{"id":14385,"date":"2021-09-30T07:20:20","date_gmt":"2021-09-30T07:20:20","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14385"},"modified":"2021-10-16T11:22:57","modified_gmt":"2021-10-16T11:22:57","slug":"insulatard-penfill","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/insulatard-penfill\/","title":{"rendered":"Insulatard Penfill &#8211; Human insulin uses, dose and side effects"},"content":{"rendered":"\n<p>100 IU \/ ml (international units \/ ml)&nbsp;for injection&nbsp;,&nbsp;suspension&nbsp;in&nbsp;cartridge<br>human&nbsp;insulin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Insulatard is and what it is used for<\/h2>\n\n\n\n<p>Insulatard is human&nbsp;insulin&nbsp;with gradual onset of&nbsp;action&nbsp;and long&nbsp;duration of action.<\/p>\n\n\n\n<p>Insulatard is used to lower high blood sugar in patients with&nbsp;diabetes mellitus&nbsp;(&nbsp;diabetes&nbsp;).&nbsp;Diabetes&nbsp;is a disease in which your body does not produce enough&nbsp;insulin&nbsp;to keep your blood sugar levels under control.&nbsp;Treatment with Insulatard helps prevent the complications of your&nbsp;diabetes.<\/p>\n\n\n\n<p>Insulatard starts lowering your blood sugar about 1\u00bd hour after you inject it and the effect lasts for about 24 hours.&nbsp;Insulatard is often given in combination with fast-acting insulin preparations.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you use Insulatard<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Insulatard<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to human&nbsp;insulin&nbsp;or any of the other ingredients of this medicine, see section 6.<\/li><li>If you feel you are experiencing insulin sensation (symptoms of low blood sugar), see Summary of serious and very common&nbsp;side effects&nbsp;in section 4.<\/li><li>in insulin pumps.<\/li><li>if&nbsp;cartridge&nbsp;one or the injection device containing&nbsp;cartridge&nbsp;one has been dropped, damaged or crushed.<\/li><li>if the&nbsp;insulin&nbsp;has not been stored properly or if it has frozen, see section 5.<\/li><li>if the reconstituted&nbsp;insulin is&nbsp;not evenly white and cloudy.<\/li><\/ul>\n\n\n\n<p>If any of these apply to you, do not use Insulatard.&nbsp;Talk to a doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p><strong>Before you use Insulatard<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Check the label to make sure it is the correct type of&nbsp;insulin&nbsp;.<\/li><li>Always check the&nbsp;cartridge&nbsp;one, including the rubber plunger at the bottom of the&nbsp;cartridge&nbsp;one.&nbsp;Do not use it if it has any visible damage or if the rubber plunger has been pulled over the white line on the label at the bottom of the&nbsp;cartridge&nbsp;.&nbsp;This may be due to an insulin leak.&nbsp;If you suspect that the&nbsp;cartridge&nbsp;is damaged, return it to the pharmacist.&nbsp;See also the instructions for use for the pen.<\/li><li>Always use a new injection needle for each&nbsp;injection&nbsp;to prevent contamination.<\/li><li>Injection needles and Insulatard&nbsp;Penfill&nbsp;must not be shared with anyone else.&nbsp;Insulatard&nbsp;Penfill&nbsp;should only be administered under the skin with a reusable pen.&nbsp;Talk to your doctor if you need to inject your&nbsp;insulin&nbsp;using another method.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Certain conditions and activities may affect your need for&nbsp;insulin.&nbsp;Consult a doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have problems with your kidneys or liver, adrenal glands,&nbsp;pituitary gland&nbsp;or thyroid gland.<\/li><li>if you exercise more than usual or want to change your diet, as this can affect your blood sugar level.<\/li><li>if you become ill: continue to take your&nbsp;insulin&nbsp;and consult a doctor.<\/li><li>if you are going to travel abroad: travel over different time zones can affect your insulin needs and when to take the&nbsp;injections&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Skin changes at the injection site<\/strong><\/p>\n\n\n\n<p>To help prevent changes in the adipose tissue under the skin, e.g.&nbsp;skin thickening, skin shrinkage, or lumps under the skin, you should always change the injection site.