1 mg \/ 2.5 mg, 1 mg \/ 5 mg, 2 mg \/ 5 mg tablets
estradiol \/ medroxyprogesterone<\/p>\n\n\n\n
Indovina is a preparation used for hormonal substitution therapy ( hormone replacement therapy, HRT ). It contains two female sex hormones; estrogen and a progestogen. Indovina is used for women whose menstruation has stopped ( menopause ), at least 3 years after their last natural menstruation.<\/p>\n\n\n\n
Indovina is used to:<\/p>\n\n\n\n
Relieve symptoms during and after menopause<\/strong><\/p>\n\n\n\n When menstruation ends ( menopause ), the woman’s estrogen drops. It can cause problems such as sweating and hot flashes. Individuals relieve these symptoms after menopause. Individuals should only be used if the problems cause problems in daily life.<\/p>\n\n\n\n Prevent osteoporosis<\/strong><\/p>\n\n\n\n After menopause, some women suffer from osteoporosis. Discuss all possible options with your doctor. If you have an increased risk of fractures (bone fractures) and other medicines that are not suitable for you, you can use Indivina to prevent osteoporosis after menopause.<\/p>\n\n\n\n Medical background and regular check-ups<\/strong><\/p>\n\n\n\n The use of HRT involves risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.<\/p>\n\n\n\n Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed). If you belong to that group, the risks of HRT may be different. Talk to your doctor.<\/p>\n\n\n\n Before starting treatment (or resuming treatment), your doctor will ask about your own, and your family’s, medical background. Your doctor may do a general medical and gynecological examination, which also includes the examination of your breasts.<\/p>\n\n\n\n Once you have started treatment, you should go for regular medical check-ups, at least once a year. During these check-ups, you should discuss with your doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n Perform regular examinations of the breasts according to the doctor’s recommendations.<\/p>\n\n\n\n Do not take Indovina<\/strong><\/p>\n\n\n\n if any of the following apply to you. If you are not sure, talk to your doctor before taking Indivina.<\/p>\n\n\n\n Do not take Indivina:<\/em><\/p>\n\n\n\n If any of the above affects you the first time you use Indovina, stop taking Indovina and contact your doctor immediately.<\/p>\n\n\n\n Talk to your doctor before starting treatment if you have or have had any of the following problems before starting treatment. They may recur or worsen during treatment with Indivina. Should this occur, have more frequent check-ups with a doctor.<\/p>\n\n\n\n You should contact a doctor immediately and discontinue treatment if any of the following occur:<\/strong><\/p>\n\n\n\n Note:<\/em> Indovina is not a contraceptive. If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy. Consult your doctor.<\/p>\n\n\n\n HRT and cancer<\/strong><\/p>\n\n\n\n Severe thickening of the uterine lining ( endometrial hyperplasia ) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n The use of HRT with estrogen alone increases the risk of severe thickening of the uterine lining and cancer of the uterine lining.<\/p>\n\n\n\n The progestogen in Indovina protects you against this extra risk.<\/p>\n\n\n\n Irregular bleeding<\/strong><\/p>\n\n\n\n Irregular spotting or spotting may occur during the first 3 to 6 months of taking Indivina.<\/p>\n\n\n\n But about the bleeding,<\/p>\n\n\n\n you should see a doctor as soon as possible.<\/strong><\/p>\n\n\n\n Breast cancer<\/strong><\/p>\n\n\n\n Data show that hormone replacement therapy ( HRT ) with a combination of estrogen-progestogen or with estrogen alone, increases the risk of breast cancer. The increased risk depends on how long you use HRT. The increased risk is seen within 3 years. When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used HRT for more than 5 years.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n Of 1,000 women aged 50\u201354 who do not take HRT, an average of 13 to 17 will be diagnosed with breast cancer over a 5-year period.<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen alone for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen-progestogen for 5 years, there will be 21 cases per 1,000 users (ie 4-8 extra cases).<\/p>\n\n\n\n Among women aged 50-59 who do not take HRT, an average of 27 out of 1,000 will be diagnosed with breast cancer over a 10-year period.