{"id":13880,"date":"2021-09-21T06:53:11","date_gmt":"2021-09-21T06:53:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13880"},"modified":"2021-11-02T10:40:37","modified_gmt":"2021-11-02T10:40:37","slug":"humalog-mix25","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/humalog-mix25\/","title":{"rendered":"Humalog MIX25 uses, dose and side effects"},"content":{"rendered":"\n

100 units\/ml solution for injection in the vial\u00a0(\u00a0insulin\u00a0lispro)<\/p>\n\n\n\n

Read all of this leaflet carefully before you start using this medicine. It contains information that is important to you.<\/h2>\n\n\n\n

– Save this information, you may need to read it again.<\/p>\n\n\n\n

– If you have any further questions, ask your doctor or pharmacist.<\/p>\n\n\n\n

– This medicine has been prescribed for you only. Do not give it to others. It can harm them, even if they show signs of illness similar to yours.<\/p>\n\n\n\n

– If you get\u00a0any side effects, talk to your doctor or pharmacist.\u00a0This also applies to any\u00a0side effects\u00a0not mentioned in this information.\u00a0See section 4.<\/p>\n\n\n\n

In this leaflet:
1. What Humalog Mix25 is and what it is used for
2. What you need to know before you use Humalog Mix25
3. How to use Humalog Mix25
4. Possible side effects
5. How to store Humalog Mix25
6. Contents of the packaging and other information<\/p>\n\n\n\n

1. What Humalog Mix25 is and what it is used for<\/h2>\n\n\n\n

Humalog Mix25 is used for treating\u00a0diabetes.\u00a0Humalog Mix25 is a ready-mixed\u00a0suspension.\u00a0The active substance is\u00a0insulin\u00a0lispro.\u00a025% of\u00a0insulin\u00a0lispro in Humalog Mix25 is dissolved in water, it acts faster than normal human insulin because the insulin molecule has changed slightly.\u00a075% of\u00a0insulin\u00a0lispro in Humalog Mix25 is contained in a\u00a0suspension\u00a0containing protamine sulphate, which prolongs the effect.<\/p>\n\n\n\n

You get\u00a0diabetes\u00a0if your\u00a0pancreas\u00a0does not produce enough\u00a0insulin.\u00a0Humalog Mix25 replaces your own\u00a0insulin\u00a0and is used to control blood glucose levels for a long time.\u00a0Humalog Mix25 works very quickly and for longer than soluble\u00a0insulin.\u00a0You should normally take Humalog Mix25 within 15 minutes before or after a meal.<\/p>\n\n\n\n

Your doctor will tell you if you should take Humalog Mix25 with longer-acting human insulin.\u00a0Each type of insulin has its own user information.\u00a0Do not\u00a0change\u00a0your\u00a0insulin\u00a0unless your doctor tells you to.\u00a0Be very careful if you change your\u00a0insulin.<\/p>\n\n\n\n

2. What you need to know before using Humalog Mix25<\/h2>\n\n\n\n

DO NOT use Humalog Mix25<\/h2>\n\n\n\n

– if you think that a so-called insulin sensation<\/strong> (low blood sugar) begins. Later in this user information, there are instructions on how to deal with a mild insulin sensation (see section 3: If you use more Humalog Mix25 than you should).<\/p>\n\n\n\n

– if you are allergic<\/strong> to insulin lispro or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n

Warnings and cautions<\/h2>\n\n\n\n
  • Always check the packaging and the label of the vial so that the name and type of insulin match when you get it from the pharmacy. Make sure you get the Humalog Mix25 prescribed by your doctor.<\/li>
  • If your blood sugar is under good control of your current insulin , you may not be able to detect the warning signs when your blood sugar gets too low. Warning signals are listed later in this user information. You should carefully keep track of when you should eat, how often you should exercise and how much you should work. You should also carefully check your blood sugar level by testing your blood sugar frequently.<\/li>
  • Some people who have had insulin sensations after switching from animal insulin to human insulin have reported that the early warning symptoms were less clear or different. If you often have insulin sensations or have difficulty recognizing them, talk to your doctor.<\/li>
  • If you answer YES to any of the following questions, talk to your doctor, pharmacist or diabetes nurse.
    – Have you recently become ill?
    – Do you have problems with your liver or kidneys?
    – Do you train more than usual?<\/li>
  • The amount of insulin you need may change with alcohol intake.<\/li>
  • You should also talk to your doctor, pharmacist or diabetes nurse if you plan to travel abroad. The time difference between countries may mean that you have to take your injections and eat at other times than when you are at home.<\/li>
  • Some patients who have had type 2 diabetes mellitus and heart disease for many years or earlier stroke , developed heart failure during treatment with pioglitazone and insulin . Tell your doctor as soon as possible if you get signs of heart failure such as unexpected shortness of breath, rapid weight gain or local swelling ( edema ).<\/li><\/ul>\n\n\n\n

