15 mg, 30 mg, 45 mg film-coated tablets
ponatinib<\/p>\n\n\n\n
Iclusig is used to treat<\/strong> adults with the following types of leukemia<\/strong> who no longer benefit from treatment with other drugs or have a specific genetic disorder called a T315I mutation:<\/p>\n\n\n\n Iclusig belongs to a group of medicines called tyrosine kinase inhibitors. In patients with CML and Ph + ALL, changes in the DNA (genome) trigger a signal that tells the body to produce abnormal white blood cells. Iclusig blocks this signal, thereby stopping the production of these cells.<\/p>\n\n\n\n Talk to your doctor or pharmacist before taking Iclusig if you have<\/p>\n\n\n\n The doctor takes\/performs:<\/p>\n\n\n\n A condition in the brain called posterior reversible encephalopathy syndrome (PRES) has been reported in patients treated with ponatinib. Symptoms include sudden, severe headaches, confusion, seizures, and vision changes. Talk to your doctor immediately if you experience any of these symptoms during treatment with ponatinib, as it may be serious.<\/p>\n\n\n\n Do not give this medicine to children under 18 years of age as there are no data available for children.<\/p>\n\n\n\n Tell your doctor or pharmacist if you have recently taken or might take any other medicines.<\/p>\n\n\n\n The following medicines may affect or be affected by Iclusig:<\/p>\n\n\n\n Avoid grapefruit products, e.g. grapefruit juice.<\/p>\n\n\n\n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n You should be especially careful when driving or using machines as patients taking Iclusig may experience visual disturbances, dizziness, drowsiness, and fatigue.<\/p>\n\n\n\n If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n Always take this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n Iclusig treatment should be prescribed by a doctor who has experience in the treatment of leukemia.<\/p>\n\n\n\n Iclusig is available as:<\/p>\n\n\n\n The recommended starting dose is<\/strong> a 45 mg film-coated tablet once daily.<\/p>\n\n\n\n <\/strong>Your doctor may reduce<\/strong> your dose or ask you to temporarily stop taking Iclusig if:<\/p>\n\n\n\n Iclusig treatment can be resumed with the same dose or a lower dose when a side effect has passed or is under control. Your doctor may evaluate your response to treatment at regular intervals.<\/p>\n\n\n\n Method of use<\/strong><\/p>\n\n\n\n Swallow the tablets whole with a glass of water. The tablets can be taken with or without food. The tablets must not be crushed or dissolved.<\/p>\n\n\n\n Do not swallow the container with desiccant contained in the bottle.<\/p>\n\n\n\n Usage time<\/strong><\/p>\n\n\n\n You must take Iclusig every day for as long as it is prescribed. This is a long-term treatment.<\/p>\n\n\n\n Talk to your doctor immediately if this happens.<\/p>\n\n\n\n Do not take a double dose to make up for a forgotten dose. Take the next dose at the usual time.<\/p>\n\n\n\n Do not stop taking Iclusig without your doctor’s permission.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n Patients over the age of 65 are more likely to experience side effects.<\/p>\n\n\n\n Seek medical attention immediately if you get any of the following serious side effects.<\/strong><\/p>\n\n\n\n If you get any abnormal results from blood tests, contact your doctor immediately.<\/p>\n\n\n\n Serious adverse s<\/strong> ( common:<\/strong> may affect up to 1 in 10):<\/p>\n\n\n\n Other<\/strong> possible side effects that may occur with the following frequencies are:<\/p>\n\n\n\n Very common side effects<\/strong> are (can occur in more than 1 in 10):<\/p>\n\n\n\n Common side effects are<\/strong> (may affect up to 1 in 10):<\/p>\n\n\n\n Less common side effects are<\/strong> (may affect up to 1 in 100):<\/p>\n\n\n\n No known frequency<\/strong> (can not be calculated from the available data)<\/p>\n\n\n\n Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist, or nurse. This also applies to any side effects not mentioned in this information. You can also report side effects directly to the Medical Products Agency. By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the can label and carton after EXP. dat. