@gsk.com<\/td><td><strong>Portugal<\/strong>&nbsp;GlaxoSmithKline &#8211; Pharmaceutical Products, LdaTel: + 351 21 412 95 00FI.PT@gsk.com<\/td><\/tr><tr><td><strong>Croatia<\/strong>GlaxoSmithKline dooTel: + 385 1 6051 999<\/td><td><strong>Romania<\/strong>GlaxoSmithKline (GSK) SRLTel: + 4021 3028 208<\/td><\/tr><tr><td><strong>Ireland<\/strong>&nbsp;GlaxoSmithKline (Ireland) LimitedTel: + 353 (0) 1 4955000<\/td><td><strong>Slovenia<\/strong>&nbsp;GlaxoSmithKline dooTel: + 386 (0) 1 280 25 00medical.x.si@gsk.com<\/td><\/tr><tr><td><strong>Iceland<\/strong>&nbsp;Visitor hf.Phone: + 354 535 7000<\/td><td><strong>Slovak Republic<\/strong>&nbsp;GlaxoSmithKline Slovakia sroTel: + 421 (0) 2 48 26 11 11recepcia.sk@gsk.com<\/td><\/tr><tr><td><strong>Italy<\/strong>GlaxoSmithKline SpATel: + 39 (0) 45 7741 111<\/td><td><strong>Finland \/ Finland<\/strong>&nbsp;GlaxoSmithKline OyPuh \/ Tel: + 358 (0) 10 30 30 30Finland.tuoteinfo@gsk.com<\/td><\/tr><tr><td><strong>\u039a\u03cd\u03c0\u03c1\u03bf\u03c2<\/strong>GlaxoSmithKline Cyprus Ltd:\u0397\u03bb: + 357 22 39 70gskcyprus@gsk.com<\/td><td><strong>Sweden<\/strong>&nbsp;GlaxoSmithKline ABTel: + 46 (0) 8 638 93 00info.produkt@gsk.com<\/td><\/tr><tr><td><strong>Latvia<\/strong>GlaxoSmithKline Latvia SIATel: + 371 67312687lv-epasts@gsk.com<\/td><td><strong>United Kingdom<\/strong>&nbsp;GlaxoSmithKline UK LtdTel: + 44 (0) 800 221441customercontactuk@gsk.com<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Integrilin is a platelet aggregation inhibitor. This means that it helps to prevent the platelets from clotting.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[12595,12600,3962,12597,12596,12601,12594,12599,3963,12598],"class_list":["post-14445","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-eptifibatide","tag-benefits-of-integrilin","tag-eptifibatide","tag-integrilin","tag-side-effects-of-eptifibatide","tag-side-effects-of-integrilin","tag-what-eptifibatide-is-used-for","tag-what-integrilin-is-used-for","tag-what-is-eptifibatide","tag-what-is-integrilin"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14445"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14445\/revisions"}],"predecessor-version":[{"id":14863,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14445\/revisions\/14863"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}