    Skin changes at the injection site<\/strong><\/p>\n\n\n\n

    To prevent skin changes, e.g. nodules under the skin, you should constantly change the injection site. It may be that insulin et not work as well if you inject in an area of nodules (see “How to use Humalog Mix25). Contact your doctor before changing the injection site if you are currently injecting in an area with lumps. Your doctor may advise you to check your blood sugar more often and to adjust your insulin dose or the dose of other diabetes medicines.<\/p>\n\n\n\n

    Other medicines and Humalog Mix25<\/h2>\n\n\n\n

    Your insulin needs may change if you take<\/p>\n\n\n\n

    • birth control pills ,<\/li>
    • cortisone ,<\/li>
    • agents for thyroid disease,<\/li>
    • tablets for the treatment of diabetes ,<\/li>
    • acetylsalicylic acid ,<\/li>
    • sulfate antibiotics,<\/li>
    • octreotide,<\/li>
    • beta 2<\/sub> stimulators (eg ritodrin, salbutamol or terbutaline ),<\/li>
    • beta blockers ,<\/li>
    • certain antidepressants ( monoamine oxidase inhibitors or selective serotonin reuptake inhibitors),<\/li>
    • danazol,<\/li>
    • certain angiotensin converting (ACE) enzyme inhibitors (eg captopril , enalapril ) and<\/li>
    • angiotensin II receptor blockers.<\/li><\/ul>\n\n\n\n

      Tell your doctor if you are taking, have recently taken, or will take any other medicines, including medicines obtained without a prescription (see \u201cWarnings and Precautions\u201d).<\/p>\n\n\n\n

      Pregnancy and breastfeeding<\/h2>\n\n\n\n

      Are you pregnant or planning to become pregnant or breastfeeding?<\/p>\n\n\n\n

      Insulin requirements usually decrease during the first 3 months of pregnancy and then increase during the remaining six months.<\/p>\n\n\n\n

      If you are breastfeeding, adjusting your insulin dose or diet may be necessary.\u00a0Consult your doctor.<\/p>\n\n\n\n

      Driving and using machines<\/h2>\n\n\n\n

      Your ability to concentrate and react may be impaired in\u00a0hypoglycaemia.\u00a0Keep this in mind in all situations where you may\u00a0expose\u00a0yourself or others to risks (eg while driving or using machines).<\/p>\n\n\n\n

      Contact your doctor about the suitability of driving again<\/p>\n\n\n\n

      • you often suffer from hypoglycemia<\/li>
      • your warning signs of hypoglycaemia are weakened or completely absent<\/li><\/ul>\n\n\n\n

        Humalog Mix25 contains sodium<\/h2>\n\n\n\n

        This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie\u00a0essentially ‘\u00a0sodium-free.\u00a0is almost “sodium-free”.<\/p>\n\n\n\n

        3. How to use Humalog Mix25<\/h2>\n\n\n\n

        Always use Humalog Mix25 exactly as your doctor has told you. Consult a doctor if you are unsure.<\/p>\n\n\n\n

        Dosage<\/strong><\/p>\n\n\n\n

        • You should normally inject Humalog Mix25 within 15 minutes before a meal. If you need to, you can inject shortly after the meal. Dose one is determined by your doctor who adjusts it individually for you. These instructions are personal and just for you. Follow them closely and visit your diabetes clinic regularly.<\/li>
        • If you change the type of insulin (eg from animal insulin or other human insulin to a Humalog product) you may need to take more or less than before. This may appear at the first injection one or it may be a gradual change over several weeks or months.<\/li>
        • Inject Humalog Mix25 under the skin. It must not be injected in any other way. Under no circumstances should Humalog Mix25 be injected intravenously .<\/li><\/ul>\n\n\n\n

