{"id":14067,"date":"2021-09-24T06:20:47","date_gmt":"2021-09-24T06:20:47","guid":{"rendered":"https:\/\/zeepedia.com\/?p=14067"},"modified":"2021-10-26T07:09:45","modified_gmt":"2021-10-26T07:09:45","slug":"ictady","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ictady\/","title":{"rendered":"Ictady &#8211; Tenofovir disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p>245 mg film-coated tablets<br>tenofovir disoproxil<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Ictady is and what it is used for<\/h2>\n\n\n\n<p>Ictady contains the active substance&nbsp;<em>tenofovir disoproxil succinate<\/em>.&nbsp;This active substance is an&nbsp;antiretroviral&nbsp;or antiviral medicine used to treat&nbsp;HIV&nbsp;or HBV&nbsp;infection&nbsp;or both.&nbsp;Tenofovir is a nucleotide-type&nbsp;reverse transcriptase inhibitor, commonly called an NRTI, and acts by affecting the normal function of&nbsp;enzymes&nbsp;(in&nbsp;HIV&nbsp;reverse transcriptase; in HBV&nbsp;DNA polymerase&nbsp;) as a&nbsp;virus&nbsp;needed for its reproduction (propagation).&nbsp;For&nbsp;HIV, Ictady should always be taken in combination with other anti-&nbsp;HIV&nbsp;medicines.<\/p>\n\n\n\n<p><strong>Ictady 245 mg tablets is a treatment for&nbsp;HIV&nbsp;&#8211;<\/strong>&nbsp;(human immunodeficiency virus)&nbsp;infection.&nbsp;The tablets are suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>adults<\/strong><\/li><li><strong>young people aged 12 to younger than 18 who have already been treated<\/strong>&nbsp;with other HIV drugs that can no longer be as effective because of resistance development, or have caused&nbsp;side effects&nbsp;are&nbsp;<strong>.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Ictady 245 mg tablets are also used to treat&nbsp;chronic&nbsp;hepatitis&nbsp;B, infection&nbsp;with HBV<\/strong>&nbsp;(&nbsp;hepatitis&nbsp;B&nbsp;virus&nbsp;).&nbsp;The tablets are suitable for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>adults<\/strong><\/li><li><strong>young people aged 12 to younger than 18 years<\/strong><\/li><\/ul>\n\n\n\n<p>You do not need to have&nbsp;HIV&nbsp;to be treated with Ictady for HBV.<\/p>\n\n\n\n<p>This medicine does not cure&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;While taking Ictady you may still develop&nbsp;infections&nbsp;you or other illnesses associated with&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;You can also pass on&nbsp;HIV&nbsp;or HBV to others, and it is therefore important that you take precautions to avoid infecting other people.<\/p>\n\n\n\n<p>Tenofovir disoproxil contained in Ictady may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before taking Ictady<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Ictady<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are allergic<\/strong>&nbsp;to tenofovir, tenofovir disoproxil succinate, or any of the other ingredients of this medicine listed in section 6.<\/li><\/ul>\n\n\n\n<p>If this applies to you,&nbsp;<strong>tell your doctor immediately and do not take Ictady.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Ictady.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Be careful not to infect other people.&nbsp;<\/strong>You can still transmit&nbsp;HIV&nbsp;infection while taking this medicine, although the risk of effective&nbsp;antiviral&nbsp;therapy is&nbsp;reduced&nbsp;.&nbsp;Discuss with your doctor the necessary steps to avoid infecting others.&nbsp;Ictady does not reduce the risk of transmitting HBV to others through sexual contact or blood transfusion.&nbsp;You still need to take precautions to avoid this.<\/li><li><strong>Talk to your doctor or pharmacist if you have a history of kidney disease or if tests have shown that you have kidney problems.&nbsp;<\/strong>Ictady should not be given to adolescents with kidney problems.&nbsp;Before starting treatment, your doctor may&nbsp;prescribe&nbsp;some blood tests to assess that your kidneys are functioning normally.&nbsp;Ictady may affect your kidneys during treatment.&nbsp;Your doctor may&nbsp;prescribe&nbsp;blood tests during treatment to check how your kidneys are working.&nbsp;If you are an adult, your doctor may advise you to take the tablets less often.