{"id":14124,"date":"2021-09-25T06:54:28","date_gmt":"2021-09-25T06:54:28","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14124"},"modified":"2021-10-23T11:14:52","modified_gmt":"2021-10-23T11:14:52","slug":"ifirmasta","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ifirmasta\/","title":{"rendered":"Ifirmasta &#8211; Irbesartan uses, dose and side effects"},"content":{"rendered":"\n<p><strong>75 mg, 150 mg, and 300 mg\u00a0film-coated tablets<br><\/strong>irbesartan<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Ifirmasta is and what it is used for<\/h2>\n\n\n\n<p>Ifirmasta belongs to a group of medicines called&nbsp;angiotensin&nbsp;-II&nbsp;receptor&nbsp;antagonists.&nbsp;Angiotensin&nbsp;-II is a substance, which is produced in the body, and which binds to certain structures (&nbsp;receptors&nbsp;) in the blood vessels and causes them to constrict.&nbsp;This leads to increased&nbsp;blood pressure.&nbsp;Ifirmasta prevents the binding of&nbsp;angiotensin&nbsp;-II to these&nbsp;receptors, which causes the blood vessels to relax and the&nbsp;blood pressure&nbsp;to drop.&nbsp;Ifirmasta delays the deterioration of renal function in patients with high&nbsp;blood pressure&nbsp;and type 2&nbsp;diabetes.<\/p>\n\n\n\n<p>Ifirmasta is used in adult patients<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>in the treatment of&nbsp;hypertension&nbsp;<em>(&nbsp;essential&nbsp;hypertension&nbsp;)<\/em><\/li><li>to protect the kidneys in patients with high&nbsp;blood pressure&nbsp;, type 2&nbsp;diabetes&nbsp;and renal impairment, detected in laboratory tests.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before using Ifirmasta<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ifirmasta<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to irbesartan or any of the other ingredients of this medicine (listed in section 6).<\/li><li>Pregnant women should not use Ifirmasta&nbsp;<strong>during the last 6 months of pregnancy<\/strong>&nbsp;.&nbsp;(Even earlier in pregnancy, it is good to avoid Ifirmasta, see Pregnancy and breast-feeding).<\/li><li>if you have&nbsp;diabetes&nbsp;or renal impairment and are being treated with a blood pressure lowering medicine containing aliskiren.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Ifirmasta and&nbsp;<strong>if any of the following apply to you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you experience&nbsp;<strong>severe vomiting or diarrhea<\/strong><\/li><li>if you suffer from&nbsp;<strong>kidney problems<\/strong><\/li><li>if you suffer from&nbsp;<strong>heart problems<\/strong><\/li><li>if you are receiving Ifirmasta for&nbsp;<strong>diabetes-related kidney disease<\/strong>&nbsp;.&nbsp;Then your doctor may take regular blood tests, especially to measure the level of potassium in the blood in case of poor kidney function.<\/li><li>if you develop&nbsp;<strong>low blood sugar levels<\/strong>&nbsp;(symptoms may include sweating, weakness, hunger, dizziness, tremors, headache,&nbsp;redness&nbsp;or paleness, numbness, having a fast, throbbing heart rhythm), especially if you are being treated for&nbsp;diabetes<\/li><li>if you&nbsp;<strong>are going to have surgery or get anesthesia<\/strong><\/li><li>if you are taking any of the following medicines used to treat high blood pressure:<\/li><li>an ACE inhibitor (such as&nbsp;enalapril&nbsp;, lisinopril, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triatec\/\">ramipril<\/a>), especially if you have diabetes-related kidney problems.<\/li><li>aliskiren.<\/li><\/ul>\n\n\n\n<p>Your doctor may need to check your kidney function,&nbsp;blood pressure,&nbsp;and the number of&nbsp;electrolytes&nbsp;(eg&nbsp;potassium&nbsp;) in&nbsp;your&nbsp;blood at regular intervals.<\/p>\n\n\n\n<p>See also the information under the heading &#8220;Do not take Ifirmasta&#8221;.<\/p>\n\n\n\n<p>If you think you may be pregnant or become pregnant during treatment, consult your doctor.&nbsp;Ifirmasta is not recommended during pregnancy and should not be used during the last 6 months of pregnancy as it may cause birth defects, see Pregnancy and breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>This medicine should not be used by children and adolescents (&lt;18 years) as the safety and efficacy of the medicine have not been fully evaluated.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ifirmasta<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Your doctor may need to change your&nbsp;dose&nbsp;and\/or take other precautions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are taking an&nbsp;ACE inhibitor&nbsp;or aliskiren (see also the information under the headings &#8220;Do not take Ifirmasta&#8221; and &#8220;Warnings and precautions&#8221;).