          Preparation of Humalog Mix25<\/strong><\/p>\n\n\n\n

          • Bottles containing Humalog Mix25 should be rolled between the palms of the hands before use so that the insulin suspension mixes well and becomes evenly cloudy or milky. Do not shake vigorously, as foam may form which may affect the dosing accuracy. The bottles should be checked frequently and should not be used if they contain lumps or if solid, white particles stick to the bottom or walls of the bottle and give a frosty appearance. Check before each injection .<\/li><\/ul>\n\n\n\n

            Injection of Humalog Mix25<\/strong><\/p>\n\n\n\n

            • Wash your hands.<\/li>
            • Clean the skin as instructed before injecting. Clean the rubber membrane on the bottle, but do not remove the membrane .<\/li>
            • Use a clean, sterile syringe and needle and insert the rubber membrane and suck up the amount of Humalog Mix25 you need. Your doctor or diabetes nurse will show you how to do this. Do not share needles or syringes with anyone else.<\/strong><\/li>
            • Inject under the skin as instructed. Do not inject directly into a blood vessel. Wait 5 seconds after finishing the injection before pulling out the needle, then you are sure that you have received the full dose one. Do not massage the injection site. Make sure that you have a margin of at least 1 cm to the previous injection site and that you change the injection site as instructed.<\/li><\/ul>\n\n\n\n

              If you use more Humalog Mix25 than you should<\/h2>\n\n\n\n

              You may get low blood sugar if you have used too much Humalog Mix25 or are unsure about how much you have injected. Check your blood sugar.<\/p>\n\n\n\n

              If your blood sugar is low (\u00a0weak insulin sensitivity<\/strong>\u00a0), take glucose tablets, sugar, or a sweet drink.\u00a0Then take fruit, biscuits, or a sandwich according to your doctor’s instructions and rest for a while.\u00a0Often, a weak insulin sensation or a slight overdose of\u00a0insulin disappears\u00a0with this treatment.\u00a0If you get worse, have shortness of breath, and turn pale, contact your doctor immediately.<\/p>\n\n\n\n

              Quite severe hypoglycaemia can be treated with a glucagon injection. Eat glucose or sugar after the glucagon injection. If you are not improved by glucagon, you should be treated in a hospital. Ask your doctor to tell you about glucagon.<\/p>\n\n\n\n

              If you forget to use Humalog Mix25<\/h2>\n\n\n\n

              You may get high blood sugar if you have used too little Humalog or are unsure about how much you have injected. Check your blood sugar.<\/p>\n\n\n\n

              Failure\u00a0to treat\u00a0hypoglycaemia\u00a0(low blood sugar) or\u00a0hyperglycaemia\u00a0(high blood sugar) can have serious consequences and can lead to headaches, nausea, vomiting, dehydration, unconsciousness,\u00a0coma,\u00a0and even death (see A and B in section 4 “Possible side effects”). ).<\/p>\n\n\n\n

              Three simple tips<\/strong> to avoid hypoglycemia or hyperglycemia:<\/p>\n\n\n\n

              • Always have a spare syringe and spare bottle of Humalog Mix25 with you<\/li>
              • Always carry something with you that shows that you are diabetic.<\/li>
              • Always have sugar with you.<\/li><\/ul>\n\n\n\n

                If you stop using Humalog Mix25<\/h2>\n\n\n\n

                You may get high blood sugar if you use too little Humalog Mix25. Do not change your insulin unless your doctor tells you to.<\/p>\n\n\n\n

                If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n

                4. Possible side effects<\/h2>\n\n\n\n

                Like all medicines, this medicine can cause\u00a0side effects,\u00a0although not everybody gets them.
                <\/p>\n\n\n\n

                \u2022 itching all over the body<\/td>\u2022 palpitations<\/td><\/tr>
                \u2022 difficulty breathing<\/td>\u2022 drop in blood pressure<\/td><\/tr>
                \u2022 wheezing<\/td>\u2022 sweating<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

