{"id":13847,"date":"2021-09-21T06:31:14","date_gmt":"2021-09-21T06:31:14","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13847"},"modified":"2021-11-02T10:08:32","modified_gmt":"2021-11-02T10:08:32","slug":"hexvix","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/hexvix\/","title":{"rendered":"Hexvix &#8211; Hexaminolevulinate uses, dose and side effects"},"content":{"rendered":"\n<p>85 mg&nbsp;Powder and liquid for&nbsp;intravesical&nbsp;solution<br>hexaminolevulinate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. WHAT HEXVIX IS AND WHAT IT IS USED FOR<\/h2>\n\n\n\n<p>This medicine is for diagnostic purposes only.<\/p>\n\n\n\n<p>This medicine is used to help diagnose bladder cancer.&nbsp;It is given to you before your doctor uses a special instrument called a cystoscope to look inside your bladder.&nbsp;A cystoscope is used to help&nbsp;you&nbsp;see any&nbsp;tumors&nbsp;that&nbsp;light&nbsp;up in blue light after&nbsp;administration&nbsp;of Hexvix.&nbsp;The abnormal cells can thus be removed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2. BEFORE YOU USE HEXVIX<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Hexvix<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to the active substance or to any of the other ingredients of this medicine, including the liquid used to dissolve it in (listed in section 6).<\/li><li>if you have&nbsp;porphyria&nbsp;(a rare, inherited blood disorder).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Tell your doctor before taking Hexvix:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have a urinary tract infection or a burning sensation when urinating.<\/li><li>If you have recently received a BCG treatment (weakened tubercle bacteria injected into the bladder).<\/li><li>If you have recently undergone bladder surgery.<\/li><\/ul>\n\n\n\n<p>These conditions can cause local reactions in the bladder, which can make it difficult for your doctor to interpret the results of the test.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Taking other medicines<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you have recently taken or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires increased attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. HOW TO USE HEXVIX<\/h2>\n\n\n\n<p>Hexvix is \u200b\u200bprepared and given to you by specially trained and authorized staff.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hexvix is \u200b\u200busually given in a hospital or doctor&#8217;s office.<\/li><\/ul>\n\n\n\n<p>Your doctor will give it to you as follows:<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>A narrow tube called a&nbsp;catheter is&nbsp;placed in the bladder.<\/li><li>Your bladder is emptied through the hose.<\/li><li>Hexvix is \u200b\u200binserted into the bladder through the tube.<\/li><li>Hexvix is \u200b\u200bkept inside the bladder for about 60 minutes.<\/li><li>Your bladder is then emptied through the tube.<\/li><li>Your doctor will use an instrument (cystoscope) to examine the inside of your&nbsp;bladder&nbsp;.<\/li><\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">If you receive more Hexvix than you should<\/h2>\n\n\n\n<p>If Hexvix is \u200b\u200bkept in the bladder for longer than 60 minutes or if more Hexvix is \u200b\u200bused than usual, no&nbsp;side effects&nbsp;are expected.&nbsp;Talk to your doctor or nurse if you are worried about this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. POSSIBLE SIDE EFFECTS<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects,&nbsp;although not everybody gets them.&nbsp;There is a risk of&nbsp;side effects&nbsp;related to the examination&nbsp;technique&nbsp;(&nbsp;cystoscopy&nbsp;) used to see the inside of the bladder.&nbsp;The use of Hexvix as a complementary procedure to standard cystoscopy for a more accurate diagnosis of your bladder cancer is usually well tolerated.&nbsp;If&nbsp;side effects&nbsp;occur, these are expected to be related to the examination technique and are usually not serious and do not last long.&nbsp;The following&nbsp;side effects&nbsp;may occur after the examination procedure when using this medicine:<\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(affects 1 to 10 users in 100):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache.<\/li><li>Nausea, vomiting.<\/li><li>Diarrhea.<\/li><li>Constipation.<\/li><li>Muscle cramps or pain in or near the abdomen.<\/li><li>Pain when emptying the bladder or difficulty throwing water.<\/li><li>Inability to empty bladder (&nbsp;urinary retention&nbsp;).<\/li><li>Blood in the urine.<\/li><li>Pain after the examination.<\/li><li>Fever.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(affects 1 to 10 users in 1000):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Burning sensation when throwing water (caused by&nbsp;inflammation&nbsp;or&nbsp;infection&nbsp;of the bladder).<\/li><li>Need to throw water more often.<\/li><li>Blood poisoning.<\/li><li>Insomnia or difficulty falling asleep.<\/li><li>Pain in the urethra.<\/li><li>Feeling you have to urinate immediately (urinary incontinence).<\/li><li>Increased&nbsp;white blood cell count&nbsp;, increased levels of&nbsp;bilirubin&nbsp;(the yellow pigment in the bile) or liver enzymes.&nbsp;These&nbsp;side effects&nbsp;are seen in blood test results.<\/li><li>Decreased&nbsp;red blood cell count&nbsp;(&nbsp;anemia&nbsp;).<\/li><li>Inflammation&nbsp;of the glans (balanitis).<\/li><li>Back pain.<\/li><li>Gout&nbsp;.<\/li><li>Rash.<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong>&nbsp;(can not be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic&nbsp;shock&nbsp;(drop in blood pressure, increased heart rate, rash).<\/li><\/ul>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist, or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. STORAGE OF HEXVIX<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the outer carton after EXP.&nbsp;Expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Powder and liquid: No special precautions for storage.<br>Solution (after&nbsp;mixing&nbsp;): Store in a refrigerator (2\u00baC \u20138\u00baC), the solution should be used within 2 hours.<\/p>\n\n\n\n<p>The medical staff ensures that the medicine is stored and disposed of correctly and is not used after the expiry date on the carton.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. FURTHER INFORMATION<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is hexaminolevulinate.<\/li><li>The other ingredients are disodium phosphate dihydrate, potassium dihydrogen phosphate, sodium chloride,&nbsp;hydrochloric acid&nbsp;, sodium hydroxide and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Each pack consists of a&nbsp;vial&nbsp;with white to off-white or light yellow powder containing 85 mg of active substance hexaminolevulinate and a prefilled&nbsp;syringe&nbsp;with or without a Mini Spike containing 50 mL of clear colorless liquid for dissolving the powder.<\/li><li>Hexvix powder is dissolved in the 50 ml liquid that comes with the package.&nbsp;When powder and liquid have been mixed, a solution containing hexaminolevulinate 1.7 mg \/ ml is obtained, which corresponds to hexaminolevulinate 8 mmol \/ l solution.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Photocure ASA<br>Hoffsveien 4<br>NO-0275 Oslo<br>Norway<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This medicine is used to help diagnose bladder cancer. It is given to you before your doctor uses a special instrument called a cystoscope to look inside your bladder. A cystoscope is used to help you see any tumors that light up in blue light after administration of Hexvix. The abnormal cells can thus be removed.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2208],"tags":[13770,13775,13766,13769,13771,13774,13768,13773,13767,13772],"class_list":["post-13847","post","type-post","status-publish","format-standard","hentry","category-medicines","category-h","tag-benefits-of-hexaminolevulinate","tag-benefits-of-hexvix","tag-hexaminolevulinate","tag-hexaminolevulinate-side-effects","tag-hexvix","tag-hexvix-side-effects","tag-what-hexaminolevulinate-is-used-for","tag-what-hexvix-is-used-for","tag-what-is-hexaminolevulinate","tag-what-is-hexvix"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13847"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13847\/revisions"}],"predecessor-version":[{"id":15278,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13847\/revisions\/15278"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}