<\/li><\/ul>\n\n\n\n<p><strong>You may need to take blood samples if you use:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>potassium supplement<\/li><li>salt substitutes containing&nbsp;potassium<\/li><li>potassium-sparing medicines (eg certain&nbsp;diuretics&nbsp;)<\/li><li>medicines containing lithium<\/li><li>repaglinide (medicines used to lower blood sugar levels)<\/li><\/ul>\n\n\n\n<p>If you use certain painkillers, so-called non-steroidal anti-inflammatory drugs, the effect of irbesartan may be reduced.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you think you may be pregnant or become pregnant during treatment, consult your doctor.&nbsp;Usually, your doctor will suggest that you stop taking Ifirmasta before pregnancy or as soon as you know you are pregnant and instead recommend another medicine for you.&nbsp;Ifirmasta should not be used in early pregnancy and should not be used during the last 6 months of pregnancy, as it may cause birth defects.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you are breastfeeding or planning to start breastfeeding.&nbsp;Ifirmasta is not recommended for breastfeeding and your doctor may choose another treatment for you if you want to breastfeed your baby, especially if your baby is newborn or premature.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ifirmasta is unlikely to affect your ability to drive or use machines.&nbsp;Occasionally, however, dizziness or fatigue may occur during treatment of high&nbsp;blood pressure.&nbsp;If you experience this, talk to your doctor before driving or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ifirmasta contains castor oil<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Ifirmasta<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<p>Ifirmasta is&nbsp;<strong>taken by mouth<\/strong>.&nbsp;Swallow the tablets with a sufficient amount of drink (eg a glass of water).&nbsp;You can take Ifirmasta with or without food.&nbsp;Try to take your daily&nbsp;dose&nbsp;at about the same time each day.&nbsp;You must continue to take Ifirmasta until your doctor tells you otherwise.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Patients with high&nbsp;blood pressure<\/strong>The usual&nbsp;dose&nbsp;is 150 mg once daily (two tablets daily).&nbsp;The dose&nbsp;can then be increased to 300 mg (four tablets daily) once daily depending on the effect on&nbsp;blood pressure&nbsp;.<\/li><li><strong>Patients with high&nbsp;blood pressure&nbsp;and type 2&nbsp;diabetes&nbsp;with kidney disease<\/strong>In patients with high&nbsp;blood pressure&nbsp;and type 2&nbsp;diabetes&nbsp;, 300 mg (four tablets daily) once daily is preferred as the maintenance dose.<\/li><\/ul>\n\n\n\n<p>The doctor may, especially when starting treatment,&nbsp;prescribe&nbsp;a lower&nbsp;dose&nbsp;to certain patients e.g.&nbsp;those treated with&nbsp;<strong>hemodialysis<\/strong>, or those&nbsp;<strong>older than 75 years<\/strong>.<\/p>\n\n\n\n<p>Maximum reduction in blood pressure is obtained 4-6 weeks after starting treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Ifirmasta should not be given to children under 18 years of age.&nbsp;If a child swallows any tablets, contact a doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Ifirmasta than you should&nbsp;<\/h2>\n\n\n\n<p>If you accidentally take too many tablets, contact a doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Ifirmasta<\/h2>\n\n\n\n<p>If you accidentally skip a daily&nbsp;dose, just take the next&nbsp;dose&nbsp;normally.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;Some&nbsp;side effects&nbsp;can be serious and may require medical attention.<\/p>\n\n\n\n<p>As with similar medications, rare cases of allergic skin reactions (skin rash,&nbsp;hives&nbsp;), as well as local swelling of the face, lips, and\/or tongue have been reported in patients taking irbesartan.&nbsp;If you get any of these symptoms or if you have difficulty breathing, stop taking Ifirmasta and&nbsp;<strong>contact a doctor immediately<\/strong>.