                If you think you may have this type of insulin allergy, talk to your doctor straight away.<\/p>\n\n\n\n

                Local\u00a0allergy\u00a0is common (\u22651 \/ 100 to <1\/10).\u00a0Some people get\u00a0redness, swelling, or\u00a0itching\u00a0at the injection site.\u00a0This usually stops after a few days or a few weeks.\u00a0If you get any of these symptoms, talk to your doctor.<\/p>\n\n\n\n

                Lipodystrophy is less common (\u22651 \/ 1000 to <1\/100). If you inject insulin too often in the same place, the adipose tissue may either shrink (lipoatrophy) or thicken (lipohypertrophy). Nodules under the skin can also be caused by the accumulation of a protein called amyloid ( cutaneous amyloidosis). It may be that insulin et not work as well if you inject in an area with nodules. Change the injection site for each injection to prevent these skin changes.<\/p>\n\n\n\n

                Edema (swollen arms, ankles; fluid retention ) has been reported, especially when starting insulin therapy or when changing treatment to improve the control of your blood sugar.<\/p>\n\n\n\n

                Common problems with diabetes<\/strong><\/p>\n\n\n\n

                A. Hypoglycemia<\/strong><\/p>\n\n\n\n

                Hypoglycaemia (low blood sugar) means that there is not enough sugar in the blood. This can be caused by:<\/p>\n\n\n\n

                • that you are taking too much Humalog Mix25 or other insulin<\/li>
                • that you skip or postpone meals or change your diet<\/li>
                • that you exercise or work too hard just before or after a meal<\/li>
                • that you have an infection or are ill (especially with diarrhea or vomiting)<\/li>
                • that your insulin needs have changed, or<\/li>
                • that you have problems with your kidneys or liver that have gotten worse<\/li><\/ul>\n\n\n\n

                  Alcohol and certain medications can affect blood sugar levels.<\/p>\n\n\n\n

                  The first symptoms of low blood sugar usually appear quickly and involve<\/p>\n\n\n\n

                  \u2022 fatigue<\/td>\u2022 palpitations<\/td><\/tr>
                  \u2022 nervousness and tremors<\/td>\u2022 nausea<\/td><\/tr>
                  \u2022 headache<\/td>\u2022 cold sweats<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

                  If you are not sure of recognizing the warning symptoms, avoid situations, such as driving a car, where you may\u00a0expose\u00a0yourself or others to risks due to\u00a0hypoglycaemia.<\/p>\n\n\n\n

                  B. Hyperglycaemia and diabetic ketoacidosis<\/strong><\/p>\n\n\n\n

                  Hyperglycemia\u00a0(too much sugar in the blood) means that your body does not have enough\u00a0insulin.\u00a0Hyperglycaemia\u00a0may recur<\/p>\n\n\n\n

                  • you have not taken your Humalog Mix25 or other insulin<\/li>
                  • you have taken less insulin than your doctor told you to<\/li>
                  • you have eaten more than your diet allows, or<\/li>
                  • you have a fever, infection or are emotionally stressed<\/li><\/ul>\n\n\n\n

                    Hyperglycaemia\u00a0can lead to diabetic\u00a0ketoacidosis\u00a0.\u00a0The first symptoms creep in for several hours or days.\u00a0They are<\/p>\n\n\n\n

                    \u2022 drowsiness<\/td>\u2022 no appetite<\/td><\/tr>
                    \u2022 flushing<\/td>\u2022 fruit smell from the breath<\/td><\/tr>
                    \u2022 thirst<\/td>\u2022 nausea or vomiting<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

                    Serious symptoms are heavy breathing and rapid\u00a0heartbeat.\u00a0Seek medical attention immediately.<\/strong><\/p>\n\n\n\n

                    C. In case of illness<\/strong><\/p>\n\n\n\n

                    If you are sick, especially if you feel nauseous or vomit, your insulin needs may change.\u00a0Even if you do not eat normally, you still need\u00a0insulin.\u00a0<\/strong>Test urine or blood, follow the instructions regarding your illness, talk to your doctor.<\/p>\n\n\n\n