&nbsp;Do not reduce the prescribed&nbsp;dose&nbsp;one unless your doctor tells you to.<\/li><\/ul>\n\n\n\n<p>Ictady is not usually taken with other medicines that can damage the kidneys (see&nbsp;<em>Other medicines and Ictady<\/em>&nbsp;).&nbsp;If this can not be avoided, your doctor will check your kidney function once a week.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Skeletal problem.&nbsp;<\/strong>Some adult&nbsp;HIV&nbsp;patients&nbsp;receiving&nbsp;combination&nbsp;antiretroviral&nbsp;therapy&nbsp;may develop a skeletal disease called&nbsp;osteonecrosis&nbsp;(bone tissue dies due to lost blood supply to the bone).&nbsp;Some of the many risk factors for developing the disease are: long-term&nbsp;antiretroviral&nbsp;combination therapy&nbsp;, use of&nbsp;corticosteroids&nbsp;, alcohol consumption, severe weakening of the immune system and higher body mass index.&nbsp;Signs of&nbsp;osteonecrosis&nbsp;are stiffness in the joints and pain (especially in the hip, knee and shoulders) and difficulty moving.&nbsp;Tell your doctor if you experience any of these symptoms.<br>Skeletal problems (which manifest as persistent or aggravated skeletal pain and sometimes lead to&nbsp;fractures&nbsp;) may also occur due to damage to renal tubules (see section 4,&nbsp;<em>Possible&nbsp;side effects&nbsp;)<\/em>&nbsp;.&nbsp;Tell your doctor if you have skeletal pain or a&nbsp;fracture&nbsp;.<br>Tenofovir disoproxil may also cause bone loss.&nbsp;The most pronounced loss of bone mass was seen in&nbsp;clinical trials&nbsp;when patients were treated with tenofovir disoproxil in combination with an enhanced&nbsp;protease inhibitor&nbsp;.<br>Overall, the effects of tenofovir disoproxil on long-term skeletal health and future fracture risk in adults and children are uncertain.<br>Tell your doctor if you know you have osteoporosis.&nbsp;Patients with osteoporosis are at higher risk for&nbsp;fractures&nbsp;.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Tell your doctor if you have or have had liver disease, including&nbsp;hepatitis&nbsp;.&nbsp;<\/strong>Patients with liver disease, including&nbsp;chronic&nbsp;hepatitis&nbsp;B or C, treated with antiretroviral agents are at increased risk of severe and potentially fatal liver complications.&nbsp;If you have&nbsp;hepatitis&nbsp;B, your doctor will carefully choose the best treatment for you.&nbsp;If you have or have had liver disease or&nbsp;chronic&nbsp;hepatitis&nbsp;B, your doctor may take blood samples to check your liver function.<\/li><li><strong>Be observant of&nbsp;infection&nbsp;is.&nbsp;<\/strong>If you have&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;in the advanced stage (&nbsp;AIDS&nbsp;) and have an&nbsp;infection&nbsp;, you may develop symptoms of&nbsp;infection&nbsp;and&nbsp;inflammation&nbsp;or worsening of the symptoms of an existing&nbsp;infection&nbsp;once treatment with Ictady begins.&nbsp;These symptoms may indicate that your body&#8217;s improved immune system is fighting&nbsp;infection&nbsp;.&nbsp;Be aware of signs of&nbsp;inflammation&nbsp;or&nbsp;infection&nbsp;during the first period after you start taking Ictady.&nbsp;If you notice signs of&nbsp;inflammation&nbsp;or&nbsp;infection,&nbsp;<strong>you should inform your doctor immediately.<\/strong><\/li><\/ul>\n\n\n\n<p>In addition to opportunistic&nbsp;infection,&nbsp;you can autoimmune disorders (conditions in which the immune system attacks healthy body tissue) may also occur after you start taking medicines to treat your&nbsp;HIV&nbsp;&#8211;&nbsp;infection.&nbsp;Autoimmune disorders can occur several months after starting treatment.&nbsp;If you notice any symptoms of&nbsp;infection&nbsp;or other symptoms such as muscle weakness, a weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, informs your doctor immediately for the necessary treatment.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Talk to your doctor or pharmacist if you are over 65 years old.&nbsp;<\/strong>Ictady has not been studied in patients over 65 years of age.&nbsp;If you are older than that and have been prescribed Ictady, your doctor will monitor you closely.