<\/p>\n\n\n\n<p>The frequency of&nbsp;side effects&nbsp;listed below is defined according to the following convention:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Very common: may affect more than 1 in 10 people<\/li><li>Common: may affect up to 1 in 10 patients<\/li><li>Uncommon: may affect up to 1 in 100 people<\/li><\/ul>\n\n\n\n<p>In&nbsp;clinical trials, the following&nbsp;adverse reactions were&nbsp;reported&nbsp;in patients treated with Ifirmasta:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Very common (may affect more than 1 in 10 people): if you have high&nbsp;blood pressure&nbsp;and type 2&nbsp;diabetes&nbsp;with kidney disease, blood tests may show an increased level of&nbsp;potassium&nbsp;.<\/li><li>Common (may affect up to 1 in 10 people): dizziness, nausea \/ vomiting, fatigue and blood tests may show increased levels of an&nbsp;enzyme&nbsp;that measures muscle and heart function (creatine kinase).&nbsp;In patients with high&nbsp;blood pressure&nbsp;and type 2&nbsp;diabetes&nbsp;with kidney disease, dizziness was reported when getting up from a lying or sitting position, low&nbsp;blood pressure&nbsp;when getting up from a lying or sitting position, and joint or muscle pain and decreased levels of a&nbsp;protein&nbsp;in the red&nbsp;blood cells&nbsp;(&nbsp;hemoglobin&nbsp;).<\/li><li>Uncommon (may affect up to 1 in 100 people): palpitations,&nbsp;redness&nbsp;, cough, diarrhea, indigestion \/ heartburn, impaired sexual ability and chest pain.<\/li><\/ul>\n\n\n\n<p>Some&nbsp;side effects&nbsp;have been reported since Ifirmasta hit the market.&nbsp;Side effects&nbsp;without known frequency are dizziness, headache, taste changes, ringing in the ears, muscle cramps, joint and muscle pain, decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;&#8211; symptoms may include fatigue, headache, shortness of breath when exercising, dizziness, and pallor), decreased number&nbsp;platelets, liver effects, increased potassium levels in the blood, impaired renal function,&nbsp;inflammation&nbsp;of fine blood vessels especially in the skin (a condition called leukocytoclastic&nbsp;vasculitis&nbsp;), severe allergic reactions (anaphylactic&nbsp;shock) and low blood sugar levels.&nbsp;Jaundice (yellowing of the skin and\/or whites of the eyes) has, as a less common&nbsp;side effect, also been reported.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Ifirmasta<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is irbesartan.Ifirmasta 75 mg: Each tablet contains 75 mg of irbesartan as irbesartan hydrochloride.Ifirmasta 150 mg: Each tablet contains 150 mg of irbesartan as irbesartan hydrochloride.Ifirmasta 300 mg: Each tablet contains 300 mg of irbesartan as irbesartan hydrochloride.<\/li><li>The other ingredients are mannitol, hydroxypropylcellulose, low-substituted hydroxypropylcellulose (&nbsp;LH-&nbsp;21), low-substituted hydroxypropylcellulose (&nbsp;LH-&nbsp;11), talc, macrogol 6000 and hydrogenated castor oil in the tablet core, polyvinyl alcohol, titanium dioxide (mac17), toluene, dioxin (film).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Ifirmasta film-coated tablets are white and oval<\/p>\n\n\n\n<p>Ifirmasta film-coated tablets: available in packs of 14, 28, 56, and 98 film-coated tablets in blisters and for packs of 56 x 1 film-coated tablets with perforated blisters.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n<p>TAD Pharma GmbH, Heinz-Lohmann-Stra\u00dfe 5, 27472 Cuxhaven, Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ifirmasta belongs to a group of medicines called angiotensin -II receptor antagonists. Angiotensin -II is a substance, which is produced in the body, and which binds to certain structures ( receptors ) in the blood vessels and causes them to constrict. This leads to increased blood pressure. Ifirmasta prevents the binding of angiotensin -II to these receptors, which causes the blood vessels to relax and the blood pressure to drop. Ifirmasta delays the deterioration of renal function in patients with high blood pressure and type 2 diabetes.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[13251,12373,13247,13252,13250,6850,6852,10172,13249,10173,13248,6853],"class_list":["post-14124","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-ifirmasta","tag-benefits-of-irbesartan","tag-ifirmasta","tag-ifirmasta-side-effects","tag-ifirmasta-tablet","tag-irbesartan","tag-irbesartan-side-effects","tag-irbesartan-tablet","tag-what-ifirmasta-is-used-for","tag-what-irbesartan-is-used-for","tag-what-is-ifirmasta","tag-what-is-irbesartan"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14124"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14124\/revisions"}],"predecessor-version":[{"id":15087,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14124\/revisions\/15087"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}