{"id":13754,"date":"2021-09-20T08:24:19","date_gmt":"2021-09-20T08:24:19","guid":{"rendered":"https:\/\/zeepedia.com\/?p=13754"},"modified":"2021-11-02T10:11:15","modified_gmt":"2021-11-02T10:11:15","slug":"herceptin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/herceptin\/","title":{"rendered":"Herceptin &#8211; Trastuzumab uses, dose and side effects"},"content":{"rendered":"\n<p>600 mg&nbsp;injection, solution in&nbsp;the vial<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/trazimera\/\">trastuzumab<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. What Herceptin is and what it is used for<\/h2>\n\n\n\n<p>Herceptin contains the active substance trastuzumab, which is a monoclonal&nbsp;antibody.&nbsp;Monoclonal&nbsp;antibodies&nbsp;are attached to specific&nbsp;proteins&nbsp;or&nbsp;antigens.&nbsp;Trastuzumab is designed to bind selectively to an&nbsp;antigen&nbsp;called&nbsp;human&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor 2 (&nbsp;HER2&nbsp;).&nbsp;HER2 is&nbsp;found in large amounts on the surface of certain cancer cells (&nbsp;HER2&nbsp;-positive cancer) and then stimulates cell growth.&nbsp;When Herceptin binds to&nbsp;HER2, the growth of the cancer cells is stopped, which leads to their death.<\/p>\n\n\n\n<p>Your doctor may prescribe Herceptin for the treatment of breast cancer then:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have early breast cancer with high levels of&nbsp;protein&nbsp;et&nbsp;HER2&nbsp;.<\/li><li>You have metastatic breast cancer (breast cancer that has spread outside the original&nbsp;tumor&nbsp;) with high levels of&nbsp;HER2&nbsp;.&nbsp;Herceptin is prescribed in combination with&nbsp;chemotherapy&nbsp;are paclitaxel or docetaxel as first treatment for metastatic breast cancer, or it can be prescribed as a sole treatment in conditions where other treatments proved unsuccessful.&nbsp;It is also used in combination with medicines called aromatase inhibitors for the treatment of patients with high levels of&nbsp;HER2&nbsp;and hormone receptor positive metastatic (spread) breast cancer (cancer that is sensitive to the presence of female sex hormone).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">2. What you need to know before you get Herceptin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Herceptin if:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to trastuzumab (the active substance in this medicine), murine (mouse)&nbsp;protein&nbsp;, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>you have severe breathing problems at rest due to your cancer or if you need oxygen therapy.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Your doctor will closely monitor your treatment with Herceptin.<\/p>\n\n\n\n<p><strong>Control of the heart<\/strong><\/p>\n\n\n\n<p>Treatment with Herceptin alone or with a taxane can affect the heart, especially if you have previously been treated with an&nbsp;anthracycline&nbsp;(taxanes and&nbsp;anthracyclines&nbsp;are two other types of medicines used to treat cancer).&nbsp;The effects can be moderate to severe and some patients have died.&nbsp;Your heart function will therefore be checked before and during treatment (every three months) and after (up to two to five years) treatment with Herceptin.&nbsp;If you develop signs of&nbsp;heart failure&nbsp;(ie insufficient pumping of blood from the heart), your heart function may be checked more often (every six to eight weeks).&nbsp;You may then receive treatment for&nbsp;heart failure&nbsp;or you may need to discontinue treatment with Herceptin.<\/p>\n\n\n\n<p><strong>Talk to your doctor, pharmacist, or nurse before receiving Herceptin about:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have had&nbsp;heart failure&nbsp;, coronary heart disease, heart valve disease (&nbsp;wheezing&nbsp;on the heart) or high&nbsp;blood pressure&nbsp;or if you have taken or are currently taking medicines for high&nbsp;blood pressure&nbsp;.<\/li><li>you have previously received or are currently receiving a medicine called doxorubicin or epirubicin (a medicine used to treat cancer).