                    Reporting of side effects<\/em><\/p>\n\n\n\n

                    If you get any side effects, talk to your doctor, pharmacist, or nurse.\u00a0This also applies to any side effects not mentioned in this information.\u00a0You can also report side effects directly to the Medical Products Agency.\u00a0By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n

                    5. How to store Humalog Mix25<\/h2>\n\n\n\n

                    Before using Humalog Mix25, store it in a refrigerator (2 \u00b0 C – 8 \u00b0 C). Do not freeze. The bottle currently in use should be stored in a refrigerator (2 \u00b0 C – 8 \u00b0 C) or at room temperature (below 30 \u00b0 C) and discarded after 28 days. Do not expose it to strong heat or sunlight.<\/p>\n\n\n\n

                    Keep out of sight and reach of children.<\/p>\n\n\n\n

                    Do not use this medicine after the expiry date which is stated on the label and carton. The expiration date is the last day of the specified month.<\/p>\n\n\n\n

                    Do not use this medicine if you notice lumps or solid, white particles sticking to the bottom or walls of the bottle and giving it a frosty appearance.\u00a0Check this before each\u00a0injection.<\/p>\n\n\n\n

                    The medicine should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n

                    6. Contents of the packaging and other information<\/h2>\n\n\n\n

                    Contents of Humalog Mix25 100 Units \/ ml suspension for injection in a vial<\/h2>\n\n\n\n

                    – The active substance is insulin lispro. Insulin lispro is manufactured in a laboratory using recombinant DNA technology. It is an altered form of human insulin and therefore differs from other human and animal insulins. Insulin lispro is closely related to human insulin, a natural hormone produced in the pancreas.<\/p>\n\n\n\n

                    The other ingredients are protamine sulphate, m-cresol, phenol,\u00a0glycerol, disodium phosphate 7 H2O, zinc oxide, and water for injections.\u00a0Sodium hydroxide or\u00a0hydrochloric acid\u00a0may have been added to adjust the acidity.<\/p>\n\n\n\n

                    What the medicine looks like and contents of the pack<\/h2>\n\n\n\n

                    Humalog Mix25 100 units\/ml\u00a0injection,\u00a0the suspension\u00a0is a white,\u00a0sterile,\u00a0suspension\u00a0containing 100 units\u00a0of insulin\u00a0lispro in each milliliter\u00a0injection\u00a0(100 units\/ml).\u00a025% of\u00a0insulin\u00a0lispro in Humalog Mix25 is dissolved in water.\u00a075% of\u00a0insulin\u00a0lispro in Humalog Mix25 is contained in a\u00a0suspension\u00a0containing protamine sulphate.\u00a0Each\u00a0vial\u00a0contains 1000 units (10 milliliters).<\/p>\n\n\n\n

                    Humalog Mix25 100 units\/ml\u00a0injection,\u00a0suspension\u00a0in the\u00a0vial\u00a0is in a pack of 1\u00a0vial.<\/p>\n\n\n\n

                    Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n

                    Humalog Mix25 100 units\/ml\u00a0injection,\u00a0suspension\u00a0in the\u00a0vial\u00a0is manufactured by<\/p>\n\n\n\n

                    • Lilly SA, Avda. de la Industria 30, 28108 Alcobendas, Madrid, Spain.<\/li><\/ul>\n\n\n\n

                      The marketing authorization is held by Eli Lilly Nederland BV, Papendorpseweg 83, 3528 BJ Utrecht, The Netherlands.<\/p>\n\n\n\n

                      Further information on this medicine can be obtained from the representative of the marketing authorization holder:<\/p>\n","protected":false},"excerpt":{"rendered":"

                      100 units\/ml solution for injection in the vial\u00a0(\u00a0insulin\u00a0lispro) Read all of this leaflet carefully before you start using this medicine. It contains information that is important to you. – Save this information, you may need to read it again. – If you have any further questions, ask your doctor or pharmacist. – This medicine has been […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2208,2200],"tags":[],"class_list":["post-13880","post","type-post","status-publish","format-standard","hentry","category-h","category-medicines"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13880"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13880\/revisions"}],"predecessor-version":[{"id":15234,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13880\/revisions\/15234"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13880"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13880"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}