<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen alone for 10 years, 34 cases per 1,000 users (ie 7 extra cases) will occur.<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen-progestogen for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur.<\/p>\n\n\n\n Check your breasts regularly. Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n It is also recommended that you participate in a mammography examination when you are called to do so. At the mammogram, it is important that you tell the nurse\/healthcare professional who performs the examination that you are using HRT, as this medicine may increase the density of the breasts. An increased density in the breasts can make it more difficult to detect lumps on the mammography images.<\/p>\n\n\n\n Ovarian cancer ( ovarian cancer )<\/strong><\/p>\n\n\n\n Ovarian cancer is rare – much more rare than breast cancer. Use of HRT with estrogen alone or combined estrogen-progestogen has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n The risk of ovarian cancer varies with age. The diagnosis of ovarian cancer will, for example, be made on about 2 women out of 2,000 aged 50 to 54 who do not take HRT for a 5-year period. For women who have taken HRT for 5 years, there will be about 3 cases per 2,000 users (ie about 1 extra case).<\/p>\n\n\n\n How HRT affects the heart and blood circulation<\/strong><\/p>\n\n\n\n Blood clots in a vein ( thrombosis )<\/strong><\/p>\n\n\n\n The risk of blood clots in the veins<\/strong> is 1.3\u20113 times higher for women who take HRT than for those who do not, especially during the first year of treatment. Blood clots can be serious. If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n You are more likely to get a blood clot in a vein if any of the following apply to you. Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n The symptoms of a blood clot are described in the section “You should contact a doctor immediately and stop the treatment”.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n For women in their 50s, who do not take HRT, over a 5-year period, an average of 4-7 out of 1,000 users are expected to get a blood clot in a vein.<\/p>\n\n\n\n For women in their 50s who have taken HRT with estrogen-progestogen for more than 5 years, 9-12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases).<\/p>\n\n\n\n Heart disease (heart attack)<\/strong><\/p>\n\n\n\n There is no evidence that HRT prevents heart attacks.<\/p>\n\n\n\n For women over the age of 60 who take HRT with estrogen-progestin, the risk of developing heart disease is slightly higher than those who do not take HRT.<\/p>\n\n\n\n Stroke (apoplexy)<\/strong><\/p>\n\n\n\n The risk of stroke is about 1.5 times higher for those who take HRT compared to those who do not. The risk of stroke is age-dependent, therefore the number of cases of stroke increases due to the use of HRT with increasing age.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n For women in their 50s who do not take HRT, an average of 8 out of 1,000 people is expected to have a stroke over a 5-year period.<\/p>\n\n\n\n For women in their 50s who have taken HRT for more than 5 years, 11 out of 1,000 users are expected to have a stroke (ie 3 extra cases).<\/p>\n\n\n\n Other conditions<\/strong><\/p>\n\n\n\n Some medicines may affect the effect of Indovina, which may lead to irregular bleeding. The following applies:<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription and herbal remedies.<\/p>\n\n\n\n Results from blood test analyze<\/strong><\/p>\n\n\n\n If you need to take a blood sample, tell your doctor, or the person taking the blood sample, that you are taking Indivina as it may affect the results of some tests.<\/p>\n\n\n\n Indovina is intended for women whose menstruation has stopped. If you become pregnant, stop taking Indovina and consult a doctor.<\/p>\n\n\n\n Indovina does not affect your ability to drive or use machines.<\/p>\n\n\n\n This medicine contains 78.9 mg (1 mg \/ 2.5 mg tablet), 76.5 mg (1 mg \/ 5 mg tablet) or 75.5 mg (2 mg \/ 5 mg tablet) of lactose (monohydrate) . If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n Your doctor will strive to give you the lowest dose, which will give you symptom relief, and that you should use Indovina for the shortest possible time. Talk to your doctor if you do not get any relief from the symptoms, or feel that the dose is too high.