{"id":14281,"date":"2021-09-28T06:17:07","date_gmt":"2021-09-28T06:17:07","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14281"},"modified":"2021-10-18T07:58:56","modified_gmt":"2021-10-18T07:58:56","slug":"impugan","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/impugan\/","title":{"rendered":"Impugan &#8211; Furosemide uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg\/ml&nbsp;oral drops, solution<br>furosemide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Impugan is and what it is used for<\/h2>\n\n\n\n<p>Furosemide&nbsp;acts directly on the kidneys, primarily by passing more&nbsp;sodium&nbsp;into the urine.&nbsp;A consequence of this is that more water is excreted and the number of urine increases.&nbsp;Impugan is a very fast-acting&nbsp;diuretic.&nbsp;The effect is often noticeable as early as 30 minutes after taking a&nbsp;dose.&nbsp;The&nbsp;diuretic&nbsp;effect depends on the size of the dose, and is maximal after 1-2 hours and subsides within about 4 hours.<\/p>\n\n\n\n<p>The impugan also has a usually weak blood pressure-lowering effect that lasts longer than the&nbsp;diuretic&nbsp;effect.<\/p>\n\n\n\n<p>The impugan is used for fluid retention (&nbsp;edema&nbsp;) due to impaired function of eg heart, lungs, kidneys or liver and high&nbsp;blood pressure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Impugan<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Impugan<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;furosemide&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to substances similar to&nbsp;furosemide&nbsp;, such as certain medicines for&nbsp;diabetes&nbsp;or medicines for&nbsp;infection&nbsp;.<\/li><li>if you have symptoms such as weakness, difficulty breathing and dizziness.&nbsp;This may be a sign of too little fluid in the body (dehydration).<\/li><li>if you have severe liver or kidney damage.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Impugan:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are older, if you are taking other medicines that can lower&nbsp;your blood pressure&nbsp;, or if you have any other illness that carries a risk of lowering your&nbsp;blood pressure&nbsp;.<\/li><\/ul>\n\n\n\n<p>You mustn&#8217;t make major changes to your eating habits and intake of salts, especially table salt (eg through fasting), without consulting a doctor.<\/p>\n\n\n\n<p>Furosemide&nbsp;should be used with caution in infants due to the risk of&nbsp;kidney stones.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Impugan<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Concomitant treatment with gentamicin (&nbsp;antibiotic&nbsp;) and other similar&nbsp;antibiotics&nbsp;(&nbsp;aminoglycosides&nbsp;) should be avoided.<\/p>\n\n\n\n<p>The treatment effect may be affected if Impugan is taken at the same time as certain other medicines.&nbsp;These include cardiac medications (&nbsp;digitalis glycosides, sotalol, or&nbsp;ACE inhibitors&nbsp;), analgesics (non-steroidal anti-inflammatory drugs), lithium (used in manic-depressive illness), or other antihypertensive agents.&nbsp;The treating physician, therefore, needs to be aware of such concomitant medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>There is a risk that the fetus is affected.&nbsp;Therefore, always consult a doctor before using Impugan during pregnancy.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>A breastfed baby may be affected.&nbsp;Do not use Impugan during lactation except on certain&nbsp;prescriptions&nbsp;from the doctor.&nbsp;Breastfeeding mothers should be aware that the amount of milk may decrease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>No known effect on the ability to drive or perform precision work.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Impugan contains alcohol and sodium<\/h2>\n\n\n\n<p><strong>The impugan contains alcohol<\/strong><\/p>\n\n\n\n<p>Impugan oral drops contain 9.8%&nbsp;ethanol&nbsp;(alcohol).&nbsp;At a normal&nbsp;dose&nbsp;for adults, 2-4 ml of Impugan oral drops, the&nbsp;ethanol&nbsp;content is&nbsp;200-400 mg, which corresponds to up to 1 cl of beer or up to 0.4 cl of wine.<br><br><strong>The impugan contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per 24 ml, ie essentially &#8216;sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Impugan<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for adults with&nbsp;edema&nbsp;or high blood pressure: 20-80 mg per day.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;for children: 1-3 mg\/kg body weight per day.<\/p>\n\n\n\n<p>The drops can be mixed in lukewarm tea and cold milk, but acidic drinks such as juice and juice should be avoided.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Impugan than you should&nbsp;<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.&nbsp;If a child has ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n<p>Dizziness and fainting can be signs of overdose as well as troublesome&nbsp;side effects.&nbsp;See below.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Stop taking Impugan and tell your doctor immediately if you get any of the following serious side effects:<\/strong><\/p>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The impugan can affect the white&nbsp;blood cells&nbsp;so that the&nbsp;defense against&nbsp;infection deteriorates.&nbsp;If you get an&nbsp;infection&nbsp;with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat \/ pharynx \/ mouth or urination problems, you should see a doctor as soon as possible so that a blood test can rule out a lack of&nbsp;white blood cells&nbsp;(&nbsp;agranulocytosis&nbsp;) .