{"id":14128,"date":"2021-09-25T06:56:24","date_gmt":"2021-09-25T06:56:24","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14128"},"modified":"2021-10-23T11:14:43","modified_gmt":"2021-10-23T11:14:43","slug":"ikervis","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ikervis\/","title":{"rendered":"Ikervis &#8211; ciclosporin uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg \/ ml&nbsp;eye drops&nbsp;,&nbsp;emulsion<br>ciclosporin (ciclosporin)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What IKERVIS is and what it is used for<\/h2>\n\n\n\n<p>IKERVIS contains the active substance ciclosporin.&nbsp;Ciclosporin belongs to a group of medicines called immunosuppressants that are used to reduce&nbsp;inflammation.<\/p>\n\n\n\n<p>IKERVIS is used to treat adults with severe&nbsp;keratitis&nbsp;(&nbsp;inflammation&nbsp;of the cornea, the transparent membrane in the front of the eye).&nbsp;It is used in patients who have chronically dry eyes, which have not improved despite treatment with tear substitutes (artificial tear fluid).<\/p>\n\n\n\n<p>You need to talk to a doctor if you do not feel better or if you feel worse.<\/p>\n\n\n\n<p><br>You should visit your doctor at least every six months to assess the effect of IKERVIS.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using IKERVIS<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use IKERVIS<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to ciclosporin or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have or have had cancer in or around your eye.<\/li><li>if you have an&nbsp;eye infection&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Use IKERVIS only to drip into the eye (s).<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist before using IKERVIS<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have previously had an&nbsp;eye infection&nbsp;with the herpes virus that may have damaged the translucent membrane of the front of the eye (cornea).<\/li><li>if you are taking medicines containing&nbsp;corticosteroids&nbsp;(&nbsp;cortisone&nbsp;).<\/li><li>if you are taking medicines to treat&nbsp;glaucoma&nbsp;.<\/li><\/ul>\n\n\n\n<p>Contact lenses can cause further damage to the transparent membrane of the front of the eye (the cornea).&nbsp;Therefore, remove contact lenses at bedtime before using IKERVIS.&nbsp;You can put them back in when you get up.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>IKERVIS should not be used by children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and IKERVIS<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Talk to your doctor if you are using&nbsp;eye drops&nbsp;that contain&nbsp;corticosteroids&nbsp;(&nbsp;cortisone&nbsp;) at the same time as IKERVIS, as these may increase the risk of&nbsp;side effects.<\/p>\n\n\n\n<p>IKERVIS&nbsp;eye drops&nbsp;should not be used until&nbsp;<strong>at least 15 minutes<\/strong>&nbsp;after the use of other&nbsp;eye drops.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>IKERVIS&nbsp;<strong>should not be used<\/strong>&nbsp;if you are pregnant.<\/p>\n\n\n\n<p>If you can get pregnant, you must use contraception while using this medicine.<\/p>\n\n\n\n<p>IKERVIS probably passes into breast milk in very small amounts.&nbsp;If you are breastfeeding, talk to your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You may see blurred right after using IKERVIS&nbsp;eye drops.&nbsp;If this happens, wait until vision has cleared before driving or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">IKERVIS contains cetalkonium chloride<\/h2>\n\n\n\n<p>Each ml of this medicine contains 0.05 mg of cetalkonium chloride.&nbsp;Contact lenses should be removed before using this medicine, and you can re-insert the contact lenses when you get up.&nbsp;Cetalkonium chloride may cause eye irritation.&nbsp;If anything feels abnormal in your eyes or if you have burning or pain in the eye after using this medicine, talk to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use IKERVIS<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose<\/strong>&nbsp;is one drop in each affected eye once daily at bedtime.<\/p>\n\n\n\n<p><strong>Instructions for use<\/strong><\/p>\n\n\n\n<p>Follow these instructions carefully and ask your doctor or pharmacist if there is anything you do not understand.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140115000022#\" rel=\"noopener\"><\/a><\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140115000022#\" rel=\"noopener\"><\/a><\/td><th scope=\"row\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20140115000022#\" rel=\"noopener\"><\/a><\/th><\/tr><tr><th scope=\"col\">1<\/th><th scope=\"col\">2<\/th><th scope=\"col\">3<\/th><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Wash your hands.<\/li><li>If you use contact lenses, remove them at bedtime before using the drops.You can put them back in when you get up.<\/li><li>Open the aluminum&nbsp;bag&nbsp;containing 5&nbsp;single-dose containers&nbsp;.<\/li><li>Take a&nbsp;single-dose container&nbsp;out of the aluminum&nbsp;bag&nbsp;.<\/li><li>Gently shake the single-dose container before using it.<\/li><li>Turn off the top&nbsp;<strong>(Fig. 1)<\/strong>&nbsp;.<\/li><li>Pull down the lower eyelid&nbsp;<strong>(Fig. 2).<\/strong><\/li><li>Tilt your head back and look up at the ceiling.<\/li><li>Gently push a drop of the drug onto the eye.&nbsp;Make sure you do not touch the eye with the tip of the single-dose container.<\/li><li>Blink a few times so that the medicine covers the eye.<\/li><li>After using IKERVIS, press with a finger in the corner of your eye at the nose and close your eyes for 2 minutes&nbsp;<strong>(picture 3)<\/strong>&nbsp;.