&nbsp;It may be that&nbsp;insulin&nbsp;et not work as well if you inject in an area with nodules or in a thickened or shriveled area (see &#8220;How to use Insulatard&#8221;).&nbsp;Contact your doctor if you notice skin changes at the injection site and before changing the injection site if you are currently injecting in an affected area.&nbsp;Your doctor may advise you to check your blood sugar more often and to adjust your insulin dose or the&nbsp;dose&nbsp;of other diabetes medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Insulatard<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you are taking or have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines affect your blood sugar level, which may mean that your insulin dose needs to be changed.&nbsp;Below is a list of the most common medicines that may affect your insulin therapy.<\/p>\n\n\n\n<p>Your blood sugar level may drop (&nbsp;hypoglycaemia&nbsp;) if you take:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Other medicines to treat&nbsp;diabetes<\/li><li>MAO inhibitors&nbsp;(for the treatment of depression)<\/li><li>Beta-blockers&nbsp;(for the treatment of high&nbsp;blood pressure&nbsp;)<\/li><li>ACE inhibitors&nbsp;(for the treatment of certain heart diseases or high&nbsp;blood pressure&nbsp;)<\/li><li>Salicylates (analgesics and antipyretics)<\/li><li>Anabolic&nbsp;steroids&nbsp;(eg&nbsp;testosterone&nbsp;)<\/li><li>Sulfonamides&nbsp;(for the treatment of&nbsp;infections&nbsp;).<\/li><\/ul>\n\n\n\n<p>Your blood sugar level may rise (&nbsp;hyperglycaemia&nbsp;) if you take:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Oral contraceptives (&nbsp;birth control pills&nbsp;)<\/li><li>Thiazides&nbsp;(for the treatment of high&nbsp;blood pressure&nbsp;or severe fluid retention)<\/li><li>Glucocorticoids&nbsp;(eg&nbsp;cortisone&nbsp;for the treatment of&nbsp;inflammation&nbsp;)<\/li><li>Thyroid hormone (for the treatment of thyroid diseases)<\/li><li>Sympathomimetics&nbsp;(eg&nbsp;adrenaline&nbsp;,&nbsp;salbutamol&nbsp;or&nbsp;terbutaline&nbsp;for the treatment of&nbsp;asthma&nbsp;)<\/li><li>Growth hormone&nbsp;(for stimulation of skeletal and body growth with a pronounced effect on the body&#8217;s metabolism)<\/li><li>Danazol (an agent that affects ovulation).<\/li><\/ul>\n\n\n\n<p>Octreotide and lanreotide (for the treatment of&nbsp;acromegaly, a rare hormonal disorder with&nbsp;pituitary&nbsp;overproduction&nbsp;one of&nbsp;the growth hormones&nbsp;usually in middle-aged adults) can either raise or lower your blood sugar level.<\/p>\n\n\n\n<p>Beta-blockers&nbsp;(for the treatment of high&nbsp;blood pressure&nbsp;) may weaken or completely eliminate the first warning signs of low blood sugar.<\/p>\n\n\n\n<p>Pioglitazone (tablets for the treatment of type 2&nbsp;diabetes&nbsp;)<\/p>\n\n\n\n<p>Some patients who have had type 2&nbsp;diabetes&nbsp;and heart disease for many years or previous&nbsp;strokes&nbsp;developed&nbsp;heart failure&nbsp;during treatment with pioglitazone and&nbsp;insulin.&nbsp;Tell your doctor as soon as possible if you get signs of&nbsp;heart failure&nbsp;such as unexpected shortness of breath, rapid weight gain, or local swelling (&nbsp;edema&nbsp;).<\/p>\n\n\n\n<p>If you have taken any of these medicines, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Insulatard and alcohol<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you drink alcohol, your need for&nbsp;insulin&nbsp;may&nbsp;change, as&nbsp;your&nbsp;blood sugar level may either rise or fall.&nbsp;Careful blood glucose monitoring is recommended.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.&nbsp;Insulatard can be used during pregnancy.&nbsp;The insulin dose may need to be changed during pregnancy and after delivery.&nbsp;Careful monitoring of your&nbsp;diabetes&nbsp;and counteracting low blood sugar is important for your baby&#8217;s health.<\/li><li>There are no restrictions on treatment with Insulatard during breast-feeding.<\/li><\/ul>\n\n\n\n<p>Ask your doctor, pharmacist, or nurse for advice before taking this medicine during pregnancy or breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ask your doctor if you can drive or use machines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you often get low blood sugar levels.