&nbsp;These medicines (or other&nbsp;anthracyclines&nbsp;) can damage the heart muscle and increase the risk of heart problems with Herceptin.<\/li><li>you suffer from shortness of breath, especially if you are treated with a taxane at the same time.&nbsp;Herceptin can cause breathing difficulties, especially when given for the first time.&nbsp;This can be more serious if you are already short of breath.&nbsp;Patients with severe respiratory distress have in very rare cases died in connection with Herceptin treatment.<\/li><li>you have previously received any other treatment for cancer.<\/li><\/ul>\n\n\n\n<p>If you are taking Herceptin with paclitaxel, docetaxel, an aromatase inhibitor, carboplatin, or cisplatin, you should also read the package leaflets for these products carefully.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Herceptin is not recommended for anyone under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Herceptin<\/h2>\n\n\n\n<p>Tell your doctor, pharmacist, or nurse if you have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>It can take up to 7 months for Herceptin to be removed from the body.&nbsp;You should therefore tell your doctor, pharmacist, or nurse that you have been treated with Herceptin if you start any new medication within 7 months of stopping treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before taking this medicine.<\/li><li>You should use effective contraception during treatment with Herceptin and for at least 7 months after stopping treatment.<\/li><\/ul>\n\n\n\n<p>Your doctor will advise you on the disadvantages and benefits of taking Herceptin during pregnancy.&nbsp;In rare cases, pregnant women treated with Herceptin have seen a decrease in the amount of (fetal) fluid that surrounds the growing fetus in the womb.&nbsp;This condition can be harmful to your baby in the womb and has been associated with the lungs not developing fully, resulting in fetal death.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Do not breastfeed your baby during treatment with Herceptin and within 7 months after the last&nbsp;dose&nbsp;of Herceptin as Herceptin may pass to your baby through breast milk.<\/p>\n\n\n\n<p>Consult a doctor, pharmacist, or nurse before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Herceptin may affect your ability to drive or use machines.&nbsp;If you experience symptoms such as dizziness, drowsiness, chills, or fever during treatment, you should not drive or use machines until these symptoms have disappeared.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Sodium<\/h2>\n\n\n\n<p>Herceptin contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per&nbsp;dose, ie essentially &#8216;sodium-free.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to get Herceptin<\/h2>\n\n\n\n<p>Before starting treatment, your doctor will decide if your&nbsp;tumor&nbsp;is&nbsp;HER2-&nbsp;positive.&nbsp;Only patients with&nbsp;HER2&nbsp;-positive cancer (large amounts of&nbsp;HER2&nbsp;) will be treated with Herceptin.&nbsp;Herceptin should only be given by a doctor or nurse.<\/p>\n\n\n\n<p>There are two different forms (dosage forms) of Herceptin:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one is given as&nbsp;an infusion&nbsp;into a vein (&nbsp;intravenous&nbsp;infusion&nbsp;)<\/li><li>the other is given as an&nbsp;injection&nbsp;under the skin (&nbsp;subcutaneous&nbsp;injection&nbsp;).<\/li><\/ul>\n\n\n\n<p>It is important to check the labeling of the product to ensure that the correct dosage form is given to the patient, and complies with the prescribed medication.&nbsp;Herceptin&nbsp;subcutaneous&nbsp;formulation is not intended for&nbsp;intravenous&nbsp;administration&nbsp;and should only be administered by&nbsp;subcutaneous&nbsp;injection.<\/p>\n\n\n\n<p>Your doctor may consider switching your Herceptin intravenous therapy to Herceptin&nbsp;subcutaneous&nbsp;therapy (and vice versa) if it is deemed appropriate for you.<\/p>\n\n\n\n<p>To prevent medication errors, it is important to check the label of the vial to ensure that the medicine is prepared and administered is Herceptin (trastuzumab) and not any other product containing trastuzumab (eg trastuzumab emtansine or trastuzumab deruxtecan).