Method of administration<\/strong><\/p>\n\n\n\nFor intravenous use. The solution should be given as an intravenous infusion over 30 minutes.<\/p>\n\n\n\n
Inspect the solution before use. The solution should be discarded if particles are visible.<\/p>\n\n\n\n
If you are given too much Ibuprofen B. Braun<\/h2>\n\n\n\n
Because the dose is controlled by a doctor or nurse, it is unlikely that you will receive too much of the solution. If you have ingested too much medicine or if e.g. If a child has ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n
Symptoms may include nausea, stomach pain, vomiting (with blood), headache, ringing in the ears, confusion, lack of coordination ( ataxia ), and jerky involuntary eye movements. At high doses, drowsiness, chest pain, palpitations, unconsciousness, seizures (mainly in children), weakness and dizziness, blood in the urine, chills, and difficulty breathing have been reported.<\/p>\n\n\n\n
You may also have low blood pressure, bluish discoloration of the skin or mucous membranes (cyanosis), bleeding in the stomach or intestines, and problems with liver or kidney function.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n
Side effects can be minimized by using the lowest effective dose for the shortest possible time needed to treat the symptoms. You may experience one or more of the known side effects of NSAIDs (see below). If you experience any of these side effects, stop taking this medicine and contact your doctor as soon as possible.<\/p>\n\n\n\n
The most commonly observed side effects affect the stomach and intestines. Peptic ulcers (ulcers in the stomach or intestines), holes in the gastrointestinal wall ( perforation ), or bleeding from the stomach or intestines, sometimes life-threatening, may occur. Indigestion, tar-like stools, bloody vomiting, inflammation of the mucous membranes of the mouth with ulceration (ulcerative stomatitis ), worsening inflammation of the colon ( colitis ), and Crohn’s disease have been reported. Gastritis ( gastritis ) has been observed in less common cases. In particular, the risk of gastrointestinal bleeding depends on the dose range and duration of treatment.<\/p>\n\n\n\n
Fluid accumulation in the tissues ( edema ), high blood pressure, and heart failure have been reported in association with NSAID treatment. Drugs such as ibuprofen may be associated with a small increased risk of heart attack (heart attack) or stroke.<\/p>\n\n\n\n
Very rare cases of severe allergic reactions (including infusion site reactions, anaphylactic shock ) and severe side effects on the skin such as Bladder-forming reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis ( Lyell’s syndrome ), erythema multiforme, and allergic inflammation of blood vessels have been reported.<\/p>\n\n\n\n
Very rare cases of exacerbation of inflammation associated with infection (eg development of a tissue-destroying disease called necrotizing fasciitis) that coincide with the use of NSAIDs have been reported. <\/p>\n\n\n\n
In rare cases, severe skin infections and soft tissue complications can occur during a chickenpox infection.<\/p>\n\n\n\n
Very common side effects (may affect more than 1 in 10 people):<\/u><\/em><\/p>\n\n\n\n- Fatigue or insomnia, headache and dizziness.<\/li>
- Heartburn, abdominal pain, nausea, vomiting, flatulence, diarrhea, constipation and minor blood loss in the stomach and intestines which in some cases can cause anemia .<\/li><\/ul>\n\n\n\n
Common side effects (may affect up to 1 in 10 people):<\/u><\/em><\/p>\n\n\n\n- Dizziness.<\/li>
- Skin reaction.<\/li>
- Pain and burning sensation at the site of administration.<\/li>
- Ulcers in the gastrointestinal tract, possibly with bleeding and perforation . Mouth inflammation with ulcers (ulcerative stomatitis ), exacerbated colitis ( colitis ) and Crohn’s disease .<\/li><\/ul>\n\n\n\n
Uncommon side effects (may affect up to 1 in 100 people):<\/u><\/em><\/p>\n\n\n\n- Difficulty sleeping, agitation, irritability or fatigue, anxiety and restlessness.<\/li>
- Visual disturbances.<\/li>
- Earrings ( tinnitus ).<\/li>
- Decreased urine production and, especially in patients with high blood pressure or kidney problems, symptoms caused by kidney damage ( nephrotic syndrome ), interstitial kidney inflammation that may be accompanied by acute renal failure .<\/li>
- Hives, itching , red spots on the skin (including allergic purpura), skin rash.<\/li>
- Allergic reactions with rash and itching , as well as asthma attacks (possibly with a drop in blood pressure).<\/li><\/ul>\n\n\n\n
Rare side effects (may affect up to 1 in 1,000 people):<\/u><\/em><\/p>\n\n\n\n- Reversible double vision (toxic amblyopia).<\/li>
- Hearing loss.<\/li>
- Narrowing of the esophagus (blood vessels in the esophagus), complications with pockets in the colon, nonspecific bleeding colon inflammation characterized by severe cramps and diarrhea. Bleeding in the stomach or intestines can cause anemia .<\/li>
