75 mg, 100 mg, 125 mg film-coated tablets
palbociclib (palbociclib.)<\/p>\n\n\n\n
IBRANCE is a cancer medicine that contains the active substance palbociclib.<\/p>\n\n\n\n
Palbociclib works by blocking proteins called cyclin-dependent kinases 4 and 6 which regulate cell growth and division. When these proteins are blocked, the growth of cancer cells can be slowed down so that the disease develops more slowly.<\/p>\n\n\n\n
IBRANCE is used to treat patients with a certain type of breast cancer<\/p>\n\n\n\n
(hormone receptor-positive, human epidermal growth factor receptor 2 \u2011 negative) which has spread outside the original tumor one and\/or to other organs. It is given together with aromatase inhibitors or fulvestrant, which are hormone treatments for cancer.<\/p>\n\n\n\n
Talk to your doctor, pharmacist, or nurse before taking IBRANCE.<\/p>\n\n\n\n
IBRANCE can reduce the number of white blood cells and weaken your immune system. Therefore, the risk of getting an infection while taking IBRANCE may increase.<\/p>\n\n\n\n
Tell your doctor, pharmacist, or nurse if you get any signs or symptoms of an infection, such as chills or fever.<\/p>\n\n\n\n
Blood samples are taken regularly during treatment to see if IBRANCE affects your blood cells (white and red blood cells and platelets ).<\/p>\n\n\n\n
IBRANCE can cause severe or life-threatening inflammation of the lungs during treatment, which can lead to death. Tell your healthcare provider immediately if you experience new or worsening symptoms that include:<\/p>\n\n\n\n
Children and young people<\/strong><\/p>\n\n\n\n IBRANCE should not be used in children or adolescents (under 18 years of age).<\/p>\n\n\n\n Other medicines and IBRANCE<\/strong><\/p>\n\n\n\n Tell your doctor or pharmacist if you have recently taken or might take any other medicines. IBRANCE may affect the way other medicines work.<\/p>\n\n\n\n In particular, the following medicines may increase the risk of side effects of IBRANCE:<\/p>\n\n\n\n The following medicines may increase the risk of side effects if taken with IBRANCE:<\/p>\n\n\n\n The following medicines may reduce the effect of IBRANCE:<\/p>\n\n\n\n IBRANCE tablets can be taken with or without food.<\/p>\n\n\n\n Avoid grapefruit and grapefruit juice while taking IBRANCE as it may increase the side effects of IBRANCE.<\/p>\n\n\n\n You should not use IBRANCE if you are pregnant.<\/p>\n\n\n\n You should avoid getting pregnant while taking IBRANCE.<\/p>\n\n\n\n Discuss contraception with your doctor if there is a risk that you or your partner may become pregnant.<\/p>\n\n\n\n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n Women of childbearing potential receiving this medicine, or their male partner, should use appropriate contraception (eg two barrier methods such as condoms and diaphragms ). These contraceptives should be used during treatment and for at least 3 weeks after the end of treatment for women and 14 weeks for men.<\/p>\n\n\n\n Breast-feeding Fertility Men should therefore consider sperm storage before taking IBRANCE.<\/p>\n\n\n\n Fatigue is a very common side effect of IBRANCE. If you feel unusually tired, take special care when driving or using machines.<\/strong><\/p>\n\n\n\n Always take this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n The recommended dose of IBRANCE is 125 mg once daily for 3 weeks, followed by 1 week when you are not taking IBRANCE. Your doctor will tell you how many IBRANCE tablets to take.<\/p>\n\n\n\n If you get some side effect is when you take IBRANCE (see section 4 “Possible side effects”) may be the physician lower the dose of one or stop treatment, either temporarily or completely. Dose one can be reduced to one of the other available strengths, 100 mg or 75 mg.<\/p>\n\n\n\n Take IBRANCE once a day, at about the same time each day, with or without food.