<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 600 mg.&nbsp;Herceptin is given as a&nbsp;subcutaneous&nbsp;injection&nbsp;(under the skin) for 2 to 5 minutes every three weeks.<\/p>\n\n\n\n<p>The injection site should be alternated between the left and right thighs.&nbsp;Injection&nbsp;should be given at least 2.5 cm away from the previous injection site, and never in areas where the skin is red, bruised, tender, or hard.<\/p>\n\n\n\n<p>If other&nbsp;subcutaneous&nbsp;drugs are&nbsp;used during treatment with Herceptin&nbsp;subcutaneous&nbsp;formulation, the drugs should be given at different injection sites on the body.<\/p>\n\n\n\n<p>Herceptin must not be mixed or diluted with other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Herceptin<\/h2>\n\n\n\n<p>Do not stop using this medicine without talking to your doctor first.&nbsp;All&nbsp;doses&nbsp;should be taken at the right time every three weeks.&nbsp;This helps the drug to work as well as possible.<\/p>\n\n\n\n<p>It can take up to 7 months before Herceptin disappears from the body.&nbsp;Therefore, your doctor may decide to continue to monitor your heart function even after treatment is stopped.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4. Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.&nbsp;Some of these&nbsp;side effects&nbsp;may be serious and may involve hospitalization.<\/p>\n\n\n\n<p>During treatment with Herceptin, chills, fever and other&nbsp;flu-like symptoms&nbsp;may occur.&nbsp;These&nbsp;side effects&nbsp;are very common (may affect more than 1 in 10 people).&nbsp;Other symptoms include: nausea, vomiting, pain, increased muscle tension and tremor, headache, dizziness, difficulty breathing, high or low&nbsp;blood pressure, altered heart rhythm (palpitations, palpitations, or irregular heartbeat), swelling of the face and lips, rash, and lethargy.&nbsp;Some of these symptoms may be severe and some patients have died (see section &#8220;Warnings and precautions&#8221;).<\/p>\n\n\n\n<p>Your doctor or nurse will check for any&nbsp;side effects&nbsp;during&nbsp;injection&nbsp;one and for 30 minutes after the first&nbsp;injection&nbsp;one and for 15 minutes after the second&nbsp;injection.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Other&nbsp;side effects&nbsp;may occur at any time during treatment with Herceptin.&nbsp;<strong>Tell a doctor or nurse immediately if you notice any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heart problems can sometimes occur during treatment and sometimes after treatment has stopped and can be serious.&nbsp;They include weakening of the heart muscle which can possibly lead to&nbsp;heart failure&nbsp;,&nbsp;inflammation&nbsp;around the heart and altered heart rhythm.&nbsp;This can lead to symptoms such as shortness of breath (including shortness of breath during the night), cough, fluid retention (swelling) in the legs or arms, palpitations (heart flutter or irregular heartbeat) (see section 2. Checking the heart).<\/li><\/ul>\n\n\n\n<p>Your doctor will check your heart regularly during and after treatment, but you should tell your doctor immediately if you experience any of the above symptoms.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tumor light syndrome (group of metabolic complications that occur after cancer treatment and are characterized by high levels of&nbsp;potassium&nbsp;and&nbsp;phosphate&nbsp;in the blood and low levels of&nbsp;calcium&nbsp;in the blood).&nbsp;Symptoms may include kidney problems (weakness, shortness of breath, fatigue and confusion), heart problems (heart flutter with a faster or slower heartbeat), cramps, vomiting or diarrhea and tingling in the mouth, hands or feet.<\/li><\/ul>\n\n\n\n<p>If you experience any of the above symptoms after stopping your treatment with Herceptin, talk to your doctor and tell your doctor that you have previously been treated with Herceptin.<\/p>\n\n\n\n<p>There are two different forms (dosage forms) of Herceptin:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>one given as&nbsp;an infusion&nbsp;into a vein for 30 to 90 minutes<\/li><li>the other is given as a&nbsp;subcutaneous&nbsp;injection&nbsp;(under the skin) for 2 to 5 minutes.