folic acid<\/a> deficiency and therefore your doctor may recommend regular check-ups of your folic acid levels.<\/p>\n\n\n\nIt is important to drink plenty of fluids during treatment.<\/p>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
The safety and efficacy of Hydrea in children have not been established.<\/p>\n\n\n\n
Other medicines and Hydrea<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you have recently taken or might take any other medicines. The treatment effect may be affected if this medicine is taken at the same time as certain other medicines. The treating physician, therefore, needs to be aware of such concomitant medication.<\/p>\n\n\n\n
Concomitant use of Hydrea with other drugs that affect the bone marrow (eg chemotherapy ) or radiation therapy may increase the risk of certain side effects.<\/p>\n\n\n\n
Concomitant use of Hydrea and live vaccines is not recommended as it may increase the side effects of the vaccine and increase the risk of serious infection as the body’s normal defense mechanisms may be impaired by treatment with Hydrea.<\/p>\n\n\n\n
Hydrea can increase the concentration of uric acid in the blood. Dose one of the drugs used against high levels of uric acid, e.g. allopurinol, may therefore need to be changed.<\/p>\n\n\n\n
In patients treated with Hydrea in combination with HIV – infection (didanosine, stavudine), inflammation of the pancreas and liver damage (in some cases, these side effects have led to death), as well as nerve effects in the hands and feet ( peripheral neuropathy ),.<\/p>\n\n\n\n
Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n
You should avoid becoming pregnant while being treated with Hydrea.<\/p>\n\n\n\n
Risk of fetal harm. Hydrea should not be used during pregnancy except on strict prescription by a doctor.<\/p>\n\n\n\n
Due to the risk of serious side effects in the baby, Hydrea should not be used during breastfeeding. If your doctor thinks that treatment is necessary, you should stop breastfeeding during treatment with Hydrea.<\/p>\n\n\n\n
Men<\/em>
Sperm production can be affected. Before treatment, the possibility of preserving semen should be considered. Hydroxycarbamide can be harmful to DNA, the genetic material in the cells. It is recommended that you use a safe method of contraception during treatment and for at least one year after stopping treatment.<\/p>\n\n\n\nDriving and using machines<\/h2>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention. One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects. Descriptions of these effects and side effects can be found in other sections. Read all the information in this leaflet for guidance. If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Hydrea contains lactose and sodium<\/h2>\n\n\n\n
This medicine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n
This medicine contains 11.67 mg sodium (the main ingredient in table salt\/table salt) per capsule. This corresponds to 0.6% of the maximum recommended daily sodium intake for adults.<\/p>\n\n\n\n
3. How to take Hydrea<\/h2>\n\n\n\n
Always take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure. Dose one is determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n
The capsules are swallowed whole.<\/p>\n\n\n\n
The Hydrea capsules should be handled with care. Keep Hydrea away from children and pets. The following measures prevent exposure:<\/p>\n\n\n\n
- Wash hands with soap and water after each handling of the product or wear protective gloves.<\/li>
- If the capsule breaks or dissolves, wash hands thoroughly with water.<\/li><\/ul>\n\n\n\n
If you take more Hydrea than you should<\/h2>\n\n\n\n
If you have ingested too much medicine or if e.g. If a child has ingested the medicine by mistake, contact a doctor, hospital, or the Poison Information Center for risk assessment and advice.<\/p>\n\n\n\n
If you forget to take Hydrea<\/h2>\n\n\n\n
Do not take a double dose to make up for a forgotten dose. Contact your doctor if you forget to take a dose.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n
4. Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n
Contact a doctor immediately if you experience the following symptoms:<\/p>\n\n\n\n
- Severe infection<\/li>
- Fatigue and \/ or pallor<\/li>
- Unexplained bruising or bleeding
These symptoms may be signs of decreased activity in the blood-forming organs, a very common side effect (may affect more than 1 user in 10).<\/li> - Difficulty breathingThis may be a sign of lung effects, a common side effect (may affect up to 1 in 10 people).<\/li><\/ul>\n\n\n\n
- Sores on the skinThese symptoms may be signs of inflammation of the blood vessels of the skin, a very common side effect (may affect more than 1 user in 10).<\/li>
- Drug-induced feverHigh fever with or without concomitant symptoms in the gastrointestinal tract, lungs, skeleton and muscles, liver and bile, skin or heart and vessels have been reported with the use of the drug. These may occur several weeks after starting to use the medicine. Has been reported (occurs in an unknown number of users).<\/li>