<\/p>\n\n\n\n Take one Indivina tablet daily, preferably at about the same time. Calendar days printed on the blister disc help you keep track of your daily tablet intake. Swallow the tablet whole, with a drink. Normally you start with the lowest dose of Indovina, which is increased if needed. Your doctor will strive to prescribe the lowest possible dose for the shortest possible time which will give you symptom relief. Contact your doctor if you do not get symptom relief after three months. If you have the impression that the effect of Indovina is too strong or too weak, do not change the dose or stop taking the tablets on your own, without consulting your doctor.<\/p>\n\n\n\n If you are not menstruating and if you have not previously used hormone replacement therapy or are switching from another continuous HRT combination medicine, treatment with Indovina can be started at any day.<\/p>\n\n\n\n If you switch from a cyclic HRT treatment, start treatment with Indovina one week after taking the last tablet of cyclic HRT. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n While using Indovina<\/em><\/p>\n\n\n\n When you start using Indovina, you may experience bleeding at odd times for a few months (see also the section above on endometrial cancer). Tell your doctor if this still happens after a few months or if the bleeding is heavy.<\/p>\n\n\n\n If you have ingested too much medicine or if e.g. If a child has ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice. Overdose of Indivina may cause nausea, headache and uterine bleeding.<\/p>\n\n\n\n It is best to take the tablet at the same time each day. Do not take a double dose to make up for a forgotten dose . Then continue to take the next tablet at the usual time. Forgetting a tablet or irregular use of Indivina tablets may cause breakthrough bleeding or splashing.<\/p>\n\n\n\n If you want to stop taking Indivina, you should first discuss this with your doctor. Your doctor will explain what it means to stop treatment and discuss other options with you.<\/p>\n\n\n\n If you need surgery<\/strong><\/p>\n\n\n\n If you are going to have surgery, tell your surgeon that you are taking Indivina. You may need to stop taking Indivina for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein ( thrombosis )\u201d).<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause side effects , although not everybody gets them. Especially in the beginning (during the first months of treatment) e.g. irregular bleeding occur. Side effects often disappear with continued treatment.<\/p>\n\n\n\n There are several situations in which you may need to stop taking<\/strong> Indivina. Tell your doctor immediately if you:<\/p>\n\n\n\n \u2022 Gets symptoms of jaundice (yellow skin and whites of the eyes)<\/p>\n\n\n\n \u2022 Having migraine- like headaches for the first time<\/p>\n\n\n\n \u2022 If you become pregnant<\/p>\n\n\n\n \u2022 If you get noticeably higher blood pressure .<\/p>\n\n\n\n The following diseases are more common in women who take HRT than those who do not:<\/p>\n\n\n\n \u2022 Breast cancer<\/p>\n\n\n\n \u2022 Severe thickening of the uterine lining ( endometrial hyperplasia ) or cancer of the uterine lining (endometrial cancer)<\/p>\n\n\n\n \u2022 Ovarian cancer ( ovarian cancer )<\/p>\n\n\n\n \u2022 Blood clot in veins in bones or lungs (venous thromboembolism )<\/p>\n\n\n\n \u2022 Heart disease<\/p>\n\n\n\n \u2022 Stroke (apoplexy)<\/p>\n\n\n\n \u2022 Probable memory loss, if treatment with HRT is started after the age of 65.<\/p>\n\n\n\n See section 2 for more information on these side effects .<\/p>\n\n\n\n The following side effects have been associated with HRT treatment:<\/p>\n\n\n\n Common<\/em> (may affect up to 1 in 10 people):<\/p>\n\n\n\n Uncommon<\/em> (may affect up to 1 in 100 people):<\/p>\n\n\n\n Rare<\/em> (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n Has been reported<\/em> (occurs in an unknown number of users):<\/p>\n\n\n\n The following side effects have been reported with other HRTs:<\/em><\/p>\n\n\n\n Reporting of side effects ar<\/strong><\/p>\n\n\n\n If you get any side effects , talk to your doctor or pharmacist. This also applies to any side effects not mentioned in this information. You can also report side effects directly (see details below). By reporting side effects , you can help increase drug safety information.