{"id":14132,"date":"2021-09-25T06:58:49","date_gmt":"2021-09-25T06:58:49","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14132"},"modified":"2021-10-23T11:14:29","modified_gmt":"2021-10-23T11:14:29","slug":"ilomedin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ilomedin\/","title":{"rendered":"Ilomedin &#8211; Iloprost uses, dose and side effects"},"content":{"rendered":"\n<p>20 micrograms \/ mL&nbsp;concentrate for&nbsp;infusion&nbsp;solution<br>iloprost<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Ilomedin is and what it is used for<\/h2>\n\n\n\n<p>Ilomedin mimics a naturally occurring substance in the body called&nbsp;prostacyclin.&nbsp;It inhibits unwanted blockage or narrowing of blood vessels and thus improves microcirculation in&nbsp;tissues&nbsp;with poor blood circulation.<\/p>\n\n\n\n<p>Ilomedin is used to treat severe&nbsp;chronic&nbsp;peripheral&nbsp;circulatory insufficiency (insufficient blood circulation), where there is a risk of amputation and where vascular surgery or radiological treatment is not possible or can not be used for other medical reasons.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you receive Ilomedin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ilomedin<\/h2>\n\n\n\n<p>Do not use Ilomedin if you have any of the conditions listed below.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to iloprost or any of the other ingredients of Ilomedin.<\/li><li>If you have an increased risk of bleeding &#8211; e.g.&nbsp;an active&nbsp;stomach ulcer&nbsp;, bodily injury or other bleeding.<\/li><li>If you have an accumulation of fluid in your lungs, that makes it difficult to breathe.<\/li><li>If you are pregnant or breastfeeding.<\/li><li>If you have or have had a heart problem, for example:<ul><li>a heart attack in the last six months<\/li><li>severe heart rate disorders<\/li><li>poor blood flow to the heart muscle (severe coronary heart disease or&nbsp;unstable angina&nbsp;).&nbsp;Symptoms of this can be chest pain<\/li><li>if you have&nbsp;acute&nbsp;or&nbsp;chronic&nbsp;heart failure&nbsp;.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you think any of these apply to you, tell your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Take special care with Ilomedin<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have low&nbsp;blood pressure<\/li><li>if you have liver problems or have very severe kidney problems, your doctor may prescribe a lower&nbsp;dose&nbsp;of Ilomedin than other patients<\/li><li>When you get up after&nbsp;an infusion&nbsp;, you may experience a drop in blood pressure, which makes you feel dizzy for a short while until&nbsp;your blood pressure&nbsp;returns to normal&nbsp;.&nbsp;Therefore, get up slowly.&nbsp;In this way, you help the body get used to the change in posture and&nbsp;blood pressure<\/li><li>if you have had a&nbsp;stroke&nbsp;in the last 3 months, or any other disruption in blood flow to the brain.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ilomedin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<p>Be especially careful to tell if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs used to treat high&nbsp;blood pressure&nbsp;or heart disease.<\/li><li>drugs that inhibit blood coagulation e.g.&nbsp;warfarin&nbsp;,&nbsp;heparin&nbsp;,&nbsp;acetylsalicylic acid&nbsp;(a substance found in many medicines that have antipyretics and painkillers), NSAIDs (non-steroidal anti-inflammatory \/ anti-rheumatic drugs).<\/li><li>drugs containing phosphodiesterase inhibitors e.g.&nbsp;sildenafil, tadalafil, vardenafil.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<p><em>Ilomedin is not intended for use by pregnant women<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant or think you may be, talk to your doctor straight away.&nbsp;Pregnant women are not allowed to take Ilomedin.<ul><li>Women of&nbsp;childbearing potential&nbsp;should use a reliable method of contraception from the start of treatment and at all times (consult your doctor).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><em>Ilomedin is not for breastfeeding<\/em> women<br>Stop breastfeeding when you start treatment with Ilomedin.