<\/li><\/ul>\n\n\n\n<p>In the clinical study comparing these two&nbsp;dosage forms,&nbsp;infection&nbsp;and cardiac side effects leading to hospitalization were more common with the subcutaneous dosage form.&nbsp;There were also more local reactions at the injection site and more people had high&nbsp;blood pressure.&nbsp;Other&nbsp;side effects&nbsp;were comparable.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;of Herceptin<\/strong>&nbsp;may occur in more than 1 in 10 patients<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>infection&nbsp;is<\/li><li>diarrhea<\/li><li>constipation<\/li><li>heartburn (&nbsp;dyspepsia&nbsp;)<\/li><li>fatigue<\/li><li>rash<\/li><li>chest pain<\/li><li>abdominal pain<\/li><li>joint pain<\/li><li>low levels of&nbsp;red blood cells&nbsp;and&nbsp;white blood cells&nbsp;(which help the body fight&nbsp;you&nbsp;infection&nbsp;) sometimes with fever<\/li><li>muscle pain.<\/li><li>conjunctivitis&nbsp;(conjunctivitis of the eye)<\/li><li>watery eyes<\/li><li>nosebleeds<\/li><li>rinnsnuva<\/li><li>hair loss<\/li><li>tremors<\/li><li>hot flashes<\/li><li>dizziness<\/li><li>nail changes<\/li><li>weight loss<\/li><li>loss of appetite<\/li><li>insomnia (&nbsp;insomnia&nbsp;)<\/li><li>taste changes<\/li><li>decreased&nbsp;platelet count<\/li><li>bruises<\/li><li>numbness or tingling in the fingers and toes, which can sometimes spread to the rest of the arm or leg<\/li><li>redness&nbsp;, swelling or sores in the mouth and \/ or throat<\/li><li>pain, swelling,&nbsp;redness&nbsp;or tingling in the hands and \/ or feet<\/li><li>shortness of breath<\/li><li>headache<\/li><li>cough<\/li><li>vomiting<\/li><li>nausea<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;of Herceptin<\/strong>&nbsp;may occur in up to 1 in 10 patients<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>allergic reactions<\/td><td>dry eyes<\/td><\/tr><tr><td>throat infection<\/td><td>sweating<\/td><\/tr><tr><td>infection&nbsp;you in the&nbsp;bladder&nbsp;and on the skin<\/td><td>feeling of weakness and not feeling well<\/td><\/tr><tr><td><\/td><td>concern<\/td><\/tr><tr><td>inflammation&nbsp;of the chest<\/td><td>Depression<\/td><\/tr><tr><td>inflammation&nbsp;of the liver<\/td><td><\/td><\/tr><tr><td>kidney effects<\/td><td>asthma<\/td><\/tr><tr><td>increased&nbsp;muscle tone&nbsp;or tension (hypertension)<\/td><td>lung infection<\/td><\/tr><tr><td>pain in arms and \/ or legs<\/td><td>lung impact<\/td><\/tr><tr><td>itchy rash<\/td><td>back pain<\/td><\/tr><tr><td>drowsiness (&nbsp;somnolence&nbsp;)<\/td><td>neck pain<\/td><\/tr><tr><td>hemorrhoids&nbsp;<\/td><td>skeletal pain<\/td><\/tr><tr><td>itching<\/td><td>acne<\/td><\/tr><tr><td>dry mouth and skin<\/td><td>leg cramps<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;for Herceptin<\/strong>&nbsp;: may&nbsp;<strong>affect<\/strong>&nbsp;up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>deafness<\/li><li>lumpy skin rash<\/li><li>hissing \/ wheezing breathing<\/li><li>inflammation&nbsp;or scarring of the lungs<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;side effects&nbsp;for Herceptin<\/strong>&nbsp;: may&nbsp;<strong>affect<\/strong>&nbsp;up to 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>jaundice<\/li><li>anaphylactic reactions<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;reported with Herceptin<\/strong>&nbsp;no known frequency (can not be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal or impaired blood coagulation (blood clotting)<\/li><li>high potassium levels<\/li><li>swelling or bleeding behind the eyes<\/li><li>shock<\/li><li>abnormal heart rhythm<\/li><li>respiratory distress<\/li><li>breathing problems<\/li><li>acute&nbsp;accumulation of fluid in the lungs<\/li><li>acutely&nbsp;narrower airways<\/li><li>abnormally low oxygen content in the blood<\/li><li>difficulty breathing when lying upright<\/li><li>liver damage<\/li><li>swelling of the face, lips and neck<\/li><li>kidney failure<\/li><li>abnormally little amniotic fluid around the fetus in the womb<\/li><li>underdeveloped lungs of the fetus in utero<\/li><li>abnormal development of the kidneys of the fetus in the womb<\/li><\/ul>\n\n\n\n<p>Some of the&nbsp;side effects&nbsp;you are experiencing may be due to your underlying breast cancer disease.