<\/li><li>if you find it difficult to recognize signs of low blood sugar (insulin detection).<\/li><\/ul>\n\n\n\n<p>If your blood sugar is low or high, it can affect your ability to concentrate and react and therefore also your ability to drive or use machines.&nbsp;Remember that you can&nbsp;put&nbsp;yourself and others at risk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Insulatard contains sodium<\/h2>\n\n\n\n<p>Insulatard contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;dose, ie Insulatard is essential &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Insulatard<\/h2>\n\n\n\n<p><strong>Dose&nbsp;and when you take your&nbsp;insulin<\/strong><\/p>\n\n\n\n<p>Always use your&nbsp;insulin&nbsp;and make dose adjustments exactly as your doctor advised.&nbsp;If you are not sure, talk to a doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p>Only change insulin preparations on the advice of a doctor.&nbsp;If your doctor has switched you from one type of insulin or brand to another, your&nbsp;dose&nbsp;may need to be adjusted by&nbsp;your&nbsp;doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Insulatard can be used in children and adolescents.<\/p>\n\n\n\n<p><strong>Use for special patient groups<\/strong><\/p>\n\n\n\n<p>If you have impaired kidney or liver function or if you are over 65, you need to check your blood sugar more regularly and discuss changes in your insulin dose with your doctor.<\/p>\n\n\n\n<p><strong>How and where to inject<\/strong><\/p>\n\n\n\n<p>Insulatard is injected under the skin (&nbsp;subcutaneously&nbsp;).&nbsp;You should never inject yourself directly into a vein (&nbsp;intravenously&nbsp;) or muscle (&nbsp;intramuscularly&nbsp;).&nbsp;Insulatard&nbsp;Penfill&nbsp;should only be administered under the skin with a reusable pen.&nbsp;Talk to your doctor if you need to inject your&nbsp;insulin&nbsp;using another method.<\/p>\n\n\n\n<p>At each&nbsp;injection, change the injection site within the same area of \u200b\u200bskin you are using.&nbsp;This may reduce the risk of developing lumps or pits in the skin, see section 4. The best area to&nbsp;inject&nbsp;is the front of the waist (abdomen), buttocks, front of the thighs, or upper arms.&nbsp;Insulin&nbsp;works faster if you inject it into your waist.<\/p>\n\n\n\n<p>Always check your blood sugar regularly.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not refill&nbsp;cartridges&nbsp;a.&nbsp;When empty, it must be discarded.<\/li><li>Insulatard&nbsp;Penfill&nbsp;cartridge&nbsp;s are designed for use with the injection device for&nbsp;insulin&nbsp;from Novo Nordisk and NovoFine or NovoTwist needles.<\/li><li>If you take both Insulatard&nbsp;Penfill&nbsp;and another&nbsp;insulin&nbsp;in&nbsp;Penfill&nbsp;cartridge&nbsp;, you should use two insulin delivery systems, one for each type of insulin.<\/li><li>Always carry a spare&nbsp;Penfill&nbsp;cartridge&nbsp;if you use is lost or damaged.<\/li><\/ul>\n\n\n\n<p><strong>Mixing of Insulatard<\/strong><\/p>\n\n\n\n<p>Always check that there is enough&nbsp;insulin&nbsp;left (at least 12 units) in&nbsp;cartridge&nbsp;one.&nbsp;This gives an even&nbsp;mixture.&nbsp;If there is not enough&nbsp;insulin&nbsp;left, use a new&nbsp;cartridge.&nbsp;See also the instructions for use for the pen.<\/p>\n\n\n\n<p><strong>Every time you use a new Insulatard&nbsp;Penfill<\/strong>&nbsp;(before&nbsp;cartridge&nbsp;a is inserted into the injection device).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allow&nbsp;insulin&nbsp;to reach room temperature before using.&nbsp;This makes it easier to remix&nbsp;insulin&nbsp;.<\/li><li>Move&nbsp;cartridge&nbsp;one up and down between position&nbsp;<strong>a<\/strong>&nbsp;and position&nbsp;<strong>b<\/strong>&nbsp;(see figure), so that the glass ball is moved from one end of the&nbsp;ampoule&nbsp;one to the other at least 20 times.<\/li><li>Repeat this movement at least 10 times before each&nbsp;injection&nbsp;.&nbsp;The movement should always be repeated until the liquid is evenly white and cloudy.<\/li><li>Complete the other injection steps without delay.