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Ictady 245 mg tablets are&nbsp;<strong>suitable<\/strong>&nbsp;for:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>HIV-1&nbsp;-infected adolescents aged 12 to younger than 18 years who weigh at least 35 kg and who have already been treated<\/strong>&nbsp;with other&nbsp;HIV&nbsp;medicines that no longer have a satisfactory effect due to the development of resistance or have caused&nbsp;side effects&nbsp;.<\/li><li><strong>HBV-infected adolescents aged 12 years to younger than 18 years who weigh at least 35 kg<\/strong>&nbsp;.<\/li><\/ul>\n\n\n\n<p>Ictady 245 mg tablets are&nbsp;<strong>not<\/strong>&nbsp;suitable for the following groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Not for&nbsp;HIV&nbsp;-1 infected children<\/strong>&nbsp;under 12 years of age.<\/li><li><strong>Not for HBV-infected children<\/strong>&nbsp;under 12 years.<\/li><\/ul>\n\n\n\n<p>For&nbsp;dosage, see section 3,&nbsp;<em>How to take Ictady.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ictady<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Do not stop taking any&nbsp;HIV&nbsp;<\/strong>medicine prescribed by your doctor when you start taking Ictady, if you have both HBV and&nbsp;HIV&nbsp;.<\/li><li><strong>Do not take Ictady<\/strong>&nbsp;if you are already taking other medicines containing tenofovir disoproxil.&nbsp;Do not take Ictady with medicines containing adefovir dipivoxil (a medicine used to treat&nbsp;chronic&nbsp;hepatitis&nbsp;B).<\/li><li><strong>It is very important that you tell your doctor if you are taking other medicines that may damage your kidneys.<\/strong><br>Such drugs are:<ul><li>aminoglycosides&nbsp;, pentamidine or vancomycin (against bacterial&nbsp;infection&nbsp;),<\/li><li>amphotericin B (against fungal infection),<\/li><li>foscarnet, ganciclovir or cidofovir (for virus infection),<\/li><li>interleukin&nbsp;-2 (for the treatment of cancer),<\/li><li>adefovir dipivoxil (for HBV),<\/li><li>tacrolimus (for&nbsp;suppression&nbsp;of the immune system),<\/li><li>non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;, to relieve skeletal or muscle pain).<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Other medicines containing didanosine (for&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;):<\/strong>&nbsp;If you take Ictady with other antiviral medicines that contain didanosine, blood levels of didanosine and increase CD4 cell counts.&nbsp;Rare cases of pancreatitis and lactic acidosis (excess&nbsp;lactic acid&nbsp;in the blood), in some cases fatal, have been reported during concomitant treatment with drugs containing tenofovir disoproxil and didanosine.&nbsp;Your doctor will carefully consider whether you can be treated with a combination of tenofovir and didanosine.<\/li><li><strong>It is also important that you tell your doctor<\/strong>&nbsp;if you are taking ledipasvir \/ sofosbuvir to treat&nbsp;hepatitis&nbsp;C infection.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Ictady with food, drink and alcohol<\/h2>\n\n\n\n<p><strong>Take Ictady with food<\/strong>&nbsp;(eg a meal or a snack).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are pregnant, you should not take Ictady<\/strong>&nbsp;until you have specifically discussed this with your doctor.&nbsp;Although there are limited clinical data on the use of Ictady during pregnancy, it is not usually used unless absolutely necessary.<\/li><li><strong>If you are becoming<\/strong>&nbsp;or planning to become&nbsp;<strong>pregnant<\/strong>&nbsp;, you should contact your doctor to discuss the potential benefits and risks of your antiretroviral therapy for you and your baby.<\/li><li><strong>If you have taken Ictady<\/strong>&nbsp;during your pregnancy, your doctor may ask you to have regular blood tests and other diagnostic tests to check your baby&#8217;s development.&nbsp;For children with a&nbsp;mother&nbsp;who has taken medicines such as Ictady (NRTIs) during pregnancy, the benefit of&nbsp;HIV&nbsp;protection&nbsp;outweighs the&nbsp;risk of&nbsp;side effects&nbsp;.<\/li><li>If you are a mother and you have HBV, and your baby has been treated to prevent&nbsp;hepatitis&nbsp;B&nbsp;transmission&nbsp;at birth, you may be able to breast-feed your baby, but talk to your doctor first for more information.