&nbsp;It is important that you then inform about your medication.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Intense skin rash including&nbsp;hives&nbsp;, severe&nbsp;itching&nbsp;, blisters, skin loosening and swelling of the skin and&nbsp;inflammation&nbsp;of the mucous membranes, or blisters and loosening of the top layer of the skin (&nbsp;Stevens-Johnson syndrome&nbsp;,&nbsp;toxic epidermal necrolysis&nbsp;)<br><\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Red, scaly, widespread rash with nodules under the skin, blisters mainly in the folds of the skin, on the torso and arms together with fever, in connection with the&nbsp;start of&nbsp;treatment (&nbsp;acute&nbsp;generalized exanthematous&nbsp;pustulosis&nbsp;, AGEP).<\/li><li>Widespread rash, fever and enlarged&nbsp;lymph nodes&nbsp;(DRESS).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;that may occur:<\/strong><\/p>\n\n\n\n<p>&nbsp;<strong>Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kidney stones&nbsp;in infants<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased potassium content in the blood, which can manifest itself in the form of muscle weakness.<\/li><li>Reduced levels in the blood of e.g.&nbsp;sodium,&nbsp;magnesium&nbsp;, chlorine and&nbsp;calcium&nbsp;.<\/li><li>Elevated uric acid content in the blood.<\/li><li>Decreased blood volume due to reduced amount of fluid in the&nbsp;tissues&nbsp;.&nbsp;This is especially true for treatment with high&nbsp;doses&nbsp;and for long-term treatment.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may&nbsp;<\/strong><strong>affect&nbsp;<\/strong><strong>up to&nbsp;<\/strong><strong>1 in&nbsp;<\/strong><strong>100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea and vomiting.<\/li><li>Low&nbsp;blood pressure&nbsp;.<\/li><li>Severe decrease in the number of&nbsp;blood cells&nbsp;, which can cause weakness, bruising and increased susceptibility to infection (&nbsp;aplastic anemia&nbsp;).<\/li><li>Dehydration.<\/li><li>Deafness (sometimes persistent).<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduction of&nbsp;platelets&nbsp;, which may increase the risk of bleeding and bruising.<\/li><li>Severe decrease in the number of&nbsp;white blood cells&nbsp;, which increases the susceptibility to infection.<\/li><li>Inflammation&nbsp;of the blood vessels, often with skin rashes or red to purple discolorations of the skin.<\/li><li>Liver effects that cause changes in blood tests.<\/li><li>Rash,&nbsp;itching&nbsp;, red to purple skin discoloration.<\/li><li>Red, scaly patches on the skin, hair loss or loosening of nails (called exfoliative&nbsp;dermatitis&nbsp;).<\/li><li>Circular, irregular red spots on the skin of the hands and arms (erythema multiforme).<\/li><li>Skin reactions to sunlight.<\/li><li>Increased blood sugar levels.<\/li><li>Ringing in the ears, and hearing loss may occur during treatment with high&nbsp;doses&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the pancreas which can cause severe pain in the abdomen and back.<\/li><li>Deterioration of renal impairment and&nbsp;inflammation&nbsp;.<\/li><li>Liver effects.<\/li><li>dizziness, fainting and unconsciousness (caused by low&nbsp;blood pressure&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store the Impugan<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Used before the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;furosemide&nbsp;.&nbsp;1 ml (milliliter) of Impugan contains 10 mg of&nbsp;furosemide&nbsp;.<\/li><li>The other ingredients are saccharin sodium (sweetener), sodium hydroxide,&nbsp;ethanol&nbsp;(alcohol content 9.8%) and water.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p><em>Impugan appearance:<\/em><\/p>\n\n\n\n<p>The oral drops are a colorless or slightly yellowish solution.<\/p>\n\n\n\n<p><em>Pack sizes:<\/em><\/p>\n\n\n\n<p>Bottle (30 ml) with graduated dose pipette<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Actavis Group PTC EHF.<\/p>\n\n\n\n<p>Reykjavikurvegur 76-78<\/p>\n\n\n\n<p>IS-220 Hafnarfj\u00f6r\u00f0ur<\/p>\n\n\n\n<p>Iceland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Balkanpharma Troyan AD<\/p>\n\n\n\n<p>1 Krayrechna Str<\/p>\n\n\n\n<p>BG-5600 Troyan<\/p>\n\n\n\n<p>Bulgaria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Furosemide acts directly on the kidneys, primarily by passing more sodium into the urine. A consequence of this is that more water is excreted and the number of urine increases. Impugan is a very fast-acting diuretic. The effect is often noticeable as early as 30 minutes after taking a dose. The diuretic effect depends on the size of the dose, and is maximal after 1-2 hours and subsides within about 4 hours.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[12934,12939,2375,12933,2401,12935,12938,12940,12932,12937,12931,12936],"class_list":["post-14281","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-furosemide","tag-benefits-of-impugan","tag-furosemide","tag-furosemide-drops","tag-furosemide-side-effects","tag-impugan","tag-impugan-drops","tag-side-effects-of-impugan","tag-what-furosemide-is-used-for","tag-what-impugan-is-used-for","tag-what-is-furosemide","tag-what-is-impugan"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14281"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14281\/revisions"}],"predecessor-version":[{"id":14983,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14281\/revisions\/14983"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}