- Damage to kidney tissue (papillary necrosis ) especially during long-term treatment, increased serum uric acid concentration .<\/li>
- Yellow skin and whites of the eyes, liver disorder, liver damage, especially when long term therapy, acute liver inflammation ( hepatitis ).<\/li>
- Psychotic reactions, nervousness, irritability, confusion or disorientation and depression.<\/li>
- Neck stiffness.<\/li><\/ul>\n\n\n\n
Very rare side effects (may affect up to 1 in 10,000 people):<\/u><\/em><\/p>\n\n\n\n- Blood disorders ( anemia , leukopenia , thrombocytopenia , pancytopenia, agranulocytosis ). The first symptoms are: fever, sore throat, superficial sores in the mouth, flu-like symptoms , severe fatigue, nosebleeds and bleeding in the skin.<\/li>
- Rapid heart rate (palpitations), heart failure , heart attack.<\/li>
- High blood pressure .<\/li>
- Aseptic meningitis (neck stiffness, headache, nausea, vomiting, fever or confusion). Patients with autoimmune diseases ( SLE , mixed connective tissue diseases) appear to be more sensitive.<\/li>
- Inflammation of the esophagus (esophagus) or pancreas, constriction of the intestine.<\/li>
- Hair loss.<\/li>
- Photosensitivity and allergic inflammation of blood vessels.<\/li>
- Asthma , difficulty breathing (bronchial spasm), shortness of breath and wheezing.<\/li>
- An autoimmune disease called systemic lupus erythematosus, severe allergic reaction ( edema of the face, swelling of the tongue, swelling of the throat with contraction of the airways, difficulty breathing, rapid heart rate, drop in blood pressure and life-threatening shock ).<\/li><\/ul>\n\n\n\n
Has been reported (occurs in an unknown number of users)<\/u><\/em><\/p>\n\n\n\n- Hepatic impairment.<\/li>
- Injection site reactions, e.g. swelling, bruising or bleeding.<\/li>
- A severe skin reaction called DRESS syndrome can occur. Symptoms of DRESS include: rash, fever, swollen lymph nodes and an increase in eosinophils (a type of white blood cell ).<\/li>
- Widespread red, scaly rash with bumps under the skin and blisters mainly in the folds of the skin, on the torso and arms together with fever at the beginning of the treatment ( acute generalized exanthematous pustulosis ). Stop using Ibuprofen B. Braun immediately if you develop these symptoms and seek medical attention immediately. See also section 2.<\/li><\/ul>\n\n\n\n
Reporting of side effects<\/em><\/p>\n\n\n\nIf you get any side effects, talk to your doctor, pharmacist, or nurse. This also applies to any side effects not mentioned in this information. You can also report side effects directly to the Medical Products Agency. By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n
5. How to store Ibuprofen B. Braun<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
No special storage instructions.<\/p>\n\n\n\n
Do not use immediately after opening. Do not use this medicine if you notice any particles.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the label after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n- The active substance is ibuprofen . One ml of solution contains 4 mg of ibuprofen . One 50 ml bottle contains 200 mg of ibuprofen .<\/li>
- The other ingredients are L- arginine , sodium chloride, hydrochloric acid (for pH adjustment ), sodium hydroxide (for pH adjustment ), water for injections.<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Clear and colorless to pale yellow infusion solution, without any particles.<\/p>\n\n\n\n
The solution is available in sealed 50 ml LDPE bottles with Twin cap lids. The pack sizes are 10 bottles and 20 bottles.<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n
B. Braun Melsungen AG<\/p>\n\n\n\n
Carl-Braun-Stra\u00dfe 1<\/p>\n\n\n\n
34212 Melsungen, Germany<\/p>\n\n\n\n
Postal address:
34209 Melsungen, Germany<\/p>\n\n\n\n
Manufacturer<\/strong><\/p>\n\n\n\nB. Braun Medical, SA<\/p>\n\n\n\n
Ctra. Terrasa, 121<\/p>\n\n\n\n
Rub\u00ed<\/p>\n\n\n\n
08191 Barcelona<\/p>\n\n\n\n
Spain<\/p>\n\n\n\n
Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n
B. Braun Medical AB<\/p>\n\n\n\n
Box 110<\/p>\n\n\n\n
182 12 Danderyd<\/p>\n","protected":false},"excerpt":{"rendered":"
Ibuprofen belongs to a group of medicines called non-steroidal anti-inflammatory drugs or NSAIDs.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[5320,13361],"class_list":["post-14057","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-ibuprofen","tag-whajt-is-ibuprofen"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14057"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14057\/revisions"}],"predecessor-version":[{"id":15136,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14057\/revisions\/15136"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}