<\/li><li>If you are an&nbsp;HIV&nbsp;-infected mother, do not breast-feed your baby to avoid transmitting the&nbsp;virus&nbsp;to&nbsp;your&nbsp;baby through breast milk.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ictady may cause dizziness.&nbsp;<strong>Do not drive or cycle or<\/strong>&nbsp;use tools or machines if you feel dizzy while taking Ictady.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ictady contains lactose<\/h2>\n\n\n\n<p><strong>Talk to your doctor before taking Ictady<\/strong>&nbsp;if you are lactose intolerant or if you do not tolerate any sugar.<\/p>\n\n\n\n<p><strong>Ictady contains&nbsp;sodium<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg) per tablet, ie.&nbsp;is almost sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to take Ictady<\/h2>\n\n\n\n<p><strong>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;<\/strong>Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Adults:<\/strong>&nbsp;1 tablet a day with food (eg a meal or a snack).<\/li><li><strong>Adolescents aged 12 to younger than 18 years weighing at least 35 kg:<\/strong>&nbsp;1 tablet a day with food (eg a meal or a snack).<\/li><\/ul>\n\n\n\n<p>If you have particular difficulty swallowing, you can crush the tablet with the tip of a spoon.&nbsp;Then mix the powder with about 100 ml (half a glass) of water, orange juice, or grape juice and drink immediately.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Always take the&nbsp;dose&nbsp;prescribed<\/strong>&nbsp;by&nbsp;<strong>your&nbsp;<\/strong><strong>doctor<\/strong>&nbsp;to ensure that the medicine is effective and to reduce the development of&nbsp;resistance&nbsp;to treatment.&nbsp;Do not change the&nbsp;dose&nbsp;unless your doctor tells you to.<\/li><li><strong>If you are an adult and have kidney problems,<\/strong>&nbsp;your doctor may advise you to take Ictady less often.<\/li><li>If you have HBV, your doctor may offer you an&nbsp;HIV&nbsp;test to see if you have both HBV and&nbsp;HIV&nbsp;.&nbsp;<\/li><\/ul>\n\n\n\n<p>Read the package leaflets of the other antiretroviral medicines for information on how to take these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Ictady than you should<\/h2>\n\n\n\n<p>If you accidentally take too many tablets Ictady, you risk getting any&nbsp;side effects of this medicine (see section 4,&nbsp;Possible&nbsp;side effects).&nbsp;If you have ingested too much medicine or if e.g.&nbsp;If a child has accidentally ingested the medicine, contact your doctor, the nearest emergency department, or the Poison Information Center for risk assessment and advice.&nbsp;Save the jar so you can easily describe what you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Ictady<\/h2>\n\n\n\n<p>It is important that you do not miss any&nbsp;dose of&nbsp;Ictady.&nbsp;If you miss a&nbsp;dose, calculate when you should have taken it.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If less than 12 hours have passed<\/strong>&nbsp;since the time it is usually taken, take it as soon as possible, and then take the next&nbsp;dose&nbsp;at its usual time.<\/li><li><strong>If it has been more than 12 hours<\/strong>&nbsp;since you should have taken it, do not take the missed&nbsp;dose&nbsp;.&nbsp;Wait and take the next&nbsp;dose&nbsp;at its regular time.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/li><\/ul>\n\n\n\n<p><strong>If you vomit within less than 1 hour after a&nbsp;dose of&nbsp;Ictady,<\/strong>&nbsp;take a new tablet.&nbsp;You do not need to take a new tablet if you vomit more than 1 hour after taking Ictady.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Ictady<\/h2>\n\n\n\n<p>Do not stop taking Ictady without consulting a doctor.&nbsp;Discontinuation of Ictady treatment may result in a reduced effect of the treatment recommended by your doctor.<\/p>\n\n\n\n<p><strong>If you have&nbsp;hepatitis&nbsp;B or&nbsp;HIV&nbsp;&#8211;&nbsp;infection&nbsp;and&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;at the same time,<\/strong>&nbsp;it is very important not to stop Ictady treatment without first talking to your doctor.&nbsp;Some patients&#8217; blood tests or symptoms have shown that their&nbsp;hepatitis&nbsp;has worsened when treatment with Ictady is stopped.