<\/li><\/ul>\n\n\n\n<p><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20021007000385#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p><strong>How Insulatard is injected<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inject&nbsp;insulin&nbsp;under the skin.&nbsp;Use the injection technique shown to you by your doctor or nurse and described in the instructions for use of the injection aid.<\/li><li>Hold the injection needle under the skin for at least 6 seconds to ensure that the entire&nbsp;dose&nbsp;has been injected.&nbsp;Hold down the push-button completely until the injection needle has been withdrawn from the skin.&nbsp;This ensures that the correct&nbsp;dose&nbsp;has been injected and restricts any blood flow into the injection needle or insulin container.<\/li><li>Be sure to remove and discard the injection needle after each&nbsp;injection&nbsp;.&nbsp;Always keep Insulatard without a needle.&nbsp;Liquid may otherwise leak and cause incorrect&nbsp;dosing&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more insulin than you should<\/h2>\n\n\n\n<p>If you take too much&nbsp;insulin, your blood sugar may become too low (&nbsp;hypoglycaemia&nbsp;).&nbsp;See Summary of Serious and Very Common&nbsp;Side Effects&nbsp;in Section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take your insulin<\/h2>\n\n\n\n<p>If you forget to take your&nbsp;insulin, your blood sugar may become too high (&nbsp;hyperglycaemia&nbsp;).&nbsp;See&nbsp;Diabetes Disorders&nbsp;in Section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking your insulin<\/h2>\n\n\n\n<p>Do not stop insulin treatment without talking to a doctor, who will tell you what needs to be done.&nbsp;It can lead to very high blood sugar (severe&nbsp;hyperglycaemia&nbsp;) and&nbsp;ketoacidosis.&nbsp;See&nbsp;Diabetes Disorders&nbsp;in Section 4.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Summary of serious and very common&nbsp;side effect&nbsp;s<\/strong><\/p>\n\n\n\n<p><strong>Low blood sugar (&nbsp;hypoglycemia&nbsp;)<\/strong>&nbsp;is a very common&nbsp;side effect.&nbsp;It may occur in more than 1 in 10 users.<\/p>\n\n\n\n<p>Low blood sugar can occur if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>injecting too much&nbsp;insulin&nbsp;.<\/li><li>eat too little or skip a meal.<\/li><li>exercise more than usual.<\/li><li>drinking alcohol, see Insulatard and alcohol in section 2.<\/li><\/ul>\n\n\n\n<p><strong>Signs of low blood sugar:<\/strong>&nbsp;Cold sweats;&nbsp;cool and pale skin;&nbsp;headache;&nbsp;palpitation;&nbsp;nausea;&nbsp;strong hunger;&nbsp;temporary vision changes;&nbsp;drowsiness;&nbsp;unusual fatigue and weakness;&nbsp;anxiety or trembling;&nbsp;feelings of anxiety;&nbsp;confusion;&nbsp;concentration difficulties.<\/p>\n\n\n\n<p>Very low blood sugar can lead to unconsciousness.&nbsp;If left untreated for a very long time, very low blood sugar can cause brain damage (temporary or permanent) and even death.&nbsp;You can regain consciousness faster if you receive an&nbsp;injection&nbsp;of the&nbsp;hormone&nbsp;et glucagon from someone who knows how to use it.&nbsp;If you are given glucagon, you will need&nbsp;glucose&nbsp;or a sugar-containing snack as soon as you regain consciousness.&nbsp;If you do not respond to glucagon therapy, you will need to be treated in hospital.<\/p>\n\n\n\n<p><strong>What to do if you get low blood sugar:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you feel that your blood sugar is too low, eat grape sugar tablets or any other snack that contains a lot of sugar (sweets, cakes, fruit juice).&nbsp;If possible, check your blood sugar and rest.&nbsp;Always take glucose tablets or snacks with a lot of sugar in them for safety.<\/li><li>When the symptoms of low blood sugar have disappeared or when your blood sugar level has stabilized, you should continue with the insulin treatment as usual.<\/li><li>If you have had low blood sugar and lost consciousness or if you have needed a&nbsp;glucagon&nbsp;injection&nbsp;, or if you have had many insulin sensations, talk to your doctor.&nbsp;The amount of&nbsp;insulin&nbsp;or when you take it, diet or exercise may need to be adjusted.<\/li><\/ul>\n\n\n\n<p>Tell them that you have&nbsp;diabetes&nbsp;for people who need to know it, what the consequences can be, and also the risk of becoming unconscious due to low blood sugar.