&nbsp;Breast-feeding women should not take Ilomedin because it is not known whether the active substance is transmitted through milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ilomedin lowers&nbsp;blood pressure&nbsp;and may cause dizziness in some people.&nbsp;Do not drive or use any tools or machines if you feel such effects of low&nbsp;blood pressure.<br>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ilomedin contains excipients<\/h2>\n\n\n\n<p><strong>Ilomedin contains&nbsp;ethanol&nbsp;and&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains 1.62 mg alcohol (&nbsp;96%&nbsp;ethanol&nbsp;) per ml.&nbsp;The amount in 1 ml of this medicine corresponds to less than 0.04 ml of beer or 0.02 ml of wine.<\/p>\n\n\n\n<p>The low amount of alcohol in this medicine does not produce any noticeable effects.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per ml, ie essentially &#8216;sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to get Ilomedin<\/h2>\n\n\n\n<p>Ilomedin should only be given under close supervision, in a hospital with&nbsp;adequate&nbsp;equipment.<br>Use and&nbsp;dosage&nbsp;are determined by your doctor<\/p>\n\n\n\n<p>The treatment time is 6 hours\/day for a maximum of 4 weeks.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Ilomedin than you should<\/h2>\n\n\n\n<p>If you may have an overdose, your doctor will stop the treatment and treat the symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><strong>The most common&nbsp;side effect&nbsp;is<\/strong>&nbsp;(can occur in 1 or more of 10 patients) in patients receiving iloprost are headache, flushing (flushing),&nbsp;hyperhydrosis&nbsp;(sweating), and gastrointestinal symptoms such as&nbsp;nausea and vomiting.&nbsp;These&nbsp;side effects&nbsp;usually occur at the beginning of treatment when the&nbsp;dose is&nbsp;adjusted to find the most appropriate&nbsp;dose&nbsp;for the individual patient.&nbsp;However, all of these&nbsp;side effects&nbsp;usually go away quickly if you reduce the&nbsp;dose.<\/p>\n\n\n\n<p><strong>The most serious&nbsp;adverse reactions, for which a life-threatening or fatal outcome has been observed in patients treated with iloprost, are<\/strong>&nbsp;:<\/p>\n\n\n\n<p><em>Common<\/em>&nbsp;(may affect 1 to 10 users in 100)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hypotension&nbsp;(abnormally low&nbsp;blood pressure&nbsp;)<\/li><li>tachycardia&nbsp;(increased heart rate)<\/li><li>angina (chest pain or pressure over the chest caused by insufficient blood flow to the heart)<\/li><li>dyspnoea&nbsp;(difficulty breathing)<\/li><\/ul>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(may affect 1 to 10 users in 1,000)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cerebrovascular&nbsp;injury (&nbsp;stroke&nbsp;)<\/li><li>heart attack (heart attack)<\/li><li>Pulmonary embolism&nbsp;(breathing difficulties or chest pain when inhaled caused by a blood clot in the lungs)<\/li><li>heart failure<\/li><li>seizures<\/li><li>asthma<\/li><li>pulmonary edema&nbsp;(difficulty breathing or blood clots caused by fluid accumulation in the lungs).<\/li><\/ul>\n\n\n\n<p>If any of the above serious&nbsp;side effects&nbsp;occur, treatment with Ilomedin should be stopped.<\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are listed below according to how often they occur:<\/strong><\/p>\n\n\n\n<p><em>Common<\/em>&nbsp;(may affect 1 to 10 users in 100)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased appetite<\/li><li>indifference<\/li><li>state of confusion<\/li><li>dizziness \/&nbsp;vertigo&nbsp;(feeling of spinning)<\/li><li>paresthesia&nbsp;(numbness and tingling \/ throbbing sensation \/&nbsp;hyperesthesia&nbsp;(increased sensitivity to pain or pressure) \/ burning sensation<\/li><li>restlessness \/ anxiety<\/li><li>silence<\/li><li>somnolence<\/li><li>bradycardia&nbsp;(decreased heart rate)<\/li><li>increased&nbsp;blood pressure<\/li><li>diarrhea<\/li><li>abdominal discomfort \/ abdominal pain<\/li><li>jaw pain \/ trismus (difficult to open mouth)<\/li><li>myalgia&nbsp;(muscle&nbsp;pain)&nbsp;\/&nbsp;arthralgia&nbsp;(joint pain)<\/li><li>pain<\/li><li>fever \/ increased body temperature<\/li><li>feeling of warmth<\/li><li>asthenia&nbsp;(weakness) \/ general malaise<\/li><li>overindulge<\/li><li>fatigue \/ drowsiness<\/li><li>thirst<\/li><li>reactions at the infusion site