&nbsp;You may need to submit blood samples for several months after stopping treatment.&nbsp;In patients with advanced liver disease or&nbsp;cirrhosis, discontinuation of treatment is not recommended as this may lead to a worsening of hepatitis infection in some patients.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Talk to your doctor before stopping Ictady for any reason, especially if you experience any&nbsp;side effects&nbsp;or have any other illness.<\/li><li>Inform your doctor immediately about any new and unexpected symptoms that occur after stopping treatment, especially symptoms that you usually associate with your&nbsp;hepatitis&nbsp;B&nbsp;infection&nbsp;.<\/li><li>Contact your doctor before taking Ictady again.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood lipids, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.<\/p>\n\n\n\n<p><strong>Possible serious side effects: inform your doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Lactic acidosis<\/strong>&nbsp;(excess&nbsp;lactic acid&nbsp;in the blood) is a&nbsp;<strong>rare<\/strong>&nbsp;(&nbsp;<em>may occur in up to 1 in 1,000 patients<\/em>&nbsp;) but serious&nbsp;side effect&nbsp;that can be fatal.&nbsp;The following&nbsp;side effects&nbsp;may be signs of lactic acidosis:<ul><li>deep, rapid breathing<\/li><li>drowsiness<\/li><li>nausea, vomiting and abdominal pain<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If you think you may have&nbsp;<strong>lactic acidosis, contact your doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Other possible serious&nbsp;side effect&nbsp;s<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>uncommon<\/strong>&nbsp;(&nbsp;<em>they may affect up to 1 in 100 people<\/em>&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>pain in the stomach<\/strong>&nbsp;(abdomen) caused by&nbsp;inflammation&nbsp;of the pancreas<\/li><li>damage to the kidney (renal tubules)<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(&nbsp;<em>may affect up to 1 in 1,000 patients<\/em>&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney inflammation, that you&nbsp;<strong>urinate a lot and that you feel thirsty<\/strong><\/li><li><strong>changes in urine<\/strong>&nbsp;and&nbsp;<strong>back pain<\/strong>&nbsp;caused by kidney problems, including&nbsp;kidney failure<\/li><li>impaired bone hardness (which causes&nbsp;<strong>bone pain<\/strong>&nbsp;and sometimes leads to&nbsp;fractures&nbsp;), which can occur due to damage to kidney tubules<\/li><li><strong>fatty liver<\/strong><\/li><\/ul>\n\n\n\n<p><strong>If you think you may have any of these serious&nbsp;side effects, talk to your doctor.<\/strong><\/p>\n\n\n\n<p><strong>The most common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>very common<\/strong>&nbsp;(&nbsp;<em>side effects&nbsp;that occur in more than 10 in 100 patients<\/em>&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea, vomiting, nausea, dizziness, rash, feeling weak<em>Samples can also show:<\/em><ul><li>lowering of the phosphate content in the blood<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>common<\/strong>&nbsp;(&nbsp;<em>side effects&nbsp;that occur in up to 10 in 100 patients<\/em>&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache, abdominal pain, feeling tired, feeling bloated, gas<em>Samples can also show:<\/em><ul><li>liver problems<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>uncommon<\/strong>&nbsp;(&nbsp;<em>side effects&nbsp;that occur in up to 1 in 100 patients<\/em>&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>muscle breakdown, muscle pain or muscle weakness<em>Samples can also show:<\/em><ul><li>decreased potassium levels in the blood<\/li><li>elevated creatinine content in the blood<\/li><li>pancreatic problems<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Muscle breakdown decreased bone hardness (which causes bone pain and sometimes leads to&nbsp;fractures&nbsp;), muscle pain, muscle weakness, and decreased&nbsp;potassium&nbsp;or phosphate levels in the blood can occur due to damage to kidney tubules.