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Store in the original package. Sensitive to light.<\/p>\n\n\n\n The jar contains a sealed plastic container that contains a desiccant in the form of a molecular sieve. The container must remain in the jar. Do not swallow the container with desiccant.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Iclusig film-coated tablets are white, round, and rounded on the top and bottom.<\/p>\n\n\n\n Iclusig 15 mg film-coated tablets are approximately 6 mm in diameter with \u201cA5\u201d on one side.<\/p>\n\n\n\n Iclusig 30 mg film-coated tablets are approximately 8 mm in diameter with \u201cC7\u201d on one side.<\/p>\n\n\n\n Iclusig 45 mg film-coated tablets are approximately 9 mm in diameter with \u201cAP4\u201d on one side.<\/p>\n\n\n\n Iclusig is supplied in plastic jars, each containing a container with a desiccant in the form of a molecular sieve. The jars are packed in a box.<\/p>\n\n\n\n Cans of Iclusig 15 mg contain either 30, 60, or 180 film-coated tablets.<\/p>\n\n\n\n Cans of Iclusig 30 mg contain 30 film-coated tablets.<\/p>\n\n\n\n Cans of Iclusig 45 mg contain either 30 or 90 film-coated tablets.<\/p>\n\n\n\n Not all pack sizes may be marketed.<\/p>\n\n\n\n Incyte Biosciences Distribution BV<\/p>\n\n\n\n Paasheuvelweg 25<\/p>\n\n\n\n 1105 BP Amsterdam<\/p>\n\n\n\n Netherlands<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n Haupt Pharma Amareg GmbH<\/p>\n\n\n\n Donaustaufer Str. 378<\/p>\n\n\n\n 93055 Regensburg Incyte Biosciences Distribution BV<\/p>\n\n\n\n Paasheuvelweg 25<\/p>\n\n\n\n 1105 BP Amsterdam<\/p>\n\n\n\n Netherlands<\/p>\n\n\n\n Tjoapack Netherlands BV 4879 AC Etten-Leur Iclusig is used to treat adults with the following types of leukemia who no longer benefit from treatment with other drugs or have a specific genetic disorder called a T315I mutation:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[13359,13354,13356,13360,13350,13355,13353,13358,13357,13351,13352],"class_list":["post-14061","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-iclusig","tag-benefits-of-ponatinib","tag-iclusig","tag-iclusig-side-effects","tag-ponatinib","tag-ponatinib-side-effects","tag-ponatinib-tablet","tag-wat-iclusig-is-used-for","tag-what-is-iclusig","tag-what-is-ponatinib","tag-what-ponatinib-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14061"}],"version-history":[{"count":6,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14061\/revisions"}],"predecessor-version":[{"id":15111,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14061\/revisions\/15111"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}2. What you need to know before taking Iclusig<\/h2>\n\n\n\n
Do not take Iclusig<\/h2>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
A serum protein called lipase will be checked every two weeks for the first 2 months and then regularly. You may need to discontinue treatment or reduce the dose of Iclusig if your lipase level is high.<\/li>
tests Liver function tests will be performed regularly according to your doctor’s instructions.<\/li><\/ul>\n\n\n\nChildren and young people<\/h2>\n\n\n\n
Other drugs and Iclusig<\/h2>\n\n\n\n
Iclusig with food and drink<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Use Iclusig during pregnancy only if your doctor tells you it is absolutely necessary<\/strong> , as there is a potential risk to the unborn baby.<\/li>
Stop breast-feeding during treatment with Iclusig. It is not known if Iclusig passes into breast milk.<\/li><\/ul>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
Iclusig contains lactose<\/h2>\n\n\n\n
How to take Iclusig<\/h2>\n\n\n\n
If you take more Iclusig than you should<\/h2>\n\n\n\n
If you forget to take Iclusig<\/h2>\n\n\n\n
If you stop taking Iclusig<\/h2>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
5. How to store Iclusig<\/h2>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n
Germany<\/p>\n\n\n\n
Nieuwe Donk 9<\/p>\n\n\n\n
Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"