such as&nbsp;redness, pain or&nbsp;phlebitis&nbsp;(&nbsp;inflammation&nbsp;of a vein at the infusion site<\/li><\/ul>\n\n\n\n<p><em>Uncommon<\/em>&nbsp;(may affect 1 to 10 users in 1,000)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>thrombocytopenia&nbsp;(blood disease that causes bruising or bleeding easily)<\/li><li>hypersensitivity (&nbsp;allergy&nbsp;)<\/li><li>anxiety, depression, hallucinations<\/li><li>syncope&nbsp;(short-term loss of consciousness)<\/li><li>tremor&nbsp;(shaking or trembling)<\/li><li>migraine<\/li><li>dimsyn<\/li><li>eye irritation<\/li><li>eye pain<\/li><li>arrhythmia&nbsp;\/ extrasystoles (irregular heartbeat)<\/li><li>deep&nbsp;vein thrombosis&nbsp;(pain in the legs caused by a blood clot in the blood vessels in the legs)<\/li><li>diarrhea with blood in the stool<\/li><li>rectal bleeding<\/li><li>dyspepsia&nbsp;(heartburn and abdominal pain)<\/li><li>rectal tenesmus (pain caused by constipation)<\/li><li>constipation<\/li><li>eruktation (belching)<\/li><li>dysphagia&nbsp;(difficulty swallowing)<\/li><li>dysgeusi&nbsp;(taste disturbances)<\/li><li>dry mouth<\/li><li>jaundice<\/li><li>itching<\/li><li>tetani&nbsp;(muscle cramps)<\/li><li>increased tension in muscles<\/li><li>kidney pain<\/li><li>vesical tenesmus (feeling of need to urinate)<\/li><li>abnormal urine<\/li><li>dysuria&nbsp;(painful urination or difficulty urinating)<\/li><li>urinary tract diseases<\/li><\/ul>\n\n\n\n<p><em>Rare<\/em>&nbsp;(may affect 1 to 10 users in 10,000)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>vestibular diseases (dizziness caused by disease of the inner ear)<\/li><li>cough<\/li><li>proctitis&nbsp;(&nbsp;inflammation of the&nbsp;rectum)<\/li><\/ul>\n\n\n\n<p>Iloprost can cause angina, which causes pain or pressure over the chest, especially in patients with coronary heart disease.<\/p>\n\n\n\n<p>The risk of bleeding is increased in patients receiving Ilomedin at the same time as medicines that inhibit blood coagulation,&nbsp;heparin,&nbsp;or coumarin-type medicines.<\/p>\n\n\n\n<p>One group of&nbsp;side effects&nbsp;is related to infusion site reactions.&nbsp;For example.&nbsp;can&nbsp;redness&nbsp;and pain occur at the infusion site or so-called&nbsp;cutaneous&nbsp;vasodilation&nbsp;that may cause striped erythema above the infusion vein?<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Ilomedin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<br>Do not use this medicine after the expiry date which is stated on the carton and vial.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>For information for healthcare professionals, see section 6, under &#8220;The following information is intended for healthcare professionals only&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is iloprost<\/li><li>The other ingredients are <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tribonate\/\">trometamol<\/a>,&nbsp;ethanol&nbsp;(96%), sodium chloride,&nbsp;hydrochloric acid&nbsp;1N, water for injections<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Ilomedin is a clear, particle-free solution.<\/p>\n\n\n\n<p>Ilomedin is supplied in packs of:<br>5 x 1 ml<br>5 x 2.5 ml<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Bayer AB<\/p>\n\n\n\n<p>Box 606<\/p>\n\n\n\n<p>SE-169 26 Solna<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ilomedin mimics a naturally occurring substance in the body called prostacyclin. It inhibits unwanted blockage or narrowing of blood vessels and thus improves microcirculation in tissues with poor blood circulation.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[13214,13209,13211,13215,13206,13210,13213,13208,13212,13207],"class_list":["post-14132","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-ilomedin","tag-benefits-of-iloprost","tag-ilomedin","tag-ilomedin-side-effects","tag-iloprost","tag-side-effects-of-iloprost","tag-what-ilomedin-is-used-for","tag-what-iloprost-is-used-for","tag-what-is-ilomedin","tag-what-is-iloprost"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14132"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14132\/revisions"}],"predecessor-version":[{"id":15083,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14132\/revisions\/15083"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}