&nbsp;Tell them that if you become unconscious, they should put you on the side and get medical attention immediately.&nbsp;They must not give you anything to eat or drink as there is a risk that you will suffocate.<\/p>\n\n\n\n<p><strong>Severe allergic reactions<\/strong>&nbsp;to Insulatard or to any of the other ingredients (so-called systemic&nbsp;allergic reaction&nbsp;) are very rare but can be life-threatening.&nbsp;It may affect less than 1 in 10,000 users.<\/p>\n\n\n\n<p>Contact a doctor immediately:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if signs of&nbsp;allergy&nbsp;spread to other parts of the body.<\/li><li>if you suddenly feel unwell and you: start sweating;&nbsp;begins to vomit;&nbsp;have difficulty breathing;&nbsp;get palpitations;&nbsp;feel dizzy.<\/li><\/ul>\n\n\n\n<p>If you experience any of these, seek medical attention immediately.<\/p>\n\n\n\n<p><strong>Skin changes at the injection site:<\/strong>&nbsp;If you inject&nbsp;insulin&nbsp;at the same site, the adipose tissue may either shrink (lipoatrophy) or thicken (lipohypertrophy) (may affect up to 1 in 100 people).&nbsp;Nodules under the skin can also be caused by the accumulation of a&nbsp;protein&nbsp;called amyloid (&nbsp;cutaneous&nbsp;amyloidosis. How often this occurs is not known).&nbsp;It may be that&nbsp;insulin&nbsp;et not work as well if you inject in an area with nodules or in a thickened or shriveled area.&nbsp;Change the injection site for each&nbsp;injection&nbsp;to prevent these skin changes.<\/p>\n\n\n\n<p><strong>List of&nbsp;adverse reactions&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>May affect less than 1 in 100 users.<\/p>\n\n\n\n<p><strong>Signs of allergy:<\/strong>&nbsp;Local allergic reactions (pain,&nbsp;redness,&nbsp;hives,&nbsp;inflammation, bruising, swelling, and&nbsp;itching&nbsp;) may occur at the injection site.&nbsp;These symptoms usually go away after taking your&nbsp;insulin&nbsp;for a few weeks.&nbsp;If they do not disappear or spread throughout the body, talk to a doctor immediately.&nbsp;See also Severe allergic reactions above.<\/p>\n\n\n\n<p><strong>Diabetic retinopathy<\/strong>&nbsp;(an eye disease associated with&nbsp;diabetes&nbsp;that&nbsp;can lead to vision loss): If you have diabetic retinopathy, it can worsen if your blood sugar levels improve very quickly.&nbsp;Ask your doctor about this.<\/p>\n\n\n\n<p><strong>Swollen joints:<\/strong>&nbsp;When you start taking&nbsp;insulin, your body may bind water, causing you to swell around the ankles and other joints.&nbsp;This usually goes away soon, otherwise, you should talk to a doctor.<\/p>\n\n\n\n<p><strong>Very rare&nbsp;side effect&nbsp;s<\/strong><\/p>\n\n\n\n<p>May affect less than 1 in 10,000 users.<\/p>\n\n\n\n<p><strong>Vision problems:<\/strong>&nbsp;At the beginning of insulin treatment, visual disturbances may occur, but these are usually temporary.<\/p>\n\n\n\n<p><strong>Painful&nbsp;neuropathy<\/strong>&nbsp;(pain due to nerve damage): If your blood sugar level improves very quickly, you may get nerve-related pain.&nbsp;This is called&nbsp;acute&nbsp;painful&nbsp;neuropathy&nbsp;and is usually transient.<\/p>\n\n\n\n<p>If you get&nbsp;any side effects, talk to your doctor, nurse, or pharmacist.&nbsp;This also applies to any&nbsp;side effects&nbsp;not mentioned in this information.<\/p>\n\n\n\n<p><strong>Problems with&nbsp;diabetes<\/strong><\/p>\n\n\n\n<p><strong>High blood sugar (&nbsp;hyperglycaemia&nbsp;)<\/strong><\/p>\n\n\n\n<p>High blood sugar can occur if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have not injected enough&nbsp;insulin&nbsp;.<\/li><li>forget to take your&nbsp;insulin&nbsp;or stop taking&nbsp;insulin&nbsp;.<\/li><li>repeatedly take less&nbsp;insulin&nbsp;than you need.<\/li><li>gets an&nbsp;infection&nbsp;and \/ or fever.<\/li><li>eat more than usual.<\/li><li>exercise less than usual.<\/li><\/ul>\n\n\n\n<p><strong>Warning signs for high blood sugar:<\/strong><\/p>\n\n\n\n<p>The warning signals appear gradually.&nbsp;They manifest as: increased urine output;&nbsp;thirst;&nbsp;loss of appetite;&nbsp;feeling sick (nausea or vomiting);&nbsp;drowsiness or fatigue;&nbsp;redness;&nbsp;dry skin;&nbsp;dry mouth&nbsp;and a breath that smells of fruit (acetone).