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;are&nbsp;<strong>rare<\/strong>&nbsp;(&nbsp;<em>side effects&nbsp;that occur in up to 1 in 1,000 patients<\/em>&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain in the stomach (abdomen) caused by&nbsp;inflammation&nbsp;of the liver<\/li><li>swelling of the face, lips, tongue or throat<\/li><\/ul>\n\n\n\n<p><strong>Reporting of&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>If you get&nbsp;any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to&nbsp;side effects&nbsp;that are not mentioned in this information.&nbsp;You can also report&nbsp;side effects&nbsp;directly (see details below).&nbsp;By reporting&nbsp;side effects, you can help increase the safety of medicines.<\/p>\n\n\n\n<p>L\u00e4kemedelsverket, Box 26, 751 03 Uppsala<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Ictady<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the jar and carton after {EXP}.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Opened packaging must be used within 30 days and stored at a maximum of 25&nbsp;<sup>o<\/sup>&nbsp;C.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><strong>Content declaration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>The active substance is<\/strong>&nbsp;tenofovirEach Ictady tablet contains 245 mg of tenofovir disoproxil (as succinate).<\/li><li><strong>Other ingredients are:<\/strong>lactose&nbsp;, microcrystalline cellulose (E460), pregelatinised&nbsp;starch&nbsp;, croscarmellose sodium and magnesium stearate (E470b) which form the tablet core and indigo carmine (E132), titanium dioxide (E171), polyvinyl alcohol (E1203), macrogol talc (E1521 .&nbsp;See section 2 &#8220;Ictady contains lactose&#8221;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Ictady 245 mg film-coated tablets are light blue, almond-shaped, measuring approximately 17.0 mm x 10.5 mm.<\/p>\n\n\n\n<p>Ictady 245 mg film-coated tablets are supplied in cans containing 30 tablets.&nbsp;Each jar contains desiccant (silica gel) which must remain in the jar to protect the tablets.&nbsp;The desiccant (silica gel) is in a separate container and should not be swallowed.<\/p>\n\n\n\n<p>The following pack sizes are available:<\/p>\n\n\n\n<p>30 (1 x 30) film-coated tablets<\/p>\n\n\n\n<p>90 (3 x 30) film-coated tablets<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Rivopharm Ltd.<\/p>\n\n\n\n<p>17 Corrig Road<\/p>\n\n\n\n<p>Sandyford, Dublin 18<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Remedica Ltd<\/p>\n\n\n\n<p>Aharnon Street, Limassol Industrial Estate<\/p>\n\n\n\n<p>3056 Limassol<\/p>\n\n\n\n<p>Cyprus<\/p>\n\n\n\n<p><strong>Local representative<\/strong><\/p>\n\n\n\n<p>SanoSwiss UAB<\/p>\n\n\n\n<p>Lvovo 25-701<\/p>\n\n\n\n<p>LT-09320 Vilnius<\/p>\n\n\n\n<p>Lithuania<\/p>\n\n\n\n<p>info@sanoswiss.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ictady contains the active substance tenofovir disoproxil succinate. This active substance is an antiretroviral or antiviral medicine used to treat HIV or HBV infection or both. Tenofovir is a nucleotide-type reverse transcriptase inhibitor, commonly called an NRTI, and acts by affecting the normal function of enzymes (in HIV reverse transcriptase; in HBV DNA polymerase ) as a virus needed for its reproduction (propagation). For HIV, Ictady should always be taken in combination with other anti- HIV medicines.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[13328,13323,13324,13327,13329,3389,4331,4332,13326,13325,4330,13322],"class_list":["post-14067","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-ictady","tag-benefits-of-tenofovir-disoproxil","tag-ictady","tag-ictady-tablet","tag-side-effects-of-ictady","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-side-effects","tag-tenofovir-disoproxil-tablet","tag-what-ictady-is-used-for","tag-what-is-ictady","tag-what-is-tenofovir-disoproxil","tag-what-tenofovir-disoproxil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14067","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14067"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14067\/revisions"}],"predecessor-version":[{"id":15107,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14067\/revisions\/15107"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}