<\/p>\n\n\n\n Swallow the tablet whole with a glass of water. The tablets should not be chewed or crushed. Do not divide the tablets before swallowing them. Do not take a tablet that is broken, cracked, or otherwise intact.<\/p>\n\n\n\n If you have taken too much IBRANCE, see a doctor or go to the hospital immediately. You may need emergency treatment.<\/p>\n\n\n\n Take the carton and this leaflet with you so that your doctor knows what you have taken.<\/p>\n\n\n\n If you miss a dose or vomit it up, take the next dose as planned. Do not take a double dose to make up for a forgotten tablet.<\/p>\n\n\n\n Do not stop taking IBRANCE unless your doctor tells you to.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n Contact your doctor immediately if you get any of the following symptoms:<\/p>\n\n\n\n Other side effects of IBRANCE can be:<\/p>\n\n\n\n Very <\/strong>common side effects (may affect more than 1 user in 10):<\/strong><\/p>\n\n\n\n Infection is.<\/p>\n\n\n\n Decreased number of white blood cells, red blood cells, and platelets.<\/p>\n\n\n\n Fatigue.<\/p>\n\n\n\n Decreased appetite.<\/p>\n\n\n\n Inflammation of the mouth and lips ( stomatitis ), nausea, vomiting, diarrhea.<\/p>\n\n\n\n Rash.<\/p>\n\n\n\n Hair loss.<\/p>\n\n\n\n Weakness.<\/p>\n\n\n\n Fever.<\/p>\n\n\n\n Abnormal liver function values \u200b\u200bin blood samples.<\/p>\n\n\n\n Dry skin.<\/p>\n\n\n\n Common side effects (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n Fever with decreased white blood cell count (febrile neutropenia )<\/p>\n\n\n\n Blurred vision, watery eyes, dry eyes.<\/p>\n\n\n\n Taste change ( dysgeusia ).<\/p>\n\n\n\n Nasal blood<\/p>\n\n\n\n Uncommon side effects (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n Inflammation of the skin causes red, scaly patches and which may occur together with pain in joints and fever ( cutaneous lupus erythematosus [CLE]).<\/p>\n\n\n\n Reporting of side effects<\/em><\/p>\n\n\n\n If you get any side effects, talk to your doctor, pharmacist, or nurse. This also applies to any side effects not mentioned in this information. You can also report side effects directly to the Medical Products Agency. By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the blister and carton after \u201cEXP\u201d. The expiration date is the last day of the specified month.<\/p>\n\n\n\n No special temperature instructions. Store in the original blister. Moisture sensitive.<\/p>\n\n\n\n Do not use this medicine if you notice that the packaging is damaged or appears to have been tampered with.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n Film coating: hypromellose (E464), titanium dioxide (E171), triacetin, indigo carmine aluminum lacquer (E132), red iron oxide (E172) (only 75 mg and 125 mg tablets), yellow iron oxide (E172) (only 100 mg tablets).<\/p>\n\n\n\n IBRANCE 75 mg, 100 mg, and 125 mg are available in blister packs containing 21 or 63 tablets in a carton.<\/p>\n\n\n\n IBRANCE 75 mg, 100 mg, and 125 mg are supplied in blister cards of 7 tablets (1 tablet per cell) in a wallet pack. Each carton contains 21 tablets (3 wallet packs per carton).<\/p>\n\n\n\n Not all pack sizes may be marketed.<\/p>\n\n\n\n Pfizer Europe MA EEIG<\/p>\n\n\n\n Boulevard de la Plaine 17<\/p>\n\n\n\n 1050 Brussels<\/p>\n\n\n\n Belgium<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n Pfizer Manufacturing Deutschland GmbH<\/p>\n\n\n\n Establishment Freiburg<\/p>\n\n\n\n Mooswaldallee 1<\/p>\n\n\n\n Germany<\/p>\n\n\n\n Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n IBRANCE is a cancer medicine that contains the active substance palbociclib.