<\/p>\n\n\n\n<p><strong>What should I do if I get high blood sugar:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you get any of the above warning signs: check your blood sugar, do a ketone test on your urine if possible and then contact a doctor immediately.<\/li><li>The symptoms can be a sign of a very serious condition called diabetic&nbsp;ketoacidosis&nbsp;(accumulation of acid in the blood when the body breaks down fat instead of sugar).&nbsp;If left untreated, it can lead to diabetic coma and eventually death.<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Insulatard<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<\/p>\n\n\n\n<p>The expiry date stated on the label and carton&nbsp;cartridges&nbsp;one after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Unopened packaging:<\/strong>&nbsp;Store in a refrigerator at 2 \u00b0 C-8 \u00b0 C.&nbsp;Do not place near the heat sink.&nbsp;Do not freeze.<\/p>\n\n\n\n<p><strong>During use or taken as a spare:<\/strong>&nbsp;Do not refrigerate or freeze.&nbsp;You can take it with you and store it at room temperature (maximum 30 \u00b0 C) for up to 6 weeks.<\/p>\n\n\n\n<p>In order to protect the&nbsp;insulin-&nbsp;et against the light, always store the&nbsp;cartridge&nbsp;one in the outer carton when you are not using it.<\/p>\n\n\n\n<p>Discard the injection needle after each&nbsp;injection&nbsp;.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is human&nbsp;insulin&nbsp;.&nbsp;Insulatard is a&nbsp;suspension&nbsp;of isofant (NPH) human&nbsp;insulin&nbsp;.&nbsp;Each ml contains 100 IU human&nbsp;insulin&nbsp;.&nbsp;Each&nbsp;cartridge&nbsp;contains 300 IU human&nbsp;insulin&nbsp;in 3 ml&nbsp;injection&nbsp;,&nbsp;suspension&nbsp;.<\/li><li>The other ingredients are zinc chloride,&nbsp;glycerol&nbsp;, metacresol, phenol, disodium phosphate dihydrate, sodium hydroxide,&nbsp;hydrochloric acid&nbsp;, protamine sulphate and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Insulatard is in the form of&nbsp;injection&nbsp;,&nbsp;suspension&nbsp;.&nbsp;After mixing, the liquid should be evenly white and cloudy.<\/p>\n\n\n\n<p>Pack sizes: 1, 5 or 10&nbsp;cartridges&nbsp;are 3 ml.&nbsp;Not all pack sizes may be marketed.<\/p>\n\n\n\n<p>Suspension&nbsp;one is cloudy, white and watery.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder<\/p>\n\n\n\n<p>Novo Nordisk A \/ S, Novo All\u00e9, DK-2880 Bagsv\u00e6rd, Denmark<\/p>\n\n\n\n<p>Manufacturer<\/p>\n\n\n\n<p>The manufacturer can be identified by the batch number printed on the tab on the carton and on the label:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If the second and third characters are S6, P5, K7, R7, VG, FG or ZF, the manufacturer is Novo Nordisk A \/ S, Novo All\u00e9, DK-2880 Bagsv\u00e6rd, Denmark.<\/li><li>If the second and third characters are H7 or T6, the manufacturer is Novo Nordisk Production SAS, 45 Avenue d&#8217;Orl\u00e9ans, F-28000 Chartres, France.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Insulatard is human insulin with gradual onset of action and long duration of action.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[11712,12658,11708,11711,12654,12657,12659,11713,11710,12656,11709,12655],"class_list":["post-14385","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-human-insulin","tag-benefits-of-insulatard-penfill","tag-human-insulin","tag-human-insulin-injection","tag-insulatard-penfill","tag-insulatard-penfill-injection","tag-insulatard-penfill-side-effects","tag-side-effects-of-human-insulin","tag-what-human-insulin-is-used-for","tag-what-insulatard-penfill-is-used-for","tag-what-is-human-insulin","tag-what-is-insulatard-penfill"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14385","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14385"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14385\/revisions"}],"predecessor-version":[{"id":14912,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14385\/revisions\/14912"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14385"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14385"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}