<\/p>\n\n\n\n The Medical Products Agency<\/p>\n\n\n\n Box 26<\/p>\n\n\n\n 751 03 Uppsala<\/p>\n\n\n\n <\/p>\n\n\n\n Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist or nurse. This also applies to any side effects not mentioned in this information. You can also report side effects directly to the Medical Products Agency. By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the carton or blister. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Do not store above 25 \u00b0 C.<\/p>\n\n\n\n Store in the original package. Moisture sensitive.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n The active substances in Indivina tablets are estradiol valerate and medroxyprogesterone acetate.<\/p>\n\n\n\n The tablets are available in three strengths.<\/p>\n\n\n\n Individual 1 mg \/ 2.5 mg tablets contain 1 mg estradiol valerate and 2.5 mg medroxyprogesterone acetate.<\/p>\n\n\n\n Individual 1 mg \/ 5 mg tablets contain 1 mg estradiol valerate and 5 mg medroxyprogesterone acetate.<\/p>\n\n\n\n Individual 2 mg \/ 5 mg tablets contain 2 mg estradiol valerate and 5 mg medroxyprogesterone acetate.<\/p>\n\n\n\n The other ingredients in all Indivina tablets are lactose monohydrate , corn starch, gelatin and magnesium stearate.<\/p>\n\n\n\n Individual 1 mg \/ 2.5 mg tablets are white, round, with a bevelled edge, 7 mm in diameter, flat tablets marked 1 + 2.5 on one side.<\/p>\n\n\n\n Individual 1 mg \/ 5 mg tablets are white, round, bevelled edge, 7 mm in diameter, flat tablets marked 1 + 5 on one side.<\/p>\n\n\n\n Indivina 2 mg \/ 5 mg tablets are white, round, with a bevelled edge, 7 mm in diameter, flat tablets marked 2 + 5 on one side.<\/p>\n\n\n\n The tablets are packaged in PVC \/ PVDC aluminum blisters with 28 tablets. Pack sizes of 1 x 28 tablets and 3 x 28 tablets for all three strengths. Not all pack sizes may be marketed.<\/p>\n\n\n\n Orion Corporation<\/p>\n\n\n\n Orionv\u00e4gen 1<\/p>\n\n\n\n FI-02200 Espoo<\/p>\n\n\n\n Finland<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n Orion Corporation Orion Pharma<\/p>\n\n\n\n Orionv\u00e4gen 1<\/p>\n\n\n\n 02200 Espoo<\/p>\n\n\n\n Finland<\/p>\n\n\n\n Delpharm Little Sas – Lys Lez Lannoy<\/p>\n\n\n\n Roubaix-Est Activity Park<\/p>\n\n\n\n 22 rue de Toufflers<\/p>\n\n\n\n CS 50070<\/p>\n\n\n\n Lys Lez Lannoy 59452<\/p>\n\n\n\n France<\/p>\n\n\n\n For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n Orion Pharma AB, Danderyd<\/p>\n\n\n\n medinfo@orionpharma.com<\/p>\n\n\n\n This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n Indivina, Duova<\/p>\n","protected":false},"excerpt":{"rendered":" Indovina is a preparation used for hormonal substitution therapy ( hormone replacement therapy, HRT ). It contains two female sex hormones; estrogen and a progestogen. Indovina is used for women whose menstruation has stopped ( menopause ), at least 3 years after their last natural menstruation.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[12864,12859,3093,10344,12860,12863,5410,5413,10345,10343,12862,12861,5411,12858],"class_list":["post-14297","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-indivina","tag-benefits-of-medroxyprogesterone","tag-estradiol","tag-estradiol-tablet","tag-indivina","tag-indivina-tablet","tag-medroxyprogesterone","tag-medroxyprogesterone-tablet","tag-side-effects-of-estradiol","tag-what-estradiol-is-used-for","tag-what-indivina-is-used-for","tag-what-is-indivina","tag-what-is-medroxyprogesterone","tag-what-medroxyprogesterone-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14297"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14297\/revisions"}],"predecessor-version":[{"id":14975,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14297\/revisions\/14975"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}2. What you need to know before taking Indivina<\/h2>\n\n\n\n
Do not use Indivina<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Other drugs and Indivina<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Indivina contains lactose<\/h2>\n\n\n\n
3. How to take Indivina<\/h2>\n\n\n\n
If you take more Indivina than you should<\/h2>\n\n\n\n
If you forget to take Indivina<\/h2>\n\n\n\n
If you stop taking Indivina<\/h2>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
5. How to store Indivina<\/h2>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n