&nbsp;This helps prevent IKERVIS from entering the rest of the body.<\/li><li>If you use drops in both eyes, repeat the same step for the other eye.<\/li><li>Dispose of the single-dose container as soon as you have used it, even if there is still some liquid left in it.<\/li><li>The rest of the single-dose containers should be stored in the aluminum bag.<\/li><\/ul>\n\n\n\n<p>If a drop falls out of sight, try again.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much IKERVIS &nbsp;<\/h2>\n\n\n\n<p>rinse your eye with water.&nbsp;Do not drip in more drops until it is time for the next regular&nbsp;dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use IKERVIS<\/h2>\n\n\n\n<p>continue with the next&nbsp;dose&nbsp;as planned.&nbsp;Do not use a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.&nbsp;Do not use more than one drop each day in the affected eye (s).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using IKERVIS<\/h2>\n\n\n\n<p>without talking to your doctor,&nbsp;inflammation&nbsp;is not kept&nbsp;under control in the transparent membrane of the front of the eye (&nbsp;inflammation&nbsp;is called&nbsp;keratitis&nbsp;) which can lead to impaired vision.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported:<\/strong><\/p>\n\n\n\n<p>The most common&nbsp;side effects&nbsp;occur in and around the eyes.<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Eye pain<\/li><li>Eye irritation<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Redness&nbsp;of the eyelid<\/li><li>Tear flow<\/li><li>Redness&nbsp;in the eye<\/li><li>Dimsyn<\/li><li>Swollen eyelid<\/li><li>Redness&nbsp;of the conjunctiva (thin membrane covering the front of the eye)<\/li><li>Itching&nbsp;in the eye<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Discomfort,&nbsp;itching&nbsp;or irritation in or around the eye when the drops are placed in the eye, including a feeling of having something in the eye<\/li><li>Irritation or swelling of the conjunctiva (thin membrane covering the front of the eye)<\/li><li>Disorder in the tear flow<\/li><li>Excretion from the eye<\/li><li>Irritation or&nbsp;inflammation&nbsp;of the conjunctiva (thin&nbsp;membrane&nbsp;covering the front of the eye)<\/li><li>Inflammation&nbsp;of the&nbsp;iris&nbsp;(the colored part of the eye) or the eyelid<\/li><li>Drug residues in the eye<\/li><li>Abrasion in the outer layer of the cornea<\/li><li>Red or swollen eyelids<\/li><li>Cyst&nbsp;in the eyelid<\/li><li>Immunological reaction or scarring of the cornea<\/li><li>Itching&nbsp;of the eyelid<\/li><li>Bacterial infection or&nbsp;inflammation&nbsp;of the cornea (transparent membrane in the front of the eye)<\/li><li>Painful rash around the eye due to&nbsp;herpes&nbsp;zoster&nbsp;virus&nbsp;.<\/li><li>Headache<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store IKERVIS<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the outer carton, aluminum sachet, and single-dose containers after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Once the aluminum bags have been opened, the single-dose containers should be stored in the bags as protection against light and evaporation.&nbsp;Dispose of an opened individual single-dose container&nbsp;with any remaining solution immediately after use.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is cyclosporine.&nbsp;One milliliter IKERVIS contains 1 mg ciclosporin.<\/li><li>The other ingredients are&nbsp;triglyceride&nbsp;s medium chain, cetalkonium chloride,&nbsp;glycerin&nbsp;, tyloxapol, poloxamer 188, sodium hydroxide (for&nbsp;pH&nbsp;-reglering) and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>IKERVIS is a cloudy white eye drop emulsion.<\/p>\n\n\n\n<p>The drug is supplied in&nbsp;single-dose&nbsp;low-density polyethylene (LDPE) containers.&nbsp;A&nbsp;single-dose&nbsp;container contains 0.3 ml of&nbsp;eye drops,&nbsp;emulsion.<br>The single-dose containers are packed in a sealed aluminum bag.<\/p>\n\n\n\n<p>Pack sizes: 30 and 90&nbsp;single-dose containers.<br>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>SANTEN Oy<\/p>\n\n\n\n<p>Niittyhaankatu 20<\/p>\n\n\n\n<p>33720 Tampere<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>EXCELVISION<br>Rue de la Lombardi\u00e8re<\/p>\n\n\n\n<p>ZI la Lombardi\u00e8re<\/p>\n\n\n\n<p>F-07100 Annonay<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>SANTEN Oy<\/p>\n\n\n\n<p>Kelloportinkatu 1<\/p>\n\n\n\n<p>33100 Tampere<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<p>Santen Oy<\/p>\n\n\n\n<p>Tel: +46 (0) 850598833<\/p>\n","protected":false},"excerpt":{"rendered":"<p>IKERVIS contains the active substance ciclosporin. Ciclosporin belongs to a group of medicines called immunosuppressants that are used to reduce inflammation.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[13230,13237,7155,13229,13231,13232,13235,13236,13228,13234,7157,13233],"class_list":["post-14128","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-ciclosporin","tag-benefits-of-ikervis","tag-ciclosporin","tag-ciclosporin-eye-drops","tag-ciclosporin-side-effects","tag-ikervis","tag-ikervis-eye-drops","tag-side-effects-of-ikervis","tag-what-ciclosporin-is-used-for","tag-what-ikervis-is-used-for","tag-what-is-ciclosporin","tag-what-is-ikervis"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14128"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14128\/revisions"}],"predecessor-version":[{"id":15085,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14128\/revisions\/15085"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}