- Fever, cough or difficulty breathingThese can be signs of serious lung disease. Has been reported (occurs in an unknown number of users).<\/li><\/ul>\n\n\n\n
Other side effects that may occur:<\/p>\n\n\n\n
Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n- anemia<\/li>
- loss of appetite<\/li>
- inflammation of the pancreas (sometimes fatal)<\/li>
- nausea and vomiting<\/li>
- diarrhea<\/li>
- inflammation of the oral mucosa<\/li>
- constipation<\/li>
- irritation of the stomach and \/ or digestive tract<\/li>
- skin rashes, including rashes in the form of spots and blemishes and raised rashes<\/li>
- hair loss<\/li>
- inflammation of the skin, subcutaneous tissue and adjacent muscles<\/li>
- reddening of the face or arms and legs \/ hands and feet<\/li>
- exfoliating skin<\/li>
- pigment spots<\/li>
- skin and nail loss<\/li>
- increased amount of uric acid<\/li>
- increased amount of urea in the blood<\/li>
- increased amount of creatinine in the blood<\/li>
- urination difficulties<\/li>
- ceased or reduced sperm production<\/li>
- fever<\/li>
- chills<\/li>
- impotence<\/li>
- feeling sick<\/li><\/ul>\n\n\n\n
Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n- skin cancer<\/li>
- disorientation<\/li>
- hallucinations<\/li>
- seizures<\/li>
- dizziness<\/li>
- headache<\/li>
- nerve impact in hands and feet<\/li>
- drowsiness<\/li>
- increased amount of liver enzymes in the blood<\/li>
- impaired bile flow<\/li>
- liver inflammation ( hepatitis )<\/li>
- liver damage (sometimes fatal).<\/li><\/ul>\n\n\n\n
Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n- abnormal blood levels caused by residual products of the disintegrating tumor and which can lead to changes in heart rhythm and impaired kidney function (tumor lysis syndrome)<\/li>
- local tissue death as a result of inflammation of the blood vessels of the skin with concomitant ulcers (usually associated with concomitant or previous treatment with interferon ).<\/li><\/ul>\n\n\n\n
Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n- pigmented (colored) nails<\/li>
- inflammation of the skin which causes red, scaly spots and which can occur simultaneously with pain in the joints<\/li>
- low number of red blood cells due to their destruction faster than they are replaced ( hemolytic anemia ).<\/li><\/ul>\n\n\n\n
Reporting of side effects<\/em><\/p>\n\n\n\nIf you get any side effects, talk to your doctor, pharmacist, or nurse. This also applies to any side effects not mentioned in this information. You can also report side effects directly to the Medical Products Agency. By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n
5. How to store Hydrea<\/h2>\n\n\n\n
Do not store above 25 \u00b0 C.<\/p>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the label after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
6. Contents of the packaging and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n- The active substance is hydroxycarbamide. One capsule contains 500 mg of hydroxycarbamide.<\/li>
- The other ingredients are lactose monohydrate 42.2 mg, anhydrous disodium phosphate, anhydrous citric acid, magnesium stearate, gelatin, erythrosine (E127), indigo carmine (E132), titanium dioxide (E171) and yellow iron oxide (E172).<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Hydrea 500 mg hard capsules are two-part opaque gelatin capsules with a pink base and a green top. The capsules are marked with “BMS 303” in black.<\/p>\n\n\n\n
Pack size: 100 capsules in a glass jar.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/em><\/strong><\/p>\n\n\n\nBristol-Myers Squibb AB<\/p>\n\n\n\n
Box 1172<\/p>\n\n\n\n
171 23 Solna<\/p>\n\n\n\n
Manufacturer<\/strong><\/em><\/p>\n\n\n\nCorden Pharma Latina SpA<\/p>\n\n\n\n
Via del Murillo Km 2,800<\/p>\n\n\n\n
IT 04013 Sermoneta<\/p>\n\n\n\n
Latina, Italy<\/p>\n","protected":false},"excerpt":{"rendered":"
Hydrea is a cytostatic, that is, drug that reduces cell division in rapidly dividing cells, such as cancer cells. This causes the cells to die.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2208],"tags":[13592,13516,13588,13591,13593,13512,13515,13517,13590,13514,13589,13513],"class_list":["post-13948","post","type-post","status-publish","format-standard","hentry","category-medicines","category-h","tag-benefits-of-hydrea","tag-benefits-of-hydroxycarbamide","tag-hydrea","tag-hydrea-capsule","tag-hydrea-side-effects","tag-hydroxycarbamide","tag-hydroxycarbamide-capsule","tag-hydroxycarbamide-side-effects","tag-what-hydrea-is-used-for","tag-what-hydroxycarbamide-is-used-for","tag-what-is-hydrea","tag-what-is-hydroxycarbamide"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13948"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13948\/revisions"}],"predecessor-version":[{"id":15225,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13948\/revisions\/15225"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13948"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}