&nbsp;If you are treated with Herceptin with&nbsp;chemotherapy&nbsp;you can some of the&nbsp;side effects&nbsp;are also due to&nbsp;chemotherapy&nbsp;engines.<\/p>\n\n\n\n<p><em>Reporting of side effects<\/em><\/p>\n\n\n\n<p>If you get any side effects, talk to your doctor, pharmacist or nurse.&nbsp;This also applies to any side effects not mentioned in this information.&nbsp;You can also report side effects directly to the Medical Products Agency.&nbsp;By reporting side effects, you can help increase drug safety information.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5. How to store Herceptin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the outer carton (EXP) and on the vial label (EXP).&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00baC &#8211; 8 \u00baC).<\/p>\n\n\n\n<p>Keep the vial in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>After opening the vial, the solution should be used immediately.<\/p>\n\n\n\n<p>Do not use this medicine if you see particles or discoloration before&nbsp;administration&nbsp;.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the packaging and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is trastuzumab.&nbsp;A&nbsp;vial&nbsp;of 5 ml containing 600 mg trastuzumab.<\/li><li>The other ingredients are&nbsp;recombinant&nbsp;human hyaluronidase (rHuPH20), L \u2011 histidine, L \u2011 histidine hydrochloride monohydrate, \u03b1, \u03b1 \u2011 trehalose dihydrate, L-methionine, polysorbate 20, water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Herceptin is a&nbsp;solution for injection&nbsp;in a&nbsp;glass&nbsp;vial&nbsp;with a rubber stopper and contains 5 ml (600 mg) of trastuzumab.&nbsp;Clear to opalescent, colorless to pale yellow.<\/p>\n\n\n\n<p>Each carton contains 1&nbsp;vial&nbsp;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Roche Registration GmbH<\/p>\n\n\n\n<p>Emil-Barell-Strasse 1<\/p>\n\n\n\n<p>79639 Grenzach-Wyhlen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Roche Pharma AG<br>Emil-Barell-Strasse 1<br>79639 Grenzach-Wyhlen<br>Germany<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<br><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Sverige<\/strong><br>Roche AB<br>Tel: +46 (0) 8 726 1200<\/td><td><strong>Suomi \/ Finland<\/strong><br>Roche Oy<br>Puh \/ Tel: +358 (0) 10 554 500<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Herceptin contains the active substance trastuzumab, which is a monoclonal antibody. Monoclonal antibodies are attached to specific proteins or antigens. Trastuzumab is designed to bind selectively to an antigen called human epidermal growth factor receptor 2 ( HER2 ). HER2 is found in large amounts on the surface of certain cancer cells ( HER2 -positive cancer) and then stimulates cell growth. When Herceptin binds to HER2, the growth of the cancer cells is stopped, which leads to their death.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,2208],"tags":[13808,13803,13805,13809,13800,13804,13807,13806,13801,13802],"class_list":["post-13754","post","type-post","status-publish","format-standard","hentry","category-medicines","category-h","tag-benefits-of-herceptin","tag-benefits-of-trastuzumab","tag-herceptin","tag-herceptin-side-effects","tag-trastuzumab","tag-trastuzumab-side-effects","tag-what-herceptin-is-used-for","tag-what-is-herceptin","tag-what-is-trastuzumab","tag-what-trastuzumab-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=13754"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13754\/revisions"}],"predecessor-version":[{"id":15292,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/13754\/revisions\/15292"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=13754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=13754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=13754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}