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,12116],"tags":[13403,13396,13398,13401,13392,13397,13395,13402,13400,13399,13393,13394],"class_list":["post-14047","post","type-post","status-publish","format-standard","hentry","category-medicines","category-i","tag-benefits-of-ibrance","tag-benefits-of-palbociclib","tag-ibrance","tag-ibrance-tablet","tag-palbociclib","tag-palbociclib-side-effects","tag-palbociclib-tablet","tag-side-effects-of-ibrance","tag-what-ibrance-is-used-for","tag-what-is-ibrance","tag-what-is-palbociclib","tag-what-palbociclib-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=14047"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14047\/revisions"}],"predecessor-version":[{"id":15141,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/14047\/revisions\/15141"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=14047"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=14047"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=14047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}IBRANCE with food, drink and alcohol<\/h2>\n\n\n\n
Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n
You should not breastfeed while taking IBRANCE. It is not known whether IBRANCE is excreted in human milk.<\/p>\n\n\n\n
Palbociclib may reduce male fertility.<\/p>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
3. How to take IBRANCE<\/h2>\n\n\n\n
If you take more IBRANCE than you should<\/h2>\n\n\n\n
If you forget to take IBRANCE<\/h2>\n\n\n\n
If you stop taking IBRANCE<\/h2>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
5. How to store IBRANCE<\/h2>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
Tablet core: microcrystalline cellulose, colloidal silica, crospovidone, magnesium stearate, succinic acid.<\/li><\/ul>\n\n\n\nWhat the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Belgique \/ Belgi\u00eb \/ Belgien<\/strong>Pfizer SA \/ NVTel: +32 (0) 2 554 62 11<\/td> Lithuania<\/strong>Pfizer Luxembourg SARL branches in LithuaniaTel. + 370 52 51 4000<\/td><\/tr> Bulgaria<\/strong>Pfizer Luxembourg SAR, Clone of BulgariaTel: +359 2 970 4333<\/td> Luxembourg \/ Luxemburg<\/strong>Pfizer SATel: +32 (0) 2 554 62 11<\/td><\/tr> Czech Republic<\/strong>Pfizer, spol. s roTel .: + 420-283-004-111<\/td> Hungary<\/strong>Pfizer Kft.Tel .: + 36-1-488-37-00<\/td><\/tr> Denmark<\/strong>Pfizer ApSTel: +45 44 20 11 00<\/td> Malta<\/strong>Vivian Corporation Ltd.Tel: +356 21344610<\/td><\/tr> Germany<\/strong>Pfizer Pharma GmbHTel: +49 (0) 30 550055 51000<\/td> The Netherlands<\/strong>Pfizer BVTel: +31 (0) 10 406 43 01<\/td><\/tr> Eesti<\/strong>Pfizer Luxembourg SARL Eesti subsidiaryTel: +372 666 7500<\/td> Norway<\/strong>Pfizer ASTel: +47 67 52 61 00<\/td><\/tr> Greece<\/strong>Pfizer A\u03bb\u03bb\u03ac\u03c2 AE:\u0397\u03bb: +30 210 6785 800<\/td> Austria<\/strong>Pfizer Corporation Austria Ges.mbHTel: +43 (0) 1 521 15-0<\/td><\/tr> Spain<\/strong>Pfizer, SLTel: +34 91 490 99 00<\/td> Poland<\/strong>Pfizer Polska Sp. z ooTel .: +48 22 335 61 00<\/td><\/tr> France<\/strong>PfizerTel: +33 (0) 1 58 07 34 40<\/td> Portugal<\/strong>Pfizer Laboratories, Lda.Tel: +351 21 423 5500<\/td><\/tr> Croatia<\/strong>Pfizer Croatia dooTel: + 385 1 3908 777<\/td> Romania<\/strong>Pfizer Romania SRLTel: +40 (0) 21 207 28 00<\/td><\/tr> Ireland<\/strong>Pfizer Healthcare IrelandTel: 1800 633 363 (toll free)+44 (0) 1304 616161<\/td> Slovenia<\/strong>Pfizer Luxembourg SARLPfizer, a company in the field of pharmaceuticals, LjubljanaTel .: + 386 (0) 1 52 11 400<\/td><\/tr> Iceland<\/strong>Icepharma hf.Phone: +354 540 8000<\/td> Slovak Republic<\/strong>Pfizer Luxembourg SARL, organizerTel .: + 421 2 3355 5500<\/td><\/tr> Italy<\/strong>Pfizer SrlTel: +39 06 33 18 21<\/td> Finland \/ Finland<\/strong>Pfizer OyPuh.\/Tel: +358 (0) 9 43 00 40<\/td><\/tr> \u038e\u03c0\u03c1\u03bf\u03c2<\/strong>Pfizer \u0391\u03bb\u03bb\u03ac\u03c2 \u0391.\u0395. (Cyprus Branch)T\u03b7\u03bb + 357 22 817690<\/td> Sweden<\/strong>Pfizer ABTel: +46 (0) 8 550 520 00<\/td><\/tr> Latvia<\/strong>Pfizer Luxembourg SARL subsidiary Latvij\u0101Tel .: + 371 670 35 775<\/td> United Kingdom (Northern Ireland)<\/strong>Pfizer LimitedTel: +44 (0) 1304 616161<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"